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A case of primary biliary cirrhosis complicated by Behcet's disease and palmoplantar pustulosis

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World Journal of Gastroenterology 2006年第13期12卷 2136-2138页

作者： Haruyo Iwadate Hiromasa Ohira Hironobu Saito Atsushi Takahashi Tsuyoshi Rai junko Takiguchi Tomomi Sasajima Hiroko Kobayashi Hiroshi Watanabe Yukio Sato Department of Internal Medicine Ⅱ Fukushima Medical University School of Medicine Fukushima Japan

A 46-year-old woman was diagnosed with palmoplantar pustulosis （PPP） at the Department of Dermatology, Fukushima Medical University Hospital in 2000, and was treated with ointment. However, because liver dysfunction developed in 2003, she was referred to our department, where primary biliary cirrhosis （PBC） was also diagnosed on the basis of clinical findings. One year later, at the age of 49, she developed manifestations of Behcet＇s disease （BD）, including erythema nodosum in the lower extremities. Because she had a history of uveitis, recurrent oral ulceration was present, and the HLA typing was positive for B51, BD was additionally diagnosed. Liver function normalized within three months of the start of treatment with ursodesoxycholic acid （UDCA）. This is the first case of PBC associated with BD and PPP.

关键词： Primary biliary cirrhosis Behcet's disease Palmoplantar pustulosis

Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: A case report

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World Journal of Gastroenterology 2008年第35期14卷 5474-5477页

作者： Atsushi Takahashi Yukiko Kanno Yuta Takahashi Natsumi Sakamoto Kyoko Monoe Hironobu Saito Kazumichi Abe junko Yokokawa Atsushi Irisawa Hiromasa Ohira Department of Internal Medicine Ⅱ Fukushima Medical University School of MedicineFukushimaJapan

A 43-year-old woman with multiple sclerosis （MS） was treated with pulsed methylprednisolone and interferon 13 at a hospital. Four weeks after initiating treatment, liver dysfunction occurred and she was referred and admitted to our hospital. Clinical and laboratory findings were consistent with and fulfilled the criteria for drug-induced hepatitis, but not for autoimmune hepatitis （AIH）. She was successfully treated with corticosteroids. As ataxia developed after i year, she was treated with pulsed methylprednisolone for 3 days, then readmitted to our hospital when liver dysfunction occurred. Clinical and laboratory findings led to the diagnosis of AIH. To the best of our knowledge, this is the second case of AIH developed after pulsed methylprednisolone for MS.

关键词： Multiple sclerosis Autoimmune hepatitis Pulsed methylprednisolone

Historical Sources on the Hakka in Thai An Introductory Note

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客家研究辑刊 2005年第2期 38-42页

作者： junko KOIZUMI 小泉顺子

日本学者小泉顺子在泰国国家档案馆发现了20世纪早期关于客家的一些重要资料。在本文中，小泉顺子通过对这些资料的介绍和分析，向读者说明了客家在泰国和东亚、东南亚社会中比起其它族群（如潮州、广府），虽然人数相对较少，却扮演着... 详细信息

日本学者小泉顺子在泰国国家档案馆发现了20世纪早期关于客家的一些重要资料。在本文中，小泉顺子通过对这些资料的介绍和分析，向读者说明了客家在泰国和东亚、东南亚社会中比起其它族群（如潮州、广府），虽然人数相对较少，却扮演着十分重要的角色。

关键词：泰国国家档案馆客家历史资料角色扮演地方志

Challenges of Bioethics Education in Pediatric Basic Nursing Education: A Faculty Perspective

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Health 2024年第2期16卷 105-117页

作者： junko Nemoto Chikage Kubota Yukiko Yoshikawa Faculty of Nursing Hyogo University Kakogawa Japan Department of Emergency Medical Science Suzuka University of Medical Science Suzuka Japan

In the field of pediatric nursing, in the perinatal period, numerous ethical issues arise alongside the advancement of medical technology. However, sufficient education on bioethics is not provided in the pediatric nursing domain of basic nursing education. The purpose of this research is to examine the current status of bioethics education in the pediatric nursing domain of basic nursing education and explore the challenges perceived by the pediatric nursing faculty regarding bioethics education. The research method was a questionnaire survey on 100 randomly selected pediatric nursing faculty members from nursing universities across Japan. The results revealed that although bioethics issues were considered important, the emphasis remained primarily on addressing bioethics as part of nursing that respects children’s rights. Furthermore, respondents expressed difficulties regarding teaching methods and content related to bioethics.

