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Quantitative and qualitative subgenomic RNA profiles of sARs-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way yin Ng Grace Lui Lowell Ling Agnes s.y.Leung Chit Chow siaw shi Boon Wendy C.s.Ho Maggie Haitian Wang Renee Wan yi Chan Albert Martin Li David shu Cheong Hui Paul Kay sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club school of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The sARs-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus sARs-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq subgenomic RNA(sgRNA)

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Enabling Technologies for Autonomous Robotic systems in Manufacturing

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 403-431页

作者： ERDŐs Gábor ABAI Kristóf BEREGI Richárd CsEMPEsZ János CsERTEG Tamás GODÓGábor HAJÓs Mátyás HÁy Borbála HORVÁTH Dániel HORVÁTH Gergely JUNIKIÁdám KEMÉNy Zsolt KOVÁCs András NACsA János PANITI Imre PEDONE Gianfranco TAKÁCs Emma TIPARy Bence ZAHORÁN László VÁNCZA József Institute for Computer science and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary Department of Manufacturing science and Technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC InnoLabs Nonprofit Ltd. BudapestHungary Eötvös Loránd University(ELTE) BudapestHungary

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the *** operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication *** enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such *** case studies will be presented from recent practice at HUN-REN sZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and *** various solutions have in common that they use a generic digital twin concept as their *** making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

关键词： industrial robotics autonomy digital twin enabling technology

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Enhancing fatigue performance of AZ31 magnesium alloy components fabricated by cold metal transfer-based wire arc directed energy deposition through LPB

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Journal of Magnesium and Alloys 2024年第4期12卷 1638-1662页

作者： shambhu Kumar Manjhi srikanth Bontha A.s.s.Balan Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkalSrinivasanagarMangaloreKarnataka 575025India

Cold Metal Transfer-Based Wire Arc Directed Energy Deposition(CMT-WA-DED)presents a promising avenue for the rapid fabrication of components crucial to automotive,shipbuilding,and aerospace ***,the susceptibility to fatigue of CMT-WA-DED-produced AZ31 Mg alloy components has impeded their widespread adoption for critical load-bearing *** this study,a comprehensive investigation into the fatigue behaviour of WA-DED-fabricated AZ31 Mg alloy has been carried out and compared to commercially available wrought AZ31 *** findings indicate that the as-deposited parts exhibit a lower fatigue life than wrought Mg alloy,primarily due to poor surface finish,tensile residual stress,porosity,and coarse grain microstructure inherent in the WA-DED *** Plasticity Burnishing(LPB)treatment is applied to mitigate these issues,which induce significant plastic deformation on the *** treatment resulted in a remarkable improvement of fatigue life by 42%,accompanied by a reduction in surface roughness,grain refinement and enhancement of compressive residual stress ***,during cyclic deformation,WA-DED specimens exhibited higher plasticity and dislocation density compared to both wrought and WA-DED+LPB specimens.A higher fraction of Low Angle Grain Boundaries(LAGBs)in WA-DED specimens contributed to multiple crack initiation sites and convoluted crack paths,ultimately leading to premature *** contrast,wrought and WA-DED+LPB specimens displayed a higher percentage of High Angle Grain Boundaries(HAGBs),which hindered dislocation movement and resulted in fewer crack initiation sites and less complex crack paths,thereby extending fatigue *** findings underscore the effectiveness of LPB as a post-processing technique to enhance the fatigue performance of WA-DED-fabricated AZ31 Mg alloy *** study highlights the importance of LPB surface treatment on AZ31 Mg components produced by CMT-WA-DED to remove surface d

关键词： Wire arc additive manufacturing AZ31 Mg alloy Low plasticity burnishing Low cycle fatigue test strain amplitude

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Evaluation of the nutritional value of Artemia nauplii for European seabass(Dicentrarchus labrax L.)larvae

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Aquaculture and Fisheries 2024年第1期9卷 78-84页

