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乳腺癌新辅助化疗的再思考

英国医学杂志中文版 2018年第11期21卷 633-636页

作者： Jayant S vaidya Samuele Massarut Hrisheekesh J vaidya Emma C Alexander Thomas Richards Jochem A Caris Bhawna Sirohi Jeffrey S Tobias 程琳(译) 陈雷(校) Division of Surgery and Interventional Science University College LondonLondonUK 北京大学人民医院肝胆外科 Department of Surgery Whittington HospitalRoyal Free Hospital and University College London HospitalLondonUK Centro di Riferimento Oncologico di Aviano AvianoItaly Impeerial College School of Medicine Imperial College LondonLondonUK GKT School of Medical Education King's College LondonLondonUK Department of Clinical Oncology University College London HospitalLondonUK Department of Surgery Whittington HospitalLondonUK Department of Medical Oncology Barts Heahh NHS TrustLondonUK 北京大学人民医院乳腺外科

质疑乳腺癌新辅助化疗合理性的证据逐渐增多,Jayant vaidya和同事们认为必须对当下的治疗方案进行再思考。乳腺癌是世界范围内女性最常见的恶性肿瘤。2014年英国有55000名女性被诊断为乳腺癌,其中11000名死于该疾病。早期乳腺癌传统上... 详细信息

质疑乳腺癌新辅助化疗合理性的证据逐渐增多,Jayant vaidya和同事们认为必须对当下的治疗方案进行再思考。乳腺癌是世界范围内女性最常见的恶性肿瘤。2014年英国有55000名女性被诊断为乳腺癌,其中11000名死于该疾病。早期乳腺癌传统上会应用手术、联合放疗以及必要时辅助系统药物治疗的综合治疗模式。

关键词：早期乳腺癌化疗治疗方案恶性肿瘤世界范围综合治疗药物治疗辅助系统

IMPACT OF HUMIDITY DATA ON THE PREDICTION OF ONSET VORTEX WITH A LIMITED AREA MODEL

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Acta meteorologica Sinica 1992年第4期6卷 511-518页

作者： AnuradhaKulkarni S.S.vaidya S.S.Singh

A limited area model has been applied to study the impact of satellite-derived relative humidity data on the predic- tion of onset vortex of monsoon *** results show that inclusion of satellite-derived relative humidity data im- proved the prediction of track of the cyclonic circulation and the rainfall rates in the region of the vortex.

关键词： relative humidity onset vortex limited area model short-range prediction

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Some New Results on Domination Integrity of Graphs

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Open Journal of Discrete Mathematics 2012年第3期2卷 96-98页

作者： Samir K. vaidya Nirang J. Kothari B. H. Gardi college of Engineering & Technology Rajkot India Saurashtra University Rajkot India

The domination integrity of a connected graph G= (V(G), E(G)) is denoted as DI(G) and defined by DI(G) = min{*S*+ m(G-S) : S is a dominating set } where m(G-S) is the order of a maximum component of G-S . We discuss domination integrity in the context of some graph operations like duplication of an edge by vertex and duplication of vertex by an edge.

关键词： Integrity Dominating Set Domination Integrity

Separation, Identification, Isolation and Characterization of Degradation Product of Osimertinib Tablets by UPLC-QTOF-MS/MS and NMR: Evaluation of <i>In-Silico</i>Safety Assessment for Osimertinib (OSM) and Degradation Product (DP)

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Advances in Biological Chemistry 2021年第1期11卷 15-29页

作者： Arun D. Bhutnar Seema R. Saple Vikas V. vaidya Department of Chemistry Kirti M Doongursee College Mumbai University Mumbai India Royal college of Arts Science and commerce Mumbai University Thane India

The present work encompasses identification and characterization of major degradation product (DP) of OSM observed in base hydrolytic stress study. The separation of DP was carried out on a non-polar stationary phase by using high-performance liquid chromatography system (HPLC). Using waters X-bridge (250 mm × 4.6 mm, 5 μm) C18 column with gradient elution program. For the characterization study, stress samples were subjected to HPLC and UPLC-QTOF-MS/MS and based on mass fragmentation pattern, plausible structure was deduced. Further, the DP was isolated using semi-prepara- tive liquid chromatography and concentrated the fractions using lyophilization. The isolated DP was subjected to extensive 1D (1H, 13C, and DEPT-135) and 2D (COSY, HSQC and HMBC) nuclear magnetic resonance (NMR) studies to authenticate the structure. The impurity was unambiguously named as N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-metho-xy-5-

关键词： Osimertinib Mesylate (OSM) Base Degradation Semi-Preparative Isolation and Characterizations by HPLC UPLC-QTOF-MS/MS NMR Techniques

Assessment of Interference Effect on Glucose Biosensor

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分析测试学报 1994年第3期 30-45页

作者： Ebtisam Wilkins Rajesh vaidya Plamen Atanasov (Department of Chemical and Nuclear Engineering,University of New Mexico, Albuquerque, NM 87131, U. S.A.)

