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Effect of autologous mesenchymal stem cells induced by low level laser therapy on cardiogenesis in the infarcted area following myocardial infarction in rats

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Journal of Biomedical Science and Engineering 2013年第8期6卷 24-31页

作者： Hana Tuby Tali Yaakobi Lidya Maltz Yaakov Delarea Orit Sagi-Assif uri Oron Department of Cell Biology and Immunology The George S. Wise Faculty of Life Sciences Tel-Aviv University Tel-Aviv Israel Department of Zoology The George S. Wise Faculty of Life Sciences Tel-Aviv University Tel-Aviv Israel

In this study, we investigated the hypothesis that photobiostimulation by low-energy laser therapy (LLLT) applied to the bone marrow (BM) of myocardial infarcted rats may attenuate the scarring processes that follow myocardial infarction (MI). Wistar rats underwent experimental MI. LLLT (Ga-Al-As diode laser) was applied to the BM of the exposed tibia at different time intervals post-MI (4 hrs, 48 hrs and 5 days). Sham-operated infarcted rats served as control. Infarct size was significantly reduced (55%) in the laser-treated rats as compared to the control non-treated rats, at 2 weeks post-MI. A significant 3-fold increase was observed in the density of desmin immunopositive stained cells 14 days post-MI in the infarcted area of the laser-treated rats as compared to the non-laser-treated controls. The electron microscopy from the control infarcted rat hearts revealed a typical interphase area between the intact myocardium and the infarcted area, with conspicuous fibroblasts with collagen deposition dispersed among them. In rats that were laser treated (to BM), the interphase zone demonstrated cells with different intracellular structures. There was also a significant increase in the percentage of c-kit positive cells and macrophages in the circulating blood of the laser treated rats as compared to control non treated ones. In the majority of the cells clusters of myofibrils anchored to well-developed Z-lines and structures resembling the morphological characteristics of mature intact cardiomyocytes were evident. In conclusion, LLLT to the BM of rats post-MI induces cardiogenesis mainly at the borders of the infarcted area in the heart.

关键词： Low-Level Laser Therapy Myocardial Infarction Macrophage Desmin Ultrastructure c-Kit Positive Cells

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Validation of glaucoma-like features in the rat episcleral vein cauterization model

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Chinese Medical Journal 2014年第2期127卷 359-364页

作者： Bai Yujing Zhu Yingting Chen Qin Xu Jing Marinko V. Sarunic uri H. Saragovi Zhuo Yehong Key Laboratory of Vision Loss and Restoration Ministry of Education Department of Ophthalmology Peking University People's Hospital Beijing 100044 China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou Guangdong 510060 China Department of Ophthalmology First'Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Engineering Science Simon Fraser University Burnaby BC Canada V5A 1S6 Department of Pharmacology and Therapeutics Department of Oncology and the Cancer Center Bloomfield Centre for Research in Aging Lady Davis Institute-Jewish General Hospital McGill University Montreal Quebec Canada H3T 1E2

Background Glaucoma,an irreversible optic nerve neuropathy,always results in *** study aimed to evaluate glaucoma-like features in the rat episcleral vein cauterization （EVC） model by multiple in vivo and in vitro *** Wistar rat was used in this *** elevated intraocular pressure （IOP） was induced by cauterization of three episcleral *** was monitored with Tono-Pen XL ***-dependent changes to the neuronal retinal layers were quantified by Fourier domain-optical coherence *** function of retina was evaluated by electroretinogram （ERG）.Survival of retinal ganglion cells （RGCs） was quantified by retrograde *** study was performed with retinal sections stained with hematoxylin-eosin,glial fibrillary acidic protein,and neuronal nuclear *** and aqueous humor protein were extracted and cytotoxic protein tumor necrosis factor alpha （TNF-α） and alpha-2 macroglobulin （α2m） were measured with Western *** EVC is a relatively facile intervention,with low failure rates （＜5％）.After surgical intervention,chronic mild lOP elevation （about 1.6-fold over normal,P ＜0.05） was induced for at least 6 weeks without requiring a second *** lOP causes chronic and progressive loss of RGCs （averaging about 4％ per week）,progressive thinning of neuronal retinal layers （3-5 μm per week）,and reduction of a-and b-wave in *** method can also induce glial cell activation and alterations of inflammation proteins,such as TNF-α and α*** EVC method can establish a robust,reliable,economic and highly reproducible glaucomatous animal model.

