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Behaviour and perception of parents on irrational use of antibiotics in children at primary care level:A cross-sectional study from Turkey

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 253-260页

作者： burak Mete Tarik Salcan Hakan Demirhindi Department of Public Health Faculty of MedicineCukurova UniversityAdana01330Turkey

Objective:To investigate the perception of antibiotics,the frequency of inappropriate antibiotic use,and the factors that lead to inappropriate antibiotic use by parents who apply to primary healthcare ***:This cross-sectional study included 973 parents who applied to primary healthcare *** analyzed basic concepts related to antibiotics prescribed for their children,antibiotic administration,and antibiotic resistance,as well as parents'knowledge and attitudes towards antibiotic use,and their experiences,practices,and perceptions related to purchasing antibiotics without ***:In the past one year,78.9%of the parents gave antibiotics to their children at least once,and 39.1%gave antibiotics three or more *** of the participants(7.1%)reported having forced the physician to prescribe antibiotics and purchased antibiotics without a prescription(13.2%).The knowledge about antibiotics and awareness about antibiotic resistance were found to be more frequent;among parents who had university degrees,higher income levels,two or fewer children,social insurance and negative behaviours were lower in those who received information about antibiotics from healthcare *** probability of taking antibiotics without prescription was lower in that of with higher income level(OR 0.460;95%CI 0.219-0.965),and the probability of forcing antibiotic prescription was higher in those with 3 or more children(OR 6.94;95%CI 2.37-20.26).The score obtained from the awareness of antibiotic resistance sub-dimension was found to negatively affect the behavior of forcing antibiotic prescription(OR 0.852;95%CI 0.732-0.993)but the score obtained from the behaviour sub-dimension was positively affect this behaviour(OR 1.136;95%CI 1.011-1.276).Conclusions:Inappropriate antibiotic use appears to be a problem with negative perception,lack of knowledge and socioeconomic *** should be conducted to increase antibiotic knowledge in parents

关键词： Antibiotics Attitudes Social insurance Educational activities

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Self-assembly of coumarin molecules on plasma electrolyzed layer for optimizing the electrochemical performance of AZ31 Mg alloy

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Journal of Magnesium and Alloys 2023年第5期11卷 1618-1628页

作者： Mosab Kaseem burak Dikici Ali Dafali Arash Fattah-alhosseini Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Metallurgical and Materials Engineering Ataturk UniversityErzurum 25240Turkey Faculty of Sciences Oujda Department of ChemistryMohamed the First UniversityOujdaMorocco Department of Materials Engineering Bu-Ali Sina UniversityHamedan 65178-38695Iran

A novel inorganic-organic layer with outstanding corrosion resistance in a 3.5wt.% NaCl solution was fabricated by taking advantage of the unique interactions between coumarin (COM) molecules and the porous layer formed on Mg alloy. To achieve this aim, the AZ31 Mg alloy coated via microarc oxidation (MAO) coating was placed in an ethanolic solution of COM for 6 and 12 h at 25 ℃. By reducing the surface area exposed to the corrosive species, the donor-acceptor complexes produced by the particular interactions between the COM and MAO surface would successfully prevent the corrosion of Mg alloy substrate. The MAO layer would provide the ideal sites for the charge-transfer-induced physical and chemical locking, leading to uneven organic layer nucleation and crystal growth with a thatch-like structure. To evaluate the formation mechanism of such hybrid composites and highlight the key bonding modes between the COM and MAO, theoretical simulations were conducted.

