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Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study

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World Journal of Gastroenterology 2007年第47期13卷 6356-6364页

作者： em Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung Department of Diagnostic Radiology University Hospital RegensburgFranz-Josef Strauss-Allee 11Regensburg 93043Germany Department of Radiology Ultrasound SectionGroβhadern HospitalLudwig Maximilian University of MunichMarchioninistr15Mnchen 81377Germany Department of Trauma Surgery Passau HospitalInnstraβe 76Passau 94034Germany Institutes of Radiology Nuclear Medicine and UltrasoundPirmasens HospitalGermany Center for Biomaterial Development Institute of Polymer ResearchGKSSKantstr55Teltow 14513Germany

AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the poss

关键词： Liver tumors Malignant tumor Contrast harmonic imaging Quantitative contrast enhancement

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Sequelae of long-term opioid therapy in patients with polyneuropathy

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中华物理医学与康复杂志 2017年第9期39卷 717-717页

作者： Hoffman em Watson JC St Sauver

BACKGROUND AND OBJECTIVE Polyneuropathy is a common condition,with related impairments including neuropathic *** study examined the prevalence of long-term opioid therapy among patients with polyneuropathy and the ass... 详细信息

关键词：药物治疗神经病多发性后遗症治疗时间患病率死亡率

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Vitamin D and clinically isolated syndrome

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中华物理医学与康复杂志 2016年第4期38卷 258-258页

作者： Mowry em Pelletier D Gao Z

BACKGROUND AND OBJECTIVE Previous studies have demonstrated that levels of 25-hydroxyvitamin D are associated with inflammatory activity among patients with multiple sclerosis (MS). As the loss of gray matter volume predicts long-term disability among patients with MS, this study was designed to determine any association between 25-hydroxyvitamin D levels among patients with clinically isolated syndrome (CIS) and imaging measures of *** Data were obtained from subjects in the STAy CIS trial, a randomized study of atorvastatin in patients with recent CIS, used to assess the association of 25-hydroxyvitamin D levels with imaging measures thought to reflect neurodegeneration. All subjects were evaluated clinically and by brain MRI at baseline and at months three, six, nine, and 12. The primary endpoint was the development of at least one MS relapse or at least three new T2 lesions on brain MRI at month 12. The data were reviewed for the relationship between 25-hydroxy vitamin D levels and clinical and MRI measures of inflammatory *** Of the 65 patients included in this study, 55% met the composite inflammatory endpoint, while 29% had a second attack during the follow-up period. Every 25 nmol/l higher 25-hydroxyvitamin D level was associated with a 7.8 mL higher gray matter volume (P=0.025). A trend was noted for an inverse association between vitamin D levels and the composite endpoint of at least three new brain T2 lesions or at least one relapse within the first 12 *** This study of patients with early CIS found that increased levels of 25-hydroxyvitamin D are associated with preserved gray matter volume.

关键词：维生素D 临床分离综合征神经退行性疾病多发性硬化体积损失患者影像学

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Ultrasound assessment of steroid injections to the knee

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中华物理医学与康复杂志 2015年第4期 290-290页

作者： Keen HI Hensor em Wakefield RJ

BACKGROUND AND OBJECTIVE Osteoarthritis (OA) is a common form of arthritis, affecting up to 10% of the North American elderly population. In addition, the prevalence of radiographically established OA in the United States is estimated to be 33% among individuals over 63 years of age. This study was designed to determine whether ultrasound (US) can be effective in demonstrating a response to intra-articular corticosteroid injections to the *** Subjects included 35, consecutive subjects who met the American College of Rheumatology''s radiologic criteria for OA. All subjects completed a symptom assessment and US examination at baseline, and returned for follow-up at 14 weeks. Of those, 19 participants were determined to be in need of a corticosteroid injection, and received 80 mg of methylprednisolone mixed with 2 mL of lidocaine one percent. The remaining subjects underwent no therapeutic intervention. All participants were asked to rate their knee pain on a visual analogue scale, and to complete the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC). The knee joints were assessed with US at baseline and at four *** At follow-up US, synovial thickness was noted to have decreased in 16 of the 19 patients in the treatment group, and in two of the 14 patients in the control group (P=0.012). A reduction in synovial thickness was associated with a reduction in pain greater than or equal to the predetermined minimally clinically important improvement level (>20 mm on the VAS). With both groups combined, no substantial association was seen between changes in synovial thickness and changes in *** This pilot study suggests that US may be useful in detecting early changes in synovial pathology in response to intra-articular anti-inflammatory therapy.

