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Theplant cytosolic m^(6)A RNA methylome stabilizes photosynthesis in the cold

Plant Communications 2023年第6期4卷 70-84页

作者： Alexandre Magno Vicente Nikolay Manavski Paul Torben Rohn Lisa-Marie Schmid Antoni Garcia-Molina Dario Leister Charlotte Seydel Leo bellin Torsten Möhlmann Gregor Ammann Stefanie kaiser Jörg Meurer Plant Molecular biology Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany Plant Development Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany Plant Physiology Faculty of BiologyUniversity of KaiserslauternErwin-Schröodinger-Street767663 KaiserslauternGermany Pharmaceutical Chemistry Goethe University FrankfurtMax-von-Laue-Str.960438 Frankfurt am MainGermany Present address:Loewe biochemica GmbH Möuhlweg 2a82054 SauerlachGermany Present address:Center for Research in Agricultural Genomics 08193

The sessile lifestyle of plants requires an immediate response to environmental stressors that affect photosynthesis,growth,and crop ***,we showed that three abiotic perturbations—heat,cold,and high light—triggered considerable changes in the expression signatures of 42 epitranscriptomic factors(writers,erasers,and readers)with putative chloroplast-associated functions that formed clusters of commonly expressed genes in *** expression changes under all conditions were reversible upon deacclimation,identifying epitranscriptomic players as modulators in acclimation *** dysfunctions,particularly those induced by the oxidative stress-inducing norflurazon in a largely GENOME UNCOUPLED-independent manner,triggered retrograde signals to remodel chloroplastassociated epitranscriptomic expression patterns.N6-methyladenosine(m^(6)A)is known as the most prevalent RNA modification and impacts numerous developmental and physiological functions in living *** cold treatment,expression of components of the primary nuclear m^(6)A methyltransferase complex was upregulated,accompanied by a significant increase in cellular m^(6)A mRNA *** the cold,the presence of FIP37,a core component of the writer complex,played an important role in positive regulation of thylakoid structure,photosynthetic functions,and accumulation of photosystemⅠ,the Cytb6f complex,cyclic electron transport proteins,and Curvature Thylakoid1 but not that of photosystemⅡcomponents and the chloroplast ATP *** of FIP37 affected abundance,polysomal loading,and translation of cytosolic transcripts related to photosynthesis in the cold,suggesting m^(6)Adependent translational regulation of chloroplast *** summary,we identified multifaceted roles of the cellular m^(6)A RNA methylome in coping with cold;these were predominantly associated with chloroplasts and served to stabilize photosynthesis.

关键词： m^(6)A RNA methylation cold acclimation stress response Arabidopsis thaliana photosynthesis chloroplast

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The Role of Copper and Vitamin A Deficiencies Leading to Neurological Signs in Captive Cheetahs(Acinonyx jubatus)and Lions(Panthera leo)in the United Arab Emirates

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Food and Nutrition Sciences 2014年第20期5卷 1978-1990页

作者： Claudia kaiser Ulrich Wernery Jorg Kinne Laurie Marker Annette Liesegang Central Veterinary Research Laboratory DubaiUnited Arab Emirates Institute of Animal Nutrition Vetsuisse Faculty ZurichZürichSwitzerland Cheetah Conservation Fund Farm Elandsvreugde#367OtjiwarongoNamibia Center for Applied biotechnology and Molecular Medicine University of ZurichZürichSwitzerland

Neurological signs like ataxia and hind limb paresis have often been reported in cheetahs (Acinonyx jubatus), lions (Panthera leo) and snow leopards (Panthera unica). As a cause, copper and Vitamin A deficiencies have been discussed. Many cases were seen in cheetahs and lions in the United Arab Emirates (UAE) within the last years. The aim of this study was to find correlations between nutrition, serum, and tissue levels, focusing on copper and Vitamin A. blood and tissue samples of affected and unaffected animals were analyzed at the Central Veterinary Research Laboratory in Dubai, UAE. Animals were split into three different groups (A, b and C) according to their diets. Minerals were determined in serum, tissue, food and water samples, and serum was additionally analyzed for Vitamin A and E. Liver, kidney and spinal cord samples were taken for histopathological investigations. Mean serum copper and liver copper levels of animals fed pure chicken muscle meat without supplements were significantly lower (0.41 ± 0.71 μM/L;2.16 ± 0.95 ppm wet weight) than in animals fed a whole carcass prey diet (12.16 ± 3.42 μM/L;16.01 ± 17.51 ppm wet weight) (p based on poultry without supplements.

