检索结果-南通市图书馆

Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis

引用

World Journal of Gastroenterology 2008年第16期14卷 2501-2510页

作者： Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling ulrich vogel Stephan Kaiser Department of Oncology Hematology and Palliative Care Marien Hospital Stuttgart Department of Hematology Oncology and Rheumatology University of Tuebingen Matrigene GmbH Company Reutlingen Department of Abdominal and Transplant Surgery University of Essen Department of Pathology University of Tuebingen Department of Gastroenterology Hepatology and Infectious Diseases University of Tuebingen

AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-PCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; P 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis.

关键词： Cholangiocarcinoma Oligonucleotide arrays Osteopontin Cell cycle regulation Gene expression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

武器和弹药

引用

国外坦克 1995年第2期 24-27页

作者： ulrich vogel 于德凤

德国的武器和弹药工业经60～70年代重建后,不仅达到国际水平,而且在重要的研究领域保持了先进水平。目前,它在这一领域具有很高的国际声誉和非常强的装备生产能力。当前,由于裁军,越来越多的部队减少了弹药购置量,并采用成本效应好的... 详细信息

德国的武器和弹药工业经60～70年代重建后,不仅达到国际水平,而且在重要的研究领域保持了先进水平。目前,它在这一领域具有很高的国际声誉和非常强的装备生产能力。当前,由于裁军,越来越多的部队减少了弹药购置量,并采用成本效应好的训练模拟器。

关键词：弹药武器训练模拟器成本效应生产能力研究领域部队裁军发射药先进水平

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatocellular carcinoma-the role of the underlying liver disease in clinical practice

引用

World Journal of Gastroenterology 2024年第19期30卷 2488-2495页

作者： Angelo Zambam de Mattos Isadora Zanotelli Bombassaro Arndt vogel Jose D Debes Department of Internal Medicine Universidade Federal de Ciências da Saúde de Porto AlegreRSPorto Alegre 90020090Brazil Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegreRSPorto Alegre 90050-170Brazil Division of Gastroenterology Hepatology University of TorontoHannover M5R 0A3Canada Department of Medicine University of MinnesotaMinneapolisMN 55455United States

Hepatocellular carcinoma(HCC)is one of the most common causes of cancerrelated *** particular type of cancer has the distinctive characteristic of mostly happening in individuals with an underlying liver *** makes the management of patients more challenging,since physicians must take into consideration two different conditions,the chronic liver disease and the *** underlying liver disease has several implications in clinical practice,because different kinds of chronic liver disease can lead to varying degrees of risk of developing HCC,obstacles in surveillance,and differences in the efficacy of the treatment against HCC.A shift in the prevalence of liver diseases has been evident over the last few years,with viral hepatitis gradually losing the leading position as cause of HCC and metabolic dysfunction-associated steatotic liver disease gaining ***,in an era of personalized medicine,it is imperative that physicians are aware of the underlying liver disease of individuals with HCC and its impact in the management of their tumors.

关键词： Hepatocellular carcinoma Etiology Epidemiology Surveillance Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Charmonium spectroscopy and decay at CLEO-c

引用

Chinese Physics C 2010年第6期34卷 621-625页

作者： Helmut vogel Department of Physics Carnegie Mellon University

We report recent results on charmonium spectroscopy and decay from the CLEO-c experiment at the Cornell electrompositron storage ring accelerator, CESR. Most of the results are based on the analysis of 54 pb-1 of luminosity collected at the ψ（2S） resonance, corresponding to 27 M ψ（2S） decays. We concentrate on radiative decays of ψ（2S） and J/ψ, on two-body mesonic decay of XcJ, on hadronic decay of the he, and on higher multipoles in the two-photon cascade ψ（2S）→γχcJ, XcJ→γJ/ψ.

