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NEUTRINOLESS DOUBLE-β DECAY

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Chinese Physics C 2016年第10期40卷 647-649页

作者： P. vogel A. Piepke Caltech University of Alabama

Observation of neutrinoless double-beta （0vββ） decay would signal violation of total lepton number conservation. The process can be mediated by an exchange of a light Majorana neutrino, or by an exchange of other particles. However, the existence of 0vββ-decay requires Majorana neutrino mass, no matter what the actual mechanism is. As long as only a limit on the lifetime is available, limits on the effective Majorana neutrino mass, on the lepton-number violating right-handed current or other possible mechanisms mediating 0vββ-decay can be obtained, independently of the actual mechanism by assuming that one of these ＂new physics＂ possibilities dominates. These limits are listed in the next three tables, together with a claimed 0vββ-decay signal reported by part of the Heidelberg- Moscow collaboration. There is tension between that claim and several recent experiments which did not find evidence for 0vββ decay.

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Online Healthcare Community Interaction Dynamics

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Journal of Management Science and Engineering 2016年第1期1卷 58-74页

作者： Xitong Guo Shanshan Guo Douglas vogel Yijun Li School of Management Harbin Institute of Technology150001 HarbinChina Department of Management Sciences National Natural Science Foundation of China(NSFC)Beijing 100085China

With the increasing dilemma of the rapid global demand for healthcare services(often in the presence of limited resources),how to creatively allocate and use healthcare resources across a widespread population has become a salient *** healthcare communities(OHCs)are regarded as a potential ICT-based partial *** contrast to traditional healthcare,online doctor-patient interaction is unlimited in terms of time and space limitations while an OHC is exposed to the whole *** characteristics are key to achieving synergistic doctor-patient interaction and community development in the longer *** order to explore the nature of doctor-patient interaction dynamics in an OHC,we systematically investigate doctor-patient interaction dynamics from the dual perspectives of doctor and *** doctor-patient interaction dual-cycle model has been built based on six doctor-patient interaction processes(i.e.,searching,choosing,knowledge sharing,providing,receiving and balancing).According to our dual-cycle model,four key managerial issues in OHC(information asymmetry,incentive mechanisms,service delivery processes and interaction mechanisms)have been identified as *** and directions for future research,with challenges as well as opportunities,have been elaborated.A broad view with fruitful research potential is ensured and new theories and methods ultimately provide implications for effectively and efficiently allocating scarce healthcare resources to a broader population.

关键词： Online Healthcare Community Doctor-Patient Interaction Dual-Cycle Model Interaction Dynamics Incentive Mechanisms

Immune aspects of hepatocellular carcinoma:From immune markers for early detection to immunotherapy

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1132-1143页

作者： Ângelo Z Mattos Jose D Debes Andre Boonstra Arndt vogel Angelo A Mattos Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Department of Medicine Division of Gastroenterology and Infectious DiseasesUniversity of MinnesotaMinneapolisMN 55812United States Department of Gastroenterology and Hepatology Erasmus Medical CenterRotterdam NL-3015The Netherlands Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany

Hepatocellular carcinoma(HCC)is one of the most prevalent cancers and one of the main causes of cancer-related deaths *** HCCs develop in an inflammatory microenvironment,and mounting evidence emphasizes the importance of immune aspects in *** normal physiology,both innate and adaptive immune responses are responsible for eliminating malignantly transformed cells,thus preventing the development of liver ***,in the setting of impaired natural killer cells and exhaustion of T cells,HCC can *** immunogenic features of HCC have relevant clinical *** is a large number of immune markers currently being studied for the early detection of liver cancer,which would be critical in order to improve surveillance ***,novel immunotherapies have recently been proven to be effective,and the combination of atezolizumab and bevacizumab is currently the most effective treatment for advanced *** is expected that in the near future different subgroups of patients will benefit from specific *** better we understand the immune aspects of HCC,the greater the benefit to patients through surveillance aiming for early detection of liver cancer,which allows for curative treatments,and,in cases of advanced disease,through the selection of the best possible therapy for each individual.

关键词： Hepatocellular carcinoma Immunology Hepatocarcinogenesis Surveillance Biomarker Immunotherapy

INTRODUCTION TO THE NEUTRINO PROPERTIES LISTINGS

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Chinese Physics C 2016年第10期40卷 645-646页

作者： P. vogel A. Piepke Caltech University of Alabama

The following Listings concern measurements of various properties of neutrinos. Nearly all of the measurements, all of which so far are limits, actually concern superpositions of the mass eigenstates vi, which are in ...

