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In vitro Response of Human Mesenchymal Stromal Cells to Titanium Coated Peek Films and Their Suitability for Magnetic Resonance Imaging

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Journal of Materials Science & Technology 2015年第5期31卷 427-436页

作者： Cindy Elschner Carolin Noack Carolin PreilBler Andreas Krause ulrich Scheler Ute Hempel Leibniz-Institut fr Polymerforschung Dresden e.V. Hohe Str.601069 DresdenGermany CRTD/DFG-Center for Regenerative Therapies Dresden Fetscherstr.10501307 DresdenGermany Institut fr Physiologische Chemie Technische Universitt DresdenFiedlerstr.4201307 DresdenGermany NaMlab gGmbH Nthnitzer Str.6401187 DresdenGermany

Medical imaging is an important tool for the post-operative checkup of an accurate position of an implant as well as for monitoring the integration in the adjacent tissue that may influence the success of a medical ***,the possibility to use imaging methods is associated with the implant material and all the established metallic materials for surgery do not show a proper 'imaging compatibility'.The present study is a combined investigation of the in vitro response to human mesenchymal stromal cells（hMSC） and magnetic resonance imaging（MRI） compatibility of the potential material combination polyetheretherketone/titanium（PEEK/Ti） for medical *** of the advantageous imaging properties and the mechanical and chemical stability,PEEK becomes more and more an alternative to common metallic implant materials like titanium or ***,PEEK is a bioinert material having a limited ability for direct bone *** to its excellent biocompatibility,Ti was chosen as coating material to enhance the cellular *** result is a combination with advantageous properties:the magnetic susceptibility and elastic modulus close to bone,corrosion resistance and mechanical flexibility of PEEK and the excellent biocompatibility of *** appearance of metal-related artifact was discussed in electrical resistivity and magnetic ***,two titanium coatings have been investigated:a complete coating and a structured surface avoiding surface *** determine the in vitro biocompatibility,the cell responses were assessed in terms of the overall morphology of the hMSC and their cell area distribution,proliferation,osteogenic differentiation and mineral *** cellular stress was evaluated by the prostaglandin *** bonded materials both produced no disturbing artifacts in magnetic resonance *** to the pure PEEK material,the titanium coated specimens showed an enhanced biocompatibilit

关键词： Polyetheretherketone Titanium coating Biocompatibi

Impulse Capacitor Discharge Welding of Hollow Structure Made of Nickel-Base Alloy

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Tsinghua Science and Technology 2007年第4期12卷 453-458页

作者：王剑钊 Peter ohse 吴甦 ulrich Dilthey Department of Industrial Engineering Tsinghua University Welding and Joining Institute RWTH Aachen Aachen 52062 Germany

Future steam turbines will use hollow structures so that the turbine inlet temperature can be increased to improve the thermal efficiency. These hollow structures are made of the nickel-base alloy Nicrofer 6025 HT and consist of a wire mesh between two cover sheets. The cover sheets can be joined to the wire mesh by capacitor discharge welding due to its extremely short welding duration. The goal of this research is to investigate suitable welding parameters so that the weld spots form in an optimum way to increase the tensile shear strength and reduce spattering. Tensile shear tests, three-point bending tests, and micrographs were used to judge the joint quality of structures made with various welding parameters. The results show that the best welds are obtained with a transmission ratio of 1：200, welding energy of 70% to 95%, and electrode force of 7 to 9 MPa.

关键词： capacitor discharge welding nickel-base alloy hollow structure tensile shear test three-point bending test micrographs

Decoupling SERT-nNoS Interaction to Generate Fast-onset Antidepressants

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Neuroscience Bulletin 2023年第8期39卷 1327-1329页

作者： Qing Ye Si‑Si Lin Henning ulrich Yong Tang International Joint Research Centre on Purinergic Signalling/School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Biochemistry Institute of ChemistryUniversity of São PauloSão Paulo 05508Brazil Acupuncture and Chronobiology Key Laboratory of Sichuan Province/School of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610075China

Major depressive disorder(MDD)is one of the most common psychiatric disorders,and~4.7%of the world's population has an onset of depression in any one-year *** causes constant distress,impairs social function and physiological health,and even leads to suicide[1].Numerous studies support the classic monoamine hypothesis of depressive *** majority of clinical antidepressants have been developed on the basis of this hypothesis to increase 5-hydroxytryptamine(5-HT).

