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Atmospheric and Oceanic Science Letters 2024年第3期17卷 32-36页

作者： Said Benjeddou denis Bourras Christopher Luneau Aix Marseille universite National Center for Scientific ResearchMediterranean Institute of OceanographyMarseilleFrance Observatory of the Sciences of the Universe Pytheas Institute National Center for Scientific ResearchMarseilleFrance

Turbulent fluxes at the air-sea interface were estimated with data collected in 2011-2020 with a low-profile platform named OCARINA during eight experiments in five regions:2011,2015,and 2016 in the Iroise Sea;2012 in the tropical Atlantic;2014 in the Chilie-Peru upwelling;2017 and 2018 in the Mediterranean Sea,and 2018 and 2020 in *** observations were carried out with moderate winds(2-10 m s^(-1))and average wave heights of 1.5 *** this study,the authors used the fluxes calculated by the bulk method using OCARINA-sampled data as the *** data can validate the fluxes estimated from ERAS reanalysis *** OCARINA and ERA5 data were taken *** do this,the authors established an algorithm to extract the OCARINA data as closely as possible to the reanalysis data in time and *** measurements of the OCARINA platform can conclude on the relevance of the widely used reanalysis data.

关键词： Ocarina ECMWF ERA5 Turbulent fluxes Louis formulation

HIV drug resistance:viral strategies for treatment escape

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HIV drug resistance:viral strategies for treatment escape

围术期神经肌肉阻滞的管理:欧洲麻醉和重症监护学会临床指南

第十五届国际药理学大会

作者： Francois Clavel Inserm U552 and Faculté de Médecine Université denis diderot paris F-75018 France Francois Clavel Inserm U552 and Faculté de Médecine Université Denis Diderot Paris F-75018 France

＜正＞ In order to ensure escape from the intense pharmacological pressure exerted by HAART. HIV must fulfill three main requirements:1. Ensure HIV resistance per se. through mutations that promote structural and functional changes in the viral proteins that are targeted by antiretroviral drugs. Resistance mutations generally accumulate gradually along with viral escape, starting with low levels of resistance and evolving progressively toward levels that are relevant to the concentrations of drugs found in the most drug-permeable infected tissues in vivo. These mutations often vary from one drug to another and promote resistance through a variety of mechanisms.2. Preserve viral"fitness" or replicative capacity, the frequently observed replica-tive cost of resistance mutations. Because they modify the properties of viral proteins and most notably the catalytic efficiency of viral enzymes, most resistance mutations have a negative impact on HIV replication. HIV. however, has developed a number of compensatory mechanisms to limit resistance-associated loss of viral fitness, some of which are still poorly understood and can involve regions of the HIV genome that are distinct from those directly targeted by the drugs. Although it is well established that resistant viruses are clearly less fit in vivo than their wild-type parental counterparts, the consequences of reduced viral fitness on HIV pathogenicity still need to be fully evaluated.3. Preserve viral diversity, an essential property of viral populations observed in treated patients. Resistance evolves through the constant coevolution of multiple viral species bearing different genotypes and phenotypes, which can act as a reservoir from where new genotypes can be recuited depending on the pharmacological pressure. Furthermore, genetic recombination, a remarkable property of retroviruses. ensures that following the strong bottlenecks that often accompany pharmacological selection of resistant viral species. HIV can rapid

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中华麻醉学杂志 2024年第6期44卷 641-656页

作者： Thomas Fuchs-Buder Carolina S.Romero Heidrun Lewald Massimo Lamperti Arash Afshari Ana-Marjia Hristovska denis Schmartz Jochen Hinkelbein Dan Longrois Maria Popp Hans Dde Boer Massimiliano Sorbello Radmilo Jankovic Peter Kranke 法国南锡大学医学院附属医院麻醉学、重症监护与围术期医学科法国南锡54000 巴伦西亚大学综合医院麻醉与重症监护科西班牙巴伦西亚46014 慕尼黑工业大学麻醉学与重症监护科德国慕尼黑80333 克利夫兰阿布扎比诊所麻醉学研究所阿联酋阿布扎比31250 哥本哈根大学医院小儿和产科麻醉科丹麦哥本哈根2100 哥本哈根大学医院麻醉学与重症监护科丹麦赫维德2650 布鲁塞尔自由大学Erasme医院麻醉科比利时布鲁塞尔1070 科隆大学医院麻醉学与重症监护科德国科隆50937 巴黎大学附属比查特克劳德伯纳德医院麻醉学与重症监护医学科法国巴黎75018 维尔茨堡大学医院麻醉学、危重病医学、急诊医学和疼痛医学科德国维尔茨堡97080 格罗宁根大学医院麻醉学、疼痛医学与程序性镇静与镇痛科荷兰格罗宁根9713 GZ 卡坦尼亚大学医院麻醉与重症监护科意大利卡坦尼亚95123 尼什大学医学院尼什临床中心麻醉学与重症治疗科塞尔维亚尼什18000

