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Is There a Link between Circadian Clock Protein PERIOD 3 (PER3) (rs57875989) Variant and the Severity of COVID-19 Infection?

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Current Medical Science 2021年第6期41卷 1075-1080页

作者： Gozde YESIL SAYIN Sacide PEHLIVAN Istemi SERIN Alpay MEDETALIBEYOGLU Murat ROSE Ali AGACFIDAN Naci SENKAL ummihan isoglu-alkac Tufan TUKEK Department of Medical Genetics Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Medical Biology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Hematology Istanbul Training and Research HospitalUniversity of Health SciencesIstanbul 34098Turkey Department of Internal Medicine Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Microbiology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey Department of Physiology Istanbul Faculty of MedicineIstanbul UniversityIstanbul 34098Turkey

Objective:Corona Virus Disease-2019(COVID-19)has been among the major infectious events of the *** today’s literature where COVID-19 and host factor effects are frequently examined,we aimed to examine another factor:Circadian Clock Protein PERIOD 3(PER3).There is a significant correlation between PER3 gene polymorphism and circadian rhythm disturbances and immune system ***:In our study,we recruited 200 patients diagnosed with COVID-19 in our hospital between April-June 2020,and 100 volunteers without known comorbidities to create a healthy control *** comparing the initial gene polymorphisms of the patients with healthy controls,three separate clinical subgroups were *** polymorphism distribution and statistical significance were examined in the formed patient ***:No significant difference was found between the patient group and the healthy controls(P>0.05,for all).When patients were divided into two separate clinical subgroups as exitus/alive according to their last condition during their 28-day follow-up,the 4R/5R genotype was significantly more common in patients with a mortal course(P=0.007).The PER34R75R genotype was found at a significantly higher rate in the group of patients with the need for intensive care(P=0.034).Conclusion:The 4R/5R genotype may be associated with the need for intensive care and mortality in COVID-19 *** important results will be a guide for future studies.

关键词： corona virus disease 2019 circadian rhythm PER3 prognosis

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ELECTRORHEOLOGICAL PROPERTIES OF TALC POWDER/SILICONE OIL SUSPENSIONS UNDER DC FIELDS

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Chinese Journal of Polymer Science 2007年第3期25卷 245-252页

作者： Hasim Yilmaz ummihan Yilmaz Chemistry Department Sciences FacultyHarran University63190 OsmanbeySanliurfaTurkey Chemistry Department Sciences FacultyGazi University06500 TeknikokullarAnkaraTurkey

In this study, the electrorheological （ER） behavior of suspensions prepared from d50 = 2.4 lam talc powder, dispersed in insulating silicone oil （SO） medium was investigated. Sedimentation stabilities of suspensions （c = 5 wt%） prepared using these talc powder powders were determined to be 78 days. The ER activity of all the suspensions was observed to increase with increasing electric field strength, concentration and decreasing shear rate. The shear stress of talc powder suspensions increased linearly with increasing concentrations of the particles and with the applied electric field strength. Electric field viscosity of all the suspensions decreased sharply with increasing shear rate and showed a typical shear thinning non-Newtonian visco-elastic behavior. Effects of frequency on the ER activity of talc powder/SO system were also investigated.

关键词： Electrorheological fluids Talc powder/silicone oil suspensions Shear stress

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A new approach for development of vaccine against visceral leishmaniasis: Lipophosphoglycan and polyacrylic acid conjugates

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 877-886页

作者： Adil M.Allahverdiyev Rabia Cakir Koc Melahat Bagirova Serhat Elcicek Serap Yesilkir Baydar Olga Nehir Oztel Emrah Sefik Abamor Sezen Canim Ates Murat Topuzogullari Sevil isoglu Dincer Zeynep Akdeste Yildiz Technical University Department of Bioengineering Firat University Department of Bioengineering Yeni Yuzyil University Biomedical Engineering Abdullah Gul University Material Science and Nanotechnology Department

Objective: To determine the antileishmanial vaccine effectiveness of lipophosphoglycan(LPG) and polyacrylic acids(PAA) conjugates on in vivo mice ***: LPG molecule was isolated and purified from large-scale Leishmania donovani parasite culture. Protection efficacies of LPG alone, in combination with Freund's adjuvant, in a physical mixture and in conjugate(consisting of various LPG concentrations) with PAA, were comparatively determined by various techniques, such as cultivation with the micro-culture method, assessment of in vitro infection rates of peritoneal macrophages, determination of parasite load in liver with Leishman-Donovan Units, and detection of cytokine ***: Obtained results demonstrated that the highest vaccine-mediated immune protection was provided by LPG-PAA conjugate due to all parameters investigated. According to the Leishman-Donovan Units results, the sharpest decline in parasite load was seen with a ratio of 81.17% when 35 mg LPG containing conjugate was applied. This value was 44.93% for the control group immunized only with LPG. Moreover, decreases in parasite load were 53.37%, 55.2% and 65.8% for the groups immunized with 10 mg LPG containing LPG-PAA conjugate, a physical mixture of the LPG–PAA, and a mixture of LPG + Freund's adjuvant, respectively. Furthermore, cytokine results supported that Th1 mediated protection occurred when mice were immunized with LPG-PAA ***: It has been demonstrated in this study that conjugate of LPG and PAA has an antileishmanial vaccine effect against visceral leishmaniasis. In this respect, the present study may lead to new vaccine approaches based on high immunogenic LPG molecule and adjuvant polymers in fighting against Leishmania infection.

关键词： Leishmania Lipophosphoglycan Vaccine Polymer Polyacrylic acid

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Optimization of Supercritical CO2 Extraction of Lycopene from Tomato Skin

Optimization of Supercritical CO2 Extraction of Lycopene fro...

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第四届中美化学工程会议和第三届中日化工研讨会合并的三边化学工程大会

作者： ummihan Topal Mitsuru Sasaki Motonobu Goto Kiro Hayakawa Go Momma Kumamoto University Japan

Lycopene is the red carotenoid pigment found predominantly in tomatoes and in a few other fruits and vegetables. Increasing clinical evidence suggests lycopene is an important natural anti- oxidant and it appears to provide protection against a broad range of epithelial cancers. Supercritical carbon dioxide (SCCO2) as a non-toxic alternative to traditional organic solvent extraction methods has been most widely used in extracting materials from natural products. The solvent strength of a supercritical fluid, which is directly related to its density, can be modified by changing the extraction pressure and temperature. The experiments were carried out by optimizing the operating conditions at pressures and temperatures ranging from 20 to 50 MPa at 10 MPa intervals and 40 to 100 oC at 10 oC intervals,

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