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Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli uros marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

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Challenges and pitfalls of youth-onset type 2 diabetes

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World Journal of Diabetes 2024年第5期15卷 876-885页

作者： Lavinia La Grasta Sabolic Sanda marusic Maja Cigrovski Berkovic Department of Pediatric Endocrinology and Diabetology University Hospital Centre Sestre MilosrdniceZagreb 10000Croatia School of Medicine Catholic University of CroatiaZagreb 10000Croatia Department for Sport and Exercise Medicine University of Zagreb Faculty of KinesiologyZagreb 10000Croatia

The incidence and prevalence of youth-onset type 2 diabetes mellitus(T2DM)are *** rise in frequency and severity of childhood obesity,inclination to sedentary lifestyle,and epigenetic risks related to prenatal hyperglycemia exposure are important drivers of the youth-onset T2DM epidemic and might as well be responsible for the early onset of diabetes ***,youth-onset T2DM has a more extreme metabolic phenotype than adult-onset T2DM,with greater insulin resistance and more rapid deterioration of beta cell ***,intermediate complications such as microalbuminuria develop in late childhood or early adulthood,while end-stage complications develop in *** to the lack of efficacy and safety data,several drugs available for the treatment of adults with T2DM have not been approved in youth,reducing the pharmacological treatment *** this mini review,we will try to address the present challenges and pitfalls related to youth-onset T2DM and summarize the available interventions to mitigate the risk of microvascular and macrovascular complications.

关键词： Youth-onset type 2 diabetes mellitus Insulin resistance Beta cell failure Risk factors Therapy Complications

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Age-specific causes of upper gastrointestinal bleeding in children

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World Journal of Gastroenterology 2023年第47期29卷 6095-6110页

作者： Marija Kocic Petar Rasic Vuk marusic Dragan Prokic Djordje Savic Maja Milickovic Ivana Kitic Tanja Mijovic Adrijan Sarajlija Department of Gastroenterology Hepatology and NutritionMother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia Department of Abdominal Surgery Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia Institute of Epidemiology Faculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia Pediatric Day Care Hospital Department Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Belgrade 11000Serbia Department of Abdominal Surgery Mother and Child Health Care Institute of Serbia“Dr.Vukan Cupic”Radoja Dakica 6-8Belgrade 11000Serbia

The etiology of upper gastrointestinal bleeding(UGIB)varies by age,from newborns to adolescents,with some of the causes overlapping between age *** particular causes such as vitamin K deficiency and cow’s milk protein allergy are limited to specific age groups,occurring only in neonates and infants,others such as erosive esophagitis and gastritis may be identified at all ***,the incidence of UGIB is variable throughout the world and in different hospital *** North America and Europe,most UGIBs are nonvariceal,associated with erosive esophagitis,gastritis,and gastric and duodenal *** recent years,the most common causes in some Middle Eastern and Far Eastern countries are becoming similar to those in Western ***,variceal bleeding still predominates in certain parts of the world,especially in South *** most severe hemorrhage arises from variceal bleeding,peptic ulceration,and disseminated intravascular *** is a credible indicator of a UGI source of bleeding in the majority of *** familiar with the most likely UGIB causes in specific ages and geographic areas is especially important for adequate orientation in clinical settings,the use of proper diagnostic tests, and rapid initiation of the therapy. The fundamental approach to the management of UGIBincludes an immediate assessment of severity, detecting possible causes, and providing hemodynamic stability,followed by early endoscopy. Unusual UGIB causes must always be considered when establishing a diagnosis inthe pediatric population because some of them are unique to children. Endoscopic techniques are of significantdiagnostic value, and combined with medicaments, may be used for the management of acute bleeding. Finally,surgical treatment is reserved for the most severe bleeding.

关键词： Upper gastrointestinal bleeding Age-specific Epidemiology Pediatric Unusual cause

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Influence of various proton pump inhibitors on intestinal metaplasia in noneradicated Helicobacter pylori patients

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World Journal of Gastroenterology 2005年第15期11卷 2334-2336页

作者： Marinko marusic Zarko Babic Mirjana Nesanovic Mira Lucijanic-Mlinac Vesna Stajcar Division of Gastroenterology Department of Internal Medicine Department of Pathology

AIM: Intestinal metaplasia (IM) is more often found in patients with Helicobacter pylori (H pylori) infection, while eradication of H pylori results in significant reduction in the severity and activity of chronic gastritis. We aimed to determine in patients with unsuccessful eradication of H pylori the role of various proton pump inhibitors (PPIs) having different mechanisms in the resolution of IM. METHODS: We confirmed endoscopically and pathohistologically (Sydney classification) the IM in 335 patients with gastritis before and after medication for eradication of H pylori (Maastricht Protocol 2002). H pylori infection was determined by using histology, urease test and culture. Control endoscopy and histology were done after 30d and thereafter (within 1year). Unsuccessful eradication was considered if only one of the three tests (histology, urease and culture) was negative after therapy protocol. We used omeprazole, pantoprazole, lansoprazole in therapy protocols (in combination with two antibiotics).RESULTS: We found no significant difference in resolution of IM by using different PPI between the groups of eradicated and noneradicated patients (P<0.4821 and P<0.4388, respectively).CONCLUSION: There is no significant difference in resolution of intestinal metaplasia by different proton pump inhibitors.