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(Europea... 详细信息

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(European Society of Anaesthesiology and Intensive Care,ESAIC)首次发布围术期神经肌肉阻滞管理临床指南,旨在为临床医生提供最佳医疗管理的循证建议,以提高围术期患者安全。本指南主要聚焦在3个临床问题:肌松药是否有助于成人气管插管?神经肌肉阻滞深度是否影响腹部手术患者的预后?肌松药残留阻滞的诊断和治疗策略有哪些?根据PICO原则(患者、干预、对照、结局;patient,intervention,comparator,outcome;PICO)构建临床问题并进行文献检索。初始纳入的临床研究为24 000篇,采用逐步筛选策略,最终临床研究88篇纳入指南分析。应用GRADE方法学(Grading of Recommendations,Assessment,Development and Evaluation,GRADE)对结局指标证据、质量等级进行评价。运用两轮德尔菲法收集专家组建议并形成统一推荐:R1推荐应用肌松药辅助气管插管(1A)。R2推荐应用肌松药以减少气管插管导致的咽部和(或)喉部损伤(1C)。R3推荐在快速顺序诱导插管(rapid sequence induction intubation,RSII)时使用短效肌松药,例如琥珀胆碱1 mg/kg或罗库溴铵0.9~1.2 mg/kg(1B)。R4推荐在需要改善外科手术条件时,加深神经肌肉阻滞深度(1B)。R5尚无足够的证据推荐深度神经肌肉阻滞可减轻术后疼痛或降低围术期并发症的发生率(2C)。R6推荐在拇内收肌处刺激尺神经,定量监测神经肌肉阻滞深度以排除肌松药残留阻滞(1B)。R7推荐应用舒更葡糖钠逆转甾体类肌松药(罗库溴铵、维库溴铵)诱导的深、中及浅度神经肌肉阻滞(1A)。R8推荐在使用新斯的明前,TOFr自行恢复至>0.2,并继续定量监测神经肌肉功能,直至TOFr超过0.9(1C)。

关键词：神经肌肉阻滞神经肌肉功能肌松药临床指南罗库溴铵琥珀胆碱外科手术定量监测

Dimuon Production from Heavy Quark Decay in Heavy-Ion Collisions at √s-5.5 TeV

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Chinese Physics Letters 1999年第7期16卷 496-498页

作者： ZHOU Dai-cui denis JOUAN LIU Han CAI Xu Institute of Particle Physics Huazhong Normal UniversityWuhan 430079 Institut de Physique Nucleairej universite paris-Sud et IN2P3-CNRS 91406 OrsayFrance

The production of heavy-Havor quark c(c)and b(b)in pp collisions is described under perturbative quantum chromodynamics framework,the extrapolation from hadron-hadron up to nucleus-nucleus collisions is based on geometrical model by taking into account the nucleus shadowing *** simulate the heavy quark production,the decay to dilepton and effects of detection and analysis technique of the pairs,and predict the muon rate and the invariant mass spectrum of dimuons that could be detected in forward region in Pb-Pb collisions at large hadron collider energies.

关键词： effect. quark hadron

Delayed sexual maturity in males of Vespa velutina

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Insect Science 2018年第4期25卷 679-689页

作者： Juliette Poidatz Christophe Bressac Olivier Bonnard denis Thiery INRA UMR1065 Santé et Agroecologie du Vignoble ISVV Bordeaux Sciences Agro Villenave d'Omon France IRBI Universite Francois Rabelais UMR CNRS 7261 Tours France

Vespa velutina var nigrithorax （Lepelletier, 1835） is an invasive predator of bees accidentally introduced in France in 2004, and it is having a serious impact on apiculture and ecosystems. Studying the reproduction of an invasive species is key to assess its population dynamic. This study explores the sexual maturation of IT. velutina males and the evolution of their fertility. The main studied parameters were physiologic （spermiogenesis, spermatogenesis） and anatomic （testes size and structure, head width）. Two populations of males were described based on their emergence period： early males in early summer or classic males in autumn. Each testis has an average of 108 testicular follicles. Spermatogenesis is synchronous, with only 1 sperm production wave, and completed, on average, at 10.3 d after emergence with the degeneration of the testes. The sperm counts in seminal vesicles of mature males are 3 x 106 in October/November and 0.8 ~ 106 in June. In com- parison, females store 0.1 x 106 sperm in their spermathecae. The early males emerged from colonies made by fertilized queens. The reproductive potential of these early males seemed limited, and their fimction in the colony is discussed. The sperm stock evolution in autumn males suggests the occurrence of a reproductive pattern of male competition for the access to females and a single copulation per male. The synchronicity of male and foundress emergences and sexual maturation is of primary importance for the mating success and the future colony development.