作者： Alaa A.El-Dahhar Rashwan s.Rashwan samy y.EL-Zaeem shaimaa A.shahin Mona M.Mourad Mohammed F.El Basuini Animal and Fish Production Department Faculty of Agriculture-Saba BashaAlexandria UniversityAlexandria21526Egypt National Institute of Oceanography and Fisheries(NIOF) Cairo11562Egypt Department of Animal Production Faculty of AgricultureTanta UniversityTanta31527Egypt Faculty of Desert Agriculture King Salman International UniversitySouth Sinai46618Egypt

Adapted European seabass(Dicentrarchus labrax L.)larvae at 25 days post-hatching(dph)with a primary weight and length of 23 mg and 9.92 mm,start the weaning up to 46 dph using the weaning micro-diet(54%crude protein from fish meal,powder milk,and poultry egg)concurrently with Artemia enriched with fortification emulsions(0.6 g/L)of DHA selco®as a control group(DHAs)or Fish oil+20%Vitamin C(FOVC),or Fish oil+20%Vitamin E(FOVE),or Fish oil+10%Vit.C+10%Vit.E(FOCE),or Fish oil only(FO).At 46 dph,groups of larvae fed enriched Artemia with DHAs and FOVE exhibited the highest final body weight,weight gain,average daily gain,specific growth rate,feed intake,protein efficiency ratio,and survival%as well as the lowest feed conversion ***,larvae in FOVC displayed the lowest final body weight,total length,weight gain,average daily gain,specific growth rate,feed intake,protein efficiency ratio,and survival%as well as the highest feed conversion *** histological assessment exhibited no pathological alteration as well as an improvement in the structure with DHAs,FOVE,FOVC,and FOCE co-additives compared to *** peroxidase enzyme(GPx)recorded the highest rates(Ps fed Artemia supplemented with DHAs and FOVE followed by FOCE and *** the lowest record for GPx activity was noted in the FO *** conclusion,Using augmented Artemia nauplii with fish oil+vitamin E in single or in companion with vitamin C as cheap antioxidants support *** larval growth,survival,and antioxidant efficacy during the critical weaning period.

关键词： European seabass Gastrointestinal histology Antioxidants Vitamin C Vitamin E DHA

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In-situ construction of grass-like hybrid architecture responsible for extraordinary corrosion performance: Experimental and theoretical approach

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Nano Materials science 2024年第1期6卷 44-59页

作者： T.suhartono F.Hazmatulhaq y.sheng A.Chaouiki M.P.Kamil y.G.Ko Materials Electrochemistry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan38541Republic of Korea Research Center for Advanced Materials National Research and Innovation Agency(BRIN)South TangerangBanten15314Indonesia

Despite the engineering potential by the co-existence of inorganic and organic substances to protect vulnerable metallic materials from corrosive environments,both their interaction and in-situ formation mechanism to induce the nature-inspired composite remained less *** present work used three distinctive mercaptobenzazole(MB)compounds working as corrosion inhibitors,such as 2-mercaptobenzoxazole(MBO),2-mercaptobenzothiazole(MBT),and 2-mercaptobenzimidazole(MBI)in a bid to understand how the geometrical structure arising from O,s,and N atoms affected the interaction toward inorganic *** compounds that were used here to control the corrosion kinetics would be interacted readily with the pre-existing MgO layer fabricated by plasma *** phenomenon triggered the nucleation of the root network since MB compounds were seen to be adsorbed actively on the defective surface through the active sites in MB ***,the molecule with twin donor atoms adjacent to the mercapto-sites affected the facile growth of the grass-like structures with‘uniform’distribution via molecular self-assembly,which showed better corrosion performance than those with having dissimilar donor atoms with the inhibition efficiency(η)of 97%*** formation mechanism underlying nucleation and growth behavior of MB molecule was discussed concerning the theoretical calculation of density functional theory.

