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Investigation of possible risk factors in the development of seasonal allergic conjunctivitis

International Journal of Ophthalmology(English edition) 2018年第9期11卷 1508-1513页

作者： umit dogan Sümeyra Agca Department of Ophthalmology Medical FacultyAbant Izzet Baysal UniversityBolu 14280Turkey Department of Ophthalmology Ardahan State HospitalArdahan 75000Turkey

AIM： To analyze the possible risk factors in the development of seasonal allergic conjunctivitis（SAC） through an evaluation of skin allergy tests and data obtained from ***： The study included a total of 75 SAC patients and 71 control subjects without SAC diagnosis who were admitted to the Abant Izzet Baysal University Medical Faculty Ophthalmology Clinic between March 2016 and December 2016. Skin prick tests were performed for all participants. Serum levels of total IgE and 25-OH vitamin D were also measured. In the tear, total IgE levels were measured. Moreover, possible risk factors for the onset of SAC（smoking, paracetamol exposure, vitamin D supplementation and environmental factors etc.） were examined for all patients by both prenatal and postnatal ***： The patients with SAC were found to have a history of maternal paracetamol exposure during the prenatal period. Likewise, in the same patient group, the duration of postnatal vitamin D supplementation was shorter（P〈0.001）. However, no significant correlation was found between SAC and maternal antibiotic exposure, maternal smoking, the mode of delivery and birth weight, as well as presence of pets. Moreover, patients with SAC were more likely to have asthma, allergic rhinitis and oral allergy syndrome. We have also found that SAC patients＇ mothers and siblings were more likely to have allergic conjunctivitis. Likewise, their fathers were more likely to have allergic rhinitis. CONCLUSION： Prenatal maternal paracetamol exposure and shorter duration of vitamin D supplementation in the postnatal period may play a role in development of SAC. Therefore prevention of unnecessary gestational paracetamol intake and vitamin D supplementation during infancy could potentially reduce the onset and development of SAC.

关键词： conjunctival disease seasonal allergic conjunctivitis type I hypersensitivity reaction

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Effect of nepafenac 0.1% on retinal thickness after cataract surgery in patients without risk factors for cystoid macular edema

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1901-1907页

作者： Asena Keles Sahin Ahmet Sahap Kükner Fatih Ulas umit dogan Department of Ophthalmology Training and Research HospitalOrdu UniversityOrdu 52000Turkey Department of Ophthalmology Faculty of MedicineBolu Abant Izzet Baysal UniversityBolu 14280Turkey

AIM:To evaluate the effect of topical preoperative nepafenac 0.1%treatment on postoperative macular edema using optical coherence tomography(OCT)after uncomplicated cataract ***:Ninety eyes of 90 patients without any risk factors were included in the *** patients were assigned to three groups:group 1,treated with topical prednisolone acetate 1%;group 2,treated with topical nepafenac 0.1%in addition to prednisolone acetate(1%);and group 3,those who started receiving nepafenac 0.1%treatment 3 d prior to surgery and continued the treatment postoperatively in addition to prednisolone acetate(1%).Central retinal thickness(CRT)and macular volume values were recorded using OCT at weeks 3 and ***:The increases in macular volume in the central 1 mm area after 3 and 6 wk were significantly lower in patients who used prophylactic topical nepafenac preoperatively(group 3)compared with those in group 1(P=0.028 and 0.008,respectively).No significant differences in the increase in macular volume and CRT were noted between groups 2 and 3(P>0.05).In group 1,the increases in macular volume in the central 3 mm area at weeks 3 and 6 were significantly higher than that in group 2 and 3(3rd week,P=0.004;6th week,P=0.005).CONCLUSION:Nepafenac 0.1%treatment in addition to topical steroids after uncomplicated cataract surgery reduce the increase in macular volume in the early postoperative period.

关键词： cataract surgery cystoid macular edema nepafenac optic coherence tomography retinal thickness

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Alanine aminotransferase normalization at week 8 predicts viral response during hepatitis C treatment

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World Journal of Gastroenterology 2013年第46期19卷 8678-8686页

作者： umit Bilge dogan Mustafa Salih Akin Serkan Yalaki Departments of Gastroenterology Adana Numune Training and Research Hospital

