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A Comparison of Quality of Life, Medication Side-Effect and Adherence among Schizophrenia Patients on Conventional versus Atypical Antipsychotics

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Open Journal of Psychiatry 2023年第2期13卷 94-105页

作者： Fawaz Babandi umar musa usman Zahraddeen Garba Habib Desola Shakirat Owolabi Mustapha Ibrahim Gudaji Aminu Abdullahi Taura Chikaodiri Nkeweurem Aghukwa Abubakar Sulaiman Baguda Auwalu Sani Salihu Aminu Kano Teaching Hospital Kano Nigeria Department of Psychiatry Bayero University Kano Nigeria

Quality of life (QoL) is becoming a widely accepted schizophrenia management outcome. But it is still not very clear if there are any significant differences between the conventional and atypical antipsychotics in terms of QoL improvement among people with schizophrenia (PWS). It is also imperative that antipsychotic drug-related factors, such as medication adherence and side-effect, which could directly or indirectly affect the QoL of PWS, are determined and compared among PWS on different classes of the drugs. Data were collected on Socio-demographic Characteristics, Quality of Life and Medication adherence using Socio-demographic and Schizophrenia Clinical Characteristics questionnaire, World Health Organization Quality of Life (WHOQoL)-Brief, and Morisky Medication Adherence Scale (MMAS) respectively from 250 respondents attending a tertiary health center’s Psychiatric clinic in Kano, Nigeria. Although PWS on the two classes of antipsychotic drugs showed inequalities in different aspects and domains of QoL, as well as in the levels of adherence and side-effects, the differences were all insignificant. However, presence of drug side effects was significantly associated with lower health-related QoL in the conventional antipsychotics group (p = 0.001), and lower score in the physical domain of QoL in the atypical antipsychotics group (p = 0.044). Medication adherence was found to be associated with better scores in different domains of QoL in both groups of PWS. There are no significant differences in terms of QoL, medication side-effect and adherence among PWS on the two classes of antipsychotics. However, drug side-effects and adherence were significantly and respectively associated with lower and higher scores in different domains of QoL in both groups.

关键词： Schizophrenia Antipsychotics Quality of Life Medication Adherence

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A Prospective Study on the Incidence and Predictors of Postpartum Depression among Pregnant Women Attending an Antenatal Clinic in Kano, Northern Nigeria

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Open Journal of Psychiatry 2023年第3期13卷 207-220页

作者： Asmaul Husna Abba Fawaz Babandi umar musa usman Zahraddeen Garba Habib Desola Shakirat Owolabi Mustapha Ibrahim Gudaji Aminu Abdullahi Taura Chikaodiri Nkeweurem Aghukwa Abubakar Sulaiman Baguda Auwalu Sani Salihu Aminu Kano Teaching Hospital Kano Nigeria Department of Psychiatry Bayero University Kano Nigeria

Depressive disorder is a major contributor to years lived with disability (YLD) globally. It is estimated that 13% of all women experience the disorder in the first year postpartum. Postpartum depression (PPD) has significant implications to the physical and mental wellbeing of both the mother and her baby. Only non-depressed pregnant women (score of ≤ 6 on Edinburgh Postnatal Depression Scale) were recruited into this study. Data collection was done at 2 different stages;at recruitment stage (during the third trimester of pregnancy) and at the follow up stage (4th - 6th week postpartum). During the recruitment stage, intimate partner violence (IPV) and level of social support perception, among the women, were assessed using Hurt Insult Threaten Scream (HITS) and Multidimensional Scale of Perceived Social Support (MSPSS) questionnaires respectively. While at the follow up stage, the Obstetric questionnaire and Mini International Neuropsychiatric Interview (MINI-7) were used respectively to obtain obstetric-related data and to diagnose for occurrence of depression. The incidence of PPD was found to be 16.34%. Several factors such as level of education, husband’s socioeconomic status, stressful life events, low perception of social support, obstetric instrumentation and not having a baby of preferred gender were significantly associated with PPD. Positive predictors of PPD included not practicing breast feeding (OR = 186.72, 95% CI = 8.32 - 4188.35), family history of mental illness (OR = 4.95, 95% CI = 1.04 - 23.81) and pregnancy lasting beyond 40 weeks (OR = 7.26, 95% CI = 1.51 - 34.88). High incidence of PPD with numerous associated but largely modifiable risk factors call for more proactive measures, such as PPD screening among pregnant women.

