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Lactobacilli,bifi dobacteria and *** nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells

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World Journal of Gastroenterology 2006年第37期12卷 5978-5986页

作者： ulf helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri University Hospital Schleswig-Holstein Campus Kiel 1~(st) Medical Department Schittenhelmstr.12 24105 Kiel Germany University of Bologna Department of Internal Medicine and Gastroenterology Policlinico S. Orsola Via Massarenti 9 40138 Bologna Italy University of Bologna Department of Internal Medicine and Gastroenterology Policlinico S. Orsola Via Massarenti 9 40138 Bologna Italy University of Bologna Institute for Microbiology Via Bellmeloro 9 40138 Bologna Italy University Hospital Schleswig-Holstein Campus Kiel 1~(st) Medical Department Schittenhelmstr.12 24105 Kiel Germany University of Bologna Histology and General Embryology and Pharmaceutical Science Via Bellmeloro 9 40138 Bologna Italy Federal Research Center for Nutrition and Food Location Kiel Institute for Physiology and Bioche- mistry of Nurtition Hermann-Weigmann-Str.1 24103 Kiel Germany

AIM： To investigate whether the stimulation of peripheral blood mononuclear cells （PBMNC） with the cell debris and cell extraction of different probiotic strains is similar or species specific. METHODS： Three strains of bifidobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centrifuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 10^2 to 10^8 CFU/mL. Cell supernatants were taken and interleukin （IL）-10, IL-1β, and tumor necosis factor （TNF）-α were determined by ELISA. RESULTS： Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bitTdobacteria and/actobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had similar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifidobacteria and lactobacilli. The cell debris of bifidobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentrations were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION： The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specific reactions. High IL-10 response to cell debris of bifidobacteria and E. coli nissle can be found. This corresponds to positive effects of bihdobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactobacilli.

关键词： Lactobacilli Bifidobacteria Probiotics Interleukin-l0 Tumor necrosis factor-α Interleukin-1β Peripheral blood mononuclear cells

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Role of the tumor-associated trypsin inhibitor SPINK1 in cancer development

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Asian Journal of Andrology 2011年第4期13卷 628-629页

作者： ulf-Hakan Stenman Deparment of Clinical Chmistry Helsinki University and Helsinki University Central Hospital FIN-00014 Helsinki University PB 63 Finland

In most industrialized countries, prostate cancer is the most common non-skin cancer of men. When detected early, most cases are curable, but for tumors that have metastasized, there is no curative therapy. Pharmaceutical androgen ablation or castration induces remission in most patients with metastatic disease, but if the patient lives long enough, the tumor becomes androgenindependent. In some patients, chemotherapy induces remission, which mostly is of short duration. Therefore, new treatment modalities are needed for androgen-independent prostate cancer.

关键词： Physical sciences Nanotechnology Optical physics

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How machine learning conquers the unitary limit

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Communications in Theoretical Physics 2021年第3期73卷 64-72页

作者： Bastian Kaspschak ulf-G MeiBner Helmholtz-Institut fiir Strahlen-und Kemphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Advanced Simulation Institut fiir Kemphysikand Jiilich Center for Hadron PhysicsForschungszentrum JiilichD-52425 JiilichGermany Tbilisi State University 0186 TbilisiGeorgia

Machine learning has become a premier tool in physics and other fields of *** has been shown that the quantum mechanical scattering problem cannot only be solved with such techniques,but it was argued that the underlying neural network develops the Bom series for shallow ***,classical machine learning algorithms fail in the unitary limit of an infinite scattering *** unitary limit plays an important role in our understanding of bound strongly interacting fermionic systems and can be realized in cold atom ***,we develop a formalism that explains the unitary limit in terms of what we define as unitary limit *** not only allows to investigate the unitary limit geometrically in potential space,but also provides a numerically simple approach towards unnaturally large scattering lengths with standard multilayer *** scope is therefore not limited to applications in nuclear and atomic physics,but includes all systems that exhibit an unnaturally large scale.

