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Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease

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World Journal of Gastroenterology 2011年第2期17卷 197-206页

作者： Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup ulla vogel Department of Medical Viborg Regional Hospital Institute of Cancer Epidemiology Danish Cancer Society Department of Clinical Biochemistry Aarhus University Hospital Department of Medical Gastroenterology Aarhus University Hospital National Food Institute Technical University of Denmark Institute for Science Systems and ModelsUniversity of Roskilde National Research Centre for the Working Environment

AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy *** ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type *** never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant *** A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers.

关键词： Crohn's disease Genetic susceptibility Single nucleotide polymorphisms Smoking status Transcription factors Ulcerative colitis

GLTSCR1, ATM, PPPIR13L and CD3EAP Genetic Variants and Lung Cancer Risk in a Chinese Population

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Current Medical Science 2018年第4期38卷 734-740页

作者： Jiao-yang YIN Ye-gang MA ulla vogel Dong-hui LIU Zhen-xiang SUN Key Laboratory of Environment and Population Health of Liaoning Education Ministry (Shenyang Medical College) Shenyang 110034 China Department of Thoracic Surgery Liaoning Cancer Hospital Shenyang 110042China National Research Centre for the Working Environment Copenhagen DK-2100 Ministry

Genetic variants in glioma tumor suppressor candidate region gene 1 （GLTSCR1） and ATM serine/threonine kinase （ATM） have been associated with various cancer risks. Epidemiological studies also revealed the association of variants of GLTSCR1 and ATM genes with different brain tumors. However, little is known about the relationship between both gene polymorphisms and lung cancer risk. We conducted a Chinese hospital-based casecontrol study involving 384 lung cancer cases and 387 cancer-free controls. No significant differences in the single polymorphism （GLTSCR1 rs1035938 and ATM rs11212592） association were found in five genetic models （co-dominant, dominant, recessive, overdominant and log-additive models）（adjusted by smoking duration）. Join effect of three SNPs （PPPIR13L rs1970764, CD3EAP rs967591, GLTSCR1 rs1035938） on chromosome 19q 13.3 showed that the designated haplotype2 （rs 1970764 G-rs967591 A-rs 1035938 C） [OR （95% CI）=1.60 （1.11-2.32）, P=0.012] and haplotype8 （rs 1970764 G-rs967591 G-rs 1035938 T） [OR （95% CI）=2.45 （1.17-5.12）, P=0.018] were associated with increased risk of lung cancer （adjusted by smoking duration）. The analysis ofmultifactor dimensionality reduction revealed that two 3-way models were the best fit models in analyses of 2 loci （P〈0.001） or 4 loci （P=0.015-0.016）. The entropy-based analysis indicated the strongest synergistic effect between PPPIR13L rs1970764 and ATM rs11212592 in analysis of four genes. In conclusion, our study suggests that haplotypes consisting of PPPIR13L rs1970764- CD3EAP rs967591-GLTSCR1 rs1035938 on Chr19q13.3, interaction of smoking and GLTSCR1 rs1035938-ATM rs11212592, and synergistic action of PPPIR13L rs1970764 and ATM rs 11212592 may associate with lung cancer risk in the Chinese population.

关键词： GLTSCR1 ATM PPPIR13L CD3EAP genetic variants smoking duration interaction lung cancer Chinese

Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology

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World Journal of Gastroenterology 2015年第41期21卷 11862-11876页

作者： Vibeke Andersen Katrine Svenningsen Lina Almind Knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe ulla vogel Molecular Diagnostic and Clinical Health Research Unit Hospital of Southern Jutland Institute of Regional Health Research-Centre S?nderjylland University of Southern Denmark Medical Department Regional Hospital Viborg Experimental Animal Models University of Copenhagen Department of Cancer and Inflammation Research University of Southern Denmark Department of Health Science and Technology Aalborg University National Research Centre for the Working Environment

AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expr

关键词： ATP-binding cassette transporters Colorectal cance

Haplotypes of nine single nucleotide polymorphisms on chromosome 19q13.2-3 associated with susceptibility of lung cancer in a Chinese population

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Haplotypes of nine single nucleotide polymorphisms on chromo...

丹麦高加索人染色体19q13．2-3区域DNA修复等基因SNPs：连锁不平衡及其与基底细胞癌易感性研究

遗传学进步与人口健康高峰论坛

作者： ulla vogel National Research Center for Working Environment Lerso Parkalle 105 DK-2100 Copenhagen ODenmark

To evaluate the join effect of nine single nucleotide polymorphisms for three DNA repair genes in the region 19q13.2-3 on susceptibility of lung cancer in a Chinese population,we conducted a hospital-based case-control study consisted of 247 lung cancer cases and 253 cancer-free controls matched on age,gender and ***-RFLP was used for genotyping. Associations between the baplotypes and susceptibility of lung cancer were *** global test of baplotype association revealed a statistically significant difference between cases and controls (global test:chi2=60.45,df=15,P=2.11e-07).The two of those were negative associations (Hap5 and Hap12).The three of those were positive associations (Hap3,Hap4,and Hap10).

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丹麦高加索人染色体19q13．2-3区域DNA修复等基因SNPs：连锁不平...

