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Maternal Vitamin D Deficiency and Risk of Development of Gestational Diabetes Mellitus: A Scoping Review

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Journal of Biosciences and Medicines 2023年第4期11卷 220-238页

作者： Yureka Demini Wimalajeewa usha Pushkala kumari Hettiaratchi Thamara Dilhani Amarasekara Shamini Prathapan Mathota Arachchilage Madura Mangala Jayawardane Department of Obstetrics & Gynaecology Faculty of Medical Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Department of Biochemistry Faculty of Medical Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Department of Nursing & Midwifery Faculty of Allied Health Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka Department of Community Medicine Faculty of Medical Sciences University of Sri Jayewardenepura Nugegoda Sri Lanka

Background: Maternal vitamin D status is a critical determinant during pregnancy, because it plays an important role in the body not only in calcium homeostasis and bone remodeling, but also in the glucose metabolism. Vitamin D deficiency is associated with adverse pregnancy outcomes including gestational diabetes mellitus. Objective: To review evidence on the association between maternal vitamin D deficiency and incidence of gestational diabetes mellitus (GDM). Methods: PRISMA for scoping review guideline and scoping review guidelines of Arksey & O’Malley (2005) was followed in methodological process. A comprehensive search strategy was carried out across the Google Scholar and PubMed from January 2012 to December 2022, using the search terms of “gestational diabetes mellitus/pregnancy outcomes” combined with “vitamin D”, “cholecalciferol” or “25-hydroxyvitamin D” and/or “deficiency”. Articles were screened at the title and the abstract level and at full text by three co-investigators of the study independently with a fourth reviewer resolving discrepancies. Research studies published only in English language were selected. Research using pregnant mothers with multiple pregnancy and chronic diseases was excluded. Results: After screening 134 titles and abstracts, finally 55 original research articles were selected. It involved 48 observational studies and 7 Randomized Control Trials (RCT). Only 30 research articles had found an association between maternal vitamin D deficiency and GDM. Conclusion: As results of previous studies are mixed and inconclusive, further research including more RCTs is needed to clarify the exact mechanism of vitamin D on glucose metabolism during pregnancy.

关键词： Gestational Diabetes Mellitus Maternal Vitamin D Deficiency

COVID-19-associated mucormycosis and treatments

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Asian Pacific Journal of Tropical Medicine 2021年第9期14卷 401-409页

作者： Vetriselvan Subramaniyan Shivkanya Fuloria Hari Kumar Darnal Dhanalekshmi Unnikrishnan Meenakshi Mahendran Sekar Rusli Bin Nordin Srikumar Chakravarthi Kathiresan V.Sathasivam Shah Alam Khan Yuan Seng Wu usha kumari Kalvatala Sudhakar Rishabha Malviya Vipin Kumar Sharma Neeraj Kumar Fuloria Faculty of Medicine Bioscience and NursingMAHSA UniversityJalan SP 2Bandar Saujana Putra42610 Jenjarom SelangorMalaysia Faculty of Pharmacy&Centre of Excellence for Biomaterials Engineering AIMST UniversityBedong 08100KedahMalaysia Jeffrey Cheah School of Medicine&Health Sciences Monash UniversitySelangor 47500Malaysia College of Pharmacy National University of Science and Technology130 MuscatSultanate of Oman Department of Pharmaceutical Chemistry Faculty of Pharmacy and Health SciencesUniversiti Kuala Lumpur Royal College of Medicine PerakIpoh 30450Malaysia Faculty of Applied Science&Centre of Excellence for Biomaterials Engineering AIMST UniversityKedahBedong 08100Malaysia Centre for Virus and Vaccine Research&Department of Biological Sciences School of Medical and Life SciencesSunway UniversitySelangor 47500Malaysia Faculty of Medicine AIMST UniversityKedah 08100Malaysia School of Pharmaceutical Sciences(LIT-Pharmacy) Lovely Professional UniversityJalandhar 144411India Department of Pharmacy SMASGalgotias UniversityGreater Noida 203201India Department of Pharmaceutical Sciences Gurukul KangriHaridwarUttarakhand 249404India

In the current pandemic,COVID-19 patients with predisposing factors are at an increased risk of mucormycosis,an uncommon angioinvasive infection that is caused by fungi with Mucor genus which is mainly found in plants and *** development in COVID-19 patient is related to various factors,such as diabetes,immunocompromise and *** use of glucocorticoids for the treatment of critically ill COVID-19 patients also leads to opportunistic infections,such as pulmonary ***-19 patients with mucormycosis have a very high mortality *** review describes the pathogenesis and various treatment approaches for mucormycosis in COVID-19 patients,including medicinal plants,conventional therapies,adjunct and combination therapies.

