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Tailored Co-Extruded Cereals for Seniors: Fabrication， Palatability， and in vitro Digestibility

Food Science and Human Wellness 2024年

作者： Leehen Mashiah Omer Medini rea Araiza Calahorra Josefine Skaret Carmit Shani Levi Lotti Egger Reto Portmann Paula Varela Anwesha Sarkar uri lesmes Laboratory of Chemistry of Foods and Bioactives， Department of Biotechnology and Food Engineering， Technion-Israel Institute of Technology The International Beer Breweries Ltd. Food Colloids and Bioprocessing Group， School of Food Science and Nutrition， University of Leeds Nofima AS.P.O. Agroscope， Schwarzenburgstr Nofima AS.P.O.Box 210

The rise in life expectancies and gap between life span and health span necessitate innovative approaches， interventions， and food solutions to secure healthy aging. This study， conducted within the framework of the EAT4AGE project of the Joint Programming Initiative 'A Healthy Diet for a Healthy Life’， focuses on the rational design of functional foods for older adults. A co-extruded cereal prototype， fortified with two bioactive moieties， Maca root powder and Olive leaf extract， aims to address nutritional gaps identified in older adults， with a particular emphasis on high-quality and highly digestible proteins. Analytical determinations reveal the cereals have rich macronutrient profile exceeding 12% (w/w) protein， 20% (w/w) fat， and low sugar ( < 5% w/w)， surpassing commercially available products with texture analyses supporting improved hardness， reduced oral friction and oral comfort. An untrained consumer panel (n=21， Age 73 ± 5) confirmed high palatability in various metrics and overall acceptability that were also affirmed through a trained sensory panel. Lastly， the product digestion was explored through an age-tailored in vitro digestion model which consistently demonstrated high protein digestibility， surpassing 80%， across all product formulations. Further， calculation of the in vitro digestible indispensable amino acid score of the product affirms its high nutritional quality. Thus， this study underscores the potential of designing palatable foods that could help promote a balanced and sustainable diet towards healthy aging.

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Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

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Nano Research 2015年第5期8卷 1729-1745页

作者： Genoveva MorraI-Ruiz Pedro Melgar-lesmes Andrea Lopez-Vicente Conxita Solans Maria Jose Garcia-Celma Department of Pharmacy and Pharmaceutical Technology Faculty of Pharmacy University of Barcelona Av Joan XXIII s/n 08028 Barcelona Spain Institute of Advanced Chemistry of Catalonia (IQAC) CS/C Jordi Girona 18-26 08034 Barcelona Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN Spain

Over the past years, significant efforts have been devoted to explore novel drug delivery and detection strategies for simultaneous therapy and diagnostics. The development of biotinylated polyurethane-urea nanoparticles as theranostic nanocarriers for targeted drug and plasmid delivery, for fluorescence detection of human hepatocellular carcinoma cells, is described herein. These targeted nanoparticles are specifically designed to incorporate biotin into the polymeric matrix, since many tumor types overexpress receptors for biotin as a mechanism to boost uncontrolled cell growth. The obtained nanoparticles were spherical, exhibited an average diameter ranging 110-145 nm, and showed no cytotoxicity in healthy endothelial cells. Biotinylated nanoparticles are selectively incorporated into the perinuclear and nuclear area of the human hepatocellular carcinoma cell line, HepG2, in division, but not into growing, healthy, human endothelial cells. Indeed, the simultaneous incorporation of the anticancer drugs, phenoxodiol or sunitinib, together with plasmid DNA encoding green fluorescent protein, into these nanoparticles allows a targeted pharmacological antitumor effect and furthermore, selective transfection of a reporter gene, to detect these cancer cells. The combined targeted therapy and detection strategy described here could be exploited for liver cancer therapy and diagnostics, with a moderate safety profile, and may also be a potential tool for other types of cancer.

关键词： cancer therapy DNA nanoparticles polyurethane theranostics

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力量训练的骨骼肌适应

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浙江体育科学 1979年第3期 27-30页

作者： D·L·Costill E·F·Coyle W·F·Fink G·R·lesmes F·A·Witzman 华明

本文报道了5名被试者在7周等动力量训练前后肌肉中酶的活性与肌纤维类型组成的变化。在训练中,被试者的一条腿作每次持续6秒钟的最大伸膝运动,重复10次;而另一条腿则作每次持续30秒钟的最大伸膝运动,重复1次。所以,实际上两腿所做的总... 详细信息

本文报道了5名被试者在7周等动力量训练前后肌肉中酶的活性与肌纤维类型组成的变化。在训练中,被试者的一条腿作每次持续6秒钟的最大伸膝运动,重复10次;而另一条腿则作每次持续30秒钟的最大伸膝运动,重复1次。所以,实际上两腿所做的总工作量是相等的。每周训练4次。7周训练结束后,以训练速度(3.14半径/秒)或低于训练速度进行测验,发现两条腿获得最大力距是相同的;此外,还用60秒钟运动试验来检查训练后伸膝肌的易疲劳性,结果表明,两条腿的易疲劳性也是相似的。肌肉活组织检查表明,这两种力量训练的安排导致Ⅰ型和Ⅱα型肌纤维的面积百分比发生显著的改变。而肌肉中的酶活性的变化则只有以30秒钟训练的那条腿的肌肉中的糖酵介酶、三磷酸腺苷-磷酸肌酸水介酶和线粒体氧化酶的活性升高。尽管发现这些变化,但这些变化中没有一种变化是与肌肉最大等动收缩时力量的增加或肌肉的易疲劳性有关。

关键词：肌纤维酶的活性肌细胞伸膝运动力量训练骨骼肌一条腿等动练习横断面积乳酸脱氢酶肌乳酸活组织检查实验室诊断被试者运动试验

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