关键词： glaucoma experimental animal model retinal neurons rat

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生物防治中的螨类图示检索手册

生物防治中的螨类图示检索手册

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1996年

作者：（以）uri Gerson （美）Robert L.Smiley 梁来荣等译

在节肢动物门中，瞒类物种数仅次于昆虫类。对于它们的经济、社会和生态环境方面的作用和意义，近年来越来越引起人们的重视。农业瞒类对各种农作物的危害是和化学农药的过量使用和滥用密切联系的。但是，多年以来，对于瞒类生物学的... 详细信息

在节肢动物门中，瞒类物种数仅次于昆虫类。对于它们的经济、社会和生态环境方面的作用和意义，近年来越来越引起人们的重视。农业瞒类对各种农作物的危害是和化学农药的过量使用和滥用密切联系的。但是，多年以来，对于瞒类生物学的另一个侧面，即其对地球生物圈中的有益作用缺乏认识，更谈不上利用。有关瞒类的论述和著作，多偏重于其形态学和系统分类学的研究，而瞒类生物学作用的记载多散见于浩瀚的文献之中而未引起充分重视。

关键词：螨目-应用-生物防治(学科: 手册) 生物防治-螨目-应用(学科: 手册)

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Prediction of interphase drag coefficient and bed expansion using a variational model for fluidization of small spherical particles

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Particuology 2020年第4期18卷 184-192页

作者： Mihal Duris Zorana Arsenijevic Radmila Garic-Grulovic Tatjana Kaluderovic Radoicic Institute of Chemistry Technology and Metallurgy(National Institute)Department for Catalysis and Chemical EngineeringUniversity of BelgradeNjegoseva 12BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 4BelgradeSerbia

In this study,we applied the variational model to fluidization of small spherical *** experiments were carried out for spherical particles with 13 diameters between dp=0.13 and 5.00 *** propose a generalized form of our variational model to predict the superficial velocity U and interphase drag coefficientβby introducing an exponent n to describe the different dependences of the drag force Fd on fluid velocity for different particle sizes(different flow regimes).By comparing the predictions with the experimental results,we conclude that n=1 should be used for small particles(dp1 mm).This conclusion is generalized by proposing n=1 for particles with Ret*** average mean absolute error was 5.49%in calculating superficial velocity for different bed voidages using the modified variational model for all of the particles *** calculated values ofβwere compared with values of literature models for particles with dp<1.0 *** average mean absolute error of the modified variational model was 8.02%in calculatingβfor different bed voidages for all of the particles examined.

关键词： Calculus of variations Isoperimetric problem Bed expansion Drag coefficient Fluidization Spherical particles

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Elimination of undifferentiated cancer cells by pluripotent stem cell inhibitors

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Journal of Molecular Cell Biology 2014年第3期8卷 267-269页

作者： uri Ben-David1,2 Alva Biran2 Paola Scaffidi3,4,5 Christel Herold-Mende6 Markus Boehringer7 Eran Meshorer2 Nissim Benvenisty1,2 Stem Cell Unit Silberman Institute of Life Sciences The Hebrew University Jerusalem 91904 Israel Department of Genetics Silberman Institute of Life Sciences The Hebrew University Jerusalem 91904 Israel National Cancer Institute NIH Bethesda MD 20892 USA UCL Cancer Institute University College London London WC1E 6BT UK Cancer Research UK London Research Institute London WC2A 3LY UK Division of Neurosurgical Research Department of Neurosurgery University of Heidelberg Heidelberg Germany F. Hoffmann-La Roche AG Basel 4070 Switzerland

