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Circulating tumor DNA and its role in detection, prognosis and therapeutics of hepatocellular carcinoma

Chinese Journal of Cancer Research 2024年第2期36卷 195-214页

作者： Sana Rashid Yingchuan Sun umair ali khan saddozai Sikandar Hayyat Muhammad Usman Munir Muhammad Usman Akbar Muhammad Babar Khawar Zhiguang Ren Xinying Ji Malik Ihsan Ullah khan Institute of Molecular Biology and Biotechnology University of LahoreLahore 54590Pakistan Department of Internal Oncology(Section Ⅰ) Xuchang Municipal Central HospitalXuchang 461000China Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225001China Australian Institute for Bioengineering&Nanotechnology the University of QueenslandBrisbane 4072Australia Gomal Center of Biochemistry and Biotechnology Gomal UniversityDera Ismail Khan 29111Pakistan Applied Molecular Biology and Biomedicine Lab Department of ZoologyUniversity of NarowalNarowal Punjab 51600Pakistan Kaifeng Municipal Key Laboratory for Infection and Biosafety Henan International Joint Laboratory of Nuclear Protein RegulationSchool of Basic Medical SciencesHenan UniversityKaifeng 475004China Faculty of Basic Medical Subjects Shu-Qing Medical College of ZhengzhouZhengzhou 450064China Department of Medicine Huaxian County People's HospitalHuaxian 456400China

Hepatocellular carcinoma(HCC) is considered the fifth most prevalent cancer among all types of cancers and has the third most morbidity value. It has the most frequent duplication time and a high recurrence rate. Recently, the most unique technique used is liquid biopsies, which carry many markers;the most prominent is circulating tumor DNA(ctDNA). Varied methods are used to investigate ctDNA, including various forms of polymerase chain reaction(PCR) [emulsion PCR(ePCR), digital PCR(dPCR), and bead, emulsion, amplification, magnetic(BEAMing) PCR]. Hence ctDNA is being recognized as a potential biomarker that permits early cancer detection,treatment monitoring, and predictive data on tumor burden are subjective to therapy or surgery. Numerous ctDNA biomarkers have been investigated based on their alterations such as 1) single nucleotide variations(either insertion or deletion of a nucleotide) markers including TP53, KRAS, and CCND1;2) copy number variations which include markers such as CDK6, EFGR, MYC and BRAF;3) DNA methylation(RASSF1A, SEPT9, KMT2C and CCNA2);4) homozygous mutation includes ctDNA markers as CDKN2A, AXIN1;and 5) gain or loss of function of the genes, particularly for HCC. Various researchers have conducted many studies and gotten fruitful ***, there are some drawbacks to ctDNA namely low quantity, fragment heterogeneity, less stability, limited mutant copies and standards, and differential sensitivity. However, plenty of investigations demonstrate ctDNA's significance as a polyvalent biomarker for cancer and can be viewed as a future diagnostic, prognostic and therapeutic agent. This article overviews many conditions in genetic changes linked to the onset and development of HCC, such as dysregulated signaling pathways, somatic mutations, single-nucleotide polymorphisms, and genomic instability. Additionally, efforts are also made to develop treatments for HCC that are molecularly targeted and to unravel some of the genetic pathways that f

关键词： Hepatocellular carcinoma circulating tumor DNA biomarkers single nucleotide variations diagnosis prognosis

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Soft and flexible:core-shell ionic liquid resistive memory for electronic synapses

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Microsystems & Nanoengineering 2021年第5期7卷 119-128页

作者： Muhammad umair khan Qazi Muhammad Saqib Mahesh Y.Chougale Rayyan ali Shaukat Jungmin Kim Jinho Bae Department of Ocean System Engineering Jeju National University102 JejudaehakroJeju 63243Korea

The human brain is the most efficient computational and intelligent system,and researchers are trying to mimic the human brain using solid-state ***,the use of solid-state materials has a limitation due to the movement of ***,soft memory devices are receiving tremendous attention for smooth neurotransmission due to the ion concentration polarization *** paper proposes a core-shell soft ionic liquid(IL)-resistive memory device for electronic synapses using Cu/Ag@AgCI/Cu with multistate resistive *** presence of the Ag@AgCI core shell in the liquid electrolyte significantly helps to control the movement of Cu^(2+)ions,which results in multistate resistive switching *** core-shell IL soft memory device can open a gateway for electronic synapses.

