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Effectiveness of ChAdOx1 nCoV-19 coronavius vaccine in preventing severe disease and mortality during the second wave of pandemic:A case-case analysis from a tertiary care center in South India

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Journal of Acute Disease 2022年第5期11卷 188-193页

作者： Priyanka Rajmohan unnikrishnan uttumadathil gopinathan Nada Parvin Ashraf Saudha Maria Jose Lucy Raphael Joe Thomas Department of Community Medicine Jubilee Mission Medical College and Research InstituteThrissurKeralaIndia Department of Pharmacology Jubilee Mission Medical College and Research InstituteThrissurKeralaIndia

Objective:To determine the real-world effectiveness of the ChAdOx1 nCoV-19 coronavirus vaccine in preventing severe disease and mortality due to ***:A case-case design was used to estimate the effect of the ChAdOx1 nCoV-19 coronavirus vaccine on severe SARS-CoV-2 outcomes in individuals aged 40 years and ***(n=200)were COVID-19 patients admitted to intensive care unit(ICU)or who ***(n=223)were those with mild COVID-19,fit for home *** logistic regression model was used to estimate adjusted vaccine effectiveness for full vaccination(two doses≥14 d)and partial vaccination status(one dose≥14 d or two doses<14 d).Results:The proportion of fully vaccinated individuals was significantly lower among cases(12,6.0%)compared to controls(30,13.5%).The adjusted effectiveness of a full dose of ChAdOx1 nCoV-19 coronavirus vaccine in preventing ICU admission or death was 81.9%(95%CI:61.3%-91.6%,P=0.001).Subgroup analysis restricted to age group,sex,and comorbidities found that ChAdOx1 nCoV-19 coronavirus vaccine had a significant positive effect in all subgroups and ***:COVID-19 vaccination reduces ICU admissions or ***,increased vaccine uptake may reduce the severity of the pandemic,more so in the elderly and those with comorbidities.

关键词： Vaccine effectiveness ChAdOx1 nCoV-19 coronavirus vaccine Mortality Case-case analysis Pandemic

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Dynamics of transmission of COVID-19 cases and household contacts:A prospective cohort study

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Journal of Acute Disease 2021年第4期10卷 162-168页

作者： Priyanka Rajmohan Ponnu Jose Jubina Bency Anthoora Thodi Joe Thomas Lucy Raphael Swathi Krishna unnikrishnan uttumadathil gopinathan Praveenlal Kuttichira Departments of Community Medicine Jubilee Mission Medical College and Research InstituteThrissurKeralaIndia Departments of Psychiatry Jubilee Mission Medical College and Research InstituteThrissurKeralaIndia

Objective:To study the transmission dynamics of coronavirus disease 2019(COVID-19)among 101 confirmed cases and their 387 household contacts and to determine risk factors associated with secondary attack among the household ***:A prospective cohort study was conducted from January 1st 2021 to February 28th 2021,among 101 SARS-CoV-2 cases and 387 household contacts who were followed up for 14 days from the last day of contact with the index case of *** dynamics of disease transmission was estimated,and factors affecting transmission risk were ***,the association between various factors and household secondary attack rate was ***:The median incubation period was found to be 5 days,and the observed reproductive number(R)was found to be 1.63(95%CI:1.28-1.98).The mean household secondary attack rate was 40.7%.Contacts with comorbidities like diabetes mellitus,hypertension,dyslipidemia,and hypothyroidism had significantly higher attack rates(P<0.05).Conclusions:As new variants of SARS-CoV-2 emerges,it is crucial to know the trasmission *** study shows a high secondary attack rate of COVID-19 among household contacts that must be closely monitored.

关键词： Dynamics Transmission COVID-19 Kerala Prospective cohort

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