Dear Editor, According to the cancer stem cell （CSC） hypothesis, cancer ceils are organized in a hierarchical manner （Reya et al, 2001）. Indeed, the differentiation state of cancer cells has been linked to their proliferative potential, drug response, and ability to metastasize （Clevers, 2011）. Targeting self- renewing, undifferentiated cancer ceils could therefore be of importance for the success of cancer therapies. A classical case of a tumor composed of undifferenti- ated and differentiated cells is the tumor induced by pluripotent stem cells （PSCs）（Ben-David and Benvenisty, 2011）. We have recently identified several small mole- cules termed pluripotent-specific inhibitors （PluriSIns） that selectively target undif- ferentiated tumorigenic PSCs （Ben-David et aL, 2013）. Several of these compounds, including PluriSIn#1, inhibit the activity of stearoyl-coA desaturase （SCD1）（Ben- David et al, 2013）. SCD1 is an endoplasmic reticulum （ER）-membrane protein that plays a key role in the biosynthesis of the mono-unsaturated fatty acid oleate. This novel metabolic vulnerability is in line with the unique metabolome described in PSCs （Panopoulos et al, 2012）.

关键词： Pluripotent Stem Cells Hypersensitivity Contact Hypersensitivity cancer cell Circulating Neoplastic Cells

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Increased fibrosis progression rates in hepatitis C patients carrying the prothrombin G20210A mutation

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World Journal of Gastroenterology 2011年第45期17卷 5007-5013页

作者： Nitsan Maharshak Philippe Halfon Varda Deutsch Hava Peretz Shlomo Berliner Sigal Fishman Shira Zelber-Sagi uri Rozovski Moshe Leshno Ran Oren Department of Gastroenterology and Liver diseases Tel Aviv Sourasky Medical Center aff iliated to the Sackler School of Medicine Tel Aviv University Department of Virology Laboratoire Alphabio 23 Rue de Friedland Hpital Ambroise Paré The Hematology Institute Tel Aviv Sourasky Medical Center affi liated to the Sackler School of Medicine Tel Aviv University Clinical Biochemistry Laboratory Tel Aviv Sourasky Medical Center affiliated to the Sackler School of Medicine Tel Aviv University Internal Medicine "E" Tel Aviv Sourasky Medical Center affi liated to the Sackler School of Medicine Tel Aviv University

AIM: To examine whether hepatitis C virus (HCV)-infected patients who carry hypercoagulable mutationssuffer from increased rates of liver fi brosis. METHODS: We analyzed DNA samples of 168 HCV patients for three common hypercoagulable gene mutations: prothrombin 20210 (PT20210), factor V Leiden (FV Leiden) and methylene tetrahydrofolate reductase (MTHFR). The patients were consecutively recruited as part of the prospective "Fibroscore Study" in France. The effect of the various mutations on the rate of fi-brosis was analyzed statistically and was correlated with epidemiological, clinical and biochemical data such as grade and stage of liver biopsies, patients' risk factors for liver cirrhosis, and timing of infection. RESULTS: Fifty two of the patients were categorized as "fast fi brosers" and 116 as "slow fi brosers"; 13% of the "fast fi brosers" carried the PT20210 mutation as compared with 5.5% of the "slow fi brosers", with an odds ratio of 4.76 (P = 0.033; 95% CI: 1.13-19.99) for "fast" liver fibrosis. Carriage of MTHFR or FV Leiden mutations was not associated with enhanced liver fi brosis. CONCLUSION: Carriage of the PT20210 mutation is related to an increased rate of liver fi brosis in HCV patients.

关键词： Hepatitis C virus Liver fi brosis Hyperco-agulation Prothrombin 20210

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Cytomegalovirus positive ulcerative colitis:A single center experience and literature review

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World Journal of Gastrointestinal Pathophysiology 2013年第1期4卷 18-23页

作者： uri Kopylov Gila Sasson Bella Geyshis Michal Tepperberg Oikawa Iris Barshack Rami Eliakim Shomron Ben-Horin Department of Gastroenterology Sheba Medical CenterRamat Gan 52621Israel Internal Medicine D Sheba Medical CenterRamat Gan 52621Israel Central Virology Laboratory Public Health LaboratoriesIsrael Ministry of HealthRamat Gan 52621Israel Department of Pathology Sheba Medical CenterRamat Gan 52621Israel