AIM:To investigate alanine aminotransferase(ALT)and sustained virological response(SVR)in chronic hepatitis C(CHC)during peginterferon-ribavirin ***:One hundred and fifty-one genotype 1CHC patients underwent treatment for 48 wk with peginterferon and ribavirin,and were retrospectively divided into two groups as having a rapid virological response(RVR)(Group 1,n=52)and not having an RVR(Group 2,n=99).We also subdivided each group into two according to the initial ALT level being high(Group1h and Group 2h)or normal(Group 1n and Group 2n).HCV RNA and ALT levels were measured at baseline;at 4,12,24 and 48 wk during the treatment period;and at 24 wk *** levels were also obtained at 8 *** to the results of ALT,patients were enrolled in either the follow-up abnormal or follow-up normalized ALT groups at each *** with high and normal ALT levels were compared for each interval in terms of ***:The SVR rates were 83%vs 40%(P=0.000),82%vs 84%(P=0.830),and 37%vs 44%(P=0.466)when comparing Group 1 with 2,1h with1n,and 2h with 2n,*** Group 2h,the SVR rates were 34%vs 40%(P=0.701),11%vs 52%(P=0.004),12%vs 50%(P=0.007),7%vs 50%(P=0.003),6%vs 53%(P=0.001),and 0%vs 64%(P=0.000)when comparing patients with high and normalized ALT levels at week 4,8,12,24,48 and 72,*** multiple logistic regression analysis revealed that RVR(OR=7.05;95%CI:3.1-16.05,P=0.000),complete early virological response(cEVR)(OR=17.55;95%CI:6.32-48.76,P=0.000),normalization of ALT at8 wk(OR=3.04;95%CI:1.31-7.06,P=0.008),and at 12 wk(OR=4.21;95%CI:1.65-10.76,P=0.002)were identified as independent significant predictive factors for ***:Normalization of ALT at 8 wk may predict viral response during peginterferon-ribavirin treatment in genotype-1 CHC patients especially without RVR.

关键词： Chronic hepatitis C Genotype-1 Alanine aminotransferase Rapid virological response Sustained virological response,Interferon Ribavirin

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Is sarcopenia effective on survival in patients with metastatic gastric cancer?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1861-1868页

作者： Ozlem dogan Hayriye Sahinli Yakup Duzkopru Tuba Akdag Abdulkadir Kocanoglu Department of Medical Oncology Adıyaman University Training and Research HospitalAdiyaman 02100Turkey Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey Department of Radiology University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06000Turkey Department of Medical Oncology Ankara Ataturk Sanatoryum Training and Research HospitalAnkara 06170Turkey

BACKGROUND Sarcopenia is a progressively diminishing state characterized by the reduction of muscle mass and density,which is frequently observed in malignancies of solid *** To assess how sarcopenia affects the overall survival of individuals who have been diagnosed with metastatic gastric *** The study retrospectively included individuals who had been diagnosed with metastatic gastric cancer between January 2008 and December *** was identified through the calculation of the average Hounsfield units(HUAC)using computed tomography(CT)images taken at the time of diagnosis in *** A total of 118 patients with metastatic gastric cancer were *** was detected in 29 patients(24.6%).The median survival of all patients was 8(1-43)*** median survival of patients with sarcopenia was 2 mo,while it was 10 mo for those without sarcopenia(P<0.001).A significant relationship was found between sarcopenia and *** Sarcopenia has been observed to impact survival outcomes in various types of solid tumor *** patients can be identified in a short time,easily and inexpensively,by HUAC measurements from CT images used for diagnosis,and survival could be promoted with nutritional support.

关键词： Hounsfield units Sarcopenia Gastric cancer Survival Psoas muscle mass Muscle density

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在试验性的糖尿病的 3 个层次建模的网膜的 VEGF， TNF，和 caspase 上的 intravitreal bevacizumab 和 intravitreal fasudil 的效果的比较

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 57-61页

作者： Fatih Celik Fatih Ulas Zeynep Gunes Ozunal Tulin Firat Serdal Celebi umit dogan Department of Ophthalmology Faculty of MedicineAbant Izzet Baysal University Department of Medical Pharmacology Faculty of MedicineAbant Izzet Baysal University Department of Histology and Embryology Faculty of MedicineAbant Izzet Baysal University