关键词： Nature-inspired composite Organic-inorganic interaction Corrosion inhibitor Density functional theory Electrochemistry

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AutoRhythmAI: A Hybrid Machine and Deep Learning Approach for Automated Diagnosis of Arrhythmias

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Computers, Materials & Continua 2024年第2期78卷 2137-2158页

作者： s.Jayanthi s.Prasanna Devi Department of Computer science and Engineering SRM Institute of Science and Technology-Vadapalani CampusChennaiTamil NaduIndia

In healthcare,the persistent challenge of arrhythmias,a leading cause of global mortality,has sparked extensive research into the automation of detection using machine learning(ML)***,traditional ML and AutoML approaches have revealed their limitations,notably regarding feature generalization and automation *** glaring research gap has motivated the development of AutoRhythmAI,an innovative solution that integrates both machine and deep learning to revolutionize the diagnosis of *** approach encompasses two distinct pipelines tailored for binary-class and multi-class arrhythmia detection,effectively bridging the gap between data preprocessing and model *** validate our system,we have rigorously tested AutoRhythmAI using a multimodal dataset,surpassing the accuracy achieved using a single dataset and underscoring the robustness of our *** the first pipeline,we employ signal filtering and ML algorithms for preprocessing,followed by data balancing and split for *** second pipeline is dedicated to feature extraction and classification,utilizing deep learning ***,we introduce the‘RRI-convoluted trans-former model’as a novel addition for binary-class *** ensemble-based approach then amalgamates all models,considering their respective weights,resulting in an optimal model *** our study,the VGGRes Model achieved impressive results in multi-class arrhythmia detection,with an accuracy of 97.39%and firm performance in precision(82.13%),recall(31.91%),and F1-score(82.61%).In the binary-class task,the proposed model achieved an outstanding accuracy of 96.60%.These results highlight the effectiveness of our approach in improving arrhythmia detection,with notably high accuracy and well-balanced performance metrics.

关键词： Automated machine learning neural networks deep learning arrhythmias

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Machine learning-enhanced Monte Carlo and subset simulations for advanced risk assessment in transportation infrastructure

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Journal of Mountain science 2024年第2期21卷 690-717页

作者： Furquan AHMAD Pijush sAMUI s.s.MIsHRA Department of Civil Engineering National Institute of TechnologyPatna 800006India

The maintenance of safety and dependability in rail and road embankments is of utmost importance in order to facilitate the smooth operation of transportation *** study introduces a comprehensive methodology for soil slope stability evaluation,employing Monte Carlo simulation(MCs)and subset simulation(ss)with the"UPss 3.0 Add-in"in *** on an 11.693-meter embankment with a soil slope(inclination ratio of 2H:1V),the investigation considers earthquake coefficients(kh)and pore water pressure ratios(ru)following Indian zoning *** chance of slope failure showed a considerable increase as the Coefficient of Variation(COV),seismic coefficients(kh),and pore water pressure ratios(ru)experienced an *** ss approach showed exceptional efficacy in calculating odds of failure that are notably *** computational modeling,the study optimized the worst-case scenario using ANFIs-GA,ANFIs-GWO,ANFIs-PsO,and ANFIs-BBO *** ANFIs-PsO model exhibits exceptional accuracy(training R2=0.9011,RMsE=0.0549;testing R2=0.8968,RMsE=0.0615),emerging as the most *** study highlights the significance of conducting thorough risk assessments and offers practical insights into evaluating and improving the stability of soil slopes in transportation *** findings contribute to the enhancement of safety and reliability in real-world situations.

关键词： Monte Carlo simulation subset simulation Machine Learning seismic coefficient

