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H pylori eradication:A randomized prospective study of triple therapy with or without ecabet sodium

World Journal of Gastroenterology 2008年第6期14卷 908-912页

作者： Hyung Wook Kim Gwang Ha Kim Jong Yun Cheong ung suk yang Seung Keun Park Chul Soo Song Dae Hwan Kang Geun Am Song Department of Internal Medicine Bongseng Memorial Hospital Busan Korea Department of Internal Medicine Pusan National University School of Medicine Busan 602-739 Korea Department of Internal Medicine Maryknoll Hospital Busan Korea

AIM: To investigate whether adding ecabet sodium to the standard triple therapy for H pylori infection improve eradication rate. METHODS: Two hundred and fifty-seven H pylori-infected patients were randomly assigned to standard triple therapy (group A, n = 129) or triple therapy plus ecabet sodium (group B, n = 128). Successful eradication was defined as a negative 13C-urea breath test 6-8 wk after completion of treatment. RESULTS: After completion of therapy, 194/257 patients showed negative 13C-urea breath test results. According to intention-to-treat analysis, the infection was eradicated in 93/129 (72.1%) patients in group A and 101/128 (78.9%) in group B (P = 0.204). Per-protocol analysis showed successful eradication in 93/118 (78.8%) patients from group A and 101/114 (88.6%) from group B (P = 0.044). There were no significant differences in the side effects experienced by the patients in the two treatment groups. CONCLUSION: Our results suggest that the addition of ecabet sodium improves the efficacy of the standard triple therapy for H pylori.

关键词： H pylori Eradication Triple therapy Ecabet sodium

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Iodized oil uptake assessment with cone-beam CT in chemoembolization of small hepatocellular carcinomas

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World Journal of Gastroenterology 2009年第46期15卷 5833-5837页

作者： ung Bae Jeon Jun Woo Lee Ki Seok Choo Chang Won Kim suk Kim Tae Hong Lee Yeon Joo Jeong Dae Hwan Kang Department of Radiology Pusan National University Yangsan Hospital Department of Radiology Pusan National University Hospital Department of Internal Medicine Pusan National University Yangsan Hospital

AIM:To evaluate the utility of assessing iodized oil uptake with cone-beam computed tomography(CT)in transarterial chemoembolization(TACE)for small he-patocellular carcinoma(HCC).METHODS:Cone-beam CT provided by a biplane flat-panel detector angiography suite was performed on eighteen patients(sixteen men and two women;41-76 years;mean age,58.9 years)directly after TACE for small HCC(26 nodules under 30 mm;mean diam-eter,11.9 mm;range,5-28 mm).The pre-procedural locations of the tumors were evaluated using tripha-sic multi-detector row helical computed tomography(MDCT).The tumor locations on MDCT and the iodized oil uptake by the tumors were analyzed on cone-beam CT and on spot image directly after the ***:All lesions on preprocedural MDCT were de-tected using iodized oil uptake in the lesions on cone-beam CT(sensitivity 100%,26/26).Spot image depictediodized oil uptake in 22 of the lesions(sensitivity 85%).The degree of iodized oil uptake was overestimated(9%,2/22)or underestimated(14%,3/22)on spot image in f ive nodules compared with that of cone-beam ***:Cone-beam CT is a useful and conve-nient tool for assessing the iodized oil uptake of small hepatic tumors(< 3 cm)directly after TACE.

关键词： Chemoembolization Computed tomography Hepatocellular carcinoma Liver

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钩藤中的新成分对莨菪碱诱导的记忆缺陷的改善效果(英文)

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中国天然药物 2013年第4期11卷 391-395页

作者： SHIN suk-Chul LEE Dong-ung Institute of Bioconvergence Technology Dongguk UniversityGyeongju780-714Korea Division of Bioscience College of Science and TechnologyDongguk UniversityGyeongju780-714Korea

AIM:To study the chemical constituents and their anti-amnesic effect from the hooks of Uncaria ***:The isolation of compounds was performed by chromatographic techniques and their structures were identified on the basis of spectral *** ameliorating effects on scopolamine-induced memory impairment in vivo using a Morris water-maze task and passive avoidance task system were ***:Activity-guided fractionation of the total extracts resulted in the isolation of four constituents,trans-anethole(1),p-anisaldehyde(2),estragole(3),and 3-oxo-olean-12-en-28-oic acid(4),which were found for the first time from this ***:Compound 1 exhibited a better memory enhancing effect than tacrine,a positive agent,at the same dose in the passive avoidance test and a similar property in the water-maze test,and its action may be mediated,in part,by the acetylcholine enhancing cholinergic nervous system.

关键词：实验药理学药理病理作用天然药物

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Limited endoscopic sphincterotomy plus large balloon dilation for choledocholithiasis with periampullary diverticula

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World Journal of Gastroenterology 2010年第34期16卷 4335-4340页

作者： Hyung Wook Kim Dae Hwan Kang Cheol Woong Choi Jong Hwan Park Jin Ho Lee Min Dae Kim Il Doo Kim Ki Tae Yoon Mong Cho ung Bae Jeon suk Kim Chang Won Kim Jun Woo Lee Department of Internal Medicine Pusan National University School of Medicine and Medical Research Institute Pusan National University yangsan Hospital Department of Radiology Pusan National University School of Medicine and Medical Research Institute Pusan National University Hospital

AIM: To investigate the effectiveness and safety of limited endoscopic sphincterotomy (EST) plus large balloon dilation (LBD) for removing choledocholithiasis in patients with periampullary diverticula (PAD). METHODS: A total of 139 patients with common bile duct (CBD) stones were treated with LBD (10-20 mm balloon diameter) after limited EST. Of this total, 73 patients had PAD and 66 patients did not have PAD (controls). The results of stone removal and complications were retrospectively evaluated. RESULTS: There were no significant differences between the PAD and the control groups in overall successful stone removal (94.5% vs 93.9%), stone removal in first session (69.9% vs 81.8%), mechanical lithotripsy (12.3% vs 13.6%), and complications (11.0% vs 7.6%). Clinical outcomes were also similar between the types of PAD, but the rate of stone removal in first session and the number of sessions were significantly lower and more frequent, respectively, in type B PAD (papilla located near the diverticulum) than controls [23/38 (60.5%) vs 54/66 (81.8%), P = 0.021; and 1 (1-2) vs 1 (1-3), P = 0.037, respectively] and the frequency of pancreatitis was significantly higher in type A PAD (papilla located inside or in the margin of the diverticulum) than in controls (16.1% vs 3.0%, P = 0.047). CONCLUSION: Limited EST plus LBD was an effective and safe procedure for removing choledocholithiasis in patients with PAD. However, some types of PAD should be managed with caution.

关键词： Endoscopic sphincterotomy Large balloon dilation Choledocholithiasis Periampullary diverticula

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