检索结果-南通市图书馆

德国临床用药 1999年第3期2卷 12-13页

作者： unger,t

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

转化酶抑制剂的降压机制

国外医药.合成药.生化药.制剂分册 1985年第1期 11-14页

作者： unger t 江明华

口服有效的转化酶抑制剂(CEI)如巯甲丙脯酸或MK 421等,业已成功地作为抗高血压药进入临床。最初认为,CEI的降压机制在于抑制转化酶使循环的血管紧张素Ⅱ(ANG Ⅱ)减少,从而减弱ANG Ⅱ的直接升压作用。然而有证据表明,在高血压病人和实验... 详细信息

口服有效的转化酶抑制剂(CEI)如巯甲丙脯酸或MK 421等,业已成功地作为抗高血压药进入临床。最初认为,CEI的降压机制在于抑制转化酶使循环的血管紧张素Ⅱ(ANG Ⅱ)减少,从而减弱ANG Ⅱ的直接升压作用。然而有证据表明,在高血压病人和实验性高血压动物,不论血浆中肾素-血管紧张素系统是否兴奋,CEI均有降压作用。由于转化酶也是缓激肽的主要降解酶,故CEI亦能增加外原性缓激肽的血管扩张作用。此外,尚有些与转化酶抑制无关的作用,如血管平滑肌对钠通

关键词：降压机制升压反应酶抑制剂血管紧张素系统血浆肾素 CEI 降压作用

先天性球形红细胞增多症患者复发性溶血性贫血伴发小腿类丹毒

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 12-12页

作者： Leverkus M. Schwaaf A. Br?§unger t.M. 马慧群(译)

A 29- year- old patient presented with recurrent erythematous eruptions on both lower legs of 15 years’duration. Family history, along with clinical and laboratory examinations, revealed congenital hereditary spherocytosis and excluded other reasons for the erythematous eruptions of the lower legs. During two subsequent episodes, we detected increased hemolysis that disappeared concomittantly on spontanous resolution of the lesions. to our knowledge, this case is the first report showing a recurrent erythematous eruption on the lower legs in a patient with congenital hereditary spherocytosis. these eruptions might be caused by intermittent hemolysis- induced inflammation as a result of the increased osmotic fragility of the erythrocytes and may evolve to chronic leg ulcers later in life.

关键词：类丹毒溶血性贫血首例报道红细胞脆性慢性溃疡

维普期刊数据库

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词：

收缩压变异及平均心率与心血管病高危患者的认知功能障碍相关

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华高血压杂志 2015年第1期23卷 72-72页

作者：赵狄练桂丽 Bhm M Schumacher H Leong D Mancia G unger t Schmieder R Custodis F Diener HC Laufs U Lonn E Sliwa K teo K Fagard R Redon J Sleight P Anderson C O'Donnell M Yusuf S

收缩压升高与认知功能减退及伴随而来的痴呆有关。但心率、随诊间心率变异、随诊间收缩压变异的影响仍未明确。在单用替米沙坦或与雷米普利联用全球终点试验和替米沙坦用于治疗对血管紧张素转换酶抑制剂不耐受的心血管病患者的随机评估... 详细信息

收缩压升高与认知功能减退及伴随而来的痴呆有关。但心率、随诊间心率变异、随诊间收缩压变异的影响仍未明确。在单用替米沙坦或与雷米普利联用全球终点试验和替米沙坦用于治疗对血管紧张素转换酶抑制剂不耐受的心血管病患者的随机评估研究中,根据收缩压均值、随诊间收缩压变异（变异系数=标准差/均值×100%）、平均心率、随诊间心率变异评估之前无认知功能障碍的24593例患者。

关键词：收缩压变异平均心率替米沙坦心血管病患者变异系数雷米普利评估研究状态量 ahead 叠加效应

维普期刊数据库

Challenges to the early diagnosis and treatment of breast cancer in developing countries

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2014年第3期5卷 465-477页

作者： Karla unger-Salda?a Economy Division Centro de Investigación y Docencia Económicas (CIDE) 01210 Mexico CityMéxico

this critical review of the literature assembles and compares available data on breast cancer clinical stage, time intervals to care, and access barriers in different countries. It provides evidence that while more than 70% of breast cancer patients in most high-income countries are diagnosed in stages Ⅰ and Ⅱ, only 20%-50% patients in the majority of low- and middleincome countries are diagnosed in these earlier stages. Most studies in the developed world show an association between an advanced clinical stage of breast cancer and delays greater than three months between symptom discovery and treatment start. the evidence assembled in this review shows that the median of this interval is 30-48 d in high-income countries but 3-8 mo in low- and middle-income countries. the longest delays occur between the first medical consultation and the beginning of treatment, known as the provider interval. the little available evidence suggests that access barriers and quality deficiencies in cancer care are determinants of provider delay in low- and middle-income countries. Research on specific access barriers and deficiencies in quality of care for the early diagnosis and treatment of breast cancer is practically non-existentin these countries, where it is the most needed for the design of cost-effective public policies that strengthen health systems to tackle this expensive and deadly disease.