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superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime s.Rosa Duque samuel M.s.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang yanmei Zhang Howard H.W.Wong Leo C.H.Tsang sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing yan Li Amos M.T.Lee Jennifer H.y.Lam sau Man Chan Wilfred H.s.Wong Issan y.s.Tam Masashi Mori sophie A.Valkenburg Malik Peiris Wenwei Tu yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina school of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** spike protein(s)immunoglobulin G(IgG),s-receptor-binding domain(RBD)IgG,s IgG Fcγreceptor IIIa(FcγRIIIa)-binding,sNM[sum of individual(s),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),sNM-specific IL-2^(+)CD8^(+),s-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,s-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,s IgG avidity,s IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated sARsCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An y.Bai O.Bakina I.Balossino y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.s.Chen M.L.Chen s.J.Chen s.L.Chen s.M.Chen T.Chen X.R.Chen X.T.Chen y.B.Chen y.Q.Chen Z.J.Chen Z.y.Chen s.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang s.s.Fang W.X.Fang y.Fang y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu y.W.Fu H.Gao y.N.Gao yang Gao s.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding y.Ding y.Ding J.Dong L.y.Dong M.y.Dong X.Dong M.C.Du s.X.Du Z.H.Duan P.Egorov y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl s.Gramigna M.Greco M.H.Gu y.T.Gu C.y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz y.K.Heng C.Herold T.Holtmann P.C.Hong G.y.Hou X.T.Hou y.R.Hou Z.L.Hou B.y.Hu H.M.Hu J.F.Hu T.Hu y.Hu G.s.Huang K.X.Huang L.Q.Huang X.T.Huang y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson s.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji y.y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang s.s.Jiang T.J.Jiang X.s.Jiang y.Jiang J.B.Jiao J.K.Jiao Z.Jiao s.Jin y.Jin M.Q.Jing X.M.Jing T.Johansson s.Kabana N.Kalantar-Nayestanaki X.L.Kang X.s.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.s.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li s.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.y.Li y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics sB RAs(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central south University Changsha 410083China China Center of Advanced science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BEsIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(s)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BEsIII D^(0)meson decays amplitude analysis CP-even fraction

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Excess non-COVID-19-related mortality among inflammatory bowel disease decedents during the COVID-19 pandemic

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World Journal of Gastroenterology 2024年第20期30卷 2677-2688页

作者： sarah Rotondo-Trivette Xin-yuan He Jamil s samaan Fan Lv Emily Truong Michaela Juels Anthony Nguyen Xu Gao Jian Zu yee Hui yeo Fan-Pu Ji Gil y Melmed Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Infectious Disease The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Karsh Division of Gastroenterology and Hepatology Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States school of Mathematics and statistics Xi’an Jiaotong UniversityXi’an 710049Shaanxi ProvinceChina David Geffen school of Medicine University of CaliforniaLos AngelesLos AngelesCA 90095United States Division of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Key Laboratory of surgical Critical Care and Life support(Xi’an Jiaotong University) Ministry of EducationXi’an 710004Shaanxi ProvinceChina

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic disrupted healthcare in the United *** To investigate COVID-19-related and non-COVID-19-related death and characteristics associated with excess death among inflammatory bowel disease(IBD)*** We performed a register-based study using data from the National Vital statistics system,which reports death data from over 99%of the United states population,from January 1,2006 through December 31,***-related deaths among adults 25 years and older were stratified by age,sex,race/ethnicity,place of death,and primary cause of *** and actual age-standardized mortality rates(AsMRs)per 100000 persons were *** 49782 IBD-related deaths occurred during the study ***-COVID-19-related deaths increased by 13.14%in 2020 and 18.12%in 2021[2020 AsMR:1.55 actual vs 1.37 predicted,95%confidence interval(CI):1.26-1.49;2021 AsMR:1.63 actual vs 1.38 predicted,95%CI:1.26-1.49].In 2020,non-COVID-19-related mortality increased by 17.65%in ulcerative colitis(UC)patients between the ages of 25 and 65 and 36.36%in non-Hispanic black(NHB)Crohn’s disease(CD)*** the pandemic,deaths at home or on arrival and at medical facilities as well as deaths due to neoplasms also *** IBD patients suffered excess non-COVID-19-related death during the *** death was associated with younger age among UC patients,and with NHB race among CD *** death at home or on arrival and due to neoplasms suggests that delayed presentation and difficulty accessing healthcare may have led to increased IBD mortality.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease COVID-19 Excess death Race sex Disparities

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