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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra Pereira Leonardo Cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello ulysses ribeiro jr.Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-L1+PT staged as pN+were also tested for PD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-L1+PT,54.2%(13/24 cases)were also PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agreement between PT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both *** was no statistical difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CONCLUSION Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched *** disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center

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Chinese Journal of Cancer Research 2018年第5期30卷 546-552页

作者： adriana vaz safatle-ribeiro elisa ryoka baba rodrigo corsato scomparin sheila friedrich faraj marcelo simas de lima luciano lenz bruno costa martins carla gusmon fábio shiguehissa kawaguti caterina pennacchi bruno zilberstein ulysses ribeiro jr. fauze maluf-filho Endoscopy Unit of Department of Gastroenterology Sao Paulo Cancer Institute University of Sao Paulo Medical School (ICESP-HCFMUSP) Sao Paulo 01246-000 Brazil

Objective： Probe-based confoeal laser endomicroscopy （pCLE） technique may improve the diagnosis of gastric mucosal lesions allowing acquisition of high-resolution in vivo images at the cellular and mierovaseular levels. This study aims to evaluate the accuracy of pCLE for the differential diagnosis of non-neoplastic and neoplastic gastric ***： Twenty gastric mucosal lesions from 10 patients were evaluated during endoscopic procedure and were examined by pCLE. Diagnostic pCLE was followed by biopsies or endoscopic resection of suspected lesions. A senior pathologist evaluated the specimens and was blinded to the pCLE ***： Patients＇ mean age was 68.3 （range, 42-83） years and six were men. Thirteen suspicious flat or elevated lesions （classified as 0-Is, 0-IIa or 0-IIa ＋ IIc） and seven pre-malignant lesions （atrophy and intestinal metaplasia） were evaluated. One patient was studied during his long-term follow-up after partial gastrectomy and presented severe atrophy, intestinal metaplasia, and xanthomas at the stump mucosa. The location of gastric lesions was in the body （n=10 lesions）, the antrum （n=9） and the incisura angularis （n=1）. All neoplastic lesions and all but one benign lesion were properly diagnosed by pCLE. pCLE incorrectly diagnosed one small antrum lesion as adenoma, however the final diagnosis was intestinal metaplasia. The final histological diagnosis was neoplastic in 9 and benign lesions in 11. In this small case series, pCLE accuracy was 95% （19/20 lesions）.Conclusions： pCLE is accurate for real time histology of gastric lesions, pCLE may change the management of patients with gastric mucosal lesions, guiding biopsies and endoscopic resection, and avoiding further diagnostic workup or unnecessary therapy.

关键词： Probe-based confocal endomieroscopy gastric cancer intestinal metaplasia atrophy gastric adenoma endoscopic resection

Is gastric cancer after bariatric surgery on the rise?Will history repeat itself?

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Chinese Journal of Cancer Research 2023年第1期35卷 11-14页

作者： Adriana Vaz Safatle-ribeiro ulysses ribeiro jr Department of Gastroenterology Instituto do Cancer do Estado de Sao PauloHospital das ClinicasFaculdade de MedicinaUniversidade de Sao Paulo(ICESP-HCFMUSP)Sao PauloSP 01246-000Brazil

Gastric cancer is the fifth most common cancer and the fourth leading cause of cancer-related death worldwide(1).Despite its decreasing incidence during the last decades,a major concern has been raised in patients submitted to bariatric surgery(2).Morbid obesity incidence has increased worldwide leading to low quality of life expectancy in children。

关键词： surgery Gastric death

Advances in surgical techniques for gastric cancer:Indocyanine green and near-infrared fluorescence *** it ready for prime time?

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Chinese Journal of Cancer Research 2022年第6期34卷 587-591页

作者： Erica Sakamoto Adriana Vaz Safatle-ribeiro ulysses ribeiro jr Department of Gastroenterology Instituto do Cancer do Estado de Sao PauloHospital das ClinicasFaculdade de MedicinaUniversidade de Sao

Surgery is still the primary curative treatment for gastric cancer,which includes resection of the tumor with adequate margins and extended *** order to improve the operative results and the quality of life of patients,several endeavors have been made toward precision medicine through image-guided surgery,allowing access to real-time intraoperative anatomy and accurate tumor *** goal of the surgeon is to achieve a more precise,individualized,and less invasive surgery without compromising oncological efficiency and *** this perspective,we have demonstrated the role of indocyanine green(ICG)and near-infrared(NIR)fluorescence imaging method in gastric cancer *** technique may be used to improve localization of the tumor,detection of sentinel lymph nodes(SLN),real-time lymphatic mapping,and blood flow assessment(anastomosis perfusion).