关键词： Mg alloy Hybrid coating Coumarin Porous layer Corrosion DFT

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Spatial estimation of wind speed:a new integrative model using inverse distance weighting and power law

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International Journal of Digital Earth 2016年第8期9卷 733-747页

作者： Emre Ozelkan Gang Chen burak Berk Ustundag Agricultural&Environmental Informatics Research and Application Centre Istanbul Technical UniversityIstanbulTurkey Department of Geography and Earth Sciences University of North Carolina at CharlotteCharlotteNCUSA Laboratory for Remote Sensing and Environmental Change(LRSEC) University of North Carolina at CharlotteCharlotteNCUSA

Spatial interpolation(SI)is currently one of the most common ways to estimate wind speed(Ws).However,classic SI models either ignore the complex geography[*** distance weighting(IDW)],or demand high computational resources(***).This study aimed to develop a simple yet effective SI model for estimating Ws in Eastern Thrace of *** new method,named MIDW(Ws),is a modified IDW through the integration of IDW with wind profile model,power law(PL),representing the influence of land cover and topography on *** features and elevation data of PL were obtained using normalized difference vegetation index(NDVI)and digital elevation model(DEM),*** showed superior and comparable performance of MIDW(Ws)to standard IDW and ordinary kriging(OK)across all months of *** to ordinary cokriging(OCK)using DEM as covariate,MIDW(Ws)generated better results in the arid–semiarid seasons(around summer).Local complex atmospheric conditions during rainy seasons(around winter)may have affected the performance of incorporating PL with MIDW(Ws).Generally,the proposed MIDW(Ws)is simpler and easier to implement compared to *** landscape-scale projects,its high computational efficiency and relatively robust performance show potential to deal with large volumes of datasets.

关键词： Wind speed power law NDVI spatial interpolation modified inverse distance weighting

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Internal Validity Index for Fuzzy Clustering Based on Relative Uncertainty

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Computers, Materials & Continua 2022年第8期72卷 2909-2926页

作者： Refik Tanju Sirmen burak Berk Üstündag Graduate School of Science Engineering&Technology Istanbul Technical UniversityIstanbul34469Turkey Faculty of Computer&Informatics Istanbul Technical UniversityIstanbul34469Turkey

Unsupervised clustering and clustering validity are used as essential instruments of data *** clustering being realized under uncertainty,validity indices do not deliver any quantitative evaluation of the uncertainties in the suggested ***,validity measures may be biased towards the underlying clustering ***,neglecting a confidence requirement may result in *** the absence of an error estimate or a confidence parameter,probable clustering errors are forwarded to the later stages of the ***,having an uncertainty margin of the projected labeling can be very fruitful for many applications such as machine ***,the validity issue was approached through estimation of the uncertainty and a novel low complexity index proposed for fuzzy *** involves only uni-dimensional membership weights,regardless of the data dimension,stipulates no specific distribution,and is independent of the underlying similarity *** tests and comparisons returned that it can reliably estimate the optimum number of partitions under different data distributions,besides behaving more robust to over ***,in the comparative correlation analysis between true clustering error rates and some known internal validity indices,the suggested index exhibited the highest strong *** relationship has been also proven stable through additional statistical acceptance *** the provided relative uncertainty measure can be used as a probable error estimate in the clustering as ***,it is the only method known that can exclusively identify data points in dubiety and is adjustable according to the required confidence level.

关键词： Machine learning data science clustering validity fuzzy clustering uncertainty intelligent systems data analytics

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Characterizing functional consequences of DNA copy number alterations in breast and ovarian tumors by spaceMap

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Journal of Genetics and Genomics 2018年第7期45卷 361-371页

作者： Christopher J.Conley umut Ozbek Pei Wang Jie Peng Department of Statistics University of California Davis Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai

We propose a novel conditional graphical model -- spaceMap -- to construct gene regulatory networks from multiple types of high dimensional omic profiles. A motivating application is to characterize the perturbation of DNA copy number alterations （CNAs） on downstream protein levels in tumors. Through a penalized multivariate regression framework, spaceMap jointly models high dimensional protein levels as responses and high dimensional CNAs as predictors. In this setup, spaceMap infers an undirected network among proteins together with a directed network encoding how CNAs perturb the protein network, spaceMap can be applied to learn other types of regulatory relationships from high dimensional molecular profiles, especially those exhibiting hub structures. Simulation studies show spaceMap has greater power in detecting regulatory relationships over competing methods. Additionally, spaceMap includes a network analysis toolkit for biological interpretation of inferred networks. We applies spaceMap to the CNAs, gene expression and proteomics data sets from CPTAC-TCGA breast （n = 77） and ovarian （n = 174） cancer studies. Each cancer exhibits disruption of＇ion transmembrane transport＇ and ＇regulation from RNA polymerase lI promoter＇ by CNA events unique to each cancer. Moreover, using protein levels as a response yields a more functionally-enriched network than using RNA expressions in both cancer types. The network results also help to pinpoint crucial cancer genes and provide insights on the functional consequences of important CNA in breast and ovarian cancers.

