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Vanillin cross-linked hydrogel membranes interfacial reinforced by carbon nitride nanosheets for enhanced antibacterial activity and mechanical properties

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Chinese Chemical Letters 2023年第4期34卷 164-171页

作者： umer shahzad malik Qixiang Duan Muhammad Bilal K.Niazi Zaib Jahan Usman Liaqat Farooq Sher Yanchang Gan Honghao Hou School of Chemical and Materials Engineering National University of Sciences and TechnologyIslamabad 44000Pakistan Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510515China Department of Engineering School of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUnited Kingdom

Biopolymer based hydrogels are highly adaptable, compatible and have shown great potential in biological tissues in biomedical applications. However, the development of bio-based hydrogels with high strength and effective antibacterial activity remains challenging. Herein, a series of vanillin-cross-linked chitosan nanocomposite hydrogel interfacially reinforced by g-C_(3)N_(4)nanosheet carrying starch-caped Ag NPs were prepared for wound healing applications. The study aimed to enhance the strength, sustainability and control release ability of the fabricated membranes. Starch-caped silver nanoparticles were incorporated to enhance the anti-bacterial activities The fabricated membranes were assessed using various characterization techniques such as FT-IR, XRD, SEM, mechanical testing, Gel fraction and porosity alongside traditional biomedical tests i.e., swelling percentage, moisture retention ability, water vapor transmission rate, oxygen permeability, anti-bacterial activity and drug-release of the fabricated membranes. The mechanical strength reached as high as 25.9 ± 0.24 MPa for the best optimized sample. The moisture retention lied between 87%–89%, gel fraction 80%–85%, and water vapor transmission up to 104 ± 1.9g m^(-2)h^(-1)showing great properties of the fabricated membrane. Swelling percentage surged to 225% for blood while porosity fluctuated between 44% ± 2.1% and 52.5% ± 2.3%. Oxygen permeability reached up to 8.02 mg/L showing the breathable nature of fabricated membranes. The nanocomposite membrane shown excellent antibacterial activity for both gram-positive and gram-negative bacteria with a maximum zone of inhibition 30 ± 0.25 mm and 36.23 ± 0.23 mm respectively. Furthermore, nanoparticles maintained sustainable release following non-fickian diffusion. The fabricated membrane demonstrated the application of inorganic filler to enhance the strength of biopolymer hydrogel with superior *** results envisage the potential of synthesized m

关键词： Green synthesis Sustainable membranes Starch capped silver nanoparticles g-C_(3)N_(4)nanosheets Wound dressing Antibacterial

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Reduced bit low power VLSI architectures for motion estimation

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Journal of Systems Engineering and Electronics 2013年第3期24卷 382-399页

作者： Shahrukh Agha Shahid Khan shahzad malik Raja Riaz Department of Electrical Engineering COMSATS Institute of Information Technology

Low power and real time very large scale integration （VLSI） architectures of motion estimation （ME） algorithms for mobile devices and applications are presented. The power reduction is achieved by devising a novel correction recovery mechanism based on algorithms which allow the use of reduced bit sum of absolute difference （RBSAD） metric for calculating matching error and conversion to full resolution sum of absolute difference （SAD） metric whenever necessary. Parallel and pipelined architectures for high throughput of full search ME corresponding to both the full resolution SAD and the generalized RBSAD algorithm are synthe- sized using Xilinx Synthesis Tools （XST）, where the ME designs based on reduced bit （RB） algorithms demonstrate the reduction in power consumption up to 45% and/or the reduction in area up to 38%.

关键词： motion estimation (ME) very large scale integration (VLSI) reduced bit sum of absolute difference (RBSAD).

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Silymarin-laden PVP-PEG polymeric composite for enhanced aqueous solubility and dissolution rate: Preparation and in vitro characterization

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Journal of Pharmaceutical Analysis 2019年第1期9卷 34-39页

作者： Abid Mehmood Yousaf Usman Rashid malik Yasser shahzad Tariq Mahmood Talib Hussain Department of Pharmacy COMSATS University IslamabadLahore Campus Faculty of Pharmacy University of Central Punjab