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Long-term opioid therapy and functional status

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中华物理医学与康复杂志 2017年第10期39卷 789-789页

作者： Hoffman em Watson JC St Sauver J

BACKGROUND AND OBJECTIVE While opioids appeared to be effective for the treatment of non-cancer pain in short durations,the long-term efficacy of these medications is not well *** a longitudinal cohort format,this study followed patients with polyneuropathy,in order to examine the relationship between the duration of opioid therapy and functional status.

关键词：药物治疗状态治疗时间神经病多发性

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DIRECTIVITY OPTIMIZATION OF CURVED SURFACE DIPOLE ANTENNAS

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Journal of Electronics(China) 1994年第4期11卷 322-331页

作者：王均宏任朗 Institute of em Theory and Microwave Tech. Southwest Jiaotong University Chengdu 610031

Based on the calculation of the characteristic parameters by moment method, the curved surface dipoles are optimized by an optimization method, the maximum directivities of some V-curved and Gauss-curved surface dipol... 详细信息

关键词： Antennas Curved surface dipoles Directivity Optimization Moment method

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Rehabilitation advances following total knee arthroplasty

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中华物理医学与康复杂志 2014年第10期36卷 816-816页

作者： Elbaz A Debbi em Segal G

BACKGROUND AND OBJECTIVE While total knee arthroplasty(TKA)surgery often succeeds in improving pain and function,quality-of-life,lower extremity kinematic,and kinetic gait abnormalities often persist,This study evaluated the effects of a biomechanical therapy(Apos Therapy)for patients undergoing *** This prospective study included 17 patients,all initiating treatment at three months *** biomechanical thera-

关键词：膝关节置换康复运动步态生活质量生物力学疗法

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Frequency and Factors Associated with Periodontitis in Congolese Patients: A Cross-Sectional Study

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Open Journal of Stomatology 2021年第1期11卷 55-64页

作者： em Kalala-Kazadi Fidèle Nyimi-Bushabu Hubert Ntumba-Mulumba Michel C. Brecx Periodontology Unit Department of Dental Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Oral Maxillofacial Surgery Head and Neck Oncology Department of Dental Medicine Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Prosthodontics and Orthodontics Service Department of Dental Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Department of Periodontology Université Catholique de Louvain Brussels Belgium

Background: Periodontitis is a multifactorial disease which is highly prevalent worldwide. The control of periodontal risk factor network is of paramount importance for the management of the disease. Aim: The aim of this study was to assess the frequency and identify the factors associated with periodontitis in Congolese patients. Material and Methods: This cross-sectional study was carried out in four medical centers in the city of Kinshasa between April 2017 and April 2018. The study included patients aged at least 12 years old who consulted the dental services of these centers and who met the inclusion criteria. The participants underwent a structured interview and a clinical periodontal examination. The latter involved the entire dentition, and periodontal pocket and attachment level measurements were taken at six sites per tooth. The plaque and bleeding index were recorded. Logistic regression was used to identify associated factors. The significance level was set at p 0.05. Results: The study included 827 patients and 42% of them had periodontitis. The most represented age group was between 20 and 29 years old. In multivariate analysis, age greater than or equal to 35 years, OR = 2.45 CI 95% (1.77 - 3.45), and the amount of plaque expressed as plaque index ≥ 1, OR = 2 CI 95% (1.31 - 3.07) were factors associated with periodontitis. Conclusion: Factors associated with periodontitis found in this study are age ≥35 years and the amoun

关键词： Associated Factors Periodontitis Frequency Congolese

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