关键词： Indocyanine green near-infrared fluorescence imaging gastric cancer lymphatic mapping

Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer

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Chinese Journal of Cancer Research 2022年第6期34卷 612-622页

作者： Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan ribeiro E ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello ulysses ribeiro jr Department of Gastroenterology Instituto do Cancer do Estado de Sao PauloHospital das ClinicasFaculdade de MedicinaUniversidade de Sao Paulo(ICESP-HCFMUSP)Sao PauloSP 01246-000Brazil Department of Pathology Instituto do Cancer do Estado de Sao PauloHospital das ClinicasFaculdade de MedicinaUniversidade de Sao Paulo(ICESP-HCFMUSP)Sao PauloSP 01246-000Brazil

Objective:Remnant gastric cancer(RGC)is usually associated with a worse *** they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for *** study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated ***:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively *** resections with histological diagnosis of gastric adenocarcinoma were enrolled in the *** risk score based on immune parameters was developed using binary logistic regression *** were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune *** markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the *** score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR *** were no differences in clinicopathological and surgical characteristics between the three *** survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR *** the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse ***:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with ***,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic bi

关键词： Stomach neoplasms gastric remnant tumor-infiltrating lymphocytes immune microenvironment

Preoperative albumin-bilirubin score is a prognostic factor for gastric cancer patients after curative gastrectomy

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1125-1137页

作者： Daniel Jose Szor Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos Francisco Tustumi Andre Roncon Dias Bruno Zilberstein ulysses ribeiro jr Department of Gastroenterology Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 01246000Brazil

BACKGROUND Albumin-bilirubin(ALBI)score is an indicator of liver dysfunction and is useful for predicting prognosis of hepatocellular ***,this liver function index has been used to predict prognosis in other ***,the significance of ALBI score in gastric cancer(GC)after radical resection has not been *** To evaluate the prognostic value of the preoperative ALBI status in patients with GC who received curative *** Patients with GC who underwent curative intended gastrectomy were retrospectively evaluated from our prospective *** score was calculated as follows:(log10 bilirubin×0.660)+(albumin×-0.085).The receiver operating characteristic curve with area under the curve(AUC)was plotted to evaluate the ability of ALBI score in predicting recurrence or *** optimal cutoff value was determined by maximizing Youden’s index,and patients were divided into low and high-ALBI *** Kaplan-Meier curve was used to analyze the survival,and the log-rank test was used for comparison between *** A total of 361 patients(235 males)were *** median ALBI value for the entire cohort was-2.89(IQR-3.13;-2.59).The AUC for ALBI score was 0.617(95%CI:0.556-0.673,P<0.001),and the cutoff value ***,211(58.4%)patients were classified as low-ALBI group and 150(41.6%)as high-ALBI *** age(P=0.005),lower hemoglobin level(P<0.001),American Society of Anesthesiologists classification III/IV(P=0.001),and D1 lymphadenectomy P=0.003)were more frequent in the high-ALBI *** was no difference between both groups in terms of Lauren histological type,depth of tumor invasion(pT),presence of lymph node metastasis(pN),and pathologic(pTNM)*** postoperative complication,and mortality at 30 and 90 days were higher in the high-ALBI *** the survival analysis,the high-ALBI group had worse disease-free survival(DFS)and overall survival(OS)compared to those with low-ALBI(P<0.001).

关键词： Stomach neoplasms Adenocarcinoma Albumin-bilirubin Biomarker Prognosis Survival

Risk factors for blood transfusion and its prognostic implications in curative gastrectomy for gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 643-654页

作者： Lucas Eiki Kawakami Pedro Barzan Bonomi Marina Alessandra Pereira Fabrício Oliveira Carvalho ulysses ribeiro jr.Bruno Zilberstein Luciana ribeiro Sampaio Luiz Augusto Carneiro-D'Albuquerque Marcus Fernando Kodama Pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 01249000Brazil Blood Transfusion Unit Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 01249000Brazil

BACKGROUND Gastric cancer(GC)is still a prevalent neoplasm around the world and its main treatment modality is surgical *** need for perioperative blood transfusions is frequent,and there is a long-lasting debate regarding its impact on *** To evaluate the factors related to the risk of receiving red blood cell(RBC)transfusion and its influence on surgical and survival outcomes of patients with *** Patients who underwent curative resection for primary gastric adenocarcinoma at our Institute between 2009 and 2021 were retrospectively *** and surgical characteristics data were *** patients were divided into transfusion and non-transfusion groups for *** A total of 718 patients were included,and 189(26.3%)patients received perioperative RBC transfusion(23 intraoperatively,133 postoperatively,and 33 in both periods).Patients in the RBC transfusions group were older(P<0.001),and had morecomorbidities(P=0.014),American Society of Anesthesiologists classification III/IV(P<0.001),and lower preoperative hemoglobin(P<0.001)and albumin levels(P<0.001).Larger tumors(P<0.001)and advanced tumor node metastasis stage(P<0.001)were also associated with the RBCtransfusion *** rates of postoperative complications(POC)and 30-d and 90-d mortalitywere significantly higher in the RBC transfusion group than in the non-transfusion *** and albumin levels,total gastrectomy,open surgery,and the occurrence of POC werefactors associated with the RBC *** analysis demonstrated that the RBCtransfusions group had worse disease-free survival(DFS)and overall survival(OS)compared withpatients who did not receive transfusion(P<0.001 for both).In multivariate analysis,RBCtransfusion,major POC,pT3/T4 category,pN+,D1 lymphadenectomy,and total gastrectomywere independent risk factors related to worse DFS and *** RBC transfusion is associated with worse clinical condition

