检索结果-南通市图书馆

Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul mittal Keelin McKenna Grant Keith Evan McKenna Joana R.N.Lemos Jeenu mittal Khemraj Hirani Diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Study of structural, electrical, and photoluminescent properties of SrCeO3 and Sr2CeO4

在线全文

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2019年第3期8卷 377-388页

作者： Dharmendra Yadav upendra Kumar Shail Upadhyay Department of Physics Indian Institute of Technology(BHU)

Phase pure powders of SrCeO3 and Sr2Ce O4 have been synthesized by calcination at 1000℃for 14 h via solid state ceramic ***/pellets of these samples have been obtained by sintering at 1200℃for 12 *** Rietveld refinement of X-ray diffraction(XRD)pattern of sintered powders confirmed orthorhombic structure of both the samples with space group Pnma and Pbam for SrCeO3 and Sr2CeO4,*** electron microscopic(SEM)studies indicated that both the compounds have dense microstructure,but morphology and size of the grains are *** impedance spectroscopy technique has been employed to study the relaxation *** conductivity of the samples has been measured in the temperature range of 200–600℃to understand the conduction *** activation energy for relaxation(Erelax)and DC conduction(Econd)are found to be the same for both the *** on the numerical value of activation energies,relaxation and conduction mechanism in both the samples are attributed to migration of doubly ionized oxygen vacancies(Vo··).Photoluminescence technique has been employed to confirm the existence of oxygen *** studies have indicated that migration of oxygen vacancies in Sr2CeO4 is occurring mainly along a and c direction,i.e.,via perovskite ***,the present work has clearly indicated that besides optical properties,electrical properties of Sr2CeO4 are also interesting and can be utilized for various applications such as oxide ion conduction electrolyte in solid oxide fuel cells(SOFCs).

关键词： Sr2CeO4 SrCeO3 impedance spectroscopy DC conductivity

Nanodiamonds with powerful ability for drug delivery and biomedical applications:Recent updates on in vivo study and patents

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2020年第1期10卷 1-12页

作者： Swati Chauhan Neha Jain upendra Nagaich Department of Pharmaceutics Amity Institute of PharmacyAmity UniversityNoidaU.P.India

Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical,chemical,optical and biological properties,making them significant active moiety carriers for biomedical *** are known as the most‘captivating’crystals attributed to their chemical inertness and unique properties posing them useful for variety of applications in biomedical ***,it becomes increasingly important to find,ascertain and circumvent the negative aspects associated with *** modification or functionalization with biological molecules plays a significant role in managing the toxic behavior since nanodiamonds have tailorable surface *** take advantage of nanodiamond potential in drug delivery,focus has to be laid on its purity,surface chemistry and other considerations which may directly or indirectly affect drug adsorption on nanodiamond and drug release in biological *** review emphasizes on the basic properties,synthesis techniques,surface modification techniques,toxicity issues and biomedical applications of *** the development of nanodiamonds as an effective dosage form,researchers are still engaged in the in-depth study of nanodiamonds and their effect on life interfaces.

关键词： Nanomedicine Biochemical application Diamondoids Surface functionalization Drug targeting

ENHANCING THE DAYLIGHT AND ENERGY PERFORMANCE OF EXTERNAL SHADING DEVICES IN HIGH-RISE RESIDENTIAL BUILDINGS IN DENSE URBAN TROPICS

在线全文

学校读者我要写书评

暂无评论

Journal of Green Building 2021年第3期16卷 87-108页

作者： Nadeeka Jayaweera upendra Rajapaksha Inoka Manthilake Department of Architecture University of MoratuwaBandaranayake MawathaMoratuwa 10400Sri Lanka Department of Mechanical Engineering University of MoratuwaBandaranayake MawathaMoratuwa 10400Sri Lanka

This study examines the daylight and energy performance of 27 external shading scenarios in a high-rise residential building in the urban *** cooling energy,daytime lighting energy and the spatial daylight autonomy(sDA)of the building model were simulated in Rhino3D and Grasshopper simulation *** best per-formance scenario(vertical and horizontal shading on the twentieth floor,horizontal shading only for the eleventh floor and no shading for the second floor)satisfied 75 sDA(300lx|50)with corresponding annual enery performance of 16%-20%in the cardinal *** baseline scenario,which is the current practice of providing balconies on all floors,reduced daylight to less than 75 sDA on the eleventh and second floor,even though it had higher annual enery performance(19%-24%)than the best performance *** of the design principles to a case study indicated that 58%of the spaces had over 75 sDA for both Baseline and Best per-formance scenarios,while an increase in enery performance of 1%-3%was found in the Best performance scenario compared to the Baseline.

关键词： external shading devices tropics urban context enery performance daylight

A Study on the Far Wake of Elliptic Cylinders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2017年第1期113卷 35-55页

作者： Subhankar Sen Sanjay mittal Department of Mechanical Engineering Indian Institute of Technology KanpurIndia Department of Aerospace Engineering Indian Institute of Technology KanpurIndia

The evolution of far wake of stationary elliptic cylinders with angle of attack is investigated for the unsteady flow at Re=200 using a stabilized finite-element *** Reynolds number,Re,is based on the major axis of cylinder and free-stream *** aspect ratios,AR considered are 0.2,0.5 and 0.8 while the angle of attack,αvaries from 0° to 90°.With increasingα,the Karman or primary shedding frequency of each cylinder decreases monotonically while the primary wavelength and time-averaged as well as *** increase *** time-averaged lift and moment coefficients initially increase withαand then *** power spectrum analysis of unsteady transverse velocity signal at various stations along the wake centerline is used to study the associated *** Karman or primary shedding frequency exists for eachα.For the AR=0.2 cylinder,the secondary and subsequently,low magnitude tertiary frequencies appear in the wake asαcontinues to increase from 30°.In contrast to the decaying nature of primary frequency withα,secondary frequency exhibits a nonmonotonic *** secondary frequency in general is not a sub-harmonic of the *** suggests that the secondary structures do not form due to merging of primary *** increasingα,the location of formation of secondary structures advances *** a given orientation,the upstream advancement is more dominant with decreasing *** spectrum analysis indicates that the wake state for confined flow is characterized by the primary frequency alone,*** imposition of blockage suppresses the formation of secondary structures.