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关键词： Assessment of Interference Effect on Glucose Biosensor

Some Switching Invariant Prime Graphs

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Open Journal of Discrete Mathematics 2012年第1期2卷 17-20页

作者： S. K. vaidya U. M. Prajapati 不详

We investigate prime labeling for some graphs resulted from switching of a vertex. We discuss switching invariance of some prime graphs and prove that the graphs obtained by switching of a vertex in Pn and K1,n admit ... 详细信息

关键词： Prime Labeling Switching of a Vertex Switching Invariance

Thin Cell Layer (TCL) Culture System for Herbal Biomass Production and Genetic Transformation of Bacopa monnieri L. Wettst.

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American Journal of Plant Sciences 2016年第8期7卷 1232-1245页

作者： LaMont Alexander Croom Carissa L. Jackson Brajesh Nanda vaidya Prahlad Parajuli Nirmal Joshee Alabama A & M University Huntsville AL USA Agricultural Research Station Fort Valley State University Fort Valley GA USA Wayne State University School of Medicine Detroit MI USA

Bacopa monnieri (L.) Wettst. (Scrophulariaceae) is a highly sought after medicinal plant with therapeutic properties as cognition enhancer as well as for other brain and body functions. Research was conducted to optimize a thin cell layer explant based micropropagation system to assist mass propagation. Thin cell layers (TCL) derived from leaf and internode segments were used as explants. Murashige and Skoog medium was used to formulate shoot induction, elongation, and rooting media. Shoot induction media were prepared by supplementing three concentrations (0.1, 1.0, and 10.0 μM) of four cytokinins 6-benzylaminopurine, 2-isopentenyl-adenine, 6-3-Hydroxybenzylaminopurine, and thidiazuron to study adventitious shoot bud induction response. An optimum shoot bud induction response was observed on MS medium supplemented with 10.0 μM 6-benzylaminopurine for both leaf and stem transverse thin cell layer (tTCL) explants. The average number of shoot buds from leaf tTCL explants was 59, whereas, on an average, 33 shoot buds were regenerated from internode tTCL explants. Elongation of adventitious shoot buds was achieved best in a liquid medium using Liquid Lab Rocker® system. Elongated shoots recorded 100% rooting in MS medium supplemented with 5 μM indole butyric acid. Bacopa micropropagation employing tTCL explants for initial shoot bud induction and using LLR® boxes in subsequent elongation step can achieve cost effective way to regenerate high volume of plantlets and biomass required for herbal industry. Leaf and stem tTCL explants both were suitable for Agrobacterium tumefaciens (EHA105) mediated genetic transformation. Successful transformation was scored within three days of co-cultivation with Agrobacterium suspension on the basis of Enhanced Green Fluorescent Protein (EGFP) expression as an early and non-destructible screening device. Transformation frequencies of 83% and 76% were accomplished for leaf and stem tTCL explants, respectivel

关键词： Bacopa Plant Tissue Culture Total Polyphenols Transformation Transverse Thin Cell Layer

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未用的端口为微控制器增加PWM/模拟通道

电子设计技术 EDN CHINA 2010年第2期17卷 47-48页

作者： Vishwas vaidya 印度浦那Tata Motors公司

在片上PWM（脉冲宽度调制）资源方面．低成本的8位单片微控制器是很吝啬的。设计人员在采用PWM资源时．经常被迫要牺牲一个捕捉／比较通道或定时器通道．因为PWM通道要共用相同的片上资源。本例描述了如何用一个片上未用同步串行端口来... 详细信息

在片上PWM（脉冲宽度调制）资源方面．低成本的8位单片微控制器是很吝啬的。设计人员在采用PWM资源时．经常被迫要牺牲一个捕捉／比较通道或定时器通道．因为PWM通道要共用相同的片上资源。本例描述了如何用一个片上未用同步串行端口来产生PWM信号，并将它们转换为一个慢速移动的模拟信号（图1）。

关键词： PWM信号单片微控制器模拟通道串行端口脉冲宽度调制设计人员模拟信号低成本

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Vaginal Delivery after Pelvic Fracture Fixation with a Subcutaneous Anterior Fixator with Review of Literature of Delivery Mode in Pelvic Injuries

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Open Journal of Obstetrics and Gynecology 2014年第14期4卷 836-839页

作者： Anil Sethi Rahul vaidya Sarah Schneider Jennifer Fleming Bryant W. Oliphant Department of Orthopedics Detroit Receiving Hospital Detroit USA Wayne State University School of Medicine Detroit USA

Background: The cesarean section rate following a pelvic fracture is more than double the standard norms. This results from residual deformity and a lack of knowledge among obstetricians regarding the ability to deliver vaginally after a pelvic fracture. Aim: To present a case of pelvic fracture that delivered vaginally indicating vaginal delivery is possible even after pelvic fractures that are stabilized surgically with minimal or no residual displacement. Case presentation: We present a patient that delivered vaginally following internal fixation of an unstable pelvic fracture with a retained orthopedic implant that spanned the lower abdomen with a metallic bar. We also discuss the role of cesarean section in patients with pelvic fractures. Conclusion: Women with pelvic fractures may possibly deliver vaginally however decision regarding mode of delivery in such patients should be on a case by case basis.

关键词： Pelvic Fracture Infix Pregnancy