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Unusual presentation of nasopharyngeal carcinoma with rectal metastasis

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World Journal of Clinical Cases 2017年第5期5卷 183-186页

作者： Malvine vogel Hampig Raphael Kourie Martine Piccart Yassine Lalami Oncology Department Jules Bordet Institute Oncology Department Faculty of MedicineSaint Joseph University Department of Internal Medicine Jules Bordet Institute

Nasopharyngeal carcinoma(NPC) is a rare tumour that mainly metastasizes in lymph nodes,bones,lungs and *** metastases of NPC are extremely rare phenomenon and associated with a poor *** reported here a case of NPC with rectal metastasis,we discussed the treatment modalities and the prognosis after reviewing the similar cases described in the literature.

关键词： Nasopharyngeal carcinoma Prognosis Rectal metastasis Treatment

Transjugular intrahepatic portosystemic shunt in liver transplant recipients

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World Journal of Gastroenterology 2009年第16期15卷 1999-2004页

作者： Armin Finkenstedt Ivo W Graziadei Karin Nachbaur Werner Jaschke Walter Mark Raimund Margreiter Wolfgang vogel Department of Internal Medicine (Gastroenterology and Hepatology) Medical University of Innsbruck Department of Radiology Medical University of Innsbruck Department of Transplant Surgery Medical University of Innsbruck

AIM： To evaluate the efficacy of transjugular intrahepatic portosystemic shunts （TIPSs） after liver transplantation （LT）. METHODS： Between November 1996 and December 2005, 10 patients with severe recurrent hepatitis C virus infection （n = 4）, ductopenic rejection （n = 5） or portal vein thrombosis （n = 1） were included in this analysis. Eleven TIPSs （one patient underwent two TIPS procedures） were placed for management of therapy-refractory ascites （n = 7）, hydrothorax （n = 2） or bleeding from colonic varices （n = 1）. The median time interval between LT and TIPS placement was 15 （4-158） mo. RESULTS： TIPS placement was successful in all patients. The mean portosystemic pressure gradient was reduced from 12.5 to 8.7 mmHg. Complete and partial remission could be achieved in 43% and 29% of patients with ascites. Both patients with hydrothorax did not respond to TIPS. No recurrent bleeding was seen in the patient with colonic varices. Nine of 10 patients died during the study period. Only one of two patients, who underwent retransplantation after the TIPS procedure, survived. The median survival period after TIPS placement was 3.3 （range 0.4-20） too. The majority of patients died from sepsis with multiorgan failure. CONCLUSION： Indications for TIPS and technical performance in LT patients correspond to those in non-transplanted patients. At least partial control of therapy-refractory ascites and variceal bleeding could be achieved in most patients. Nevertheless, survival rates were disappointing, most probably because of the advanced stages of liver disease at the time of TIPS placement and the high risk of sepsis as a consequence of immunosuppression.

关键词： Portal hypertension Ascites Variceal bleeding Immunosuppression Liver transplantation

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多光子成像中的生物组织光损伤

中国激光 2023年第3期50卷 14-30页

作者：梁晓轩 Alfred vogel 张镇西德国吕贝克大学生物医学光学研究所德国吕贝克23562 西安交通大学生命学院生物医学光子学与传感研究所陕西西安710049

多光子激发荧光成像技术因低侵入性、强穿透力、高信噪比和高空间分辨率在生物医学光学领域得到广泛的应用,同时也成为最重要的研究工具之一。在多光子成像中过量的光子密度或激光功率会引起生物组织光损伤。光损伤决定了成像所能使用... 详细信息

多光子激发荧光成像技术因低侵入性、强穿透力、高信噪比和高空间分辨率在生物医学光学领域得到广泛的应用,同时也成为最重要的研究工具之一。在多光子成像中过量的光子密度或激光功率会引起生物组织光损伤。光损伤决定了成像所能使用的激光功率的上限。光损伤强度与激光、组织光学参数有关,其背后的作用机制可分为光化学作用和光热作用。重点论述了光损伤的基本原理和形成机制,阐述了光损伤分析数学模型。讨论和分析了不同组织、不同波长下光损伤的一些研究进展。总结了光损伤规律:无色素组织双光子成像中光损伤以光化学作用为主,色素组织双光子成像中光损伤以光热作用为主,三光子深层组织成像中光损伤很可能来自光化学和光热协同作用。展望了降低光损伤和优化成像参数的可行策略。