关键词： Integrative genomics Proteogenomics Conditional graphical models Network analysis

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Effect of Si addition on microstructure and wear properties of Mg-Sn as-cast alloys

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Journal of Magnesium and Alloys 2018年第4期6卷 384-389页

作者： Erdem Karakulak Yusuf burak Küçüker Kocaeli University Faculty of EngineeringDepartment of Metallurgical and Materials Engineering41380 KocaeliTurkey AKKAR Silah Sanayi Orhanli Mah.34956 IstanbulTurkey BCAST Brunel University London UxbridgeMiddlesex UB83PHUK

Effect of Si addition on microstructure,hardness and wear resistance of as cast Mg-5Sn and Mg-10Sn alloys were *** this purpose alloys with wt.-%0,0.5,1,1.5 Si were cast using an induction *** of Si to both alloys caused an increasement in the amount of intermetallic phases at the grain *** refined grain structure was reported with increasing Si content in the cast *** increased amount of intermetallics and decreased grain size caused an increase in the hardness of the *** resistance of the binary alloys first increased with Si addition and then *** amounts of Si in the alloys caused crack formation during wear tests and decreased wear *** speed also has a dramatical effect on the wear resistance of the *** sliding speed resulted with higher wear *** surfaces of the alloys also investigated under scanning electron microscope to understand the wear mechanisms operated during wear tests.

关键词： Magnesium Casting Microstructure Hardness Wear

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Comparison of the impact of epigallocatechin gallate and ellagic acid in an experimental cataract model induced by sodium selenite

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 499-506页

作者： Irfan Ergen burak Turgut Nevin Ilhan Diskapi YildirimBeyazit Training and Research Hospital Eye Diseases Clinic Ankara 06330 Turkey Department of Ophthalmology Faculty of Medicine Firat University Elazig 23119 Turkey Department of Biochemistry Faculty of Medicine Firat University Elazig 23119 Turkey

AIM：To compare the potential protective effects of epigallocatechin gallate（EGCG） and ellagic acid（EA） in an experimental cataract model.●METHODS：Twenty-eight Spraque-Dawley rat pups were assigned into four *** the rats,except for those in the control group,were injected subcutaneously sodium selenite to induce experimental cataract on the postpartum ninth day,and between 10 th and 14 th *** in the sham,EGCG,and EA groups were intraperitoneally administered 50 mg/（kg·d） saline solution,50 mg/（kg·d） EGCG and 200 mg/（kg·d） EA,*** reduced glutathione（GSH） and malondialdehyde（MDA） levels,total antioxidant status（TAS） and total oxidant status（TOS） in lens supernatants were ***：The mean cataract gradings in EGCG and EA groups were found to be significantly lower than that in sham group（P〈0.001）.The mean GSH levels and TASs in EGCG and EA groups were significantly higher than that in sham group while mean MDA levels and TOSs in EGCG and EA groups were significantly lower than that in the sham group（P〈0.001）.CONCLUSION：EGCG and EA have protective effects on cataract development via the inhibition of oxidative stress.

关键词： sodium selenite experimental cataract epigallocatechin gallate ellagic acid total oxidant status totalanti-oxidant status.