关键词： Postpartum Depression Pregnant Women

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A Comparison of Quality of Life, Medication Side-Effect and Adherence among Schizophrenia Patients on Conventional versus Atypical Antipsychotics

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Open Journal of Psychiatry（精神病学期刊） 2023年第2期

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A Prospective Study on the Incidence and Predictors of Postpartum Depression among Pregnant Women Attending an Antenatal Clinic in Kano, Northern Nigeria

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Open Journal of Psychiatry（精神病学期刊） 2023年第3期

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Assessment of breast cancer immunohistochemistry and tumor characteristics in Nigeria

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World Journal of Clinical Oncology 2020年第11期11卷 935-944页

作者： usman Malami Aliyu Abdulrahaman Auwal musa Department of Radiotherapy and Oncology Usmanu Danfodiyo University/Teaching HospitalSokoto 840212Nigeria Department of Histopathology Usmanu Danfodiyo University Teaching HospitalSokoto 840221Nigeria

BACKGROUND Female breast cancer is the leading type of cancer worldwide with an incidence of approximately 2.1 million in *** receptor status plays a vital role in its *** To determine the molecular expression pattern of biomarkers in breast cancer and their correlation with tumor *** This prospective study was designed to analyze expression patterns of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor(HER2/neu)in breast cancer *** dataset has been taken from the Department of Radiotherapy and Oncology of usmanu Danfodiyo University Teaching Hospital Sokoto,Nigeria from 1 January 2015 to 2 December *** dataset had 259 records and 7 *** version 23.0 for statistical analysis was *** data analyzed demographic and other clinicopathological characteristics as categorical *** mean and standard deviation were determined for the quantitative *** A total of 259 breast cancer cases were included in the *** mean age was 48.3±11.0,with an age range of 26-80 years and a median age of 46 *** morphological categories were invasive ductal carcinoma 258(99.6%)and invasive lobular carcinoma 1(0.4%).ER,positivity increased in 73 patients(50%)under the age of 50 years,as well as PR positivity increased in 34 patients(23.6%)under the age of 50 ***/2neupositivity decreased in 8 patients(5.6%)under the age of 50 *** receptors were statistically significant with clinicopathological characteristics(P<0.05).CONCLUSION Our study showed that ER,PR and HER2/neuexpression had a strong correlation with age,tumor grade,tumor size and lymph node ***,hormone receptor assessment is highly recommended because of its significance in clinical management and prognostication.

关键词： Breast cancer Hormonal receptors Sokoto state Tertiary Health Institution Northwestern Nigeria

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Assessment on Radiation Hazard Indices from Selected Dumpsites in Lafia Metropolis,Nasarawa State,Nigeria

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Journal of Oncology Research 2022年第1期4卷 20-26页

作者： Bello Aisha Ademoh usman Rilwan musa Yusuf Department of Physics Federal UniversityLafiaNasarawa StateNigeria Department of Physics Nigerian Army UniversityPMB 1500 BiuBorno StateNigeria

This research reports an assessment of ionizing radiation in some chosen Dumpsites in Lafia Local government area of Nasarawa *** radiation measurement was conducted at four Dump *** survey was done using a radiation survey meter(Radex one Outdoor 55130719 NA).Radiation exposure rate in micro sievert per hour(μSvhr^(-1))was *** were taken by placing the detector at gonad level about 1 meter above the *** showed that the average annual effective dose rate in the selected dumpsites were 0.22 mSv/yr for Lafia modern market,0.17 mSv/yr for dumpsite opposite governor Isa house,0.15 mSv/yr for Timber shade Lafia and 0.20 mSv/yrfor Science School Lafia respectively with a mean value of 0.19 mSv/yr for all location,while the mean calculated excess life cancer risk(ELCR)is 0.65×10^(-3).Dumpsites yearly absorbed dose rate and their corresponding ELCR values did not exceed the 1.0 mSv/y Basic Safety Standard set for the masses by International Council on Radiation Protection(ICRP,1999)and mean world average ECLR value of 1.16×10^(-3).Based on these results there are no radiation consequence to the scavengers,dumpsite workers and residents living around the dumpsites.