关键词： mechanism gateway electronic

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Spatio-temporal variations in trends of vegetation and drought changes in relation to climate variability from 1982 to 2019 based on remote sensing data from East Asia

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Journal of Integrative Agriculture 2023年第10期22卷 3193-3208页

作者： Shahzad ali Abdul BASIT Muhammad umair Tyan alice MAKANDA Fahim Ullah khan Siqi SHI NI Jian College of Chemistry and Life Sciences Zhejiang Normal UniversityJinhua 321004P.R.China Department of Agriculture Hazara UniversityMansehra 21120Pakistan Department of Computer Science University of PeshawarPeshawar 25000Pakistan Faculty of Geo-Information Science and Earth Observation(ITC) University of TwenteEnschede 7500 AENetherlands

Studying the significant impacts on vegetation of drought due to global warming is crucial in order to understand its dynamics and interrelationships with temperature,rainfall,and normalized difference vegetation index(NDVI).These factors are linked to excesses drought frequency and severity on the regional scale,and their effect on vegetation remains an important topic for climate change *** Asia is very sensitive and susceptible to climate *** this study,we examined the effect of drought on the seasonal variations of vegetation in relation to climate variability and determined which growing seasons are most vulnerable to drought risk;and then explored the spatio-temporal evolution of the trend in drought changes in East Asia from 1982 to *** data were studied using a series of several drought indexes,and the data were then classified using a heat map,box and whisker plot analysis,and principal component *** various drought indexes from January to August improved rapidly,except for vegetation health index(VHI)and temperature condition index(TCI).While these indices were constant in September,they increased again in October,but in December,they showed a descending *** seasonal and monthly analysis of the drought indexes and the heat map confirmed that the East Asian region suffered from extreme droughts in 1984,1993,2007,and 2012among the study *** distribution of the trend in drought changes indicated that more severe drought occurred in the northwestern region than in the southeastern area of East *** drought tendency slope was used to describe the changes in drought events during 1982–2019 in the study *** correlations among monthly precipitation anomaly percentage(NAP),NDVI,TCI,vegetation condition index(VCI),temperature vegetation drought index(TVDI),and VHI indicated considerably positive correlations,while considerably negative correlations were found among the three pairs of NDVI and VHI,TVDI and VHI,and NDV

关键词： climate change drought severity vegetation dynamics heat mapping TVDI spatial correlation East Asia

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Coronavirus: A “Mild” Virus Turned Deadly Infection

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Computers, Materials & Continua 2021年第5期67卷 2631-2646页

作者： Rizwan ali Naqvi Muhammad Faheem Mushtaq Natash ali Mian Muhammad Adnan khan Atta-ur-Rahman Muhammad ali Yousaf Muhammad umair Rizwan Majeed Department of Unmanned Vehicle Engineering Sejong UniversitySeoul05006Korea Department of Information Technology Khwaja Fareed University of Engineering and Information TechnologyRahim Yar Khan64200Pakistan School of Computer and Information Technology Beaconhouse National UniversityTarogilLahore53700Pakistan Riphah School of Computing&Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia Faculty of Information Technology University of Central PunjabLahore54782Pakistan Directorate of IT The Islamia University of BahawalpurBahawalpur63100Pakistan

Coronaviruses are a family of viruses that can be transmitted from one person to *** strains have only been mild viruses,but the current form,known as coronavirus disease 2019(COVID-19),has become a deadly *** outbreak originated in Wuhan,China,and has since spread *** symptoms of COVID-19 include a dry cough,sore throat,fever,and nasal *** drugs,pathogen–host interaction,and 2 weeks of isolation have been recommended for the treatment of the *** operating procedures,such as the use of face masks,hand sanitizer,handwashing with soap,and social distancing,are also ***,travel bans for cities,states,and countries have been put in place,along with lockdowns to control the *** restrictions,mask use,sanitizer or soap use,and avoidance of touching the face and nose have produced encouraging results,whereas the effectiveness of antibiotics has not been *** results of isolation for the recovery of infected people have also been *** bans and lockdowns have caused a slump in economies,and unemployment has risen sharply,resulting in an increase in mental health cases *** date,vaccines have been developed and are in use in certain countries,but following standard operating procedures remain *** countries following the guidelines can eradicate this *** Zealand was the rst country to eliminate the virus from their territory.