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A simulation-based method to investigate occupant-centric controls

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Building Simulation 2021年第4期14卷 1017-1030页

作者： Mohamed M.Ouf June Young Park H.burak Gunay Department of Building Civil and Environmental EngineeringConcordia University1515Rue Sainte-Catherine O.MontrealQCH3G 1MCanada Department of Civil Engineering The University of Texas at ArlingtonArlingtonTX76019USA Department of Civil Engineering Carleton University1125 Colonel By DriveOttawaONK1S 5B6Canada

Occupant-centric control (OCC) strategies rely on different algorithms to learn and predict occupants’ patterns and preferences, then utilize these predictions to optimize building operations. However, testing different OCC algorithms or fine-tuning their configurations in real buildings can be a lengthy process. To this end, we present a framework for testing OCCs in a simulation environment prior to field implementation. The proposed workflow entails using synthetic occupant behaviour models and simulating OCC strategies to learn their preferences. The goal is to enable quick comparison of different OCC configurations under various scenarios by modifying occupant behaviour assumptions, as well as climate and design parameters. For proof-of-concept, the proposed method was applied in a case-study to simulate OCCs for lighting and heating/cooling setpoint adjustments in a single office under various occupant types, as well as OCC settings and design configurations. Results demonstrated the benefits of the proposed framework and its potential for providing a more holistic evaluation of OCCs under different scenarios. Using the proposed framework, building designers and operators can identify potential issues with OCCs and fine-tune their settings prior to field implementation.

关键词： occupant-centric controls building simulations energy efficiency comfort building operations lighting HVAC controls

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Higher Order Collocation Methods for Nonlocal Problems and Their Asymptotic Compatibility

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Communications on Applied Mathematics and Computation 2020年第2期2卷 261-303页

作者： burak Aksoylu Fatih Celiker George A.Gazonas CCDC Army Research Laboratory Attn:FCDD-RLW-MBAberdeen Proving GroundAberdeenMD 21005USA Department of Mathematics Wayne State UniversityDetroitMI 48202USA

We study the convergence and asymptotic compatibility of higher order collocation methods for nonlocal operators inspired by peridynamics,a nonlocal formulation of continuum *** prove that the methods are optimally convergent with respect to the polynomial degree of the approximation.A numerical method is said to be asymptotically compatible if the sequence of approximate solutions of the nonlocal problem converges to the solution of the corresponding local problem as the horizon and the grid sizes simultaneously approach *** carry out a calibration process via Taylor series expansions and a scaling of the nonlocal operator via a strain energy density argument to ensure that the resulting collocation methods are asymptotically *** fnd that,for polynomial degrees greater than or equal to two,there exists a calibration constant independent of the horizon size and the grid size such that the resulting collocation methods for the nonlocal difusion are asymptotically *** verify these fndings through extensive numerical experiments.

关键词： Nonlocal operator Inhomogeneous local boundary condition Nonlocal difusion Asymptotic compatibility Collocation method Peridynamics Functional calculus

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European Research Project’s Contributions to a Safer Automated Road Traffic

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Automotive Innovation 2023年第4期6卷 521-530页

作者： Felix Fahrenkrog Susanne Reithinger burak Gülsen Florian Raisch BMW AG Konzepte Integrale Sicherheit(EG-34)KnorrstraBe 14780788 MunichGermany

Automated driving is poised to become a pivotal technology in the future automotive ***,it is evident that the implementation of automated driving presents significant technical *** accelerate the development and deployment of automated driving the European Commission initiated the research project L3Pilot in *** a budget of 65 million Euros and the involvement of 13 car manufacturers,L3Pilot stands as the largest European project on automated driving(AD).This paper serves as a comprehensive account of BMW’s main activities in the L3Pilot project that ended in *** research questions addressed in this project are related to the following topics:what are the guidelines for the development of AD?How do potential customers interact with AD?And what is the safety impact assessment of AD?The paper presents the findings related to all three research questions to contribute to the further development of automated *** this purpose together with other partners the Code of Practice of AD was defined as a guideline for the development of future AD *** to the second question,BMW conducted tests with AD systems on motorways and in parking scenarios,with over 100 test subjects experiencing *** studies provide input and considerations for future AD ***,in the safety impact assessment,BMW investigated with other project partners the potential safety benefits of AD through *** results show a potential to improve road *** conclusion,the exploration of all three research questions has led to a deeper understanding of SAE Level 3 AD.

关键词： Automated driving L3Pilot Code of Practice Pilot Safety impact assessment User acceptance

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