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American Journal of Plant Sciences 2017年第11期8卷 2860-2870页

作者： Feng Zhao Werner Heller Susanne Stich Jorg Durner J. Barbro Winkler Claudia Traidl-Hoffmann Dieter Ernst ulrike frank Institute of Biochemical Plant Pathology Helmholtz Zentrum München Germany Neuherberg Germany Biochemical Plant Pathology Technische Universitat München Center of Life and Food Sciences Weihenstephan Freising-Weihenstephan Germany Research Unit Environmental Simulation Helmholtz Zentrum München München Germany Institute of Environmental Medicine UNIKA-T Technische Universitat München Augsburg Germany CK-CARE Christine Kühne—Center for Allergy Research and Education Davos-Wolfgang Switzerland

Ambrosia artemisiifolia L. (common ragweed) is an annual ruderal plant that is native to Northern America but nowadays is also spreading across Europe, and its pollen is known to be highly allergenic. Air pollution, e.g. NOx and climate change may affect the plant growth, pollen production and duration of the entire pollen season. In this study, ragweed plants were grown over an entire vegetation period under 40 ppb NO2/clean air (control) and 80 ppb NO2 (treatment). The inflorescence length was not affected by this air pollutant. However, the pollen amount increased, while the seed production decreased in both populations upon elevated NO2 concentrations. Regarding phenolic metabolites elevated NO2 had no effect on the amount of total phenolic metabolites, while individual metabolites showed significant changes.

关键词： Air Pollution Ambrosia artemisiifolia Flavonoids Pollen Ragweed Seeds

Application of machine learning in perovskite materials and devices:A review

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Journal of Energy Chemistry 2024年第7期94卷 254-272页

作者： Ming Chen Zhenhua Yin Zhicheng Shan Xiaokai Zheng Lei Liu Zhonghua Dai Jun Zhang Shengzhong(frank)Liu Zhuo Xu School of Electric Power Civil Engineering and ArchitectureCollege of Physics and Electronics EngineeringState Key Laboratory of Quantum Optics and Quantum Optics DevicesShanxiUniversityTaiyuan030006ShanxiChina Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of EducationShanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710119ShaanxiChina State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Metal-halide hybrid perovskite materials are excellent candidates for solar cells and photoelectric *** recent years,machine learning(ML)techniques have developed rapidly in many fields and provided ideas for material discovery and *** can be applied to discover new materials quickly and effectively,with significant savings in resources and time compared with traditional experiments and density functional theory(DFT)*** this review,we present the application of ML in per-ovskites and briefly review the recent works in the field of ML-assisted perovskite ***,the advantages of perovskites in solar cells and the merits of ML applied to perovskites are ***,the workflow of ML in perovskite design and some basic ML algorithms are ***,the applications of ML in predicting various properties of perovskite materials and devices are ***,we propose some prospects for the future development of this *** rapid devel-opment of ML technology will largely promote the process of materials science,and ML will become an increasingly popular method for predicting the target properties of materials and devices.

关键词： Machine learning Perovskite Materials design Bandgap engineering Stability Crystal structure

Assessment of laryngologists'ratings on physician review websites

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 1-6页

作者： Meleeka Akbarpour Karen Tawk Madelyn frank Alizah S.Gomez Navid Mostaghni Mehdi Abouzari Department of Otolaryngology-Head and Neck Surgery University of CaliforniaIrvineUSA

Objective:To assess and characterize online ratings and comments on laryngologists and determine factors that correlate with higher ***:All the American Laryngological Association(ALA)members were queried across several online *** were normalized for comparison on a five-point Likert *** were categorized based on context and for positive/negative ***:Of the 331 ALA members,256(77%)were rated on at least one online *** all platforms,the average overall rating was 4.39±0.61(range:1.00-5.00).Specific positive ratings including“bedside manners,”“diagnostic accuracy,”“adequate time spent with patient,”“appropriate follow-up,”and“physician timeliness”had significant positive correlations to overall ratings,by Pearson's correlation(P<0.001).Long wait times had significant negative correlations to overall ratings(P<0.001).Conclusion:Online ratings and comments for laryngologists are significantly influenced by patient perceptions of bedside manner,physician competence,and time spent with the patient.