关键词： Basic Nursing Education Bioethics Education Pediatric Nursing

Processes through Which the Grandparents of a Child with Severe Motor and Intellectual Disabilities (SMID) May Become Involved in Raising the Child

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Open Journal of Nursing 2020年第12期10卷 1251-1264页

作者： Yuki Konoshima junko Takemura Yuko Tomari Department of Nursing Faculty of Health and Science Nagoya Women’s University Aichi Japan Faculty of Nursing Osaka Medical College Osaka Japan Graduate School of Nursing Kansai University of Social Welfare Ako Hyōgo Japan

In Japan, it is common practice to involve grandparents in the care of children with severe motor and intellectual disabilities (SMID), as it may be difficult for nuclear families to handle such children by themselves. This study aimed to explore and describe the process through which the grandparents of children with SMID may be involved in their upbringing. Data were obtained via semi-structured interviews with 13 grandparents who had a grandchild with SMID. The collected data were examined using Yasuhito Kinoshita’s modified grounded theory approach. Altogether, 11 categories were identified from 29 themes. The results revealed two broad patterns concerning the nature of the grandparents’ involvement and their definition of grandparenthood in the context of raising a grandchild with SMID. In one process, grandparents supported the child’s family. They also learned to relate to the child and their family, despite experiencing a lack of responsiveness from the child initially. This ultimately resulted in them being inspired by their grandchild. In the other process, the grandparents left the care of their grandchild to the child’s family and chose to monitor the child’s welfare indirectly. In both the processes, the level of involvement was determined by the extent to which the family chose to ask grandparents for help. The study’s findings can be used to identify the kind of support that grandparents of children with SMID require while highlighting the role of considering the needs and intentions of the children’s families.

关键词： Grandparents Children Severe Motor and Intellectual Disabilities Support Extended Family Caregiving Japan

Examining the Hypothesis of Common Factors Shared by Different Addictive Behaviors and Gender Effects on Propensity to Addiction Type

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Open Journal of Medical Psychology 2024年第3期13卷 58-70页

作者： Masayo Uji junko Watanabe Toshinori Kitamura Department of Clinical Psychology Human Development Education Graduate School of Education Hyogo University of Teacher Education Kat Japan Academic Skill Support Center Kumamoto Health Science University Kumamoto Japan Kitamura Institute Mental Health Tokyo Tokyo Japan

Background: From the two facts reported by previous research: 1) frequent co-occurrence of more than one addictive behavior, 2) childhood adversities identified as origins of different types of addictive behaviors, it is assumed that all types of addictive behaviors, regardless of substance, behavioral, or relationship, share common factors which have not yet been proven by epidemiological research. The Shorter PROMIS Questionnaire (SPQ) was previously developed to assess 16 types of addictive behaviors. Its factor structure, however, has not been fully investigated. Confirming the factor structure will enable us to hypothesize the common factor(s) shared by all, or if not all, most types of addictive behaviors. Aims: This study aimed at 1) examining the factor structure of the SPQ, 2) confirming the reliability of the questionnaire, and 3) examining the impacts of gender and age on each addictive behavior. Methods: Data obtained from 232 Japanese adults who completed all items of the SPQ were used for the analyses. After confirming the one-factor structure model for each of the 16 subscales, the validity of the one-factor structure of the SPQ was evaluated using Confirmatory Factor Analysis (CFA), by adapting 16 subscale scores as observed variables. If its validity was not confirmed, another model which showed better compatibility to the data was explored. The reliability of the SPQ as well as that of all 16 subscales was evaluated. Also, the impacts of gender and age on each subscale score were examined. Results: The one-factor structure for each of the 16 subscales was confirmed. The compatibility of the SPQ one-factor model was not acceptable. The best fit model was a bi-factor model in which one main factor was shared by all 16 subscales, and three factors were shared by some specific addictive behaviors. Male respondents were more likely than female respondents to show high scores in Alcohol, Tobacco, Gambling, Sex, and Recreational Drugs, and low scores only

关键词： Addictive Behaviors Shorter PROMIS Questionnaire Confirmatory Factor Analysis

Severe Cytomegalovirus anterior uveitis and corneal endotheliitis after use of topical tacrolimus

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 468-471页

作者： Yukiko Tsubota Yujiro Fujino Kazayoshi Ohtomo Koji Ueda junko Yoshida Takashi Miyai Toshikatsu Kaburaki Chihiro Mayama Japan Community Healthcare Organization Tokyo Shinjuku Medical Center Tokyo 1628543Japan The University of Tokyo Graduate School of Medicine Tokyo 1130033Japan International University of Health and Welfare Mita Hospital Tokyo 1088329Japan Jichi Medical University Saitama Medical Center Saitama 3308503Japan

Dear Editor,Cytomegalovirus(CMV) uveitis is typically characterized by anterior segment inflammation with coin-shaped or linear keratic precipitates(KPs), mild cells and aqueous flare in the aqueous humor, corneal end... 详细信息

关键词： corneal uveitis inflammation

中日同传过快语速下的听辨问题及对策分析——以“中国发展高层论坛”模拟会议为例

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中日同传过快语速下的听辨问题及对策分析——以“中国发展高层论...

