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Potential effects of L-NAME on alcohol-induced oxidative stress

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World Journal of Gastroenterology 2005年第4期11卷 600-604页

作者： Hafize Uzun Gonul Simsek Seval Aydin ethem unal Yesari Karter Nermin Karaturan Yelmen Suphi Vehid Asl Curgunlu Safiye Kaya Department of Biochemistry Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Physiology Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of General Surgery Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Internal Medicine Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Physiology Istanbul University Cerrahpapa School of MedicineIstanbul Turkey Department of Public Health Istanbul University Cerrahpapa School of MedicineIstanbulTurkey

AIM: Nitric oxide (NO) is a highly reactive oxidant synthesized from L-arginine by nitric oxide synthase (NOS). NO may cause injury through the generation of potent radicals. Nwnitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 ***: Thirty-six male Wistar rats were divided into 3 equal groups: group 1 (control group-isocaloric dextrose was given), group 2 (6 g/kg.d ethanol-induced group) and group 3 (both ethanol 6 g/kg.d and L-NAME 500 mg/L in drinking water-given group). Animals were sacrificed at the end of 4 wk-experimental period, and intracardiac blood and liver tissues were obtained. Biochemical measurements were performed both in plasma and in homogenized liver tissues. Alanine amino transferase (ALT), aspartate amino transferase (AST), malondialdehyde (MDA), NO, superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels were measured by ***: ALT and AST in group 2 (62 U/L and 128 U/L,respectively) were higher than those in group 1 (24 U/L and 38 U/L) and group 3 (37 U/L and 81 U/L) (P＜0.001 for both).Plasma and tissue levels of MDA in group 2 (4.66 μmol/L and 0.55 nmol/mg protein) were higher than in group 1 (2.65 μmol/L and 0.34 nmol/mg protein) and group 3 (3.43 μmol/L and 0.36 nmol/mg protein) (P＜0.001 for both). Plasma and liver tissue levels of NO in group 2 (54.67 μmol/L and 586.50 nmol/mg protein) were higher than in group 1 (34.67 μmol/L and 435.33 nmol/mg protein)and group 3 (27.50 μmol/L and 412.75 nmol/mg protein )(P＜0.001 for both). Plasma and liver tissue SOD activities in group 2 (15.25 U/mL and 5.38 U/ mg protein,respectively) were lower than in group 1 (20.00 U/mL and 8.13 U/mg protein) and group 3 (19.00 U/mL and 6.93 U/mg protein) (P＜0.001 for both). Plasma and liver tissue CAT activities in group 2 (145 U/mL and 37 U/ mg

关键词： L-NAME 酒精肝诱导作用氧化作用精氨酸

Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals

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World Journal of Gastroenterology 2005年第23期11卷 3570-3573页

作者： Titiz Izzet Krand Osman unal ethem Yavuz Nihat Kusaslan Ramazan Dogan Mustafa Uzun Hafize Kiziler Ali Riza Aydemir Birsen Genc Habibe Aydin Seval Simsek Gonul Department of Surgery Department of Biochemistry Department of Biophysics Department of Physiology

AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity *** activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase used asa superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under light microscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P＜0.05 was considered statistically ***: Histopathological studies confirmed PVL induced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL and control groups (P＜0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P＜0.05 and P＜0.001, respectively in tissue; P＜0.001 for each in serum), and Zn only in tissue (P＜0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tis

关键词：肝门静脉高压氧化损伤小鼠动物实验一氧化氮

Prognostic significance of tumor budding,desmoplastic reaction,and lymphocytic infiltration in patients with gastric adenocarcinoma

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 9-25页

作者： Aysen Yavuz Kubra Simsek Anil Alpsoy Busra Altunay Elif Ocak Gedik Betul unal Cumhur Ibrahim Bassorgun Ali Murat Tatli Gulsum Ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Türkiye Department of Medical Oncology Akdeniz University Medical SchoolAntalya 07070Türkiye