AIM: To evaluate the influence of an intravitreal injection of bevacizumab and fasudil on the retinal vascular endothelial growth factor(VEGF),tumor necrosis factor alpha(TNFα),and caspase 3 levels in a diabetic rabbit model. · METHODS: The study included 6 healthy rabbits(Group 1),6 rabbits with experimentally induced diabetes mellitus(DM)(Group 2),7 rabbits with experimentally induced DM to which intravitreal bevacizumab was administered(Group 3),and 7 rabbits with experimentally induced DM to which intravitreal fasudil was administered(Group 4). An intravitreal injection of 1.25mg/50μL bevacizumab in the right eye of rabbits in Group 3 and an intravitreal injection of 0.0064mg/50μL fasudil in the right eye of rabbits in Group 4 were administered on day 21 after the induction of DM. The studied eyes of the rabbits were enucleated three days after the intravitreal injection. The TNFα,VEGF,and caspase 3 levels were determined using the ELISA method. · RESULTS: There was a statistically significant difference in the VEGF and caspase 3 levels between groups(P =0.005 and P =0.013,respectively),but the TNF α level did not differ significantly between groups(P = 0.792). It was found that VEGF levels were significantly lower in Group 1 and Group 3 than in Group 2 using the Mann-Whitney U test with the Bonferroni correction(P = 0.004 for both comparison). There was no statistically significant difference between other groups with regard to VEGF levels(the P value ranged between 0.015 and 0.886). Although the P values of the caspase 3 levels were 0.015 for Group 1 and Group 4,0.038 for Group 2and Group 3,and 0.018 for Group 3 and Group 4,these P values remained above the threshold P value of 0.0083,which was the statistically significant level for post hoc tests. ·CONCLUSION: An intravitreal injection of bevacizumab decreased both the VEGF level,which plays a role in angiogenesis,and the caspase 3 level,which plays a role in apoptosis. Although not as effective as bevacizum

关键词： bevacizumab caspase 3 experimental diabetes fasudil tumor necrosis factor alpha vascular endothelial growth factor

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Experimental analysis on the nonlinear behavior of DC barrier discharge plasmas

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Plasma Science and Technology 2017年第1期19卷 44-50页

作者： dogan MANSUROGLU Ilker umit UZUN-KAYMAK Physics Department CanakkaleOnsekiz Mart University Canakkale 17100 Turkey Physics Department Middle East Technical University Ankara 06800 Turkey

Nonlinear behavior of glow discharge plasmas is experimentally *** glow is generated between a barrier semiconductor electrode,Chromium doped namely Gallium Arsenide（Ga As：Cr）,as a cathode and an Indium–Tin Oxide（ITO） coated glass electrode as an anode,in reverse *** planar nature of electrodes provides symmetry in spatial *** discharge behaves oscillatory in the time domain,with single and sometimes multiperiodicities in plasma current and voltage *** this paper,harmonic frequency generation and transition to chaotic behavior is *** observed current–voltage characteristics of the discharge are discussed in detail.

关键词： DC glow discharges nonlinear behavior digital signal analysis

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Axial gas mixing in conical spouted beds with high density particles

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Particuology 2023年第10期81卷 45-57页

作者： Neslin dogan Murat Koksal Gorkem Kulah Department of Chemical Engineering Middle East Technical UniversityAnkaraTurkey Department of Mechanical Engineering Hacettepe UniversityBeytepeAnkaraTurkey

Conical spouted beds operating with high-density particles(ρp>2500 kg/m^(3))have recently gained attention because of their potential use as nuclear fuel coaters for next-generation nuclear *** the literature,the number of axial gas mixing studies in conical and conical-cylindrical spouted beds is very limited and all axial mixing studies were carried out with relatively light particles(ρp≤2500 kg/m^(3)).Therefore,the objective of this study was to generate experimental data that can be used to explain the gas axial mixing behavior in conical spouted beds operating with both low-and high-density *** were conducted in two(γ=30°,60°)conical spouted beds with three different types of particles:zirconia(ρp=6050 kg/m^(3)),zirconia toughened alumina(ρp=3700 kg/m^(3))and glass beads(ρp=2460 kg/m^(3)).In order to be able to compare experimental data obtained at different conditions,a 1-D convection-diffusion gas mixing model originally developed by San Joséet al.(1995)was implemented to determine the axial dispersion *** results show that the axial dispersion coefficients range between m^(2)/s and m^(2)/s,increase with superficial gas velocity and are higher than the corresponding dispersion coefficients of fixed beds,lower than the dispersion coefficients of fluidized beds and in the same range with the cylindrical spouted beds reported in the *** corresponding Peclet numbers were in the range of 0.6–7.8 for all operating conditions and slightly higher Peclet numbers were obtained with glass beads indicating the relative importance of gas convective transport over gas dispersion for light particles compared to heavy particles.

关键词： Conical spouted bed Gas dispersion coefficient Axial gas mixing High-density particles

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Solving vehicle routing problem with time windows using metaheuristic approaches

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International Journal of Intelligent Computing and Cybernetics 2023年第1期16卷 121-138页

