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Embolization of liver tumors:Past,present and future

World Journal of Radiology 2012年第9期4卷 405-412页

作者： Ashwin Rammohan Jeswanth Sathyanesan Sukumar Ramaswami Anand Lakshmanan perumal Senthil-Kumar ulagendra perumal srinivasan Ravi Ramasamy Palaniappan Ravichandran The Institute of Surgical Gastroenterology and Liver Transplantation Centre for GI BleedDivision of HPB DiseasesStanley Medical College Hospital Interventional RadiologistInstitute of Surgical Gastroenterology and Liver TransplantationCentre for GI BleedDivision of HPB DiseasesStanley Medical College Hospital

Curative therapies for hepatocellular carcinoma(HCC),such as resection and liver transplantation,can only be applied in selected patients with early *** advanced stages require local or systemic *** of HCC offers the only hope for *** in patients undergoing resection,recurrences are ***,a technique combining intraarterial chemotherapy with selective tumor ischemia,has been shown by randomized controlled trials to be efficacious in the palliative *** is now renewed interest in transarterial embolization/transarterial chemoembolization(TACE) with regards to its use as a palliative tool in a combined modality approach,as a neoadjuvant therapy,in bridging therapy before transplantation,for symptomatic indications,and even as an alternative to *** have also been rapid advances in the agents being embolized trans-arterially(genes,biological response modifiers,etc.).The current review provides an evidence-based overview of the past,present and future trends of TACE in patients with HCC.

关键词： Liver tumors Embolization Chemoembolization Review

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Bacteriological and pathological studies of egg peritonitis in Commercial layer chicken in Namakkal area

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Asian Pacific Journal of Tropical Biomedicine 2013年第12期3卷 988-994页

作者： Palani srinivasan Gurusamypalayam Amirthalingam Balasubramaniam Thippichettipalayam Ramasamy Gopala Krishna Murthy perumal Balachandran Department of Veterinary Pathology Veterinary College and Research Institute Poultry Disease Diagnosis and Surveillance Laboratory Veterinary College and Research Institute

Objective:To detect the various bacteriological agents and pathological changes in commercial layer chicken affected with egg yolk peritonitis in Namakkal region of ***:A total of 6572 layer chicken from 85 commercial farms were subjected for the study,out of which 1715 showed various types of oviduct *** the 1715,264 birds from six farms were identified as egg peritonitis on the basis of postmortem ***,lung,heart blood,liver,peritoneal exudate,oviduct(infundibulum,magnum,uterus)and cloacal swabs were collected from the 264 birds with egg peritonitis lesion for screening of bacterial ***,clinical signs and pathological changes were recorded in the affected ***:The results of the present investigation indicated that the *** associated egg peritonitis was responsible for 15.39%of the reproductive tract abnormalities in commercial layers between 21 and 80 week of *** the affected flocks egg production drop and mortality varied from 3%to 20%and 0.5%to 7.0%*** was noticed during peak egg production(21 to 60week)and southwest monsoon season(58%).Statistical analysis of age,season and egg production by Chi square test of independence revealed highly significant *** was isolated as a pure culture and concurrent with other bacterial agents in 226 and 38 birds *** the fifteen *** serotypes identified serotype O_(166),O_(?)and O_(111)were *** examination of affected birds revealed the presence of amorphous or insipissiated yolk material in the abdominal cavity with inflammatory changes in the ovary,oviduct and *** the oviduct surface epithelium showed degeneration and desquamation,moderate to marked infiltration of inflammatory cells especially heterophils and lymphocytes in various regions and lumen contained serofibrinous exudate,inflammatory and desquamated epithelial cells with bacterial *** follicles r

关键词： Egg peritonitis Layer chicken Prevalence E.coli Pathology

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A gist of gastrointestinal stromal tumors: A review

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World Journal of Gastrointestinal Oncology 2013年第6期5卷 102-112页

作者： Ashwin Rammohan Jeswanth Sathyanesan Kamalakannan Rajendran Anbalagan Pitchaimuthu Senthil-Kumar perumal UP srinivasan Ravi Ramasamy Ravichandran Palaniappan Manoharan Govindan The Institute of Surgical Gastroenterology and Liver Transplantation Centre for GI Bleed Division of HPB Diseases Stanley Medical College Hospital

Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive tumor type, different from smooth muscle and neural tumors of the gastrointestinal tract (GIT). They constitute the majority of gastrointestinal mesenchymal tumors of the GIT and are known to be refractory to conventional chemotherapy or radiation. They are defined and diagnosed by the expression of a proto-oncogene protein detected by immunohistochemistry which serves as a crucial diagnostic and therapeutic target. The identification of these mutations has resulted in a better understanding of their oncogenic mechanisms. The remarkable antitumor effects of the molecular inhibitor imatinib have necessitated accurate diagnosis of GIST and their distinction from other gastrointestinal mes-enchymal tumors. Both traditional and minimally invasive surgery are used to remove these tumors with minimal morbidity and excellent perioperative outcomes. The revolutionary use of specific, molecularlytargeted therapies, such as imatinib mesylate, reduces the frequency of disease recurrence when used as an adjuvant following complete resection. Neoadjuvant treatment with these agents appears to stabilize disease in the majority of patients and may reduce the extent of surgical resection required for subsequent complete tumor removal. The important interplay between the molecular genetics of GIST and responses to targeted therapeutics serves as a model for the study of targeted therapies in other solid tumors. This review summarizes our current knowledge and recent advances regarding the histogenesis, pathology, molecular biology, the basis for the novel targeted cancer therapy and current evidence based management of these unique tumors.

关键词： Gastrointestinal stromal tumors c-KIT Imatinib mesylate Surgery Review

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