关键词： male fertility seminal vesicles spermiogenesis sperm stock testis Vespidae yellow-legged hornet

Spatial distribution of Vespa velutina individuals hunting at domestic honeybee hives： heterogeneity at a local scale

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Insect Science 2014年第6期21卷 765-774页

作者： Karine Monceau Olivier Bonnard Jerome Moreau denis Thiery INRA UMR1065 Sante et Agroecologie du Vignoble F-33883 Villenave d'Omon ISVV UMR1065 Sante et Agroecologie du Vignoble Bordeaux Sciences Agro Universite de Bordeaux F-33883 Villenave d'Omon Equipe Ecologie Evolutive UMR 6282 Biogeosciences 6 Bd Gabriel Universite de Bourgogne F-21000 Dijon France

Since its recent introduction into Europe, the yellow-legged hornet, Vespa velutina, has become a major predator of the domestic honeybee, Apis mellifera, but little is known about its hunting behavior. We studied V. velutina hunting behavior by a capture- mark-recapture procedure in an experimental apiary. A total of 360 hornets were captured and tagged, and we determined：（i） the number of hornets visiting the apiary and the changes in time, （ii） the average number of individual visits per half-day and the time elapsed between consecutive recaptures, and （iii） the individual and global distribution of the hornets in the apiary. More than 50% of the marked hornets were recaptured at least once, this increased to 74% in considering the first marked individuals. We estimated 350 hornets visiting the patch daily with at least 1 visit per half-day. The number of marked hornets decreased over time while the number of unmarked ones increased, suggesting a turnover of individuals. The reduction of the delay between consecutive visits indicates that hornets became more efficient over time. Most of the hornets （88%） were recaptured in front of different hives but, overall, the global distribution was aggregative. Hornets were mainly recaptured in front of 1 hive which was neither the smallest nor the biggest colony, suggesting that the major cue used by hornets is not the amount of food. We hypothesize that the defensive behavior of the honeybee colony could explain our results which may be promising to further studies.

关键词： Apis mellifera capture-mark-recapture learning predation Vespidae yellow-legged hornet

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狄德罗文集

Behavioral syndrome in a native and an invasive hymenoptera species

1997年

作者：（法）德尼·狄德罗（denis diderot）王雨陈基发编译

本书主要内容包括：哲学思想录、对自然的解释、关于物质和运动的原理等。

ISBN: (数字)780088953X

ISBN: (纸本)780088953X

本书主要内容包括：哲学思想录、对自然的解释、关于物质和运动的原理等。

关键词：哲学地点:法国年代:近代学科:文集

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Insect Science 2015年第4期22卷 541-548页

作者： Karine Monceau Jerome Moreau Juliette Poidatz Olivier Bonnard denis Thiery INRA UMR 1065 Sante et Agroecologie du Vignoble F-33883 Villenave d'Omon France ISVV UMR 1065 Sante et Agroecologie du Vignoble Bordeaux Sciences Agro Universite de Bordeaux F-33883 Villenave d'Omon France universite de Bourgogne UMR CNRS 6282 Biogeosciences 6 bd Gabriel 21000 Dijon France

Recent studies have focused on the role of behavior in biological invasions. Individuals may differ consistently in time for several behavioral traits （personality） which covary （behavioral syndrome） resulting in different behavioral types, some of them favoring invasion. Social hymenopterans have a strong potential to be invaders and their success depends primarily on the foundresses＇ ability to found viable colonies. They are expected to be active, explorative and bold for optimally establishing their nest. In Europe, 2 homet species coexist： the native Vespa crabro and the invasive Vespa velutina. These 2 species may compete for nesting sites and we suggest that the initial success of V. velutina has been favored by its behavior in outperforming V. crabro for the traits involved in nest initiation. Here, we （i） defined the personality of V. crabro and V：. velutina, （ii） tested for the existence of behavioral syndrome in these species, and （iii） compared their performances using an open-field test. Our results show that V. crabro foundresses behave consistently but not V. velutina; this lack of consistency being mainly due to reduced variance among individuals. This result questions the possibility of detecting consistent behavioral differences in species having recently undergone a strong bottleneck. Both species exhibit the same correlations between activity, boldness and exploration and V. velutina clearly outperforms 14. crabro for all traits. Our results suggest that activity, boldness, and exploration are implicated in both hornet nest initiation and invasion process which contributed to explain why social hymenopterans are so successful at colonization.

关键词： animal personality biological invasion invasion syndrome Vespa crabro Vespa velutina Vespidae

单硫醚在不同极性固定相上的气相色谱保留指数与结构的相关性研究

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色谱 2002年第5期20卷 415-418页

作者：王亚伟高玉红姚小军刘满仓胡之德范波涛兰州大学化学化工学院甘肃兰州730000 ITODYS University of paris 7-denis diderot

在计算出 61个单硫醚的各种量化参数之后 ,用逐步回归方法 ,预测了单硫醚在 4种极性固定相上的气相色谱保留值 ,建立了相应的定量模型。结果表明 ,该模型具有较强的预测能力 ,回归方程的均方根误差不超过 4 %。

关键词：固定相气相色谱单硫醚多元线性回归定量结构-色谱保留相关保留值 QSRR