作者： Zeynep Aydınalp doganÖzgen Yıldız Technical University IstanbulTurkey

Purpose-Drugs are strategic products with essential functions in human *** optimum design of the pharmaceutical supply chain is critical to avoid economic damage and adverse effects on human *** vehicle-routing problem,focused on finding the lowest-cost routes with available vehicles and constraints,such as time constraints and road length,is an important aspect of *** this paper,the vehicle routing problem(VRP)for a pharmaceutical company in Turkey is ***/methodology/approach-A mixed-integer programming(MIP)model based on the vehicle routing problem with time windows(VRPTW)is presented,aiming to minimize the total route cost with certain *** the model provides an optimum solution for small problem sizes with the GUROBI®solver,for large problem sizes,metaheuristic methods that simulate annealing and adaptive large neighborhood search algorithms are proposed.A real dataset was used to analyze the effectiveness of the metaheuristic *** proposed simulated annealing(SA)and adaptive large neighborhood search(ALNS)were evaluated and compared against GUROBI®and each other through a set of real problem ***-The model is solved optimally for a small-sized dataset with exact algorithms;for solving a larger dataset,however,metaheuristic algorithms require significantly lesser *** the problem addressed in this study,while the metaheuristic algorithms obtained the optimum solution in less than one minute,the solution in the GUROBI®solver was limited to one hour and three hours,and no solution could be obtained in this time ***/value-The VRPTW problem presented in this paper is a real-life *** vehicle fleet owned by the factory cannot be transported between certain suppliers,which complicates the solution of the problem.

关键词： Pharmaceutical supply chain Network design Mixed-integer linear programming Vehicle routing problem Simulated annealing Adaptive large neighborhood search

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Hemoglobin, albumin, lymphocyte, and platelet score as a predictor of prognosis in metastatic gastric cancer

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1626-1635页

作者： Yakup Duzkopru Abdulkadir Kocanoglu Ozlem dogan Hayriye Sahinli Ebru Cilbir Mustafa Altinbas Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey

BACKGROUND The hemoglobin,albumin,lymphocyte,and platelet(HALP)score,derived from a composite evaluation of markers reflecting the tumor-inflammation relationship and nutritional status,has been substantiated as a noteworthy prognostic determinant for diverse *** To investigate how the HALP score relates to prognosis in patients with metastatic gastric *** The cutoff values for the HALP score,neutrophil/lymphocyte ratio,and platelet/lymphocyte ratio were determined using receiver operating characteristic *** HALP scores were defined as those less than 24.79 and high HALP scores as those greater than *** The study cohort comprised 147 patients and 110 of them(74.8%)were *** patients'median age was 63(22-89)*** median overall survival was significantly superior in the patients with high HALP scores than in those with low HALP scores(10.4 mo vs 7.5 mo,respectively;P<0.001)CONCLUSION The HALP score was found to be a prognostic factor in patients with metastatic gastric cancer.

关键词： Biomarker Hemoglobin,albumin,lymphocyte,and platelet score Gastric cancer Nutritional index Prognosis Survival

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Evaluation of macular choroidal and microvascular network changes by activity scores and serum antibodies in thyroid eye patients and healthy subjects

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2089-2094页

作者： Mehmet Erkan dogan Ibrahim Basol Hatice Deniz Ilhan Yusuf Ayaz Olgar Ocal Department of Ophthalmology Akdeniz UniversityKonyaalti 07070AntalyaTurkey Department of Ophthalmology Kepez State HospitalAntalya 07320Turkey Department of Ophthalmology Suruc State HospitalSanliurfa 63800Turkey

AIM:To investigate the choroidal thickness and the microvascular network changes around the macula in thyroid eye disease(TED)patients at different stages and the relationship of those changes with risk factors,serum antibodies and the severity of ***:A total of 85 participants were *** participants underwent ophthalmology and endocrinology *** choroidal thickness(SFCT),superficial(s)and deep(d)foveal avascular zone(FAZ)area,mean(m)and central(c)superficial vascular density(SVD),deep vascular density(DVD)measurements of the enrolled cases were performed with Topcon swept source optical coherence tomography(OCT)/OCT angiography(OCTA)DRI OCT *** linear regression analysis was used to explore the associations between SFCT,FAZ area,SVD,DVD and the relevant factors of ***:Those with active TED patients had higher c-DVD and m-DVD levels(P<0.05),however there is no statistically significant difference in SFCT between active and stable TED *** the serum antibodies,it was observed that s-FAZ and d-FAZ increased,c-SVD and m-SVD decreased in patients with high thyroid stimulating hormone-receptor autoantibodies(TRAB)level,whereas SFCT thickened in patients with high levels of both TRAB and human thyroglobulin(hTG).There was no significant difference in SFCT,FAZ,SVD and DVD measurement at gender,between hyperthyroid and euthyroid patients and among those with or without thyroid papillary ***:The results show that both disease activation and serum antibodies differentially affect both superficial and deep retinal vascular *** has also been shown that high serum antibody levels affect choroidal thickness independent of clinical activity.

关键词： thyroid eye disease optic coherence tomography angiography vascular density choroidal thickness foveal avascular zone area

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