BACKGROUND Recent studies have shown that the tumor microenvironment significantly influences the behavior of solid *** this context,Accumulated data suggests that pathological evaluation of tumor budding(TB),desmoplastic reaction(DR),and tumor-infiltrating lymphocytes(TILs)may be crucial in determining tumor behavior in the gastrointestinal *** gastric adenocarcinoma(GAC),although some results suggest that TB and TILs may be effective in determining the course of the disease,the data do not ***,very few studies have investigated the relationship between DR and *** present,the associations between tumor TB,DR and TILs in GAC patients have not been *** To establish the relationships between TB,DR,and TILs in patients with GAC and to assess their influence on *** Our study group comprised 130 patients diagnosed with *** definition of TB was established based on the International TB Consensus *** DR was categorized into three groups according to the level of tumor stroma *** assessment of TILs was conducted using a semiquantitative approach,employing a cutoff value of 5%.The statistical analysis of the whole group and 100 patients with an intestinal subtype of GAC was performed using SPSS version *** A significant correlation between peritumoral budding(PTB)and intratumoral budding(ITB)was noted(r=0.943).Tumors with high PTBs and ITBs had a greater incidence of immature DRs and low TILs(P<0.01).PTB and ITB were associated with histological subtype,lymph node metastasis(LNM),and stage(P<0.01).ITB,PTB,LNM,DR,and stage were significant risk factors associated with poor *** multivariate Cox regression analysis identified ITB,PTB,and LNM as independent prognostic variables(P<0.05).In intestinal-type adenocarcinomas,a positive correlation between PTB and ITB was noted(r=0.972).While univariate analysis revealed that LNM,stage,PTB,ITB,and DR were strong parameters for pred

关键词： Gastric cancer Tumor budding Desmoplastic stroma Tumor-infiltrating lymphocytes Prognosis

Detection of critical road roughness sections by trend analysis and investigation of driver speed interaction

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Frontiers of Structural and Civil Engineering 2022年第4期16卷 515-532页

作者： Meltem SAPLIOGLU Ayse unal Melek BOCEK Department of Civil Engineering Suleyman Demirel UniversityIsparta 32260Turkey Department of Civil Engineering Siirt UniversitySiirt 56100Turkey

Pavement roughness(IRI—International Roughness Index values)influence the stability of traffic movements both on intercity roads and urban *** study is to determine the exact locations of critical pavement roughness values that affect traffic motion stability and comfort in city centre highway *** data with 10 m intervals were collected on a 3140 m divided road containing three consecutive signalized intersections in the city centre *** data were analysed using the distance-dependent Mann-Kendall trend analysis method and checkerboard *** sections where roughness is important were determined at a 95%confidence *** results will show where future pavement improvements should be prioritized for municipalities and road maintenance engineers and will form a basis for the urban road management system.

关键词： trend analysis checkerboard model IRI driver speed

Improved population mean estimator with exponential function under non-response

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Applied Mathematics(A Journal of Chinese Universities) 2023年第4期38卷 562-580页

作者： Cerenunal Cem Kadilar Department of Statistics Hacettepe UniversityAnkara 06800Turkey

In this article,we consider a new family of exponential type estimators for estimating the unknown population mean of the study *** propose estimators taking advantage of the auxiliary variable information under the first and second non-response cases *** required theoretical comparisons are obtained and the numerical studies are *** conclusion,the results show that the proposed family of estimators is the most efficient estimator with respect to the estimators in literature under the obtained conditions for both cases.