关键词： charmonium radiative decay two-body decay photon transitions higher multipoles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma

引用

World Journal of Gastroenterology 2017年第9期23卷 1568-1575页

作者： Sumadi Lukman Anwar Till Krech Britta Hasemeier Elisa Schipper Nora Schweitzer Arndt vogel Hans Kreipe Reena Buurman Britta Skawran ulrich Lehmann ulrich Lehmann Institute of PathologyMedizinische Hochschule Hannover Department of Surgery Faculty of Medicine Universitas Gadjah Mada Department of Gastroenterology Hepatology and EndocrinologyMedizinische Hochschule Hannover Institute of Human Genetics Medizinische Hochschule Hannover

To screen clinically relevant microRNAs (miRNAs) silenced by DNA methylation in human hepatocellular carcinoma (HCC).METHODSKnockdown of DNA methyltransferases (DNMTs) using siRNAs and miRNA profiling in HCC cell lines were performed to identify DNA hypermethylation-mediated miRNA downregulation. Confirmation using individual quantitative real-time PCR (qRT-PCR) assays was then performed followed by DNA methylation quantification at the promoter of the miRNA genes. Quantification of DNA methylation and miRNA expression was then performed in primary HCC tumor samples and related with clinicopathological *** profiling after DNMT knockdown in HCC cell lines revealed upregulation of miR-23, miR-25 and miR-183. After qRT-PCR confirmation and CpG island methylation quantification of these miRNAs in cell lines, further analysis in primary HCC specimens showed that hsa-miR-183 is hypermethylated in 30% of HCC (n = 40). Expression of mature miR-183 showed an inverse correlation with DNA methylation levels. In HCC cells, DNMT knockdown and 5-aza-2’-deoxycytidine treatment reduced methylation and stimulated expression of miR-183. In HCC patients, hypermethylation at hsa-miR-183 promoter significantly correlates with poor survival (log-rank test P = 0.03). DNA methylation analysis in healthy liver, benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) and their corresponding adjacent tissues showed absence of hypermethylation supporting the notion that aberrant methylation at hsa-miR-183 is specific for the malignant transformation of *** data indicate that hypermethylation of hsa-miR-183 is a frequent event in HCC and potentially useful as a novel surrogate diagnostic and prognostic marker.

关键词： hsa-miR-183 DNA methylation DNMT knockdown microRNA microarray

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Addition of Ptyas nigromarginata (Blyth,1854) (Squamata:Colubridae) to the Snake Fauna of Thailand with Preliminary Remarks on Its Distribution

引用

Asian Herpetological Research 2013年第3期4卷 166-181页

作者： Gernot vogel Sjon HAUSER Society for Southeast Asian Herpetology

The first record of Ptyas nigromarginata （Blyth, 1854） from Thailand and a new record from China are reported. Literature and internet sources were searched for previous records of this species to establish its geographic and altitudinal distributions in Asia. The distribution in India was adapted to the new state division of the northern part of the country. The results show that the species almost exclusively occurs in hill evergreen and montane forests of the Himalayan foothills and mountain ranges continuous with it, at altitudes of 1000-2300 m above sea level.

关键词： Ptyas nigromarginata Nan Province Lijiang Himalaya distribution pattern

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel modulation and direct detection scheme of optical phase shift keying

引用

Chinese Optics Letters 2004年第3期2卷 128-130页

作者：杨永才 Wolfgang vogel College of Optic and Electronic Information Engineering Shanghai University of Science and Technology Shanghai 200093 Institute of Electric and Optical Communication University of Stuttgart Germany 70550

This paper introduces a new modulation and direct detection scheme of optical phase shift keying (PSK) which is simple and practical in fiber optical communication. A phase modulator is used to modulate a continuous wave (CW) laser source and return-to-zero (RZ) signal that is changed from the initial transmitting information is used to control a phase modulator to form a optical PSK signal. In the receiver terminal, just add a signal delayed a half of one bit to itself so that the initial information can be restored.