关键词： Coronavirus severe acute respiratory syndrome middle east respiratory syndrome world health organization

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The Impact of Internet of Things Supported by Emerging 5G in Power Systems: A Review

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CSEE Journal of Power and Energy Systems 2020年第2期6卷 344-352页

作者： Jinsong Tao Muhammad umair Muhammad ali Jian Zhou School of Electrical Engineering and Automation Wuhan UniversityHubei 430072China

The Internet of Things(IoT)is playing an important role in providing access to affordable,clean and green energy worldwide through the use of smart *** current electric power networks will be more reliable,secure,flexible and durable by implementing IoT in power *** paper presents a brief discussion about IoT contributions in the development of power systems from a generation,transmission,distribution and consumption point of view.5G cellular networks have a great potential for the development of IoT ***,5G cellular networks can be instrumental in supporting the greater communication needs of *** review provides a comprehensive analysis about the role of 5G cellular networks in the growth of IoT technology and power *** amounts of data will be generated due to the incorporation of renewable energy,deployment of the smart grid and the improvements to the electricity *** this way,in order to realize the connection between things and people,things and things and people and people in power systems,it is essential to apply IoT in power *** this case,5G is providing numerous advantages to Power IoT(PIoT)by offering greater opportunities in progress and improvements;however,there are also numerous challenges with the deployment of 5G in ***,this review article provides an overview of the role,implications and challenges of 5G in PIoT.

关键词： Fifth Generation(5G) Internet of Things(IoT) Power IoT(PIoT)

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Morphometry of leaf and shoot variables to assess aboveground biomass structure and carbon sequestration by different varieties of white mulberry(Morus alba L.)

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Journal of Forestry Research 2021年第6期32卷 2291-2300页

作者： Ghulam ali Bajwa Muhammad umair Yasir Nawab Zahid Rizwan Pakistan Forest Institute Peshawar 25130Pakistan National Textile University Faisalabad 37610Pakistan

Mulberry is economically important and can also play a pivotal role in mitigating greenhouse *** and shoot traits were measured for Morus alba ***,*** ***,*** ***,and *** ***-1 to assess aboveground biomass(AGB)and carbon ***-specific and multivariety allometric AGB models were developed using the equivalent diameter at breast height(EDBH)and plant height(H).The completeharvest method was used to measure leaf and shoot traits and biomass,and the ash method was used to measure organic carbon *** results showed significant(p<0.01)varietal differences in leaf and shoot traits,AGB and carbon ***-1 variety had the greatest leaf density(mean±SE:1828.3±0.3 leaves tree^(-1)),Karyansuban had the largest mean leaf area(185.94±8.95 cm^(2)).A diminishing return was found between leaf area and leaf *** had the highest shoot density per tree(46.6±1.83 shoots tree^(-1)),total shoot length(264.1±2.32 m),dry biomass(16.69±0.58 kg tree^(-1)),carbon sequestration(9.99±0.32 kg tree^(-1))and CO_(2) mitigation(36.67±1.16 kg).The variety-specific AGB models b(EDBH)and b(EDBH)2 showed good fit and reasonable accuracy with a coefficient of determination(R^(2))=0.98-0.99,standard error of estimates(SEE)=0.1125-0.3130 and root mean square error(RMSE)=*** multivariety models bln(EDBH)and(EDBH)0.756 showed good-fitness and accuracy with R^(2)=0.85-0.86,SEE=1.6231-1.6445 and RMSE=*** the basis of these findings,variety Latifolia has good potential for biomass production,and allometric equations based on EDBH can be used to estimate AGB with a reasonable accuracy.

关键词： Allometry Biomass estimation CO_(2)mitigation Moraceae Mulberry Regression models

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Organic single crystal phototransistors:Recent approaches and achievements

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Frontiers of physics 2021年第4期16卷 109-123页

作者： Changbin Zhao Muhammad umair ali Jiaoyi Ning Hong Meng School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China Tsinghua-Berkeley Shenzhen Institute(TBSI) Tsinghua UniversityShenzhen 518055China Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Organic phototransistors(OPTs),compared to traditional inorganic counterparts,have attracted a great deal of interest because of their inherent flexibility,light-weight,easy and low-cost fabrication,and are considered as potential candidates for next-generation wearable ***,significant advances have been made in OPTs with the development of new organic semiconductors and optimization of device fabrication *** various types of OPTs,small molecule organic single crystal phototransistors(OSCPTs)standout because of their exciting features,such as long exciton diffusion length and high charge carrier mobility relative to organic thinfilm *** this review,a brief introduction to device architectures,working mechanisms and figure of merits for OPTs is *** then overview recent approaches employed and achievements made for the development of ***,we spotlight potential future directions to tackle the existing challenges in this field and accelerate the advancement of OSCPTs towards practical applications.