关键词： non-response exponential estimators sub-sampling method population mean

Effect of Putrescine on Low-Temperature Acclimation in Chlamydomonas reinhardtii

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Phyton-International Journal of Experimental Botany 2022年第3期91卷 583-598页

作者： Muslum S.Inal Dilek unal Bengu Turkyilmaz unal Munir Ozturk Molecular Biology and Genetics Department Faculty of Science and LetterBilecikŞeyh Edebali UniversityBilecik11230Turkey Biotechnology Application and Research Center BilecikŞeyh Edebali UniversityBilecik11230Turkey Biotechnology Department Art and Sciences FacultyNiğdeÖmer Halisdemir UniversityNiğde51240Turkey Botany Department Centre for Environmental StudiesEge UniversityIzmir35100Turkey

Putrescine is reported to be necessary for cold acclimation under low-temperature *** this study,the effect of low-temperature on some physiological and biochemical parameters has been investigated using the green algae Chlamydomonas *** lipid peroxidation rate,amount of Rubisco protein,activities of antioxidant enzymes and gene expression of polyamine biosynthesis(odc2,and spd1),heat shock proteins(hsp70c,hsp90a,and hsp90c),and PSII repair mechanisms(psba,rep27,and tba1)were determined to understand the low-temperature *** putrescine application significantly increased Rubisco protein concentration and catalase enzyme activities under low-temperature ***,real-time RT-PCR results and gene expression analysis showed that polyamine metabolism induced gene expression at low-temperatures in the first 24 *** the same way,the gene expression of heat shock proteins(hsp70c,hsp90a,and hsp90c)decreased under low-temperature treatment for 72 h;however,application of putrescine enhanced the gene expression in the first 24 *** results obtained indicated that molecular response in the first 24 h could be important for cold *** psba and tba1 expressions were reduced under low-temperatures depending on the exposure *** contrast,the exogenous putrescine enhanced the expression level of the psba response to low-temperature at 24 and 72 *** results obtained in this study indicate that putrescine could play a role in the PS II repair mechanisms under low-temperature stress.

关键词： Chlamydomonas reinhardtii cold acclimation heat shock protein low-temperature stress PS II repair putrescine

Effect of prayer on the self-care agency and hope in hemodialysis patients

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Journal of Integrative Nursing 2022年第2期4卷 68-75页

作者： Kevser Sevgi unal ASLAN Funda CETINKAYA Fundamentals of Nursing Department Faculty of Health SciencesOsmaniye Korkut Ata UniversityOsmaniyeTurkey Department of Surgical Nursing Faculty of Health SciencesAksaray UniversityAksarayTurkey

Background:The level of self-care of hemodialysis patients is important in controlling the disease process and *** care has an important place in the process of resolving existing or developing problems of patients receiving hemodialysis treatment and in adapting to *** is not only a resource that encourages religious/spiritual coping,it is also a spirituality that strengthens ***:The objective of this study is to determine whether prayer has an effect on self-care agency and hope in hemodialysis *** and Methods:This is a descriptive and correlational study which was conducted with 180 patients in a private and a public dialysis *** data of 173 hemodialysis patients who met the inclusion criteria were collected using personal information form,Herth Hope Scale,Self-care Agency Scale,and Prayer Attitude ***:A positive,moderate,and statistically significant correlation was found between the Prayer Attitude Scale and total score(r=0.144,P=0.048)and sub-scale future(r=0.350,P=0.000)of Herth Hope *** there was positive correlation between the Prayer Attitude Scale and the total score of Self-care Agency Scale(r=0.599,P=0.000)and its five sub-dimensions drug use(r=0.566,P=0.000),diet(r=0.619,P=0.000),self-monitoring(r=0.522,P=0.000),hygienic care(r=0.576,P=0.000)and mental status(r=0.328,P=0.000).Conclusions:The study found that prayer had a positive effect on self-care agency and hope in hemodialysis patients.

关键词： Hemodialysis patients hope prayer self-care

Aluminum Toxicity:A Case Study on Tobacco(Nicotiana tabacum L.)