关键词： Breast cancer Early diagnosis Delays time intervals Clinical stage Access Health care delivery

Fecal microbiota transplantation in allergic diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece tüsüzÖnata ÖnerÖzdemir Division of Pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMt)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(t helper 1/t helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMt in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

Anthropogenic Pseudokarstic Depressions on Mount Bocskor(Bakony Region, Hungary)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2023年第1期34卷 214-231页

作者： Márton Veress Zoltán unger Szilárd Vetési-Foith Department of Geography Savaria University centreEötvös Lóránd UniversitySzombathely9700Hungary Institute of Geography University of PécsPécs7600Hungary

Surface forms above the mine(ármin mine) of Mount Bocskor(Southern Bakony, Hungary) were examined. We made contour maps, plan maps, morphological maps and atectonic grike(cave) maps of some of the forms and their surroundings. We examined the distribution of the depth, length, elongation ratio in case of some depressions, the relation between the depth and the diameter of some depressions, the relationship between depression group directions and mine cut directions, the standard deviation of the direction differences of depression groups and of their depressions. the forms of the mountain related to surface mining can be separated to open and closed. the former are trenches and stairs, the latter are circular, elongated, and complex depressions. the formation of these forms can be related to the balancing movements of the vault over the mountain’s mine. At thin vault, stairs develop by collapses, while at the atectonic fissures of thicker vault, trenches and depressions are formed at the surface. In areas bordered by sinking(subsidence through) and downwardly cohesive faults, depression groups of diverse features are arranged in the marginal bands. Elongated depressions are formed at atectonic blocks bounded by dispersing faults in non-banded distribution. Where there is a superficial deposit, atectonic fissures can also be inherited directly by collapse to the surface and form depressions. they can also form indirectly over atectonic fissures by compaction, subsequent collapse and/or suffosion of the superficial deposit. the results of the study make it possible to analyse the material loss due to mining on the vault if the atectonic structures of the vault are partly or completely covered by superficial deposit.

关键词： mining pseudokarstic depression atectonic fissure atectonic block collapse suffosion

维普期刊数据库

Effects of endothelin EtA receptor blocker LU 135252 on cardiac remod-eling and survival in a hypertensive rat model of chronic heart failure

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2006年第11期27卷 1417-1422页

作者： Alexander REINECKE Marc DORENKAMP Mat Jap DAEMEN Reichiger SIMON thomas unger Clinic of Cardiology Christian-Albrechts-University of Kiel24105 KielGermany Institute of Pharmacology Christian-Albrechts University of Kiel24105 KielGermany Department of Pathology University of MaastrichtMaastrichtthe Netherlands

Aim:to investigate whether the endothelin EtAreceptor blocker provides similarbenefit on cardiac remodeling and survival in a hypertensive rat model of chronicheart failure（CHF）.Methods:Male stroke-prone spontaneously hypertensive（SHR-SP）rats were subjected to permanent ligation of the left coronary artery andwere treated for 6 weeks with the endothelin EtAreceptor blocker LU 135252(***-1.d-1)starting 24 h after ligation or ***-operated rats servedas normal *** mean arterial blood pressure（MAP）,heart rate（HR）,leftventricular end-diastolic pressure（LVEDP）,left ventricular contractility(LVdp/dtmax),left ventricular inner diameter（LVD）and circumference（LVC）,septalthickness,left ventricular interstitial collagen content（ICC）and heart weight（HW）were measured at the end of the ***:Compared with the untreatedgroup,LU 135252 tended to increase HW（1.43±0.03 vs 1.38±0.04 g;P>0.05）,increased LVD（7.65±0.24 mm vs 6.58±0.14 mm;Pt ventricular ICC（3.79%±0.09% vs 6.71%±0.11%;Ptly lowered MAP（132±6mmHg vs142±4 mmHg;P>0.05）,reduced LVEDP（144mmHg vs 27±4 mmHg;Ptmax（4230±450 mmHg/s vs 1950±400 mmHg/s;Pt prolonged significantly（13% vs 11%;P=NS）.Conclusion:In this hyper-tensive rat model of CHF,chronic endothelin EtA receptor blockade with LU 135252improves cardiac hemodynamics,however,it does not affect long-term survivaland worsens cardiac ***,endothelin EtAreceptor antagonists areunlikely to have an important role in the management of patients with CHF.

关键词： myocardial infarction heart failure endothelin Et_A receptor antagonism LU 135252 cardiac remodeling ventricular function SHR-SP rats

Free vibration and transient response of double curved beams connected by intermediate straight beams

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-tALOOKOLAEI H.GHANDVAR E.JUMAEV S.KHAtIR t.CUONG-LE School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and technology Solutions Ho Chi Minh City Open University

this paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. the strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. the curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. the accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词：