关键词： Ataxia Cheetah(Acinonyx jubatus) Copper Lion(Panthera leo) Vitamin A

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Reversible hydrogenation restores defected graphene to graphene

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Science China Chemistry 2021年第6期64卷 1047-1056页

作者： Lin Jiang Pauline MGvan Deursen Hadi Arjmandi-Tash Liubov Abelyaeva Haoyuan Qi Jiao He Vincent Kofman Longfei Wu Valery Muravev Ute kaiser Harold Linnartz Emiel JMHensen Jan PHofmann Grégory FSchneider Leiden Institute of Chemistry Leiden UniversityEinsteinweg 552333CC LeidenThe Netherlands Central Facility for Electron Microscopy Electron Microscopy Group of Materials ScienceUlm UniversityAlbert-Einstein-Allee 11Ulm 89081Germany Laboratory for Astrophysics Leiden ObservatoryLeiden UniversityNiels Bohrweg 22333 CA LeidenThe Netherlands Laboratory for Inorganic Materials and Catalysis Department of Chemical Engineering and ChemistryEindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands Center for Advancing Electronics Dresden(cfaed)and Faculty of Chemistry and Food Chemistry Technical University of Dresden010069 DresdenGermany

Graphene as a two-dimensional material is prone to hydrocarbon contaminations,which can significantly alter its intrinsic electrical ***,we implement a facile hydrogenation-dehydrogenation strategy to remove hydrocarbon contaminations and preserve the excellent transport properties of monolayer *** electron microscopy we quantitatively characterized the improved cleanness of hydrogenated graphene compared to untreated *** situ spectroscopic investigations revealed that the hydrogenation treatment promoted the adsorption of water at the graphene surface,resulting in a protective layer against the re-deposition of hydrocarbon ***,the further dehydrogenation of hydrogenated graphene rendered a more pristine-like basal plane with improved carrier mobility compared to untreated pristine *** findings provide a practical post-growth cleaning protocol for graphene with maintained surface cleanness and lattice integrity to systematically carry a range of surface chemistry in the form of a well-performing and reproducible transistor.

关键词： graphene reversible hydrogenation surface cleanness in situ spectroscopy transistors

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单件产品制造中的时变复杂性控制──面向过程的质量管理方法

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工业工程与管理 1999年第1期4卷 30-35页

作者： A.Storr L.kaiser b.Rempp 陆新德国斯图加特大学机床和制造设备控制技术研究所

根据时变复杂性概念的分析，指出单件产品制造中的典型问题，并由此为协调项目管理及质量管理的各项任务推导出解决办法。介绍了透明地表达实际项目流程、最重要的过程、使用的方法及辅助手段的结构步骤。

关键词：时变复杂性单件产品项目管理质量管理

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粘结式岩石锚杆设计中的解析模型

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公路隧道 2002年第1期 19-31页

作者： b．Indraratna P．K．kaiser 刘洪洲熊有言

本文推出了一个解析模型，用来表征静水应力场中圆形地下洞室附近被加固围岩的特性。该模型采用了弹塑性理论，并考虑了地层和粘结式(或摩擦式)锚杆间适当的相互作用机理。它着重探讨了锚杆布置型式对塑性区范围和隧道变形的影响，并引... 详细信息

本文推出了一个解析模型，用来表征静水应力场中圆形地下洞室附近被加固围岩的特性。该模型采用了弹塑性理论，并考虑了地层和粘结式(或摩擦式)锚杆间适当的相互作用机理。它着重探讨了锚杆布置型式对塑性区范围和隧道变形的影响，并引入一个无量纲参数来作为设计工具，它将隧道收敛和给定锚杆长度的锚杆间距联系起来。本文介绍该模型的推求过程，并解释锚杆对洞室周围应力场和位移场的影响．扼要探讨了该模型在隧道设计中的应用。在随后的论文中将详细给出用实验室模拟和现场测试结果检验该模型的情况。

关键词：粘结式岩石锚杆解析模型应力场地下洞室弹塑性隧道设计收敛控制法等效塑性区

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Tosyl-substituted 3H-1,2,3,4-Triazaphospholes: Synthesis and Unexpected Coordination Chemistry

Tosyl-substituted 3H-1,2,3,4-Triazaphospholes: Synthesis and...