关键词： distress hypothesis clinical

From micro-scale to technical dimension—Challenges in the simulation ofdense gas-particle flows

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Particuology 2009年第4期7卷 231-232页

作者： Joachim Werther Ernst-ulrich Hartge Jinghai Li Wei Ge Institute of Solids Process Engineering and Particle Technology Hamburg University of Technology Hamburg Germany State Key Laboratory of Multi-phase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing China

Supported by the Sino-German Center for Research Promotion, an organization jointly founded by the National Natural Science Foundation of China （NSFC） and the German Research Foundation （DFG）, a joint Sino-German workshop on particle fluid systems was held for the fourth time on May 19-20, 2008 in Hamburg. Previous workshops were held on August 30-31, 1999 in Ham- burg,

关键词： From micro-scale to technical dimension EMMS Challenges in the simulation ofdense gas-particle flows

The Change of North China Climate in Transient Simulations Using the IPCC SRES A2 and B2 Scenarios with a Coupled Atmosphere-ocean General Circulation Model

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Advances in Atmospheric Sciences 2003年第5期20卷 755-766页

作者：布和朝鲁 ulrich CUBASCH 林永辉纪立人 LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029 Meteorologisches Institut der Freien Universitaet Berlin Care-Heinrich-Becker Weg 6 1012165 Institute of Severe Weather Chinese Academy of Meteorological SciencesBeijing100081

This paper applies the newest emission scenarios of the sulfur and greenhouse gases, namely IPCC SRES A2 and B2 scenarios, to investigate the change of the North China climate with an atmosphere-ocean coupled general circulation model. In the last three decades of the 21st century, the global warming enlarges the land-sea thermal contrast, and hence, causes the East Asian summer (winter) monsoon circulation to he strengthened (weakened). The rainfall seasonality strengthens and the summer precipitation increases significantly in North China. It is suggested that the East Asian rainy area would expand northward to North China in the last three decades of the 21st century. In addition, the North China precipitation would increase significantly in September. In July, August, and September, the interannual variability of the precipitation enlarges evidently over North China, implying a risk of flooding in the future.

关键词： North China Climate change Seasonality IPCC SRES A2 and B2 scenarios

The feasibility of coating by cooling crystallization on ibuprofen naked tablets

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Frontiers of Chemical Science and Engineering 2017年第2期11卷 211-219页

作者： Fatima Mameri ouahiba Koutchoukali Mohamed Bouhelassa Anne Hartwig Leila Nemdili Joachim ulrich University Constantine 3 Engineering Faculty of Pharmaceutical Processes 25000 Constantine Algeria Martin Luther University Halle-Wittenberg Center of Engineering Science Thermal Process Engineering D-06099 Halle Germany

Sugar spray coating is a frequently used process in the pharmaceutical industry. However, this process presents the disadvantage to form an amorphous coating around the active ingredient. A crystalline coating formed on the surface of a tablet is highly desirable. Recently, a new process of coating by cooling crystallization has been developed and applied on bisacodyl pastilles obtained by melt crystallization. In this work, we investigated the feasibility of coating by cooling crystallization on ibuprofen ＂naked tablets＂ manufactured by compression. In the first part of this work, the solubility and the metastable zone width have been determined experimentally for the coating solution because they are essential factors for any crystallization process. In the second part, the coating process is investigated on the operating conditions that affect the surface morphology and the crystal growth rate. These experimental conditions include concentration of the coating solution, degree of sub-cooling, agitation speed, retention time, and surface properties of the naked ibuprofen tablets. The results show that naked tablet coating by cooling crystallization is feasible and can be applied in the pharmaceutical industry.