关键词： H pylori Intestinal metaplasia

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Glucagon-like-1 receptor agonists and sodium/glucose cotransporter-2 inhibitors combination—are we exploiting their full potential in a real life setting?

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World Journal of Diabetes 2020年第11期11卷 540-552页

作者： Maja Cigrovski Berkovic Ines Bilic-Curcic Tomislav Bozek Davorka Herman Mahecic Sanja KlobucarMajanovic Silvija Canecki-Varzic Jelena Andric Srecko marusic Anna Mrzljak Faculty of Medicine J.J.Strossmayer University OsijekOsijek 31000Croatia Department for Endocrinology Diabetes and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia Department of Endocrinology and Metabolism Disorders Clinical Hospital CenterOsijek 31000Croatia University Clinic for Diabetes“Vuk Vrhovac” Merkur University HospitalZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Department for Endocrinology Diabetes and MetabolismUniversity Hospital Centre“Sestre milosrdnice”Zagreb 10000Croatia Department for Endocrinology Diabetes and MetabolismUniversity Hospital Centre RijekaSchool of MedicineUniversity of Rijeka51000 RijekaCroatia Department of Medicine Merkur University HospitalSchool of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUND The sodium/glucose cotransporter-2 inhibitors(SGLT-2i)and glucagon-like-1 receptor agonists(GLP-1RA)are antidiabetic agents effective both in hemoglobin A1c(HbA1c)reduction(with a low risk of hypoglycemia)and cardiovascular event *** patients with type 2 diabetes,the add-on value of combination therapy of GLP-1RA and an SGLT-2i seems *** To investigate whether the efficacy of GLP-1RA and SGLT-2i combination observed in randomized controlled trials translates into therapeutic benefits in the Croatian population during routine clinical practice and *** We included 200 type 2 diabetes patients with poor glycemic control and analyzed the effects of treatment intensification with(1)GLP-1RA on top of SGLT-2i,(2)SGLT-2i on top of GLP-1RA compared to(3)simultaneous addition of both *** primary study endpoint was the proportion of participants with HbA1c<7.0%and/or 5%bodyweight *** outcomes included changes in fasting plasma glucose(FPG),prandial plasma glucose,lowdensity lipoprotein cholesterol,estimated glomerular filtration rate(eGFR),and cardiovascular(CV)incidents assessment over a follow-up period of 12 *** The majority of patients were over 65-years-old,had diabetes duration for more than 10 *** initial body mass index was 39.41±5.49 kg/m2 and HbA1c 8.32±1.26%.Around half of the patients in all three groups achieved target HbA1c below 7%.A more pronounced decrease in the HbA1c seen with simultaneous SGLT-2i and GLP-1RA therapy was a result of higher baseline HbA1c and not the effect of initiating combination *** number of patients achieving FPG below 7.0 mmol/L was significantly higher in the SGLT-2i group(P=0.021),and 5%weight loss was dominantly achieved in the simultaneous therapy group(P=0.044).A composite outcome(reduction of HbA1c below 7%(53 mmol/mol)with 5%weight loss)was achieved in 32.3%of total patients included in the *** 18.2%of patients attained composite outc

关键词： Sodium/glucose cotransporter-2 inhibitors Glucagon-like-1 receptor agonists Type 2 diabetes mellitus Body weight Glycemic control Cardiovascular complications

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Early immune response in post endoscopic retrograde cholangiopancreatography pancreatitis as a model for acute pancreatitis

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World Journal of Meta-Analysis 2019年第3期7卷 96-100页

作者： Ivana Plavsic Ivana Zitinic Vera Tulic Goran Poropat Marinko marusic Goran Hauser Department of Anesthesiology and Critical care medicine Clinical Hospital CentreMedical FacultyUniversity of Rijeka Department of Emergency Medicine Clinical Hospital Centre Department of Internal Medicine Division of GastroenterologyClinical Hospital CentreMedical FacultyMedical Faculty RijekaUniversity of Rijeka Department of Internal Medicine Division of GastroenterologyClinical Hospital Sv.DuhZagrebFaculty of Health StudiesUniversity of Rijeka Department of Internal Medicine Division of GastroenterologyClinical Hospital CentreMedical FacultyFaculty of Health StudiesUniversity of Rijeka Medical Faculty Osijek University of J.J.Stossmayer

This opinion review summarizes comparison of clinical presentation and immunology of post-endoscopic pancreatitis and acute pancreatitis(AP) of other *** rationale for this topic was found in studies that mention differences in clinical presentation between these entities,stating that severe form of AP after endoscopic retrograde cholangiopancreatography was more severe than AP of other *** difference in clinical presentation may have a background in different immunology that needs to be further investigated.