Charmonium spectroscopy and decay at CLEO-c

第六次全国医学遗传学学术会议

作者：尹娇杨 ulla vogel Lars Bolund Bjorn A．Nexo 沈阳医学院生物学教研室 National Institute of Occupational Health Copenhagen O DK-2100 Denmark Institute of Human Genetics University of Aarhus Aarhus C DK-8000Denmark

皮肤基底细胞癌(Basal cell carcinoma,BCC)是高加索群体中最普通的癌症,它是由于遗传因素与环境因素相互作用所引起。DNA修复能力的变异在决定癌发易感性上是一个关键因素。我们研究了丹麦四组人群染色体19q13．2-3区域DNA修复等基因10...

皮肤基底细胞癌(Basal cell carcinoma,BCC)是高加索群体中最普通的癌症,它是由于遗传因素与环境因素相互作用所引起。DNA修复能力的变异在决定癌发易感性上是一个关键因素。我们研究了丹麦四组人群染色体19q13．2-3区域DNA修复等基因10个SNPs及其单体型与BCC的关联及其遗传易感性。研究结果表明:在银屑病群体中,DNA修复基因ERCC1 exon4[Asn118Asn(A19007G)]AA基因型纯合子个体比GG基因型纯合子个体有12倍高的BCC发生风险[AA versus GG,OR=12,

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Chinese Physics C 2010年第6期34卷 621-625页

作者： Helmut vogel Department of Physics Carnegie Mellon University

We report recent results on charmonium spectroscopy and decay from the CLEO-c experiment at the Cornell electrompositron storage ring accelerator, CESR. Most of the results are based on the analysis of 54 pb-1 of luminosity collected at the ψ（2S） resonance, corresponding to 27 M ψ（2S） decays. We concentrate on radiative decays of ψ（2S） and J/ψ, on two-body mesonic decay of XcJ, on hadronic decay of the he, and on higher multipoles in the two-photon cascade ψ（2S）→γχcJ, XcJ→γJ/ψ.

关键词： charmonium radiative decay two-body decay photon transitions higher multipoles

Addition of Ptyas nigromarginata (Blyth,1854) (Squamata:Colubridae) to the Snake Fauna of Thailand with Preliminary Remarks on Its Distribution

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Asian Herpetological Research 2013年第3期4卷 166-181页

作者： Gernot vogel Sjon HAUSER Society for Southeast Asian Herpetology

The first record of Ptyas nigromarginata （Blyth, 1854） from Thailand and a new record from China are reported. Literature and internet sources were searched for previous records of this species to establish its geographic and altitudinal distributions in Asia. The distribution in India was adapted to the new state division of the northern part of the country. The results show that the species almost exclusively occurs in hill evergreen and montane forests of the Himalayan foothills and mountain ranges continuous with it, at altitudes of 1000-2300 m above sea level.

关键词： Ptyas nigromarginata Nan Province Lijiang Himalaya distribution pattern

A novel modulation and direct detection scheme of optical phase shift keying

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Chinese Optics Letters 2004年第3期2卷 128-130页

作者：杨永才 Wolfgang vogel College of Optic and Electronic Information Engineering Shanghai University of Science and Technology Shanghai 200093 Institute of Electric and Optical Communication University of Stuttgart Germany 70550

This paper introduces a new modulation and direct detection scheme of optical phase shift keying (PSK) which is simple and practical in fiber optical communication. A phase modulator is used to modulate a continuous wave (CW) laser source and return-to-zero (RZ) signal that is changed from the initial transmitting information is used to control a phase modulator to form a optical PSK signal. In the receiver terminal, just add a signal delayed a half of one bit to itself so that the initial information can be restored.

关键词： NMD A novel modulation and direct detection scheme of optical phase shift keying PSK

In vivo bioluminescence imaging to elucidate stem cell graft differentiation

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Neural Regeneration Research 2020年第1期15卷 61-62页

作者： Stefanie vogel Mathias Hoehn Markus Aswendt Technische Universitat Dresden DFG-Research Center for Regenerative Therapies Dresden(CRTD)DresdenGermany Cognitive Neuroscience Institute of Neuroscience and Medicine(INM-3)Research Center JuelichJuelichGermany Leiden University Medical Center Department of RadiologyLeidenThe Netherlands University of Cologne Faculty of Medicine and University Hospital CologneDepartment of NeurologyCologneGermany

Neurological disorders including neurodegeneration(e.g.,Alzheimer’s disease and Parkinson’s disease)and acute injuries(e.g.,stroke and traumatic brain injury)are the leading cause group of disability-adjusted life years and the second leading cause group of *** to other tissues,the adult brain retains only a very limited repair *** neurogenesis,the lifelong generation of new neurons,declines with age and in degenerative diseases,such as Alzheimer’s ***,independently of age,the proliferation and migration of endogenous stem cells is stimulated after brain injuries and might be related to recovery processes(Adamczak et al.,2017).The limited number of endogenous stem cells during adulthood is one of the major limitations for an efficient regeneration of the injury affected brain ***,the transplantation of neural stem or progenitor cells(NSCs/NPCs)is extensively studied in mouse models and applied in first clinical trials with the aim to replace dysfunctional or lost neural cells and thus to restore brain function.

关键词： injuries endogenous replace