关键词： coating solution crystallization ibuprofen tablets sucrose

Towards Textbook Efficiency for Parallel Multigrid

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Numerical Mathematics(Theory,Methods and Applications) 2015年第1期8卷 22-46页

作者： Bjorn Gmeiner ulrich Rude Holger Stengel Christian Waluga Barbara Wohlmuth Institute for Numerical Mathematics(M2) Technische Universitat MunchenBoltzmannstrasse 3D-85748 Garching b.MünchenGermany Department of Computer Science 10 FAU Erlangen-NürnbergCauerstraße 6D–91058 ErlangenGermany Erlangen Regional Computing Center(RRZE) FAU Erlangen-NürnbergMartensstraße 1D–91058 ErlangenGermany

In this work,we extend Achi Brandt’s notion of textbook multigrid effi-ciency(TME)to massively parallel *** a finite element based geomet-ric multigrid implementation,we recall the classical view on TME with experiments for scalar linear equations with constant and varying coefficients as well as linear systems with saddle-point *** extend the idea of TME to the parallel set-ting,we give a new characterization of a work unit(WU)in an architecture-aware fashion by taking into account performance modeling *** illustrate our newly introduced parallel TME measure by large-scale computations,solving prob-lems with up to 200 billion unknowns on a ToP-10 supercomputer.

关键词： Multigrid parallel computing textbook efficiency finite element method

Enhancement of the group delay in quadratic coupling optomechanical systems subjected to an external force

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Chinese Physics B 2023年第12期32卷 325-331页

作者： Jimmi HervéTalla Mbé ulrich Chancelin Tiofack Demanou Christian Kenfack-Sadem Martin Tchoffo Research Unit of Condensed Matter Electronics and Signal ProcessingDepartment of PhysicsUniversity of DschangP.O.Box 67DschangCameroon African Institute for Mathematical Sciences P.O.Box 608LimbeCameroon

We theoretically study the effect of the quadratic coupling strength on optomechanical systems subjected to a continuous external force. Quadratic coupling strength originates from strong coupling between the optical and the mechanical degrees of freedom. We show that the quadratic coupling strength reduces the amplitude of the dispersion spectra at the resonance in both blue-and red-sideband regimes. However, it increases(decreases) the amplitude of the absorption spectrum in the blue-(red-)sideband regime. Furthermore, in both sideband regimes, the effective detuning between the pump and the cavity deviates with the quadratic coupling strength. Thereby, appropriate selection of the quadratic coupling strength results in an important magnification(in absolute value) of the group delay for both slow and fast light exiting from the optomechanical cavity.

关键词： slow and fast light optomechanical systems group delay quadratic coupling

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基于热传导逆问题方法预测材料热物性参数

化工学报 2005年第12期56卷 2415-2420页

作者：杨晨 ulrich Gross 重庆大学动力工程学院重庆400044 弗赖贝格工业大学热力学研究所德国弗赖贝格09599

建立了一种应用LevenbergMarquardt迭代过程求解非线性热传导逆问题用于预测材料热物性的方法.以平板内的一维非稳态热传导为研究对象,在准确的数值计算结果上施加非均匀随机误差来模拟瞬态温度实验数据,应用该方法分别对热传导系数为... 详细信息

建立了一种应用LevenbergMarquardt迭代过程求解非线性热传导逆问题用于预测材料热物性的方法.以平板内的一维非稳态热传导为研究对象,在准确的数值计算结果上施加非均匀随机误差来模拟瞬态温度实验数据,应用该方法分别对热传导系数为常数、热传导系数和容积比热容为常数以及热传导系数和容积比热容为温度的函数3种情况进行了预测.参数预测结果表明,方法对基于瞬态实验方法进行热物性预测具有良好的适应性,并适用于分析多类热传导逆问题,该方法还能为优化实验提供有效信息.

关键词：热传导逆问题热物性参数预测 Levenberg-Marquardt方法