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Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study

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World Journal of Stem Cells 2021年第5期13卷 470-484页

作者： Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Turkey Pediatric Allergy-Immunology Marmara UniversityInstitute of Health SciencesIstanbul 34854Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health SciencesIstanbul 34255Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Istanbul Biruni UniversityFaculty of MedicineIstanbul 34010Turkey Department of Neurosurgery Istanbul Medicine HospitalIstanbul 34203Turkey Department of Neurosurgery Istanbul Asya HospitalIstanbul 34250Turkey Pediatric Allergy-Immunology Marmara UniversityIstanbul 34899Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric *** a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from *** To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with *** The study inclusion criteria were determined as the presence of substantial deficit and disability caused by ***’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 *** different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)*** For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±*** patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 *** treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of *** exhibited significant improvements in all neurological functions through a 12-mo *** mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z

关键词： Hypoxic-ischemic encephalopathy Pediatric Stem cell Wharton jelly

Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase I study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer Ozdemir Yeliz Bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBI)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBI,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional Independence Measure(FIM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(P<0.001).The FIM scale includes both motor scores(P<0.05)and cognitive scores(P<0.001)and showed a significant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

Approaches to neuroprotection in pediatric neurocritical care

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World Journal of Critical Care Medicine 2023年第3期12卷 116-129页

作者： Angad Kochar kara Hildebrandt Rebecca Silverstein Brian Appavu Department of Neurosciences Phoenix Children's HospitalPhoenixAZ 85213United States Child Health University of Arizona College of Medicine-PhoenixPhoenixAZ 85016United States

Acute neurologic injuries represent a common cause of morbidity and mortality in children presenting to the pediatric intensive care *** primary neurologic insults,there may be cerebral brain tissue that remains at risk of secondary insults,which can lead to worsening neurologic injury and unfavorable outcomes.A fundamental goal of pediatric neurocritical care is to mitigate the impact of secondary neurologic injury and improve neurologic outcomes for critically ill *** review describes the physiologic framework by which strategies in pediatric neurocritical care are designed to reduce the impact of secondary brain injury and improve functional ***,we present current and emerging strategies for optimizing neuroprotective strategies in critically ill children.

关键词： Neuroprotection Pediatric neurocritical care Cerebral perfusion Cerebrovascular pressure reactivity

CBASP Adapted to Child Play Therapy Structure to Prevent Early-Onset Persistent Depressive Disorder

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Open Journal of Psychiatry 2022年第1期12卷 53-72页

作者： James P. McCullough Jr. kara Elizabeth Burr Department of Psychology Virginia Commonwealth University Henrico VA USA Restoration Clinic Fort Worth TX USA

The current paper is a theoretical proposal that interfaces the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and its emphasis on interpersonal consequences with the structured order of a Play Therapy Model for troubled 3 - 8-year-old children. This proposal is not a research paper or a review of literature;instead, it is a treatment proposal that is novel and untested. CBASP psychotherapy, an empirically validated treatment, was developed originally to treat the persistently depressed adult. CBASP’s major focus of interpersonal consequation will be interfaced with a Play Therapy structured model to rectify the maladaptive preoperational functioning of five interpersonal types of problem-children. The types are classified interpersonally using D.J. Kiesler’s Interpersonal Message Inventory (IMI). Kiesler’s IMI is employed in this proposal as an ongoing assessment modality, a source of information to make treatment strategy consequation decisions, and thirdly as an evaluative outcome variable. The troubled child types described herein frequently become candidates for early-onset Persistent Depressive Disorder (PDD) unless rescued by successful treatment. The origins of early-onset PDD arise in dysfunctional households where toxic interpersonal relationships predominate: where “survival from abuse,” not growth, describes the child’s modal developmental experiences. These children are often exposed to either serious traumas (e.g., sexual abuse, loss of a parent, physical abuse, physical or emotional neglect) or psychological insults (e.g., continuous, and chronic verbal and nonverbal abuse). The result, in the most serious cases, is a maturational stunting at the preoperational stage of development which, as noted above, if not successfully resolved, thrusts the child into early-onset PDD.