关键词： laryngologist online rating patient rating physician review website

Optimization of Methylene Blue Dye Adsorption onto Coconut Husk Cellulose Using Response Surface Methodology: Adsorption Kinetics, Isotherms and Reusability Studies

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Journal of Materials Science and Chemical Engineering 2024年第2期12卷 1-18页

作者： frank Ouru Omwoyo Geoffrey Otieno School of Chemistry and Material Science Technical University of Kenya Nairobi Kenya

In this study, coconut husk cellulose was employed as a cost-effective and environmentally friendly adsorbent to eliminate methylene blue (MB) dye from aqueous solutions. The successful development of response surface methodology paired with a central composite design (RSM-CCD) enabled the optimization and modelling of the adsorption process. The study investigated the individual and combined effects of three variables (pH, contact time, and initial MB dye concentration) on the adsorption of MB dye onto coconut husk cellulose. The developed RSM-CCD model exhibited a remarkable degree of precision in predicting the removal efficiency of MB dye within the specified experimental parameters. This was demonstrated by the strong regression parameters, with an R2 value of 99.79% and an adjusted R2 value of 99.6%. The study depicted that the optimal parameters for attaining a 98.8827% removal of MB dye using coconut husk cellulose were as follows: an initial MB dye concentration of 30 mg∙L−1, contact time of 120 minutes, and pH 7 at a fixed adsorbent dose of 0.5 g. The Freundlich isotherm model provided the most satisfactory description of the equilibrium adsorption isotherms, suggesting that MB dye adsorption onto coconut husk cellulose occurs on a heterogeneous surface. The experimental results demonstrated a strong agreement with the pseudo-second-order kinetics model, indicating that the number of active sites present on the cellulose adsorbent predominantly influences the adsorption process of MB dye. Additionally, the adsorbent made from coconut husk cellulose exhibited the potential to be reused, as it retained its efficiency for a maximum of three cycles of adsorption of MB dye. The results of this study show that coconut husk cellulose has the potential to be an effective and sustainable adsorbent for removing MB dye from aqueous solutions.

关键词： Adsorption Kinetics Isotherms Optimization Response Surface Methodology Cellulose

Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte Nelson frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

Magnificent Frigatebird Optimization: A New Bio-Inspired Metaheuristic Approach for Solving Optimization Problems

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Computers, Materials & Continua 2024年第8期80卷 2721-2741页

作者： Tareq Hamadneh Khalid Kaabneh Ibraheem AbuFalahah Gulnara Bektemyssova Galymzhan Shaikemelev Dauren Umutkulov Sayan Omarov Zeinab Monrazeri frank Werner Mohammad Dehghani Department of Mathematics Al Zaytoonah University of JordanAmman11733Jordan Faculty of Information Technology Al-Ahliyya Amman UniversityAmman19328Jordan Department of Mathematics Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan Department of Computer Engineering International Information Technology UniversityAlmaty050000Kazakhstan Department of Big Data Analytics and Data Science Software Development Company《QazCode》Almaty050063Kazakhstan Department of Electrical and Electronics Engineering Shiraz University of TechnologyShiraz***Iran Faculty of Mathematics Otto-von-Guericke UniversityP.O.Box 4120Magdeburg39016Germany