关键词： unitary limit machine learning quantum physics

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Isospin violation,light quark masses,and all that

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Chinese Physics C 2010年第9期34卷 1163-1168页

作者： ulf-G.Meiβner HISKP and Bethe Center for Theoretical Physics Universitt Bonn IKP-3 IAS-4 and JCHPForschungszentrum Jülich

Isospin violation is driven through the light quark mass difference and electromagnetic effects.I review recent progress in extracting the light quark mass difference and tests of the chiral dynamics of Quantum Chromo... 详细信息

关键词： quantum chromodynamics isospin violation quark masses chiral Lagrangians

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The Roper resonance in a finite volume

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Communications in Theoretical Physics 2020年第7期72卷 49-59页

作者： Daniel Severt ulf-G Meiβner Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Advanced Simulation Institut für Kernphysik and Jülich Center for Hadron PhysicsForschungszentrum JülichD-52425 JiilichGermany Tbilisi State University 0186 TbilisiGeorgia

We calculate the energy levels corresponding to the Roper resonance based on a two-flavor chiral effective Lagrangian for pions,nucleons,deltas,and the Roper resonance at the leading one-loop *** show that the Roper m... 详细信息

关键词： Lattice QCD Roper resonance finite volume methods

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Aphids-induced plant volatiles affect diel foraging behavior of a ladybird beetle Coccinella septempunctata

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Insect Science 2020年第6期27卷 1266-1275页

作者： Milda Norkute ulf Olsson Velemir Ninkovic Department of Ecology Swedish University of Agricultural SciencesUppsalaSweden Department of Energy and Technology Swedish University of Agricultural SciencesUppsalaSweden

The ladybird beetle Coccinella septempunctata(L.)is an important biocontrol agent of pests such as various aphid *** being one of the most studied coccinellid species,many aspects of its foraging behavior are still not completely *** study focuses on the diel foraging behavior of ***,investigating their olfactory orientation toward aphid-infested plants,walking activity on plants and on the soil,and feeding *** the scotophase the ladybird beetles were significantly more attracted to the odor of aphid-infested plants,on which they also showed considerably higher walking activity then on uninfested *** were more prone to utilize olfactory cues when searching for prey and fed at higher rates than males;this shows that they are better adapted to nocturnal activity,as they require higher food *** septempunctata have the same feeding rate during the scotophase as in the *** study shows that *** has the potential to forage in the scotophase if prey is *** results support the hypothesis that volatiles of aphid-infested plants can attract or arrest foraging adult ladybird beetles,even in the darkness,which makes a considerable contribution to efficient prey search and enhances feeding capacity.

关键词： aphids C7 feeding ladybirds photophase scotophase

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Predicting Amazon customer reviews with deep confidence using deep learning and conformal prediction

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Journal of Management Analytics 2022年第1期9卷 1-16页

作者： ulf Norinder Petra Norinder Department of Computer and Systems Sciences Stockholm UniversityKistaSweden Stockholm Business School Stockholm UniversityStockholmSweden

In this investigation,we have shown that the combination of deep learning,including natural language processing,and conformal prediction results in highly predictive and efficient temporal test set sentiment estimates for 12 categories of Amazon product reviews using either in-category predictions,*** model and the test set are from the same review category or cross-category predictions,*** a model of another review category for predicting the test *** similar results from in-and cross-category predictions indicate high degree of generalizability across product review *** investigation also shows that the combination of deep learning and conformal prediction gracefully handles class imbalances without explicit class balancing measures.