关键词： photodetectors organic transistors organic phototransistors organic single crystals flexible electronics

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Recognition and Tracking of Objects in a Clustered Remote Scene Environment

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Computers, Materials & Continua 2022年第1期70卷 1699-1719页

作者： Haris Masood Amad Zafar Muhammad umair ali Muhammad Attique khan Salman Ahmed Usman Tariq Byeong-Gwon Kang Yunyoung Nam Wah Engineering College University of WahWah CanttPakistan Department of Electrical Engineering University of LahoreIslamabad CampusPakistan Department of Unmanned Vehicle Engineering Sejong UniversitySeoul05006Korea Department of Computer Science HITEC University TaxilaTaxila47040Pakistan College of Computer Engineering and Sciences Prince Sattam Bin Abdulaziz UniversityAl-KhrajSaudi Arabia Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea

Object recognition and tracking are two of the most dynamic research sub-areas that belong to the field of Computer *** vision is one of the most active research fields that lies at the intersection of deep learning and machine *** paper presents an efficient ensemble algorithm for the recognition and tracking of fixed shapemoving objects while accommodating the shift and scale invariances that the object may *** first part uses the Maximum Average Correlation Height(MACH)filter for object recognition and determines the bounding box *** case the correlation based MACH filter fails,the algorithms switches to a much reliable but computationally complex feature based object recognition technique i.e.,affine scale invariant feature transform(ASIFT).ASIFT is used to accommodate object shift and scale object *** extracts certain features from the object of interest,providing invariance in up to six affine parameters,namely translation(two parameters),zoom,rotation and two camera axis ***,in this paper,only the shift and scale invariances are *** second part of the algorithm demonstrates the use of particle filters based Approximate Proximal Gradient(APG)technique to periodically update the coordinates of the object encapsulated in the bounding *** the end,a comparison of the proposed algorithm with other stateof-the-art tracking algorithms has been presented,which demonstrates the effectiveness of the proposed algorithm with respect to the minimization of tracking errors.

关键词： Object racking MACH filter ASIFT particle filter recognition

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Soliton solutions for nonlinear variable-order fractional Korteweg-de Vries(KdV)equation arising in shallow water waves

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Journal of Ocean Engineering and Science 2024年第1期9卷 50-58页

作者： umair ali Hijaz Ahmad Hanaa Abu-Zinadah Department of Applied Mathematics and Statistics Institute of Space TechnologyP.O.Box 2750Islamabad 44000Pakistan Near East University Operational Research Center in HealthcareNear East BoulevardPC:99138 Nicosia/Mersin 10Turkey Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele II3900186 RomaItaly University of Jeddah College of ScienceDepartment of StatisticsJeddahSaudi Arabia

Nonlinear fractional differential equations provide suitable models to describe real-world phenomena and many fractional derivatives are varying with time and *** present study considers the advanced and broad spectrum of the nonlinear(NL)variable-order fractional differential equation(VO-FDE)in sense of VO Caputo fractional derivative(CFD)to describe the physical *** VO-FDE transforms into an ordinary differential equation(ODE)and then solving by the modified(G/G)-expansion *** ac-curacy,the space-time VO fractional Korteweg-de Vries(KdV)equation is solved by the proposed method and obtained some new types of periodic wave,singular,and Kink exact *** newly obtained solutions confirmed that the proposed method is well-ordered and capable implement to find a class of NL-VO *** VO non-integer performance of the solutions is studied broadly by using 2D and 3D graphical *** results revealed that the NL VO-FDEs are highly active,functional and convenient in explaining the problems in scientific physics.

关键词： Space-time VO fractional KdV equation modiﬁed(G′/G)-expansion method VO Caputo fractional derivative generalized Riccati equation

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Matter accretion onto Einstein-aether black holes via well-known fluids

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Chinese Physics C 2020年第6期44卷 182-196页

作者： M.umair Shahzad Rafaqat ali Abdul Jawad Shamaila Rani Department of Mathematics University of OkaraOkaraPakistan Department of Mathematics COMSATS University IslamabadLahore-CampusPakistan

We study matter accretion onto Einstein-aether black holes by adopting the Hamiltonian *** general solution of accretion is discussed using the isothermal equation of *** types of fluids are considered,including ultra-relativistic,ultra-stiff,sub-relativistic,and radiation fluids,and the accretion process onto Einstein-aether black holes is *** behavior of the fluid flow and the existence of critical points is investigated for Einstein-aether black *** further discuss the general expression and behavior of polytropic fluid onto Einstein-aether black *** most important feature of this work is the investigation of the mass accretion rate of the above-mentioned fluids and the comparison of our findings with the Schwarzschild black hole,which generates particular ***,the maximum mass accretion rate occurs near the Killing and universal horizons,and the minimum accretion rate lies between them.

关键词： black hole accretion homo-clinic orbits

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