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Phyton-International Journal of Experimental Botany 2023年第1期92卷 165-192页

作者： Munir Ozturk Mert Metin Volkan Altay Tomonori Kawano Alvina Gul Bengu Turkyilmaz unal Dilek unal Rouf Ahmad Bhat Moonisa Aslam Dervash Kristina Toderich Esra Koc Pedro Garcia Caparros Andleeb Shahzadi Department of Botany and Centre for Environmental Studies Ege UniversityIzmir35100Turkiye Graduate School of Environmental Engineering The University of KitakyushuFukuoka808-0135Japan Department of Biology Faculty of Science and ArtsHatay Mustafa Kemal UniversityHatay31060Turkiye Atta-ur-Rahman School of Applied Biosciences National University of Sciences&TechnologyIslamabad44000Pakistan Department of Biotechnology Faculty of Science and ArtsNigde Omer Halisdemir UniversityNigde51240Turkiye Department of Molecular Biology and Genetics Faculty of Science and ArtsUniversity of Bilecik Seyh EdebaliBilecik11230Turkiye Department of Environmental Science Sri Pratap CollegeCluster University SrinagarKashmir190008India Division of Environmental Sciences Sher-e-Kashmir University of Agricultural Sciences and TechnologyKashmir190025India International Platform for Dryland Research and Education Tottori UniversityTottori680-0001Japan Department of Biology Faculty of ScienceAnkara UniversityAnkara06100Turkiye Department of Superior School Engineering University of AlmeríaAlmería04120Spain Department of Medical Pharmacology Cerrahpasa Medicine FacultyIstanbul University-CerrahpasaIstanbul34096Turkiye

Aluminum is an abundant metal in the earth’s crust that turns out to be toxic in acidic *** plants are affected by the presence of aluminum at the whole plant level,at the organ level,and at the cellular *** as a cash crop(Nicotiana tabacum L.)is a widely cultivated plant worldwide and is also a good model organism for *** there are many articles on Al-phytotoxicity in the literature,reviews on a single species that are economically and scientifically important are *** this article,we not only provide the biology associated with tobacco Al-toxicity,but also some essential information regarding the effects of this metal on other plant species(even animals).This review provides information on aluminum localization and uptake process by different staining techniques,as well as the effects of its toxicity at different compartment levels and the physiological consequences derived from *** addition,molecular studies in recent years have reported specific responses to Al toxicity,such as overexpression of various protective ***,this review discusses data on various organelle-based responses,cell death,and other mechanisms,data on tobacco plants and other kingdoms relevant to these studies.

关键词： Aluminum oxidative stress protective proteins ROS tobacco toxicity

Bladder calculi concomitant with benign prostatic enlargement:is prostate surgery mandatory in patients who have never received medical therapy?

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Asian Journal of Andrology 2023年第5期25卷 604-607页

作者： Hakan Anil Umut unal Kaan Karamik Ferhat Ortoglu Hakan Ercil Department of Urology Adana City Training and Research HospitalAdana 01000Turkiye Department of Urology Korkuteli State HospitalAntalya 07000Turkiye

The historical dogma that bladder calculi comprise the main indication for prostatic surgery has recently been *** this study,we aimed to predict which patients should undergo simultaneous prostate and bladder calculi surgery or only bladder calculi removal by evaluating preoperative risk *** hundred and seventeen men with bladder stones and concomitant benign prostate enlargement(BPE)who had not received medical treatment before were included in the *** the first step,only the bladder calculi of patients were removed and medical treatment was given for *** patients who benefited from medical treatment during the follow-up were defined as Group 1 and the patients who required prostate surgery for any indication comprised Group *** factors for prostate surgery requirements were determined by comparing preoperative characteristics between the two groups with a cox regression *** the follow-up of 117 patients with bladder stones removed and medical treatment initiated,49(41.9%)patients had prostate surgery *** indication for 33(67.3%)of 49 patients was medical treatment *** presence of intravesical prostatic protrusion(IPP;hazard ratio:2.071,95%confidence interval[Cl]:1.05-4.05,P=0.034),and high postvoiding residual urine volume(hazard ratio:1.013,95%Cl:1.007-1.019,P<0.001)were found to be preoperative risk factors for needing future prostate *** patients who have not received medical treatment for BPE before,bladder calculi developing secondary to BPE do not always constitute an indication for prostate surgery.

关键词： benign prostate hyperplasia bladder calculi intravesical prostatic protrusion medical therapy prostate surgery