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Impact of Zener-Hollomon parameter on substructure and texture evolution during thermomechanical treatment of iron-containing wrought aluminium alloys

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Transactions of Nonferrous Metals Society of China 2019年第5期29卷 893-906页

作者： Evgenii ARYSHENSKII Jürgen HIRSCH Vladimir BAZHIN Rudolf KAWALLA ulrich pral TU Bergakademie Freiberg Institut für Metallformung Samara State Aerospace University Samara National Research University Hydro Aluminium Rolled Products GmbH Research and Development St.Petersburg Mining University Institute of Automation of Manufacturing Processes

The objective of the investigation is to evaluate the influence of the Zener-Hollomon parameter on substructure and texture evolution in iron-containing wrought aluminium alloys (type AA8011). Methods applied are X-ray texture analysis, electron backscatter diffraction (EBSD) and optical microscopy. The results show a serious impact of the Zener-Hollomon parameter on cube texture evolution during the thermomechanical treatment in iron-containing aluminium alloys. An increase in the Zener-Hollomon parameter reduces the survivability of cube texture during hot deformation and reinforces particle-stimulated nucleation (PSN) during the annealing process. However, thermomechanical treatment at low temperatures leads to active precipitation and as a result fine-dispersed participles tend to block all nuclei except for those producing large cube-oriented grains. It is concluded that in iron-containing wrought aluminium alloys, the general correlation between the Zener-Hollomon parameter and subgrain size is similar to that observed in 3xxx series alloys and can be described by the specific set of equations derived.

关键词： aluminium alloy texture Zener-Hollomon parameter substructure hot rolling

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Evaluation of the Anti-Trypanosoma cruzi Effects of the Antipsychotic Drug Levomepromazine

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International Journal of Clinical Medicine 2012年第5期3卷 344-351页

作者： Inga Eva Stik Lange Elisabeth Mieko Furusho pral Anahi Magdaleno Ariel Mariano Silber Departamento de Parasitologia Instituto de CienciasUniversidade de Sao PauloSao PauloBrazil

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a relevant parasitic disease in the Americas. Current chemotherapy relies on Nifurtimox and Benznidazole, which present serious drawbacks, including high toxicity, low efficiency and the emergence of resistant strains. In the present work, the perspectives of levomepromazine, a tri-cyclic compound belonging to the family of phenotiazines with well-known properties as antipsychotics were evaluated as a potential anti-T. cruzi drug. We show that this drug is able to inhibit the proliferation of epimastigotes (IC50 = 0.41 ± 0.01 mM) and to interfere with the infection of the host cells (IC50 = 0.34 ± 0.01 mM). Interestingly, the treatment with levomepromazine affected the ability of metabolites such as glucose, proline and glutamate to fuel the recovery of epi-mastigotes after being submitted to metabolic stress. These findings prompt levomepromazine as a promising leader drug to obtain new trypanocidal activities.

关键词： Chagas Disease Phenothiazines Trypanothione Reductase Amino Acid Metabolism Chemotherapy

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