This paper introduces a groundbreaking metaheuristic algorithm named Magnificent Frigatebird Optimization(MFO),inspired by the unique behaviors observed in magnificent frigatebirds in their natural *** foundation of MFO is based on the kleptoparasitic behavior of these birds,where they steal prey from other *** this process,a magnificent frigatebird targets a food-carrying seabird,aggressively pecking at it until the seabird drops its *** frigatebird then swiftly dives to capture the abandoned prey before it falls into the *** theoretical framework of MFO is thoroughly detailed and mathematically represented,mimicking the frigatebird’s kleptoparasitic behavior in two distinct phases:exploration and *** the exploration phase,the algorithm searches for new potential solutions across a broad area,akin to the frigatebird scouting for vulnerable *** the exploitation phase,the algorithm fine-tunes the solutions,similar to the frigatebird focusing on a single target to secure its *** evaluate MFO’s performance,the algorithm is tested on twenty-three standard benchmark functions,including unimodal,high-dimensional multimodal,and fixed-dimensional multimodal *** results from these evaluations highlight MFO’s proficiency in balancing exploration and exploitation throughout the optimization *** studies with twelve well-known metaheuristic algo-rithms demonstrate that MFO consistently achieves superior optimization results,outperforming its competitors across various *** addition,the implementation of MFO on four engineering design problems shows the effectiveness of the proposed approach in handling real-world applications,thereby validating its practical utility and robustness.

关键词： Optimization metaheuristic magnificent frigatebirds exploration exploitation

Frilled Lizard Optimization: A Novel Bio-Inspired Optimizer for Solving Engineering Applications

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Computers, Materials & Continua 2024年第6期79卷 3631-3678页

作者： Ibraheem Abu Falahah Osama Al-Baik Saleh Alomari Gulnara Bektemyssova Saikat Gochhait Irina Leonova OmParkash Malik frank Werner Mohammad Dehghani Department of Mathematics Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan Department of Software Engineering Al-Ahliyya Amman UniversityAmman19328Jordan Faculty of Science and Information Technology Software EngineeringJadara UniversityIrbid21110Jordan Department of Computer Engineering International Information Technology UniversityAlmaty050000Kazakhstan Symbiosis Institute of Digital and Telecom Management Constituent of Symbiosis International Deemed UniversityPune412115India Neuroscience Research Institute Samara State Medical UniversitySamara443001Russia Faculty of Social Sciences Lobachevsky UniversityNizhny Novgorod603950Russia Department of Electrical and Software Engineering University of CalgaryCalgaryAB T2N 1N4Canada Faculty of Mathematics Otto-von-Guericke UniversityP.O.Box 4120Magdeburg39016Germany Department of Electrical and Electronics Engineering Shiraz University of TechnologyShiraz***Iran

This research presents a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization(FLO),which emulates the unique hunting behavior of frilled lizards in their natural *** draws its inspiration from the sit-and-wait hunting strategy of these *** algorithm’s core principles are meticulously detailed and mathematically structured into two distinct phases:(i)an exploration phase,which mimics the lizard’s sudden attack on its prey,and(ii)an exploitation phase,which simulates the lizard’s retreat to the treetops after *** assess FLO’s efficacy in addressing optimization problems,its performance is rigorously tested on fifty-two standard benchmark *** functions include unimodal,high-dimensional multimodal,and fixed-dimensional multimodal functions,as well as the challenging CEC 2017 test ***’s performance is benchmarked against twelve established metaheuristic algorithms,providing a comprehensive comparative *** simulation results demonstrate that FLO excels in both exploration and exploitation,effectively balancing these two critical aspects throughout the search *** balanced approach enables FLO to outperform several competing algorithms in numerous test ***,FLO is applied to twenty-two constrained optimization problems from the CEC 2011 test suite and four complex engineering design problems,further validating its robustness and versatility in solving real-world optimization ***,the study highlights FLO’s superior performance and its potential as a powerful tool for tackling a wide range of optimization problems.