关键词： Play Therapy Early-Onset Persistent Depressive Disorder CBASP Psychotherapy Preoperational Functioning Impact Message Inventory Interpersonal Circle

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研究聚合物用激光宽带声谱仪

南京大学学报（自然科学版） 1994年第2期30卷 252-255页

作者：干昌明 kara.,AA 南京大学声学研究所

本文所采用的激光宽带声谱仪包括Ｎｄ：ＹＡＧ激光，光声转换介质（水银或蓝玻璃），宽带超声换能器，瞬态波形数字化仪和计算机系统．超声脉冲源有单极性型和双极性型二种，谱仪的有用超声谱范围为２．５～５０ＭＨＺ．本文研究了几个... 详细信息

本文所采用的激光宽带声谱仪包括Ｎｄ：ＹＡＧ激光，光声转换介质（水银或蓝玻璃），宽带超声换能器，瞬态波形数字化仪和计算机系统．超声脉冲源有单极性型和双极性型二种，谱仪的有用超声谱范围为２．５～５０ＭＨＺ．本文研究了几个有机玻璃样品，有机玻璃的声吸收随频率变化为线性关系，这结果与哈脱曼所得结果一致．他采用通常的超声谱方法，最高频率为３０ＭＨｚ．

关键词：声吸收激光宽带声谱光声高聚物

Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer

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World Journal of Gastroenterology 2018年第7期24卷 810-818页

作者： Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker Illawarra Health and Medical Research Institute University of WollongongWollongong 2500Australia School of Biological Sciences University of WollongongWollongong 2500Australia Illawarra Cancer Centre Wollongong HospitalWollongong 2500Australia CONCERT-Translational Cancer Research Centre New South Wales 2000Australia Centre for Circulating Tumor Cell Diagnostics and Research Ingham Institute for Applied Medical ResearchLiverpool HospitalSydney 2170Australia School of Medicine University of Western SydneySydney 2170Australia South Western Medical School University of New South WalesSydney 2170Australia

AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal *** Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival *** While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing.

关键词： Cryopreservation Circulating tumor cells Liquid biopsy Gastroesophageal cancer Gastric cancer

Stability of Bitter Orange Juice-Olive Oil Salad Dressings Stabilized with Polysaccharides

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Journal of Food Science and Engineering 2011年第4期1卷 297-302页

作者： E. A. Ergelebi S. kara E. ibanoglu Department of Food Engineering University of Gaziantep Gaziantep 27310 Turkey

Emulsifying properties of bitter orange （Citrus aurantium） juice-olive oil salad dressings stabilized with different polysaccharides were investigated. Oil-in-water emulsions （50：50, v/v） were prepared with bitter orange juice-olive oil in the presence of various concentrations （0.1%-1.0%, w/v） of pectin or guar gum or iota-（t-）carrageenan and then these emulsions were homogenized. Emulsion activity index （EAI） and emulsion stability index （ESI） were determined spectrophotometrically by measuring time-dependent changes in turbidity. Creaming stability of emulsions was followed by visual observation of serum layer with respect to time. Microstructures of emulsions were examined by using polarized light microscopy. The addition of polysaccharides improved emulsion stability and emulsions containing higher amounts of polysaccharide were more stable against creaming. Microscopic observations showed that emulsions containing polysaccharides had small droplets as compared to that of emulsions without polysaccharides and emulsions were flocculated due to the presence of polysaccharides. Larger droplets and creaming were observed when the polysaccharide concentration was not sufficient for coverage.

关键词： Bitter orange juice salad dressings emulsion polysaccharide microstructure.

REFLECTED ZONALITY IN SUPERLARGE TIN PLACERS IN DEPRESSION STRUCTURES OF THE CENOZOIC ACTIVIZATION AREAS

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Geotectonica et Metallogenia 1994年第Z2期18卷 75-77页

作者： PATYK-kara N.G GORELIKOVA N.V InstituteofGeologyofOreDeposits PetrographyMineralogyandGeochemistry(IGEM)RussianAcademyofSciencesMoscow109017RussiaInstituteofGeologyofOreDepositsPetrographyMineralogyandGeochemistry(IGEM)RussianAcademyofSciencesMoscow109017Russia

Concurrent pulmonary Mycobacterium avium complex (MAC) infection and active Hürthle cell thyroid carcinoma: is there a connection?

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Health 2010年第5期2卷 391-394页

作者： kara M. Meinke Baehr Whitney S. Goldner 不详

We present two cases of pulmonary MAC infection in women with Hürthle cell thyroid carcinoma. Both cases were asymptomatic octogenarian women with active Hürthle cell thyroid carcinoma and prolonged periods of hypothyroidism prior to diagnosis of pulmonary MAC. Mycobacterium avium complex has never been reported in association with any type of thyroid cancer, specifically Hürthle cell carcinoma. A review of the literature and possible associations between the two are discussed in this article.

关键词： Hürthle Cell Thyroid Cancer Hypothyroidism Mycobacterium Avium Complex Cellular Immunity