The aim of this work was to develop, optimize and characterize a silymarin-laden polyvinylpyrrolidone(PVP)-polyethylene glycol(PEG) polymeric composite to resolve low aqueous solubility and dissolution rate problem of the drug. A number of silymarin-laden polymeric formulations were fabricated with different quantities of PVP K-30 and PEG 6000 by the solvent-evaporation method. The effect of PVP K-30 and PEG 6000 on the aqueous solubility and dissolution rate was investigated. The optimized formulation and its constituents were characterized using powder X-ray diffraction(PXRD), differential scanning calorimetry(DSC), scanning electron microscopy(SEM) and Fourier transform infrared spectroscopy(FTIR) techniques. Both the PEG 6000 and PVP K-30 positively affected the aqueous solubility and dissolution rate of the drug. In particular, a formulation consisting of silymarin, PVP K-30 and PEG 6000(0.25/1.5/1.5, w/w/w) furnished the highest solubility(24.3972.95 mg/mL) and an excellent dissolution profile( $100% in 40 min). The solubility enhancement with this formulation was $ 1150-fold as compared to plain silymarin powder. Moreover, all the constituents existed in the amorphous state in this silymarin-laden PVP-PEG polymeric composite. Accordingly, this formulation might be a promising tool to administer silymarin with an enhanced effect via the oral route.

关键词： Silymarin Hydrophilic polymers Inclusion Solid dispersion Aqueous solubility Dissolution rate

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A systematic study on the role of SentiWordNet in opinion mining

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Frontiers of Computer Science 2021年第4期15卷 165-183页

作者： Mujtaba HUSNAIN malik Muhammad Saad MISSEN Nadeem AKHTAR Mickael COUSTATY shahzad MUMTAZ V.B.Surya PRASATH Department of IT Faculty of ComputingThe Islamia University of BahawalpurBahawalpur 63100Pakistan Laboratoire Informatique Image et Interaction(L3i)Facultés des Sciences et TechnologiesUniversity of La RochelleLa Rochelle 17000France Division of Biomedical Informatics Cincinnati Children’s Hospital Medical CenterCincinnati 45229USA Department of Pediatrics University of Cincinnati College of MedicineCincinnati 45229USA Department of Biomedical Informatics College of MedicineUniversity of CincinnatiCincinnati 45267USA Department of Electrical Engineering and Computer Science University of CincinnatiCincinnati 45221USA

Sentiment lexicons(SL)(aka lexical resources)are the repositories of one or several dictionaries that consist of known and precompiled sentiment *** lexicons play an important role in performing several different opinion mining *** efficacy of the lexicon-based approaches in performing opinion mining(OM)tasks solely depends on selecting an appropriate opinion lexicon to analyze the ***,one has to explore the available sentiment lexicons and then select the most suitable *** available resources,SentiWordNet(SWN)is the most widely used lexicon to perform tasks related to opinion *** SWN,each synset of WordNet is being assigned the three sentiment numerical scores;positive,negative and objective that are calculated using by a set of *** this paper,a detailed and comprehensive review of the work related to opinion mining using Senti-WordNet is provided in a very distinctive *** survey will be useful for the researchers contributing to the field of opinion *** features make our contribution worthwhile and unique among the reviews of similar kind:(i)our review classifies the existing literature with respect to opinion mining tasks and subtasks(ii)it covers a very different outlook of the opinion mining field by providing in-depth discussions of the existing works at different granularity levels(word,sentences,document,aspect,clause,and concept levels)(iii)this state-ofart review covers each article in the following dimensions:the designated task performed,granularity level of the task completed,results obtained,and feature dimensions,and(iv)lastly it concludes the summary of the related articles according to the granularity levels,publishing years,related tasks(or subtasks),and types of classifiers *** the end,major challenges and tasks related to lexicon-based approaches towards opinion mining are also discussed.

关键词： opinion mining lexical based resources Senti-WordNet opinion strength

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The charge state distribution of B, C, Si, Ni, Cu and Au ions on 5 MV pelletron accelerator

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Nuclear Science and Techniques 2017年第5期28卷 43-47页

作者： Ali Awais Javaid Hussain Muhammad Usman Waheed Akram Kashif shahzad Turab Ali Ishaq Ahmad malik Maaza Experimental Physics Laboratories National Centre for Physics Islamabad 44000 Pakistan UNESCO-UNISA Africa Chair in Nanosciences/ Nanotechnology College of Graduate Studies University of South Africa Muckleneuk Ridge PO Box 392 PretoriaSouth Africa Nanosciences African Network (NANOAFNET) iThemba LABS-National Research Foundation 1 Old Faure RoadPO Box 722 Somerset West Western Cape Province 7129South Africa

Stripper gas and terminal potential play a key role for the charge state distribution in a tandem pelletron accelerator. The knowledge of this distribution is important for experiments performed on tandem accelerators. The charge state distribution of B, C, Si, Ni, Cu and Au beams is measured by using Ar as stripper gas, and terminal potential is varied from 0.3 to 3.0 MV on 5UDH-2 tandem pelletron accelerator installed at the National Centre for Physics, Islamabad. The individual charge state is measured after the switching magnet at 15° in high-energy portion. It is observed that the higher charge states are stable in the range of lower and middle atomic masses of periodic table, whereas higher atomic mass(Au) shows beam current instability in higher charge states. For carbon,the charge distribution at 1.7 MV terminal potential by varying stripper gas pressure is also studied, which resulted in decreased overall transmission with good current value for higher charge states.