关键词： Radiation Dumpsites Scavengers Absorbed dose Effective dose

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In vitro biological screening of the stem of Desmodium elegans

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Asian Pacific Journal of Tropical Biomedicine 2013年第9期3卷 711-715页

作者： Arshad Khan Rabia usman Ming-Liang Wang Abdur Rauf Naveed Muhammad Akhatar Aman Taha Hussein musa Tahir School of Chemistry and Chemical Engineering Southeast University Institute of Chemical Sciences University of Peshawar Department of Pharmacy Hazara University School of Public Health Southeast University Nanjing

Objective:To explore the medicinal importance of the stem of Desmodium elegans,methanolic extract,and its different solvent fractions were evaluated for brine shrimp lethality,insecticidal and phytotoxicity,antifungal,and antibacterial ***:The methanolic extract and its solvent fractions were tested for cytotoxic,phytotoxic,insecticidal,antifungal,and antibacterial effects using our previous published ***:The methanolic,DCM,ethyl acetate and n-butanol fractions exhibited insecticidal effect against Callosobruchus analis and Rhyzopertha *** methanolic extract,n-hexane,DCM ethyl acetate and n-butanol showed 75,85,85,65 and 5%phytotoxicity at the tested concentration of 500μg/*** solvent fractions(DCM and ethyl acetate)were effective against ***(10%and 20%,inhibition respectively).All the tested samples were devoid of cytotoxic and antibacterial ***:It was concluded diat diis plant can be practiced for control of weeds and insects.

关键词： Leguminosae Desmodium elegans Brine shrimp cytotoxicity Phytotoxic Insectioidal and antimicrobial activities

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A Case Control Study of Subjective Quality of Life in Outpatients with Depression

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Open Journal of Psychiatry 2017年第4期7卷 248-260页

作者： Francis John Davou Moses David Audu Akinwande O. Akinhanmi musa usman umar Tungchama Friday Philip Maigari Yusufu Taru Aishatu Armiya’u Yushau Department of Psychiatry University of Jos Jos Nigeria Federal Neuro-Psychiatric Hospital Aro Abeokuta Nigeria Bayero University Kano/Aminu Kano Teaching Hospital Kano Nigeria Jos University Teaching Hospital Jos Nigeria

Background: Depression is one of the leading causes of disability including impairment in the subjective Quality of Life (QOL) of the patient. Unfortunately, only a fraction receives the correct diagnosis and treatment in general practice. This study aims to determine the subjective Quality of Life of depressed patients. Method: A representative sample of adults, 18 years and above (100 each for cases and controls), were assessed for QOL using the World Health Organization Quality of Life instrument (WHOQOL-BREF). Respondents were also evaluated for socio-demographic factors. Major depressive disorder was assessed using the Mini International Neuropsychiatric Interview. Severity of depression was measured using Hamilton’s Rating Scale for Depression and global functioning was assessed with the Global Assessment of Functioning scale. Results: Majority of the participants were females (62.0%) and young with a mean age of 39.11 ± 12.40 years. Overall subjective QOL (P P P P P P Conclusion: The finding of the study showed that depression is a serious illness that affects the patient’s perception of the quality of his/her life. It is therefore very necessary to innovate better treatment modalities to reduce its burden.