关键词：生物光学多光子激发荧光成像光损伤光毒性光化学作用光热作用

A New Species of the Genus Protobothrops(Squamata: Viperidae) from Southern Tibet, China and Sikkim, India

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Asian Herpetological Research 2013年第2期4卷 109-115页

作者： Hujun PAN Basundhara CHETTRI Daode YANG Ke JIANG Kai WANG Liang ZHANG Gernot vogel Institute of Wildlife Conservation Central South University of Forestry and Technology Guangdong Entomological Institute South China Institute of Endangered Animals School of Policy Planning and Studies Sikkim University State Key Laboratory of Genetic Resources and Evolution and Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of Sciences Washington State University Society for Southeast Asian Herpetology

A new species of the genus Protobothrops Hoge ＆ Romano-Hoge, 1983, was described from Jilong County, southern Tibet, China, and Chungthang, northern Sikkim, India. It differs from congeners by the following characters： 1） relatively large body size （total length up to 1510 mm）; 2） dorsal scale rows 25-25-19; 3） except for the smooth outermost row, dorsal scales are weakly keeled; 4） relatively high number of ventral （198-216） and subcaudal （65-76 pairs） scales; 5） 7-8 supralabials; 6） 11 to 13 infralabials; 7） dorsal head uniform dark brown, laterally a reddish-brown obscure postocular streak; 8） dorsum of trtmk and tail olive, with distinct black edged red brown transverse bands across the body and tail; and 9） eye from bright brown and reddish brown to mildly brown. The new species was also observed from the Haa Valley in western Bhutan.

关键词： new species Protobothrops Viperidae Squamata Himalayan region

GLTSCR1, ATM, PPPIR13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population

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Current Medical Science 2018年第4期38卷 734-740页

作者： Jiao-yang YIN Ye-gang MA Ulla vogel Dong-hui LIU Zhen-xiang SUN Key Laboratory of Environment and Population Health of Liaoning Education Ministry (Shenyang Medical College) Shenyang 110034 China Department of Thoracic Surgery Liaoning Cancer Hospital Shenyang 110042China National Research Centre for the Working Environment Copenhagen DK-2100 Ministry

Genetic variants in glioma tumor suppressor candidate region gene 1 （GLTSCR1） and ATM serine/threonine kinase （ATM） have been associated with various cancer risks. Epidemiological studies also revealed the association of variants of GLTSCR1 and ATM genes with different brain tumors. However, little is known about the relationship between both gene polymorphisms and lung cancer risk. We conducted a Chinese hospital-based casecontrol study involving 384 lung cancer cases and 387 cancer-free controls. No significant differences in the single polymorphism （GLTSCR1 rs1035938 and ATM rs11212592） association were found in five genetic models （co-dominant, dominant, recessive, overdominant and log-additive models）（adjusted by smoking duration）. Join effect of three SNPs （PPPIR13L rs1970764, CD3EAP rs967591, GLTSCR1 rs1035938） on chromosome 19q 13.3 showed that the designated haplotype2 （rs 1970764 G-rs967591 A-rs 1035938 C） [OR （95% CI）=1.60 （1.11-2.32）, P=0.012] and haplotype8 （rs 1970764 G-rs967591 G-rs 1035938 T） [OR （95% CI）=2.45 （1.17-5.12）, P=0.018] were associated with increased risk of lung cancer （adjusted by smoking duration）. The analysis ofmultifactor dimensionality reduction revealed that two 3-way models were the best fit models in analyses of 2 loci （P〈0.001） or 4 loci （P=0.015-0.016）. The entropy-based analysis indicated the strongest synergistic effect between PPPIR13L rs1970764 and ATM rs11212592 in analysis of four genes. In conclusion, our study suggests that haplotypes consisting of PPPIR13L rs1970764- CD3EAP rs967591-GLTSCR1 rs1035938 on Chr19q13.3, interaction of smoking and GLTSCR1 rs1035938-ATM rs11212592, and synergistic action of PPPIR13L rs1970764 and ATM rs 11212592 may associate with lung cancer risk in the Chinese population.

关键词： GLTSCR1 ATM PPPIR13L CD3EAP genetic variants smoking duration interaction lung cancer Chinese