关键词： Elliptic cylinder stabilized finite-element far wake angle of attack blockage

Local and biglobal linear stability analysis of parallel shear flows

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2017年第2期113卷 219-237页

作者： Sanjay mittal Anubhav Dwivedi Department of Aerospace Engineering Indian Institute of Technology KanpurUP 208016India

Linear Stability Analysis(LSA)of parallel shear flows,via local and global approaches,is *** local analysis is carried out by solving the Orr-Sommerfeld(OS)equation using a spectral-collocation method based on Chebyshev polynomials.A stabilized finite element formulation is employed to carry out the global analysis using the linearized disturbance equations in primitive *** local and global analysis are *** per the Squires theorem,the two-dimensional disturbance has the largest growth ***,only two-dimensional disturbances are *** its very nature,the local analysis assumes the disturbance field to be spatially periodic in the streamwise *** global analysis permits a more general ***,to enable a comparison with the local analysis,periodic boundary conditions,at the inlet and exit of the domain,are imposed on the *** are carried out for the LSA of the Plane Poiseuille Flow(PPF).The relationship between the wavenumber,a,of the disturbance and the streamwise extent of the domain,L,in the global analysis is explored for Re=*** is found that a and L are related by L=2pn/a,where n is the number of cells of the instability along the streamwise direction within the domain length,*** procedure to interpret the results from the global analysis,for comparison with local analysis,is described.

关键词： Linear stability analysis local analysis plane Poiseuille flow Orr-Sommerfeld equation global analysis

Connections between biomechanics and higher infectivity: a tale of the D614G mutation in the SARS-CoV-2 spike protein

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第2期6卷 193-194页

作者： Anshumali mittal Vikash Verma Luxmi Nagar JaspurUttarakhandIndiaUniversity of MassachusettsAmherstMAUSA Biology Department University of MassachusettsAmherstMAUSA

Mutations are known to play a critical role in how a species *** a recent article that appeared in the journal Cell,Yurkovetskiy et al.1 reported the structural and functional properties of the SARS-CoV-2 spike protein variant D614G that explains the basis of its increased *** observed that the mutant(D614G)was 4 to 9-fold more infectious than the wild type(D614),and the increased infectivity was not limited to human angiotensin-converting enzyme 2(ACE2).1 The cryo-EM structure suggested that D614G mutation weakens the stability of the homotrimer that shifts protein conformation towards an ACE2-binding fusion-competent state.1 The authors additionally showed that the D614G variant is neutralized by monoclonal antibodies targeting the spike protein receptor-binding domain(RBD).

关键词： ACE2 al. D61

Strength and elongation of spray formed Al–Si–Pb alloys

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2014年第12期21卷 1222-1227页

作者： Aruna Tomar Rashmi mittal Devendra Singh Department of Metallurgical and Materials Engineering Indian Institute of Technology Roorkee

The strength and elongation to fracture of spray deposited Al-Si-Pb alloys were studied as a function of lead content, silicon content, and distance from the centre to periphery of the deposit. It is found that the ultimate tensile strength, proof stress and elongation to fracture decrease, linearly and exponentially, with the increase in lead content and porosity of the deposit, respectively. Both the strengths and elongation to fracture linearly increase with increasing distance from the centre to periphery of the deposit. The ultimate tensile strength and proof stress are higher at a higher silicon content and they have a linear relationship with the hardness of the deposit.

关键词： aluminum silicon alloys spray forming tensile strength proof stress elongation

Healing promoting potentials of roots of Ficus benghalensis *** albino rats

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2011年第11期4卷 921-924页

作者： Krishna Murti upendra Kumar Mayank Panchal Singhania University JhunjhunuRajastkanIndia College of Pharmacy AzamgarhUttar PradeshIndia Vidyabharti Trust College of Pharmacy UmrakhGujaratIndia

Objective:To screen the wound healing activity of aqueous and ethanolic extract of roots of Ficus ***:Both the extracts were evaluated for wound healing by three models ie. incision,excision and dead space *** incision and dead space the extracts were applied ilaily topically till the 10th post wounding days while in excision model it was till the complete epithelialization *** group were administered Povidone iodine ointment topically *** breaking strength,percentage of wound contraction,period of epithelialization,dry granulation weight and hydroxyproline content were ***:The result of the present study showed that both extracts were able to increase the breaking strength(incision model), decrease period of *** percentage wound contraction(excision model), increase hydroxyproline content(Dead space wound model) significantly compared with control group(P<0.05).Conclusions:Based on result we conclude that aqueous extract is more effective than ethanolic ***,it is needed more research to be carried out especially on toxicity studies of ethanolic extract.

关键词： Ficus benghalensis Incision Excision Dead Space Hydroxyproline estimation Phytochemical analysis Povidone iodine