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实验与分析 2013年第1期 50-51页

作者： ulrich pachmann

化疗效果是癌症治疗过程中关键所在，也是令患者和医生都感到困惑的问题。本文介绍了一种创新的Maintrac分析法，能在早期治疗中帮助医生选择适合的个性化治疗方案，以期达到更好的疗效。

关键词：治疗方案肿瘤细胞癌症检测解答早期治疗个性化疗效

Chemosensitivity Testing of Circulating Epithelial Tumor Cells (CETC) in <i>Vitro</i>: Correlation to in <i>Vivo</i>Sensitivity and Clinical Outcome

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Journal of Cancer Therapy 2013年第2期4卷 597-605页

作者： Nadine Rudiger Ernst-Ludwig Stein Erika Schill Gabriele Spitz Carola Rabenstein Martina Stauch Matthias Rengsberger Ingo B. Runnebaum ulrich pachmann Katharina pachmann Clinic for Internal Medicine II University Hospital Friedrich Schiller University Jena Germany Onkologische Schwerpunktpraxis Kronach Germany Transfusionsmedizinisches Zentrum Bayreuth Germany Women’s Hospital University Hospital Friedrich Schiller University Jena Germany

Background: Chemotherapy is a mainstay of tumor therapy, however, it is predominantly applied according to empirically developed recommendations derived from statistical relapse rates occurring years after the treatment in the adjuvant situation and from progression-free interval data in the metastatic situation, without any possibility of individually determining the efficacy in the adjuvant situation and with loss of time and quality of life in the metastatic situation if the drugs chosen are not effective. Here, we present a method to determine the efficiency of chemotherapeutic drugs using tumor cells circulating in blood as the part of the tumor actually available in the patient’s body for chemosensitivity testing. Methodology/Principal Findings: After only red blood cell lysis, omitting any enrichment (analogous to other blood cell enumeration methods, including rare CD34 cells), the white cells comprising the circulating epithelial tumor cells (CETC) are exposed to the drugs in question in different concentrations and for different periods of time. Staining with a fluorescence-labeled anti-epithelial antibody detects both vital and dying tumor cells, distinguishing vital from dying cells through membrane permeability and nuclear staining with propidium iodide. Increasing percentages of dying tumor cells are observed dependent on time and concentration. The sensitivity can vary during therapy and was correlated with decrease or increase in CETC and clinical outcome. Conclusions/Significance: Thus, we are able to show that chemosensitivity testing of circulating tumor cells provides real-time information about the sensitivity of the tumor present in the patient, even at different times during therapy, and correlates with treatment success.

关键词： Circulating Epithelial Tumor Cells Chemosensitivity Testing Breast Cancer Ovarian Cancer

On the Strong Limit Theorems for Double Arrays of Blockwise M-dependent Random Variables

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Acta Mathematica Sinica,English Series 2011年第10期27卷 1923-1934页

作者： ulrich STADTMULLER Department of Number and Probability Theory Ulm University 89069 Ulm Germany

For a double array of blockwise M-dependent random variables {Xmn,m ≥ 1,n ≥ 1}, ∑i^m=1 ∑^nj=1 strong laws of large numbers are established for double sums ∑m i=1 ∑j^n=1 ij, m≥ 1, n 〉 1. The main results are obtained for （i） random variables {Xmn, m≥ 1, n ≥ 1} being non-identically distributed but satisfy a condition on the summability condition for the moments and （ii） random variables {Xmn, m ≥ 1, n ≥ 1} being stochastically dominated. The result in Case （i） generalizes the main result of M6ricz et al. [J. Theoret. Probab., 21, 660-671 （2008）] from dyadic to arbitrary blocks, whereas the result in Case （ii） extends a result of Gut [Ann. Probab., 6, 469-482 （1978）] to the bockwise M-dependent setting. The sharpness of the results is illustrated by some examples.

关键词： Blockwise M-dependent random variables strong law of large numbers double arrays of random variables almost sure convergence

Multidimensional separation due to selective spherical agglomeration—Evidence of shape separation via X-ray microtomography

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Particuology 2021年第5期19卷 316-323页

作者： Julia Schreier ulrich Brockel University of Applied Sciences Trier Institute for Micro-Process-Engineering and Particle Technology(IMiP)Umwelt-Campus BirkenfeldP.O.Box 1380D-55761 BirkenfeldGermany

Objective of this work was to develop a novel method for characterizing real 3D shapes of particles smaller than 20μm by X-ray microtomography(X-RMT).Multidimensional separation of heterogenous solids through agglomeration in suspension will improve recycling processes as the particle shape and the agglomerate size are used for shape-selective *** the present paper we discuss the fundamentals of X-ray tomography and the experimental setup for selective spherical agglomeration in suspension.A specific preparation method of the particulate sample for X-RMT followed by 3D image processing,are essential for the shape analysis expressed as *** also discuss the limitation of this method due to the so-called Partial Volume Effect and particle clusters in the order of magnitude of X-RMT *** proof of concept,we used a mixture of graphite platelets and spheronized graphite particles for a shape selective-agglomeration in *** remaining fines were analyzed and showed more platelets than in the *** indicates that spheronized particles are preferably bound in the *** findings show that,based on the discussed sample preparation and a 3D image analysis in connection with X-RMT,particle shapes of micronized particles can be discriminated.