关键词： Stomach neoplasms Blood transfusion Red blood cells Postoperative complications Survival Prognosis

Gastric cancer with concurrent pancreatic schwannoma: A casereport

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World Journal of Gastrointestinal Pathophysiology 2022年第3期13卷 107-113页

作者： Mateus Barradas ribeiro Emerson Shigueaki Abe AndréKondo Adriana Vaz Safatle-ribeiro Marina Alessandra Pereira Bruno Zilberstein ulysses ribeiro jr Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSao Paulo 01249000Brazil

BACKGROUND The differential diagnosis of abdominal masses is somewhat troublesome,especially when there is a malignancy to be *** report herein a unique case of gastric adenocarcinoma concurrent with a pancreatic *** assessment of intraoperative findings is essential for adequate tumor staging and to decide the proper management of a concurrent pancreatic *** SUMMARY Computed tomography scan performed for gastric cancer staging revealed a solid and cystic pancreatic mass that had no signs of local *** resection of the pancreas was decided preoperatively since a radical approach of the gastric tumor could be *** were no signs of distant metastases,and the large pancreatic mass was in contact with the posterior gastric *** study revealed a pancreatic schwannoma,which is an uncommon neoplasm that arises from Schwann cells around peripheral *** Therefore,pancreatic masses deserve special attention regarding the differential diagnosis in patients with gastric *** presence of a large pancreatic mass should not preclude the potentially curative intent of the gastric cancer treatment.

关键词： Stomach neoplasms Gastric adenocarcinoma Schwannoma Pancreas Case report

Expression profiles of gastric cancer molecular subtypes in remnant tumors

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 265-278页

作者： Marcus Fernando Kodama Pertille Ramos Marina Alessandra Pereira Leonardo Cardili Evandro Sobroza de Mello ulysses ribeiro jr.Bruno Zilberstein Ivan Cecconello Department of Gastroenterology Instituto do CancerHospital das ClinicasHCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01249000São PauloBrazil Department of Pathology Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01249000São PauloBrazil

BACKGROUND Remnant gastric cancer(RGC)is a carcinoma arising in the stomach remnant after previous gastric *** is frequently reported as a tumor with a poor prognosis and distinct biological features from primary gastric cancer(PGC).However,as it is less frequent,its profile regarding the current molecular classifications of gastric cancer has not been *** To evaluate a cohort of RGC according to molecular subtypes of GC using a panel of immunohistochemistry and in situ hybridization to determine whether the expression profile is different between PGC and *** Consecutive RGC patients who underwent gastrectomy between 2009 and 2019 were assessed using seven GC panels:Epstein-Barr virus in situ hybridization,immunohistochemistry for mismatch repair proteins(MutL homolog 1,MutS homolog 2,MutS homolog 6,and PMS1 homolog 2),p53 protein,and E-cadherin *** characteristics and survival of these patients were compared to 284 PGC *** A total of 40 RGC patients were enrolled in this *** to PGC,older age(P<0.001),male(P<0.001),lower body mass index(P=0.010),and lower hemoglobin level(P<0.001)were associated with RGC *** difference was observed regarding Lauren’s type and pathologic Tumor Node Metastasis stage between the *** the profiles evaluated,EBV-positive tumors were higher in RGC compared to PGC(P=0.039).The frequency of microsatellite instability,aberrant p53 immunostaining,and loss of E-cadherin expression were similar between RGC and *** rates of simultaneous alterations in two or more profiles were observed in RGC compared to PGC(P<0.001).According to the molecular classification,the subtypes were defined as EBV in nine(22.5%)cases,microsatellite instability in nine(22.5%)cases,genomically stable in one(2.5%)case,and chromosomal instability in 21(52.5%)*** was no significant difference in survival between molecular subtypes in RGC *** RGC w

关键词： Stomach neoplasms Gastric remnant Gastric remnant cancer Adenocarcinoma Immunohistochemistry