关键词： Optimization engineering bio-inspired metaheuristic frilled lizard exploration exploitation

Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2992-3008页

作者： Shicheng Fan Yue Gao Pengfei Zhao Guomin Xie Yanying Zhou Xiao Yang Xuan Li Shuaishuai Zhang frank JGonzalez Aijuan Qu Min Huangb Huichang Bi NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA The State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyShenzhen Graduate School of Peking UniversityShenzhen 518055China

Fenofibrate,a peroxisome proliferator-activated receptor α(PPARα)agonist,is widely prescribed for hyperlipidemia *** studies also showed that it has therapeutic potential in various liver ***,its effects on hepatomegaly and liver regeneration and the involved mechanisms remain ***,the study showed that fenofibrate significantly promoted liver enlargement and regeneration post-partial hepatectomy in mice,which was dependent on hepatocyteexpressed PPARα.Yes-associated protein(YAP)is pivotal in manipulating liver growth and *** further identified that fenofibrate activated YAP signaling by suppressing its K48-linked ubiquitination,promoting its K63-linked ubiquitination,and enhancing the interaction and transcriptional activity of the YAP-TEAD *** inhibition of YAP-TEAD interaction using verteporfin or suppression of YAP using AAV Yap shRNA in mice significantly attenuated fenofibrate-induced *** factors,such as MYC,KRT23,RAS,and RHOA,might also participate in fenofibrate-promoted hepatomegaly and liver *** studies demonstrate that fenofibratepromoted liver enlargement and regeneration are PPARα-dependent and partially through activating the YAP signaling,with clinical implications of fenofibrate as a novel therapeutic agent for promoting liver regeneration.

关键词： Fenofibrate PPARa Hepatomegaly Partial hepatectomy Liver regeneration YAP TEAD Ubiquitination

Graphene-calcium carbonate coating to improve the degradation resistance and mechanical integrity of a biodegradable implant

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Journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerjee R.K.Singh Raman Derrek E.Lobo Christopher D.Easton Mainak Majumder frank Witte Jörg F.Löffler Department of Mechanical and Aerospace Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological Engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale Science and Engineering Laboratory(NSEL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Materials Science and Engineering Bayview AvenueClaytonVIC 3168Australia Julius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

Retrospective study of the incidence, risk factors, treatment outcomes of bacterial infections at uncommon sites in cirrhotic patients

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World Journal of Hepatology 2024年第3期16卷 418-427页

作者： Sophie Schneitler Christina Schneider Markus Casper frank Lammert Marcin Krawczyk Sören L Becker Matthias Christian Reichert Institute of Medical Microbiology and Hygiene Saarland UniversityHomburg 66421Germany Department of Medicine II Saarland University Medical CenterHomburg 66421Germany Health Sciences Hannover Medical SchoolHannover 30625Germany Laboratory of Metabolic Liver Diseases Department of GeneralTransplant and Liver SurgeryCentre for Preclinical ResearchMedical University of WarsawWarsaw 02-097Poland

BACKGROUND Bacterial infections(BI)negatively affect the natural course of *** most frequent BI are urinary tract infections(UTI),pneumonia,and spontaneousbacterial peritonitis(SBP).AIM To assess the relevance of bacterial infections beyond the commonly recognized types in patients with cirrhosis and to investigate their relationship with other clinical *** We retrospectively analyzed patients with cirrhosis and BI treated between 2015 and 2018 at our tertiary care *** were classified as typical and atypical,and clinical as well as laboratory parameters were compared between the two *** In a cohort of 488 patients with cirrhosis,we identified 225 typical BI(95 UTI,73 SBP,72 pulmonary infections)and 74 atypical BIs,predominantly cholangitis and soft tissue infections(21 each),followed by intra-abdominal BIs(n=9),cholecystitis(n=6),head/throat BIs(n=6),osteoarticular BIs(n=5),and endocarditis(n=3).We did not observe differences concerning age,sex,or etiology of cirrhosis in patients with typical vs atypical *** BIs were more common in patients with more advanced cirrhosis,as evidenced by Model of End Stage Liver Disease(15.1±7.4 vs 12.9±5.1;P=0.005)and Child-Pugh scores(8.6±2.5 vs 8.0±2;P=0.05).CONCLUSION Atypical BIs in cirrhosis patients exhibit a distinct spectrum and are associated with more advanced stages of the ***,the work-up of cirrhosis patients with suspected BI requires detailed work-up to elucidate whether typical BI can be identified.

关键词： Bacterial infection Empirical antibiotic therapy End-stage liver disease Escherichia coli Multi-resistant pathogens