关键词： Multidimensional separation X-ray microtomography Selective agglomeration Particle shape Graphite

AN ANALYTICAL SOLUTION FOR CALCULATING THE INITIATION OF SEDIMENT MOTION

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International Journal of Sediment Research 2007年第2期22卷 87-102页

作者： Thomas LUCKNER ulrich ZANKE Groundwater Research Institute DresdenGermany Institute for Hydraulic Engineering Darmstadt University of TechnologyGermany

This paper presents an analytical solution for calculating the initiation of sediment motion and the risk of river bed movement. It thus deals with a fundamental problem in sediment transport, for which no complete analytical solution has yet been found. The analytical solution presented here is based on forces acting on a single grain in state of initiation of sediment motion. The previous procedures for calculating the initiation of sediment motion are complemented by an innovative combination of optical surface measurement technology for determining geometrical parameters and their statistical derivation as well as a novel approach for determining the turbulence effects of velocity fluctuations. This two aspects and the comparison of the solution functions presented here with the well known data and functions of different authors mainly differ the presented solution model for calculating the initiation of sediment motion from previous approaches. The defined values of required geometrical parameters are based on hydraulically laboratory tests with spheres. With this limitations the derivated solution functions permit the calculation of the effective critical transport parameters of a single grain, the calculation of averaged critical parameters for describing the state of initiation of sediment motion on the river bed, the calculation of the probability density of the effective critical velocity as well as the calculation of the risk of river bed movement. The main advantage of the presented model is the closed analytical solution from the equilibrium of forces on a single grain to the solution functions describing the initiation of sediment motion.

关键词： Incipient motion Initiation of sediment motion Sediment transport Bed load movement Risk analysis Risk of river bed movement Optical surface measurement

Glacial Lakes in the Andes under a Changing Climate:A Review

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Journal of Earth Science 2021年第6期32卷 1575-1593页

作者： Bijeesh Kozhikkodan Veettil ulrich Kamp Environmental Engineering and Management Research Group Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Environment and Labour Safety Ton Duc Thang UniversityHo Chi Minh CityVietnam Department of Natural Sciences University of Michigan-DearbornDearbornMI48128USA

In this article, we review the current knowledge of the glacial recession and related glacial lake development in the Andes of South America. Since the mid-1980 s, hundreds of glacial lakes either expanded or formed, and predictions show that additional hundreds of lakes will form throughout the 21 st century. However, studies on glacial lakes in the Andes are still relatively rare. Many glacial lakes pose a potential hazard to local communities, but glacial lake outburst floods(GLOFs) are understudied. We provide an overview on hazards from glacial lakes such as GLOFs and water pollution, and their monitoring approaches. In real-time monitoring, the use of unmanned aerial systems(UASs) and early warning systems(EWSs) is still extremely rare in the Andes, but increasingly authorities plan to install mitigation systems to reduce glacial lake risk and protect local communities. In support, we propose an international remote sensing-based observation initiative following the model of, for example, the Global Land Ice Measurements from Space(GLIMS) one, with the headquarters in one of the Andean nations.

关键词： Andes glacial change glacial lake glacial lake outburst flood remote sensing water pollution

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New Relationship for Estimation of Wave Overtopping on Vertical Walls

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China Ocean Engineering 2017年第1期31卷 48-54页

作者： ESKAND ARI Hojjatollah KAMALIAN ulrich Reza Coastal Engineering Group University of Qom Qom *** Iran

Soft computing tools in the form of combination of multiple nonlinear regression and M5′ model tree were used for estimation of overtopping rate at the vertical coastal structures. For reliable and precise estimation of overtopping rate, the experimental data available in the database CLASH were used. The dimensionless overtopping rate was estimated in terms of conventional dimensionless parameters including the relative crest freeboard Rc/Hs, seabed slope tanθ, deep water wave steepness S（om）, surf similarity ξ（om） and local relative water depth ht/Hs. The accuracy of the new model was compared with other existing models and also evaluated with some field measurements. The results indicated that the model presented in this paper is more accurate than other existing models. With statistical parameters, it is shown that the accuracy of predictions in the new model is better than that of other models.