AIM:To compare the clinical outcome of cytomegalovirus(CMV)-positive ulcerative colitis(UC) patients with and without antiviral ***:This was a retrospective case-controlled *** database of UC patients in our institution was scanned for documented presence of CMV on colonic ***,clinical data,endoscopy findings and pathology reports were extracted from the patients' charts and electronic *** available,the data from colonoscopies preceding and following the diagnosis of colonic CMV infection were also *** primary outcomes of the study were colectomy/death during hospitalization and the secondary outcomes were colectomy/death through the course of the ***:Thirteen patients were included in the study,7(53.5%) of them were treated with gancyclovir and 6(46.5%) were *** treated with antivirals presented with a more severe disease and 57% of them were treated with cyclosporine or infliximab before initiation of gancyclovir,while none of the patients without antivirals required rescue *** patient died and another patient underwent urgent colectomy during hospitalization,both of them from the gancyclovir-treatment *** the entire follow-up time(13 ± 13 mo),a total of 3 colectomies and one death occurred,all among the antiviral-treated patients(for colectomy:3/7 vs 0/6 patients,P = 0.19;for combined adverse outcome:4/7 vs 0/6 patients,P = 0.07).In 9/13 patients,immunohistochemistry for CMV was performed on biopsies obtained during a subsequent colonoscopy and was positive in one patient ***:Gancyclovir-treated patients had a more severe disease and outcome,probably unrelated to antiviral ***-CMV-positive patients with mild disease may recover without antiviral therapy.

关键词： Ulcerative colitis Cytomegalovirus Gancyclovir Cyclosporine Immunohistochemistry

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Prevascularized Scaffolds Bearing Human Dental Pulp Stem Cells for Treating Complete Spinal Cord Injury

Prevascularized Scaffolds Bearing Human Dental Pulp Stem Cel...

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2021海峡两岸暨港澳精准医学青年博士论坛

作者： Shaowei Guo Idan Redenski Shira Landau Ariel Szklanny uri Merdler Shulamit Levenberg Faculty of Biomedical Engineering Technion-Israel Institute of Technology The First Affiliated Hospital Shantou University Medical College

Background: The regeneration of injured spinal cord is hampered by the lack of vascular supply and neurotrophic support. Transplanting tissue engineered constructs with developed vascular networks and neurotrophic factors, and further understanding the pattern of vessel growth in the remodeled spinal cord tissue are greatly desired. Human dental pulp stem cells (DPSCs) are a source of stem cells that originate from migrating neural crest cells and reside in the dental pulp cavity.

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不可能的历史(节选)

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城市环境设计 2010年第Z1期 208-209页

作者： Dubravka ■uri Miko uvakovi 贝尔格莱德大学

HISTORICAL AVANT-GARDES,NEO-AVANT-GARDES,AND POST-AVANT-GARDES IN YUGOSLAVIA,1918-1991南斯拉夫的历史前卫运动、新前卫运动和后前卫运动,1918-1991第一次世界大战深深地将南斯拉夫的认同感印在了斯洛文尼亚、克罗地亚和塞尔维亚等国家人民的心里。每个单独的国家都不能保全自己,所以他们需要建立一个更大的政权。从这时起,卢布尔雅那、萨格勒布和贝尔格莱德同

关键词：建筑师克罗地亚前卫南斯拉夫美术家南欧斯洛文尼亚玻璃幕墙古典主义卢布尔雅那

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最优结构设计的分解

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水利科技 1980年第1期 37-48页

作者： uri Kirsch Fred Moses 陶君裘华东水电设计院

(一) 前言在过去十五年中,采用数学程序方法的最优结构设计,已成为许多论文的主题(参考文献2,3,8,9)。鉴于常规计算技术对解算有限的几个变量和约束条件的有关问题非常有效,近来为制定出适用于大系统的新计算方法已作出相当大的努力。... 详细信息

(一) 前言在过去十五年中,采用数学程序方法的最优结构设计,已成为许多论文的主题(参考文献2,3,8,9)。鉴于常规计算技术对解算有限的几个变量和约束条件的有关问题非常有效,近来为制定出适用于大系统的新计算方法已作出相当大的努力。本文中的一项技术提议,涉及将全部优选技术分解成较小的子问题。每一部份在第一级单独解出,尔后在另一级调整。此方法的优点是:大量缩减整个计算工作;优化过程中有较好的收敛特性;总问题的

关键词：独立变量第一级子问题约束条件分界线目标函数第二级状态变量方程最优结构

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