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中国化学会第十届全国无机化学学术会议

作者： Erlin Yue Julian A.W.Sklorz Selina kaiser Christian Müller College of Chemistry and Chemical Engineering Yan'an University Institute of Chemistry and biochemistry Freie Universit?t Berlin

Triazaphospholes(TAPs) as a fascinating class of low-coordinate phosphourus heterocycle compounds, containing a conjugated π system with high degree of aromaticity and a rather high π density at the phosphorus atom have also attracted much interest over the past decades. 3 H-1,2,3,4-triazaphospholes as phosphorus analogues of the well-documented 1,2,3-triazoles, first reported by Regitz et al. in 1984, were prepared by a [3+2] cycloaddition reaction of phosphaalkynes with azides in the absence of the requirement of a catalyst. Until now, mainly TAPs with electron donating substituents have been extensively investigated. In order to gain further insight into the scope of TAPs, we start to explore the reactivity and coordination chemistry of the TAPs containing an electron-withdrawing tosyl group. Herein we report on the synthesis and characterization of the tosyl-substituted 3 H-1,2,3,4-triazaphospholes(1 a, b) and their gold(I) complexes(2 a, b) based on cyclo-1,3-diphospha-2,4-diazanes, which confirmed by single crystal X-ray crystallography analyses. by investigation the proposed mechanism of the reaction, it is notable that the tert-butyl group were converted into the iso-pentenyl substituents by methyl migration besides obvious spontaneous nitrogen extrusion which monitored by GC-TCD. The phosphorus atoms were coordinated with gold(I) precursor, respectively. The trapping experiments also showed that a key intermediate iminophosphine was confirmed by ESI-MS.

关键词： tosyl-3H-1,2,3,4-triazaphospholes Au(I) complex cyclodiphosphdiazane iminophosphine

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美国圣胡安盆地的次生生物成因和热成因煤层气

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天然气地球科学 1997年第4期8卷 29-35页

作者： Andrew R.Scott W.R.kaiser Walter b.AyersJr 吴新年美国

描述了圣胡安盆地次生生物成因煤层气和热成因煤层气(Thermogenicgases)的生成、运移和聚集成藏过程以及这两种气体的主要组成成分。分析了影响这两种煤成气产能的主导因素。

关键词：盆地煤层气热成因天然气次生生物成因

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并发脉络膜上腔出血:一个病例对照研究

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 21-22页

作者： Moshfeghi D.M. Kim b.Y. kaiser P.K. 司冰心

To identify the risk factors, prognostic factors, and clinical outcomes of pat ients with perioperative appositional suprachoroidal hemorrhage (ASCH). Case-co ntrol study. Tertiary referral center. Subjects included all patients with perio perative ASCH documented by b-scan ultrasound between May 1990 and March 2001. Two or three control patients were selected for each case, matched by surgeon, p rocedure, and date of surgery within 1 month. Surgery was performed as necessary . main outcome measures. The odds of ASCH associated with clinical risk factors. secondary outcome measure: visual acuity. Thirty-seven cases with ASCH were identified. Ninety-two proce dure-and surgeon-matched control subjects (2.48:1) were selected. Twenty-six cases (71%) of ASCH were related to a glaucoma operation. Risk factors for the development of ASCH included previous vitrectomy (P=.003, odds ratio of 12) and older age (P=.007, odds ratio 1.57/decade of increasing age). Hypertension was f ound to be protective (P=.02, odds ratio of 0.33). Factors associated with a poo r visual outcome in patients with ASCH included apposition >30 days (P=.01), his tory of uveitis (P=.04), history of dry age-related macular degeneration (P=.05 ), and history of extracapsular cataract extraction (P=.05). Median pre-ASCH vi sual acuity was 20/100, and final median visual acuity was 20/1600. Risk factors for the development of ASCH include previous vitrectomy and older age. Patients with these risk factors should be informed of their greater chance of poor visu al acuity and anatomic outcomes secondary to the development of ASCH.