关键词： NMD A novel modulation and direct detection scheme of optical phase shift keying PSK

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In vivo bioluminescence imaging to elucidate stem cell graft differentiation

引用

Neural Regeneration Research 2020年第1期15卷 61-62页

作者： Stefanie vogel Mathias Hoehn Markus Aswendt Technische Universitat Dresden DFG-Research Center for Regenerative Therapies Dresden(CRTD)DresdenGermany Cognitive Neuroscience Institute of Neuroscience and Medicine(INM-3)Research Center JuelichJuelichGermany Leiden University Medical Center Department of RadiologyLeidenThe Netherlands University of Cologne Faculty of Medicine and University Hospital CologneDepartment of NeurologyCologneGermany

Neurological disorders including neurodegeneration(e.g.,Alzheimer’s disease and Parkinson’s disease)and acute injuries(e.g.,stroke and traumatic brain injury)are the leading cause group of disability-adjusted life years and the second leading cause group of *** to other tissues,the adult brain retains only a very limited repair *** neurogenesis,the lifelong generation of new neurons,declines with age and in degenerative diseases,such as Alzheimer’s ***,independently of age,the proliferation and migration of endogenous stem cells is stimulated after brain injuries and might be related to recovery processes(Adamczak et al.,2017).The limited number of endogenous stem cells during adulthood is one of the major limitations for an efficient regeneration of the injury affected brain ***,the transplantation of neural stem or progenitor cells(NSCs/NPCs)is extensively studied in mouse models and applied in first clinical trials with the aim to replace dysfunctional or lost neural cells and thus to restore brain function.

关键词： injuries endogenous replace

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quick Response Disaster Research:Opportunities and Challenges for a New Funding Program

引用

International Journal of Disaster Risk Science 2020年第5期11卷 568-577页

作者： Greg Oulahen Brennan vogel Chris Gouett-Hanna Department of Geography and Environmental Studies Ryerson UniversityToronto.ON M5B 2K3.Canada Centre for Environment and Sustainability Western UniversityLondonON N6A 3K7Canada

Quick response research conducted by social scientists in the aftermath of a disaster can reveal important findings about hazards and their impacts on *** to collect perishable data,or data that will change or be lost over time,immediately following disaster has been supported for decades by two programs in the United States,amassing a collection of quick response studies and an associated research *** culture is currently being challenged to better address power imbalances between researchers and disaster-affected *** recently,Canada has not had a quick response grant *** order to survey the state of knowledge and draw from it in helping to shape the new program in Canada,this article systematically analyzes the body of research created by the two US *** results reveal a wide-ranging literature:the studies are theoretically,conceptually,topically,and methodologically quite unique to one *** diversity might appropriately reflect the nature of disasters,but the finding that many studies are not building on previous quick response research and other in sights indicate opportunities for how a new grant program in Canada can contribute to growing a robust subdiscipline of disaster research.

关键词： Canada Disaster research Hazards Quick response Social science

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nervous System 1 Har/Cdr

引用

丛书名： Cambridge Illustrated Surgical Pathology

2009年

作者： Hannes vogel

ISBN: (纸本)9780521881616

Nervous System is the new atlas-oriented resource in central nervous system pathology. As the fourth book in the Cambridge Illustrated Surgical Pathology series it is the most comprehensive text of methods utilized by pathologists to accurately diagnose diseases affecting the brain, meninges, and spinal cord. The book is a richly illustrated guide to surgical neuropathology, including all primary brain tumors as well as others arising near the nervous system that are also within the scope of neurosurgical practice. Numerous neuroimaging examples are provided to underscore the importance of knowing the basics of radiographic studies in accurately diagnosing CNS pathology. A complete spectrum of nonneoplastic neuropathological entities is also illustrated, including infectious, inflammatory, and epilepsy-related neuropathology. Additional chapters address intraoperative consultation and frozen sections, as well as CSF cytopathology.

关键词： surgical pathology illustrated cambridge system nervousAnatomy Basic Sciences Medical Professional & Technical

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：