关键词： Pelletron accelerator Charge state distribution Stripper gas Terminal potential

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Differential elastic scattering cross sections of protons from Al in 2.4–4.8 MeV energy range

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Nuclear Science and Techniques 2016年第2期27卷 97-100页

作者： Kashif shahzad Faisal J. Qureshi Javeria Taj Ali Awais Javaid Hussain Waheed Akram Shehla Honey Ishaq Ahmad Maaza malik National Center for Physics Quaid-i-Azam UniversityIslamabad 44000 Pakistan UNESCO-UNISA Africa Chair in Nanosciences/ Nanotechnology College of Graduate Studies University of South Africa Muckleneuk Ridge PO Box 392 Pretoria South Africa Nanosciences African Network (NANOAFNET) iThemba LABS-National Research Foundation 1 Old Faure Road Somerset West 7129 PO Box 722 Somerset West Western Cape Province South Africa

Measurement of differential elastic cross section of protons from aluminum was taken at 165° degree in the2.4–4.8 Me V energy range. The results and measured energy resonances were compared with reported *** data wi... 详细信息

关键词：能量范围微分截面弹性散射质子电子铝能量共振后向散射

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Effects of drug-polymer dispersions on solubility and in vitro diffusion of artemisinin across a polydimethylsiloxane membrane

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Chinese Science Bulletin 2012年第14期57卷 1685-1692页

作者： shahzad Yasser SHAH Syed Nisar Hussain ANSARI Muhammad Tayyab RIAZ Romana SAFDAR Aasma HUSSAIN Talib malik Madeeha Faculty of Pharmacy Bahauddin Zakariya University Division of Pharmacy and Pharmaceutical Sciences School of Applied SciencesUniversity of Huddersfield Hamdard Institute of Pharmaceutical Sciences Hamdard University

Artemisinin(ART) is a sesquiterpene lactone with an endo-peroxide bridge that is thought to be responsible for its antimalarial *** has low oral bioavailability because of aqueous insolubility,which leads to local toxicity at the site of *** present work focused on increasing its solubility and evaluating its permeation across a model membrane to mimic transdermal delivery that bypasses the hepatic *** this purpose,physical mixtures(PM),solid dispersions(SD) and lyophilized dispersions(LD) with different drug-polymer ratios(1:0.5,1:1,1:2,1:4 and 1:9) were prepared using the hydrophilic polymer polyvinylpyrrolidone(PVP).Drug-polymer dispersions were characterized using X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FTIR).Solubility was measured in three solvents:de-ionized water,phosphate buffered saline(PBS) and *** toluene-water partition coefficient was evaluated and compared with the literature and calculated logP *** vitro diffusion of ART was studied across a polydimethylsiloxane membrane from a saturated solution of drug-polymer *** patterns showed a gradual decrease in crystallinity of ART with increasing polymer concentration,while FTIR confirmed no interactions between ART and *** was increased up to 4-,5-and 8-fold for LD in water,PBS and methanol,*** logP for toluene-water was 2.65 ± 0.3,which is in good agreement with literature and calculated logP *** was enhanced,which is attributed to the decrease in crystallinity and increase in wettability of the *** ART flux was significantly higher than that of pure ART(0.12 ± 0.01) with increasing PVP concentration for SD and LD *** conclusion,drug-polymer dispersions with PVP improve the pharmaceutical properties of ART in the order LD>SD>PM.