关键词： similarity dimensionless precise Walls crest formulae trained coastal separate correction

Finite Element Simulations of Crack Propagation in Al_(2)O_(3)/6061Al Composites

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Acta Metallurgica Sinica(English Letters) 2014年第5期27卷 853-861页

作者： Galina Lasko ulrich Weber Siegfried Schmauder Institut für Materialprüfung Werkstoffkunde und Festigkeitslehre(IMWF)Universitat Stuttgart

In this work, the local fracture initiation behaviour of an Al2O3/6061Al composite is studied numerically. The damage behaviour of the microstructure is evaluated in consideration of the path and the amount of damage as well as the stress-strain performance of the microstructure. The damage behaviour of the ductile matrix has been simulated using the damage parameter D. For the simulation of fracture of the ceramic particles, a normal stress criterion is applied. For the analysis of the damage behaviour of the transition zone between particulate and matrix, both damage models （D parameter and normal stress criteria） are applied in this region. Parameter studies of crack propagation prediction in the Al2O3/6061Al composite on the basis of an Element Elimination technique have been performed for two differently heat-treated variants resulting in different mechanical properties. In addition, residual stress effects on the damage behaviour are examined for various microstructural situations.

关键词： Metal matrix composites Simulation Crack propagation Finite element method Element elimination technique

Metal Free Polymer/Graphite Electrode-Ferricyanides Catholyte System for MFC with High Performance

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China Petroleum Processing & Petrochemical Technology 2020年第3期22卷 9-18页

作者： Jiang Bolong ulrich Kunz Innovation Institute for Sustainable Maritime Architecture Research and Technology Qingdao University of TechnologyQingdao 266000 Clausthal University of Technology Institute of Chemical and Electrochemical Process EngineeringGermany

A Microbial fuel cell(MFC)with metal free polymer/graphite electrodes(150 mm×150 mm)was *** electrodes with flowing channels,which were different in roughness,were *** additional catalyst was coated on the electrode,therefore the MFC was cheaper and possessed good durability with high *** effect of roughness,K3Fe(CN)6 concentration and sprayed air on the performance of the constructed MFC was *** showed that the roughness of electrode can significantly affect the performance of *** power density of MFC increased by 1.56 times owing to the arithmetic mean roughness which has increased by 1.41 *** an increasing K3Fe(CN)6 concentration,the performance of MFC also *** MFC with K3Fe(CN)6 only(30 mM)showed the highest power density of 1260 mW/m2,which is by 21.4 times and 1.3 times higher than those of MFCs with spraying air only(59 mW/m2)and with K3Fe(CN)6+air(1005 mW/m2),*** showed that the appropriate concentration of K3Fe(CN)6 can significantly improve the power density,while the air has a negative effect when it is sprayed onto K3Fe(CN)6 catholyte.A coulombic efficiency of 34.2%and an energy efficiency of 13.3%with a COD degradation rate of 73.5%were achieved with MFC using K3Fe(CN)6 *** overpotentials of MFC were also *** can be seen that both theηohmic andηconcentration were very low as compared to theηactivation,and theηconcentration can be ignored because its effect was less than 3 *** theoretical calculation suggested that with an increasing conversion rate of K3Fe(CN)6,the cathode potential decreased and reached 0.31 V at a conversion rate of *** the anode behaves differently for constant pH and changeable pH as the reaction progresses,which reveals that the buffer solution and removal of protons play an important role in maintaining the anode potential.

关键词： microbial fuel cell wastewater treatment potassium ferricyanide air power production electrochemical performance metal free polymer/graphite electrode

Ultrastructure and function of follicle cell in the ovary of Branchiostoma belcheri

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Science China(Life Sciences) 1997年第1期40卷 60-70页

作者： ulrich Welsch 方永强 Department of Anatomy University of Munchen Munchen Germany Third Institute of Oceanography SOA Xiamen 361005 China

The ultrastructure of follicle cells in the ovary at different developmental stages of Branchiostoma has been observed in detail with a transmission electron microscope. The results indicate that only one kind of follicle cell exists with structural features related to steroid hormone biosynthesis: (i) oval or round mitochondria with tubules; (ii) smooth surfaced endoplasmic reticulum; (iii) several large lipid droplets in the cytoplasm; (iv) a well de-veloped Golgi complex and tubular rough surfaced endoplasmic reticulum, as can be found in mammalian theca interna cells. In addition, as steroid hormone synthesizing cells, they obviously play an important role in the phagocytosis of relict gametes and cellular debris and may have a nutritive function for the oocytes. They can produce abundant secre-tory granules in stages III-IV ovaries. In mature ovaries they transform into flat epithelial cells with numerous micro-filaments which may play a role in ovulation.

关键词： lancelet (amphioxus) oogenesis oocyte follicle cell ultrastructure.