关键词： Innate immunity Pancreatitis immunology Post endoscopic retrograde cholangiopancreatography pancreatitis

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Share it!对等机顶盒分权管理网络系统结构

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世界宽带网络 2005年第2期12卷 48-50,52页

作者： J·华克 O．J．Morries B．marusic 英国NDS公司成员英国Philips公司成员斯洛文尼亚Lijubljana大学成员

Share it!是欧盟投资的一个联合项目。该项目的目标是开发一个端到端的系统，以便在使用宽带接入的家庭用户之间简便地存取和传输数据。它通过将在线、广播和存储的内容无缝地组合起来，从而能在分权管理的网络中承载新业务．同时该项... 详细信息

Share it!是欧盟投资的一个联合项目。该项目的目标是开发一个端到端的系统，以便在使用宽带接入的家庭用户之间简便地存取和传输数据。它通过将在线、广播和存储的内容无缝地组合起来，从而能在分权管理的网络中承载新业务．同时该项目也积极推进了国际标准，使之为内容提供商、服务提供商和设备制造商提供了交互性。

关键词：分权管理项目设备制造商服务提供商内容提供商新业务投资对等机存取端到端

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克罗地亚地区战争对杀人和自杀行为的发生率和特征的影响(克罗地亚)

克罗地亚地区战争对杀人和自杀行为的发生率和特征的影响(克罗地...

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第十五届国际法庭科学大会

作者： Marija Definis-Gojanovic Ankica Smoljanovic Zivana marusic 朱明霞 Department of Forensic Medicine Split University Hospital and University School of MedicineSpinciceva 1Split 21000Croatia Public Health Institute Vukovarska 46Split 21000Croatia District Attorney Gunduliceva 29Split 21000Croatia

＜正＞目的：考察社会环境,即由战争所致的超强的、长时间的应激,是否影响以杀人和自杀为表现形式的暴力行为。研究目的有二：（1）分析杀人和自杀行为的流行病学特点;（2）对战前和战争期间的有关资料进行比较。

关键词：战争杀人自杀

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经皮经导管射频消融去肾交感神经术后难治性高血压患者单次交感神经放电大幅度减小

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中华高血压杂志 2013年第5期21卷 499-499页

作者： HeringD Lambert EA marusic P Walton AS Krum H Lambert GW Esler MD Schlaich MP 刘莉叶鹏

已有研究证实经皮经导管射频消融去肾交感神经术（renal denervation，RDN）可降低难治性高血压患者血压，减低其肌肉交感神经活性（muscle sympathetic nerve activity，MSNA），而交感神经受抑制的潜在机制尚未可知。该研究旨在探讨RD... 详细信息

已有研究证实经皮经导管射频消融去肾交感神经术（renal denervation，RDN）可降低难治性高血压患者血压，减低其肌肉交感神经活性（muscle sympathetic nerve activity，MSNA），而交感神经受抑制的潜在机制尚未可知。该研究旨在探讨RDN对难治性高血压患者血管收缩交感神经元的放电模式是否有特异性影响。

关键词：经导管射频消融肾交感神经高血压患者难治性电大单次术后交感神经活性

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不同组织病理亚型的中央颞叶癫的~1H-MR波谱

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国际医学放射学杂志 2009年第2期32卷 204-204页

作者： M.Hajek P.Krsek M.Dezortova P.marusic J.Zamecnik M.Kyncl 高欣 Department of Pediatric Neurology Charles University2nd Medical SchoolMotol Hospital

此研究的目的是分析质子MR波谱（1^H-MRS）对不同组织病理亚型的中央颞叶癫痫（MTLE）的定向价值，并且将结果与临床、MRI和癫痫发作的预后数据进行相关分析。回顾性研究了一组35例经癫痫手术切除的病人，评价了海马的质子MR波谱。采用L... 详细信息

此研究的目的是分析质子MR波谱（1^H-MRS）对不同组织病理亚型的中央颞叶癫痫（MTLE）的定向价值，并且将结果与临床、MRI和癫痫发作的预后数据进行相关分析。回顾性研究了一组35例经癫痫手术切除的病人，评价了海马的质子MR波谱。采用LC Model方法获得代谢物浓度，计算了NAA／Cr、NAA／Cho、NAA／（Cr＋Cho）、Cho／Cr值和不对称系数。

关键词： MR波谱颞叶癫痫海马皮质发育畸形治疗预后

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