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Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

Gastroenterology Report 2022年第1期10卷 440-450页

作者： Sang Hyun Seo Da Hyun Lee Yu Seol Lee Kyung Joo cho Hye Jung Park Hye Won Lee Beom Kyung Kim Jun Yong Park Do Young Kim Sang Hoon Ahn Soo Han Bae Seung up Kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background ursodeoxycholic acid(uDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of uDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of *** NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose uDCA(L-uDCA;15 mg/kg)or highdose uDCA(H-uDCA;30 mg/kg)was administered with RSV/*** also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 *** Co-administration of RSV/EZE with uDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all Pup fasted and refed with a high-carbohydrate diet,uDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all Pubsequently,H-uDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle *** the CDAHFD-fed mouse model,uDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all PuDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all Pusion Combination therapy involving uDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe

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连铸连轧镁合金AZ41微观结构与摩擦磨损性能

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航空学报 2014年第6期35卷 1733-1739页

作者：宋令慧王守仁赵宰炯济南大学机械工程学院山东济南250022 韩国材料科学研究所韩国昌原641010

为研究铸轧镁合金AZ41板材的摩擦磨损性能,通过连铸连轧制备出镁合金AZ41板材,并观察其铸轧态和热处理态的微观组织结构特点。研究了滑动干摩擦条件下滑动速度和载荷对AZ41镁合金板材摩擦磨损性能的影响,采用扫描电镜观察磨损表面形貌,... 详细信息

为研究铸轧镁合金AZ41板材的摩擦磨损性能,通过连铸连轧制备出镁合金AZ41板材,并观察其铸轧态和热处理态的微观组织结构特点。研究了滑动干摩擦条件下滑动速度和载荷对AZ41镁合金板材摩擦磨损性能的影响,采用扫描电镜观察磨损表面形貌,探讨了其磨损机制,并利用有限元方法模拟了其磨损时的应力分布。结果表明:制备的镁合金AZ41在(1012)上出现了大量压缩孪晶,经热处理后晶粒变为等轴晶;摩擦系数随着转速的增加而升高,在一定范围内随载荷的增加而降低;磨损量随着载荷和转速的增加而增加,低载时磨损机制为磨粒磨损,伴有氧化磨损的发生,高载时其磨损以粘着磨损为主。

关键词：连铸连轧镁合金微观结构摩擦磨损磨损机制

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基于因子分析的中国葡萄酒上市公司财务状况评价

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中国酿造 2022年第7期41卷 248-252页

作者：崔友川李淑琦朱彦旭徐绍荣中国农业大学烟台研究院山东烟台264670

当前中国葡萄酒市场正处于深度调整期,葡萄酒企业经营状况良莠不齐。为探究我国葡萄酒企业财务状况,以2016~2020年为年度研究区间,从偿债能力、盈利能力、发展能力、运营能力四个维度选取10个二级指标变量,基于因子分析法提取出三个公因... 详细信息

当前中国葡萄酒市场正处于深度调整期,葡萄酒企业经营状况良莠不齐。为探究我国葡萄酒企业财务状况,以2016~2020年为年度研究区间,从偿债能力、盈利能力、发展能力、运营能力四个维度选取10个二级指标变量,基于因子分析法提取出三个公因子,根据因子得分和综合得分对5家葡萄酒上市公司财务状况进行评判,针对研判结果提出发展建议。

关键词：葡萄酒上市公司财务状况因子分析

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NANO COMPOSITE AND NANO REPLICATION TECHNIQuES IN DIRECT METHANOL FuEL CELL

NANO COMPOSITE AND NANO REPLICATION TECHNIQUES IN DIRECT MET...

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Asia Conference on Nanoscience and Nanotechnology Abstracts Book

作者： K.LEE J.-H.NAM Y.LEE S.M.cho C.H.JuNG H.G.choI Y.-Y.JANG Y.-u.KWON J.C.SEFERIS J.-D.NAM Department of Polymer Science ＆ Engineering Department of Polymer Science ＆ Engineering Department of Chemical Engineering Department of Chemical Engineering Department of Polymer Science ＆ Engineering.Department of Chemical Engineering School of Systems Management Engineering Department of Chemistry Sungkyunkwan university SuwonKyunggi 440-746Korea Department of Chemistry Sungkyunkwan university SuwonKyunggi 440-746Korea Polymeric Composites Laboratory University of WashingtonSeattleWA 98195-1750USA Department of Polymer Science ＆ Engineering

＜正＞ In this study, the nano-sized layered plates and the hexagonal arrays of one-dimensional channels will be presented for the development of catalyst layers and polyelectrolyte membranes in direct methanol fuel cell （DMFC） applications. The positively-charged layered double hydroxides （LDH） systems were incorporated into the negatively-charged polyelectrolyte polymer in order to change the proton conductivity and diffusion coefficient of DMFC membrane. For different ion exchange capacities and its compositions of LDH, the maximum power density of a single-cell DMFC was measured and correlated with the transport properties of the proton and the methanol through the LDH/Nafion composite membrane systems. In addition, a mesoporous carbon structure based on SBA-15 silica template was used as a cathode catalyst support of platinum in the direct methanol fuel cell. The inverse carbon replica of the template was synthesized by carbonization of sucrose exhibiting a large surface area. Introducing platinum clusters on the carbon support, a large surface area was maintained and the catalytic activation was confirmed by a DMFC single-cell test The mesoporous carbon structure could be an ideal catalyst support for electrode support materials in DMFC providing favorable hosting morphology for the metallic catalyst clusters and interconnected pore network for a facile transport of feeds and products.