关键词： Mucormycosis COVID-19 Immunosuppression Pathogenesis Treatment

Application of Pomegranate Rind Extract for Improvement of Functional Properties of Various Materials—A Critical Review

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Open Journal of Composite Materials 2024年第2期14卷 71-90页

作者： Habeebunissa Nooman Narayanan Gokarneshan Murugan Umamaheswari Muthumani Dhiliphan Kumar usha kumari Ratna Jayagopal Lavanya Senthamarai Kannan Umamageshwari Sona Mohandas Anton Zahurudeen Shahanaz Venkatesan Sathya David Piriadarshani Chokkanathan Kayalvizhi Department of Knitwear Design National Institute of Fashion Technology Chennai India Department of Textile Chemistry SSM College of Engineering Komarapallayam India Department of Management Studies Dr. SNS Rajalakshmi College of Arts and Science Coimbatore India Department of Business Administration Kalasalingam Business School Kalasalingam Academy of Research and Education Srivilliputhur India Department of Textiles and Clothing Avinashi Lingam Institute for Home Science and Higher Education for Women Coimbatore India Department of Fashion Design SRM Institute of Science and Technology (Kattankalathur) Chennai India Department of Fashion Design Hindustan Institute of Technology and Science Chennai India Department of Fashion Design SRM Institute of Science and Technology (Ramapuram) Chennai India Department of Mathematics Hindustan Institute of Technology and Science Chennai India Department of Textile Technology Jaya Engineering College Tiruninravur India

Pomegranate rind is abundantly available as a waste material. Pomegranate Rind Extract (PRE) can be applied to cotton fabrics for its natural colours, as a mordanting agent and also for imparting certain functional properties such as fire retardancy and antimicrobial properties. This paper reviews the feasibility of Pomegranate Rind Extract to improve the functional properties of cellulosic fabrics. Studies show that varying concentrations and higher temperatures that were used to apply the extract on the fabric, resulted in enhanced functional properties. At a particular concentration, the treated fabric showed a 15 times lower burning rate in comparison with the control fabric. Also, antimicrobial efficacy has been observed against Gram-positive and Gram-negative bacteria. Due to the natural colouring material, it can be used as a natural dye on cotton material. The fire retardancy of pomegranate rind extract was tested on jute material under varying alkalinity. Research has indicated that pomegranate rind extract could be used to dye polyamide as well. The rubbing and wash fastness of the finished fabrics is good. The light fastness was fair, and its antibacterial efficiency against tested bacteria was good.

关键词： Natural Polymers Synthetic Polymers Pomegranate Rind Extract (PRE) Dyeing Functional Property

Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease

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World Journal of Gastroenterology 2006年第22期12卷 3602-3608页

作者： Kim Vaiphei Neeraj kumari Saroj Kant Sinha usha Dutta Birinder Nagi Kusum Joshi Kartar Singh Department of Histopathology PGIMER ChandigarhIndia Department of Gastroenterology PGIMER ChandigarhIndia

AIM： To evaluate roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease （IPSID） and to study profiles of kappa （κ） and lambda （λ） light chains and IgA heavy chain. METHODS： The study consisted of 11 cases of IPSID and similar number of controls which included 11 of normal intestinal mucosa and 11 of high grade B cell lymphoma of ileum. The parameters analyzed included clinical profiles, biochemical and other laboratory investigations, radiologic and histological findings including immunohistochemistry. RESULTS： All IPSID cases had demonstrable serum IgA heavy chain and heavy mucosal plasma cell infiltration. According to Galian＇s histological staging, there were 4 patients with stage A and 7 with stage B. κ and ;λ light chains were over-expressed in 7 patients; 1 stage A patient had H pylori-positive active gastritis and eradication of H pylori led to disease remission. Stage A biopsies had higher expression for syndecan-1, while stage B had higher expression for bcl6 and p53. Syndecan-1,κ and λ light chains and IgA heavy chain showed inverse relationship with bcl6 and p53. All patients were treated with doxycycline. CHOP regime was added in 5 patients who developed frank lymphoma. Three died of the disease due to extensive organ infiltration. CONCLUSION： Certain immunomarkers like syndecan-1,κ and λ light chains and IgA heavy chain could be of much help in identifying early stage IPSID. Stage B IPSID showed higher expression for bcl6 and p53 than stage A IPSID. bcl6 and p53 expressions correlated with a more advanced disease stage and aggressive tumour behavior.

关键词： IPSID Syndecan-1 bcl6 p53 protein κ and λ light chains Alpha heavy chain H pylori

An enhanced method for predicting and analysing forest fires using an attention-based CNN model

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Journal of Forestry Research 2024年第4期35卷 115-127页

作者： Shaifali Bhatt usha Chouhan Department of Mathematics Bioinformatics and Computer ApplicationsMANIT BhopalBhopalIndia

Prediction,prevention,and control of forest fires are crucial on at all *** effective fire detection systems can aid in their *** study proposes a novel CNN(convolutional neural network)using an attention blocks module which combines an attention module with numerous input layers to enhance the performance of neural *** suggested model focuses on predicting the damage affected/burned areas due to possible wildfires and evaluating the multilateral interactions between the pertinent *** results show the impacts of CNN using attention blocks for feature extraction and to better understand how ecosystems are affected by meteorological *** selected meteorological data,RMSE 12.08 and MAE 7.45 values provide higher predictive power for selecting relevant and necessary features to provide optimal performance with less operational and computational *** findings show that the suggested strategy is reliable and effective for planning and managing fire-prone regions as well as for predicting forest fire damage.