关键词： Depression Quality of Life Outpatients Controls

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Fournier's Gangrene: Experience with Management of 46 Cases in a Tertiary Institution

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Open Journal of Urology 2012年第3期2卷 109-112页

作者： Sani Ali Aji Sani usman Alhassan musa Muhammad Ujudud Urology Unit Department of Surgery Aminu Kano Teaching Hospital Kano Nigeria

Background: Fournier's gangrene is a rapidly spreading necrotizing gangrene affecting the perineum, Perianal and genital regions but remarkably sparing the testicles, bladder and rectum due to their separate blood supply which is directly from the aorta. The aim of this study is to share our experience with the management of 46 cases. Patients and method: We retrospectively analysed the medical records of 46 patients admitted with Fournier's gangrene between April 2005 and December 2011 in the urology unit of Aminu Kano Teaching Hospital. Data extracted from these include age, sex, hospital stay, premorbid diseases, mobility, mortality, laboratory investigations and treatments carried out. Results: Fourty six patients were admitted and managed for Fournier's gangrene during the study period. All the patients were male and mean age was 50 years (range 20 - 80 years). Five patients died (10.90%) mortality, 41 (89.10%) patients survived. The shortest hospital stay was 13 days and longest was 120 days. 45.7% of the patients had urethral stricture with watering can perineum as predisposing factor, 16 (34.80%) had diabetes mellitus, 7 (15.2%) had perineal injuries as the predisposing factors while 5 (10.90%) patients had uraemia and one patient (2.20%) each had bladder tumour and scrotal abscess as their predisposing factors, in 3 patients (6.50%) it was idiopathic. Only 34 (73.90%) patients had wound swab microscopy culture and sensitivity on admission. The culture grew Klebsiella spp. in 9 (26.50%), Staph aureus and E. coli in 5 (10.90%) of cases each, while Gram positive rod and Gram negative Cocci with 4 (11.80%) and 6 (17.60%) respectively. Conclusion: Fournier's gangrene which is a rapidly progressive, fulminant polymicrobial synergistic infection of the perineum and genitals, is now changing pattern. Extensive surgical debridement and broad spectrum intravenous antibiotics remain the mainstay of treatment.

关键词： Fournier's Gangrene Management Changing Pattern

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Occurrence of Fluoride in the Groundwater of Kaltungo Area and Environs, North Eastern Nigeria

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Journal of Geoscience and Environment Protection 2019年第8期7卷 167-179页

作者： Shehu Mukkafa Jackson Makpane Ishaku Ibrahim Abdulkarim Kwami Ahmed Buba Seli usman Adamu Abubakar Abdulwahab Mohammed Bello usman Abubakar musa usman Bappa Department of Environmental Management and Toxicology Federal University Dutse Dutse Nigeria Department of Geology School of Physical Science Modibbo Adama University of Technology Yola Nigeria Geology Department Gombe State University Gombe Nigeria Departmentof Civil Engineering Adamawa State Polytechnic Yola Nigeria Departmentof Chemistry Gombe State University Gombe Nigeria

The aim of the study is to assess the occurrence of fluoride in the groundwater of Kaltungo area and environs. Consumption of high fluoride waters clearly manifests in the majority inhabitant of the area in form of dental fluorosis especially in the majority of the populace. Thirty groundwater samples were collected from hand-dug wells and boreholes using standard method and were analyzed to determine the fluoride level. The results revealed that the Fluoride in the waters ranges from 0.8 to 1.94 mg/l with a mean value of 1.65 mg/l. No clear variations in fluoride content have been observed in both the borehole samples and those from the hand-dug wells. Ca-Mg-HCO3 and Ca-Mg-Cl are the two major water types obtained in the area, which have a good association with fluoride. Negative correlation is observed between fluoride and temperature, fluoride and magnesium, fluoride and potassium and poor correlation is observed between fluoride and chloride, fluoride and nitrate, fluoride and phosphates which rules out the possibility of anthropogenic source of the fluoride in the waters. Positive correlation between fluoride and iron, indicates that the presence of fluoride in the water is as a result of dissolution of biotite within the host rock (Basalt).

关键词： Anthropogenic Correlation Fluoride Kaltungo

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