作者： Yokote junko 上海外国语大学

学位级别：硕士

从事或学习口译的人都遇到过因为讲话者语速过快所导致的听辨问题,特别是像笔者这样的以日语为母语、以中文作为第三外语的口译学习实践者,在进行中译日的同传或交传口译时经常遇到这类问题和困惑。那么,过快的语速或高语速究竟是如何... 详细信息

从事或学习口译的人都遇到过因为讲话者语速过快所导致的听辨问题,特别是像笔者这样的以日语为母语、以中文作为第三外语的口译学习实践者,在进行中译日的同传或交传口译时经常遇到这类问题和困惑。那么,过快的语速或高语速究竟是如何造成听辨和口译的问题的?口译者应该如何解决过快语速下的听辨问题呢?本论文从这一思考出发,对中日同传中中文语速过快所导致的听辨问题进行分析,并对其应对策略进行思考。首先,本论文将中文讲话者的语速分为过快语速、适当语速以及低语速三种。过快语速是指每分钟说话260字以上;适当语速指每分钟180-260字、低语速则每分钟180字以下。然后定义了口译中的“听辨”,即译员听讲座的时候除了听取关键词和想象场景外,还需要在大脑中进行记忆和逻辑分析,为译出做准备。因为口译不是单纯的一种语言向另一个语言转换的活动,因此论文还考察了释义学派理论提出的“脱离语言外壳”的必要性。在上述基本理论基础上,本论文对个人口译案例进行了分析。案例是笔者在课堂里的模拟会议,口译方式是无稿中日同声传译,题目为《中国发展高层论坛》。讲话者脱搞发言,有一位主持人主持论坛。以主持人提问,嘉宾回答的方式进行交谈。通过案例的内容分析,笔者发现口译失败的原因主要来自于过快语速以及讲话者的个人口音两方面。口译员听到讲话者的过快语速发言时,认知负荷迅速增加并直至超过译员信息处理能力。通过对口译失败的具体文本的分析,笔者最后提出了锻炼听辨能力的训练方法、以及口译中解决听辨问题的对应策略。

关键词：过快语速听辨释义学派理论脱离语言外壳认知负荷

Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction

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World Journal of Biological Chemistry 2010年第5期1卷 69-80页

作者： Yutaka Matsui junko Morimoto Toshimitsu Uede Department of Matrix Medicine Institute for Genetic MedicineHokkaido UniversityKita-15Nishi-7Kita-kuSapporo 060-0815Japan Division of Molecular Immunology Institute for Genetic MedicineHokkaido UniversityKita-15Nishi-7Kita-kuSapporo 060-0815Japan

After onset of myocardial infarction(MI),the left ventricle(LV) undergoes a continuum of molecular,cellular,and extracellular responses that result in LV wall thinning,dilatation,and *** dynamic changes in LV shape,size,and function are termed cardiac *** the cardiac healing after MI does not proceed properly,it could lead to cardiac rupture or maladaptive cardiac remodeling,such as further LV dilatation and dysfunction,and ultimately *** the precise molecular mechanisms in this cardiac healing process have not been fully elucidated,this process is strictly coordinated by the interaction of cells with their surrounding extracellular matrix(ECM) *** components of ECM include basic structural proteins such as collagen,elastin and specialized proteins such as fibronectin,proteoglycans and matricellular *** proteins are a class of non-structural and secreted proteins that probably exert regulatory functions through direct binding to cell surface receptors,other matrix proteins,and soluble extracellular factors such as growth factors and *** small group of proteins,which includesosteopontin,thrombospondin-1/2,tenascin,periostin,and secreted protein,acidic and rich in cysteine,shows a low level of expression in normal adult tissue,but is markedly upregulated during wound healing and tissue remodeling,including *** this review,we focus on the regulatory functions of matricellular proteins during cardiac tissue healing and remodeling after MI.

关键词： Matricellular proteins Myocardial infarction Cardiac healing Cardiac remodeling Extracellular matrix