关键词： CNN Attention module Fire prediction Ecosystem Damage prediction

Energy feedback and synchronous dynamics of Hindmarsh–Rose neuron model with memristor

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Chinese Physics B 2019年第2期28卷 137-146页

作者： K usha P A Subha Department of physics University of Calicut Department of physics Farook College University of Calicut

We analyze the energy aspects of single and coupled Hindmarsh–Rose(HR) neuron models with a quadratic flux controlled memristor. The energy function for HR neuron with memristor has been derived and the dynamics have been analyzed in the presence of various external stimuli. We found that the bursting mode of the system changes with external forcing. The negative feedback in Hamilton energy function effectively stabilizes the chaotic trajectories and controls the phase space. The Lyapunov exponents have been plotted to verify the stabilization of trajectories. The energy aspects during the synchronous dynamics of electrically coupled neurons have been analyzed. As the coupling strength increases, the average energy fluctuates and stabilizes at the point of synchronization. When the neurons are coupled via chemical synapse,the average energy variations show three important regimes: a fluctuating regime corresponding to the desynchronized, a stable region indicating synchronized and a linearly increasing regime corresponding to the amplitude death states have been observed. The synchronization transitions are verified by plotting the transverse Lyapunov exponents. The proposed method has a large number of applications in controlling coupled chaotic systems and in analyzing the energy change during various metabolic processes.

关键词： HR model memristor Hamilton energy energy feedback synchronization

Analytical method for cell displacement defect quantum-dot cellular automata primitive

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Journal of Electronic Science and Technology 2023年第1期21卷 26-34页

作者： Vaishali Dhare usha Mehta Institute of Technology Nirma UniversityAhmedabad382481India

Quantum-dot cellular automata(QCA)is an emerging computational paradigm which can overcome scaling limitations of the existing complementary metal oxide semiconductor(CMOS)*** existence of defects cannot be ignored,considering the fabrication of QCA devices at the molecular level where it could alter the ***,defects in QCA devices need to be *** far,the simulation-based displacement defect analysis has been presented in the literature,which results in an increased demand in the corresponding mathematical *** this paper,the displacement defect analysis of the QCA main primitive,majority voter(MV),is presented and carried out both in simulation and mathematics,where the kink energy based mathematical model is *** results demonstrate that this model is valid for the displacement defect in QCA MV.

关键词： Displacement defect Kink energy Majority voter(MV) Quantum-dot cellular automata (QCA)

Morphological and molecular characterizations of cereal cyst nematode Heterodera avenae Wollenweber, 1924 from the Czech Republic

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Journal of Integrative Agriculture 2017年第3期16卷 532-539页

作者： Shesh kumari Division of Crop Protection and Plant Health Crop Research Institute Prague 16106 Czech Republic

The cereal cyst nematode,Heterodera avenae Wollenweber,1924,is a major pest of cereal crops throughout the world and causes serious yield losses,especially of *** studies have shown that this species is widely distributed in the Czech *** this study,seven populations of *** were molecularly studied,and one population was morphologically *** regions（18S,28S,and internal transcribed spacer 1）of ribosomal DNA were sequenced and the analysis of the 18S gene of six populations did not reveal any variation,whereas the internal transcribed spacer 1and 28S sequences of six populations differed by only two nucleotides from a population in？*** and quick identification of cereal cyst nematodes is important for effective control measures and ribosomal sequence analyses of seven populations in this study will be useful in future phylogenetic studies of Heterodera *** in the Czech Republic.

关键词： Heterodera avenae PCR ribosomal DNA sequencing nematode

Anticancer Activity of Rice Callus Suspension Cultures from Aromatic Varieties and Metabolites Regulated in Treated Cancer Cell Lines

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Rice science 2024年第4期31卷 449-462,I0027-I0030页

作者： Anuradha kumari Wusirika RAMAKRISHNA Department of Biochemistry Central University of PunjabPunjab 151401India

Tissue culture techniques were used to produce large amounts of bioactive compounds with medicinal potential, overcoming space and time constraints for cancer prevention. Rice callus suspension cultures(RCSC) and seed extracts prepared from aromatic rice varieties were used to evaluate the cytotoxic impact on human colon and lung cancer cell lines, as well as a normal control cell line, using Taxol as a positive control. RCSC and seed extracts from two Indian aromatic rice varieties were applied at different concentrations to treat the cancer cell lines and normal lung fibroblasts over varying time intervals. Apoptosis was assessed in 1:5 dilutions of the A549 and HT-29 cell lines treated with RCSC for 72 h, using propidium iodide staining and flow cytometry. RCSC showed a more potent cytotoxic effect than seed extracts with minimal effect on the normal cell line, in contrast to Taxol. Confocal microscopy and flow cytometry further confirmed the apoptotic effect of RCSC. Gas chromatography-mass spectrometry-based metabolic profiling identified metabolites involved in cytotoxicity and highlighted altered pathways. RCSC is proposed as an alternative source for the development of novel anticancer drugs with reduced side effects.

关键词： anticancer cytotoxicity metabolite profiling plant tissue culture rice callus suspension culture secondary metabolite