关键词：脉络膜上腔病例对照研究玻璃体切割术手术日期青光眼手术围手术期临床危险因素葡萄膜炎诊疗中心临床疗效

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Prevalence of Depression in Pre-Dialytic Chronic Kidney Disease Patients Attending at a Tertiary Care Hospital in bangladesh

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Journal of biosciences and Medicines 2020年第12期8卷 135-148页

作者： A. K. M. Shahidur Rahman Mohammad Shamsul Ahsan Mohammad Kamrul Ahsan A. b. M. Mobasher Alam Tanvir Rahman Shahida Mullah Md. Mustafizur Rahman Salahuddin Feroz Amir Mohammad kaiser Md. Shariful Haque Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Holy Family Red Crescent Medical College Hospital (HFRCMCH) Dhaka Bangladesh Department of Nephrology Rangpur Medical College Hospital (RMCH) Rangpur Bangladesh Department of Nephrology United Hospital Limited Dhaka Bangladesh Department of Medicine Sarkari Karmachari Hospital Dhaka Bangladesh Department of Nephrology Sheikh Hasina Medical College Tangail Bangladesh Sheikh Hasina National Institute of burn and Plastic Surgery Dhaka Bangladesh Department of Nephrology & Dialysis Gonoshaystha Somazvittik Medical College and Gonoshaystha Nagar Hospital Dhaka Bangladesh Department of Nephrology Shaheed M. Monsur Ali Medical College Sirajgonj Bangladesh

background: Depression is a common and serious medical illness around the world. It occurs more frequently in patients with chronic illness than in the general population. It is a common psychiatric problem in patients with chronic kidney disease (CKD). Objective: To assess the level of depression in pre-dialytic CKD patients attending at a tertiary care hospital in bangladesh. Methodology: This cross sectional study was conducted at Department of Nephrology, bangabandhu Sheikh Mujib Medical University (bSMMU), Dhaka, bangladesh from January 2020 to June 2020. A total of 100 pre-dialytic CKD patients were selected by convenience sampling technique and their level of depression was assessed by Zung Self-Rating Depression Scale (ZSDS). Data were collected by existing questionnaire with face to face interview and analyzed by statistical test. Results: The mean age of the participants was 49.70 ± 11.80 years. Among them 64% were male, 95% were muslim, 98% were married, 65% were completed secondary/above higher secondary level education, 65% were unemployed and 55% were lived in urban area. It was observed that 65% participants were economically dependent to their family, only 6% were engaged in regular exercise, 14% had family history of depression, 8% were smoker and 12% were alcohol/drug abuser. According to the Zung Self-Rating Depression Scale (ZSDS) we found 29% participants were mildly depressed, 39% participants were moderately depressed and 18% participants were severely depressed. Prevalence of depression was 86% in pre-dialytic CKD patients. Of them, 7% was in CKD stage-I, 17.4% was in CKD stage-II, 19.8% was in CKD stage-III, 22.1% was in CKD stage-IV and 33.7% was in CKD stage-V. Conclusion: Depression is highly prevalent in pre-dialytic CKD patients and more frequent in the advanced stages of CKD.

关键词： Chronic Kidney Disease (CKD) Depression Zung Self-Rating Depression Scale (ZSDS)

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回旋状脉络膜视网膜萎缩的临床、生化和治疗

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国际眼科纵览 1988年第4期 203-210页

作者： kaiser-Kupfer MI Valle DL 张清炯

回旋状脉络膜视网膜萎缩是一种罕见的常染色体隐性遗传病,原发缺陷是鸟氨酸-δ-氨基转移酶活性缺乏,高鸟氨酸血症是其标志,主要症状和体征包括:近视、夜盲、白内障和脉缩膜视网膜萎缩。治疗措施为:口服维生素b6;限制精氨酸饮食和用肌酸... 详细信息

回旋状脉络膜视网膜萎缩是一种罕见的常染色体隐性遗传病,原发缺陷是鸟氨酸-δ-氨基转移酶活性缺乏,高鸟氨酸血症是其标志,主要症状和体征包括:近视、夜盲、白内障和脉缩膜视网膜萎缩。治疗措施为:口服维生素b6;限制精氨酸饮食和用肌酸治疗。本文从临床、生化和治疗等方面,对回旋状脉络膜视网膜萎缩进行了讨论。

关键词：脉络膜视网膜萎缩 OAT 白内障患者饮食如银内障鸟氨酸视网膜生化

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