关键词：聚合物分散体溶解度测定聚硅氧烷外扩散青蒿素药物傅里叶变换红外光谱水性高分子

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High Resolution Computed Tomography Features of Third Wave of COVID-19 Pneumonia in Confirmed Cases

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Advances in Computed Tomography 2021年第2期10卷 11-17页

作者： Abdul malik Hayat shahzad Karim Bhatti Department of Radiology Sir Ganga Ram Hospital Lahore Pakistan Department of Radiology King Edward Medical University Lahore Pakistan

COVID-19 which is caused by its new type called SARS-CoV-2 is a viral disease predominantly involving the lungs. Objective: To investigate HRCT features of pulmonary disease in COVID-19 in Lahore, Pakistan. Methods: This is a prospective study that involved 127 COVID-19 positive patients (age 18 - 80 years, both genders) through non-probability sampling was conducted at the Radiology Department, Sir Ganga Ram Hospital, Lahore, in 2021. All patients with RT-PCR positive underwent HRCT chest. All findings in HRCT chest were assessed. Confirmed patients had positive HRCT. Excluded situations are low quality of images irrespective of its reason, HRCT indications other than COVID-19 pneumonia, and patients who do not want to participate in the study Results: Considering the exclusion and inclusion criteria, totally 127 COVID-19 confirmed patients ranging age from 18 to 80 years with a mean age of 52 ± 18 years, took part in this study. The most important and common HRCT finding was the multilobar ground-glass pattern which was present in 95% of patients. Other findings including, crazy paving pattern, consolidation, air bronchogram, and bronchiectasis were present in 8.7%, 82%, 63%, and 37% of patients respectively. Pleural effusion seen in 21% patients. 16% of patients had mediastinal lymphadenopathy. Conclusion: In our study, the ground-glass pattern was found to be the most common and important HRCT finding in patients confirmed with COVID-19 pneumonia. This important HRCT pattern is mostly found to be in posterobasal and peripheral subpleural locations. Other than ground-glass pattern, bronchiectasis, and consolidation having the air bronchogram were also reported commonly.

关键词： High Resolution Computed Tomography (HRCT) COVID-19 Ground-Glass Pattern Third Wave

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Annihilation of Antiprotons in Light Nuclei

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Chinese Physics Letters 2006年第7期23卷 1716-1718页

作者： M. A. Rana E. U. Khan M. I. shahzad I. E. Qureshi F. malik G. Sher S. Manzoor H. A. Khan Physics Research Division PINSTECH P. O. Nilore Islamabad Pakistan

CR-39 detectors have been exposed to a 5.9-MeV antiproton beam using the low energy antiproton ring （LEAR） facility at CERN. At this energy, tracks of antiprotons appear in a CR-39 detector after 135 rain of etching in 6M NaOH at 70℃. Fluence of the antiproton beam has been determined using track density. We have also found tracks in the etched CR-39 detector at different depths （250-500μm）. These tracks have resulted from the annihilation of antiprotons with the constituents （H, C and O） of the CR-39 detector. The goal of the experiment is to develop a simple and low-cost method to study properties of antiparticles and those formed after annihilation of these particles with the target matter.

关键词： STOPPED ANTIPROTONS HEAVY-NUCLEI GEV/C

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ROLE OF ACULASER THERAPY IN CEREBRAL PALSY CHILDERN (INITIAL DATA & RESULTS)

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World Journal of Acupuncture-Moxibustion 2004年第1期14卷 18-25页

作者： shahzad Anwar malik Mohammad Nadeem Khan Imtiaz Ahmed Abid Hareef Awan Anwar Shah's First C.P.& Paralysis Clinic and Research Center Children Hospital & Institute of Child HealthSheikh Zayed HospitalAnwar Shah's First C.P.& Paralysis Clinic and Research Center 17 C Main Boulevard Faisal Town LahoreLahoreLahore Pakistan 17 C Main Boulevard Faisal Town Lahore

A single, open and non-comparative study was conducted at Anwar Shah’s First C.P. & Paralysis Clinic and Research Center to evaluate the effects of Aculaser (acupoint-laser) Therapy for children suffering from cerebral palsy (CP) of various types. These children were further classified according to their major complaints. Analysis of the data indicated that 11 children with severe spasticity and stiffness all showed marked improvement (100% success rate); of the 8 children with epileptic fits, 6 patients had a significant reduction in the intensity, frequency and duration of epileptic fits, while the rest 2 cases showed no any improvement or aggravation (75% success rate); out of 5 children with cortical blindness, 2 cases showed complete recovery of vision and 3 had marked improvement (40% cure rate); out of 4 children with hearing difficulties, 2 showed marked improvement (50% success rate); out of 14 children with aphasis, 8 showed improvement (57% improvement rate). Results of this study show that Aculaser Therapy has a high improvement rate of CP children, not only improving the spasticity and stiffness but also the cortical blindness, epilepsy, deafness and speech.

关键词： Infantile cerebral palsy Acupoint-laser therapy Clinical observation

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