关键词： Amazon customer reviews machine learning conformal prediction deep learning natural language processing temporal test sets

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Towards Accurate Bit Error Simulation in Wireless Sensor Networks Including Environmental Influences

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Journal of Computer Science & Technology 2020年第4期35卷 809-824页

作者： Sven Pullwitt Robert Hartung ulf Kulau Lars Wolf Institute for Operating Systems and Computer Networks Technische Universitat BraunschweigBraunschweig 38106 Germany

Simulation is a common technique for the evaluation of new approaches and protocols in networked systems and provides many ***,it is also well known that the relevance of the simulation results for real-world applications depends on the various models which are used within the simulation,e.g.,for the characteristics of the radio *** this paper,we introduce the Extended Multipath Raytracing Model,an extension to the ray-tracing radio medium available in Cooja,to improve the modelling of wireless links in simulated Wireless Sensor *** extension allows the simulation of environmental influences onto links on a per node basis,allowing the analysis of various effects observed in experiments in a virtual ***,the packet-based modelling of transmission errors is extended to provide the simulation of bit errors,allowing new usage scenarios,like the simulation of error detection and Forward Error Correction codes in Cooja.

关键词： bit error Contiki Cooja environmental influence simulation wireless sensor network

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Analysis of Bingham fluid radial flow in smooth fractures

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第5期12卷 1112-1118页

作者： Liangchao Zou ulf Håkansson Vladimir Cvetkovic Division of Resources Energy and InfrastructureDepartment of Sustainable DevelopmentEnvironmental Science and EngineeringRoyal Institute of TechnologyStockholm10044Sweden Division of Soil and Rock Mechanics Department of Civil and Architectural EngineeringRoyal Institute of TechnologyStockholm10044Sweden Skanska Sweden AB Stockholm11274Sweden

Solutions for radial flow of a Bingham fluid are analyzed in this *** aims to eliminate confusions in the literature concerning the plug flow region in different solutions for analysis and design of grouting in rock *** analyses based on the force balance equation reveal that the plug flow region in Bingham radial flow is independent of the fracture radius,and is not a growth function adapted from the solution of one-dimensional(1D)slit flow according to‘similarity’.Based on the shear stress distribution,we analytically proposed that a non-uniform plug flow region cannot *** Bingham fluid(grout)penetration and flowrate evolution as functions of grouting time are given using the correct expression for the plug flow *** radius-independent plug flow region and the presented flowrate evolution equation are also verified *** radial flow,the relative penetration length is equal to the relative width of plug flow region,which is the same as that for 1D channel *** in analytical solutions for grout penetration and flowrate evolution were also *** clarification of the plug flow region and evaluation of discrepancies in analytical solutions presented in this work could simplify modeling and design of grouting in rock engineering applications.

关键词： Rock grouting Radial flow of Bingham fluids Plug flow region Force balance Energy dissipation Analytical solution

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Modeling of shear walls using finite shear connector elements based on continuum plasticity

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Frontiers of Structural and Civil Engineering 2017年第2期11卷 143-157页

作者： ulf Arne GIRHAMMAR Per Johan GUSTAFSSON Bo KALLSNER Division of Wood Science and Engineering Lulea University of Technology Skellefiea 93187 Sweden Division of Structural Mechanics Department of Building Sciences Lund University Lund 22100 Sweden Department of Building Technology Linnceus University Vaxjo 35195 Sweden

Light-frame timber buildings are often stabilized against lateral loads by using diaphragm action of roofs, floors and walls. The mechanical behavior of the sheathing-to-framing joints has a significant impact on the structural performance of shear walls. Most sheathing-to-framing joints show nonlinear load-displacement characteristics with plastic behavior. This paper is focused on the finite element modeling of shear walls. The purpose is to present a new shear connector element based on the theory of continuum plasticity. The incremental load-displacement relationship is derived based on the elastic-plastic stiffness tensor including the elastic stiffness tensor, the plastic modulus, a function representing the yield criterion and a hardening rule, and function representing the plastic potential. The plastic properties are determined from experimental results obtained from testing actual connections. Load-displacement curves for shear walls are calculated using the shear connector model and they are compared with experimental and other computational results. Also, the ultimate horizontal load-carrying capacity is compared to results obtained by an analytical plastic design method. Good agreements are found.

关键词： shear walls wall diaphragms finite element modelling plastic shear connector analytical modelling exoerimental comoarison

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