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Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis

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World Journal of Orthopedics 2024年第11期15卷 1056-1074页

作者： usama ismaeil hagag Fatma Mohamed Halfaya Hessah Mohammed Al-Muzafar Suhailah Saud Al-Jameel Kamal Adel Amin Wael Abou El-Kheir Emad A Mahdi Gamal Abdel-Nasser Ragab Hassan Osama Mohamed Ahmed Department of Surgery Beni-Suef UniversityBeni Suef 62111Egypt Department of Surgery Anesthesiology and RadiologyBeni-Suef UniversityBeni Suef 62111Egypt Department of Chemistry College of ScienceBasic and Applied Scientific Research CenterImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Department of Chemistry BiochemistryCollege of ScienceBasic and Applied Scientific Research Center(BASRC)Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Department of Immunology Military Medical AcademyCairo 11511Al QāhirahEgypt Department of Pathology Beni-Suef UniversityBeni Suef 62111Egypt Department of Surgery Anesthesiology and RadiologyFaculty of Veterinary MedicineBeni-Suef UniversityBeni Suef 62521Egypt

BACKGROUND No effective treatment guarantees full recovery from osteoarthritis(OA),and few therapies have *** To determine if bone marrow mesenchymal stem cells(BMMSCs)and hyaluronic acid(HA)treat ankle OA in Wistar *** BMMSCs were characterized using flow cytometry with detection of surface markers[cluster of differentiation 90(CD90),CD105,CD34,and CD45].Fifty male Wistar rats were divided into five groups of 10 rats each:Group I,saline into the right tibiotarsal joint for 2 days;Group II,monosodium iodate(MIA)into the same joint;Groups III,MIA+BMMSCs;Group IV,MIA+HA;and Group V,MIA+BMMSCs+***(1×106 cells/rat),HA(75μg/rat),and BMMSCs(1×106 cells/rat)alongside HA(75μg/rat)were injected intra-articularly into the tibiotarsal joint of the right hind leg at the end of weeks 2,3,and 4 after the MIA *** The elevated right hind leg circumference values in the paw and arthritis clinical score of osteoarthritic rats were significantly ameliorated at weeks 4,5,and *** peroxide significantly increased in the serum of osteoarthritic rats,whereas reduced serum glutathione and glutathione transferase levels were *** and HA significantly improved *** significantly elevated ankle matrix metalloproteinase 13(MMP-13)mRNA and transforming growth factor beta 1(TGF-β1)protein expression,and tumor necrosis factor alpha(TNF-α)and interleukin-17(IL-17)serum levels in osteoarthritic rats were significantly downregulated by BMMSCs and *** effects of BMMSCs and HA on serum TNF-αand IL-17 were more potent than their *** lowered serum IL-4 levels in osteoarthritic rats were significantly upregulated by BMMSCs and ***,BMMSCs and HA caused a steady decrease in joint injury and cartilage *** BMMSCs and/or HA have anti-arthritic effects mediated by antioxidant and anti-inflammatory effects on MIAinduced ***-13 and TGF-β1 expression improves BMMSCs and/or HA effects on OA in Wistar rats.

关键词： Osteoarthritis Anti-inflammatory Antioxidant Bone marrow mesenchymal stem cells Hyaluronic acid

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