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全球化领导力模型(英文)

全球化领导力模型(英文)

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北京论坛（2004）文明的和谐与共同繁荣

作者： Kisuk cho Minam Sohn Ewha Womans university

As the new millennium has arrived, last century’s prevailing paradigm of leadership study, which was culture-specific cannot satisfy contemporary needs. America-centered leadership style and theories may be enough for u.S. leaders but not for French or Japanese. Globalization, the subject of 21st century has become a detonator of change of leadership studies. Since the world has been globalized with blooming number of multinational companies around the world and frontier- transcending trade, globalized leadership model, which can be generalizable to all culture without frontier is desperately needed. This paper is a critical review of current literature on global leadership. First, it attempts to search and find the competencies and qualities of global leadership. Many scholars of leadership studies concentrated their endeavor on finding generalizable competencies and characteristics of global leadership in order to find and raise global leaders of the 21st century. Second, this paper presents a new global leadership model that encompasses important competencies suggested by existing global leadership theories and models.

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Technical skills and training of upper gastrointestinal endoscopy for new beginners

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World Journal of Gastroenterology 2015年第3期21卷 759-785页

作者： Seung-Hwa Lee Young-Kyu Park Sung-Min cho Joon-Koo Kang Duck-Joo Lee Health Promotion Center Ajou University School of MedicineSuwon 443-380South Korea Health Promotion Center Bundang Jaesang HospitalKwandong University School of MedicineSeongnam 463-774South Korea Department of Gastroenterology Ajou University School of MedicineSuwon 443-380South Korea

The incidence of gastric cancer remains high in *** gastrointestinal(GI) endoscopy,i.e.,esophagogastroduodenoscopy(EGD),has a higher diagnostic specificity and sensitivity than the upper GI ***,EGD has the ability to biopsy,through taking a tissue of the pathologic *** training of EGD procedural skills require a few important things to be learned and remembered,including the posture of an examinee(e.g.,left lateral decubitus and supine) and examiner(e.g.,one-man standing method vs one-man sitting method),basic skills(e.g.,tip deflection,push forward and pull back,and air suction and infusion),advanced skills(e.g.,paradoxical movement,J-turn,and u-turn),and intubation techniques along the upper GI tract(e.g.,oral cavity,pharynx,larynx including vocal cord,upper and middle and lower esophagus,gastroesophageal junction,gastric fundus,body,and antrum,duodenal bulb,and descending part of duodenum).In the current review,despite several limitations,we explained the intubation method of EGD for *** hope this will be helpful to beginners who wish to learn the procedure.

关键词： upper gastrointestinal endoscopy Esophagogastroduo

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Transverse Flux Induction Coil for uniform Bar Heating Excluding Edge

Transverse Flux Induction Coil for Uniform Bar Heating Exclu...

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第七届冶金与材料电磁过程国际会议（EPM2012）

作者： PARK Jong-Soo BAE Jin-Su cho un-Kwan HA Tae-Jong KIM Goo-Hwa Process Engineering Design Research Group Engineering Research CenterPOSCO

This work particularly focuses on compensating Joule heat in under-heated areas occurred when thin steel bar is(< 20 mm) heated by transverse flux induction heater(TFIH).The under-heated areas take place in range of 5... 详细信息

This work particularly focuses on compensating Joule heat in under-heated areas occurred when thin steel bar is(ux induction heater(TFIH).The under-heated areas take place in range of 50 150 mm from the both edges,so Transverse Flux Induction Coil(TFIC) including a magnetic core is proposed and optimized to supplement this *** solutions on the electromagnetic field are obtained numerically by commercial code MAXWELL 3D software from ANSYS *** then,verified experimentally by pilot-scale tests,in which the TFIH was manufactured with a nominal power of 100 kW at a fundamental frequency of 1 ***,TFIC having geometrically the optimized magnetic core made the heating pattern u-shaped,so could supply a desirable temperature profile for the rolling process.

关键词： Transverse Flux Induction heating(TFIH) induction coil magnetic core uniform heating

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溴化丁基橡胶/丁腈橡胶并用胶微观结构和性能研究

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橡胶工业 2018年第9期65卷 971-974页

作者：纪玲慧李京超金振涣李宇晟卢咏来张立群弹性体节能和资源化教育部工程研究中心北京100029 北京市新型高分子材料制备与加工重点实验室北京100029 北京化工大学先进弹性体材料研究中心北京100029 中策橡胶集团有限公司浙江杭州310018

用改性沥青作相容剂,研究溴化丁基橡胶(BIIR)/丁腈橡胶(NBR)并用胶的微观结构和性能。结果表明:与未添加改性沥青CJ-100的BIIR/NBR并用胶相比,添加改性沥青CJ-100的BIIR/NBR并用胶的相容性较好,加工性能改善,气密性、耐屈挠和耐臭氧性... 详细信息

用改性沥青作相容剂,研究溴化丁基橡胶(BIIR)/丁腈橡胶(NBR)并用胶的微观结构和性能。结果表明:与未添加改性沥青CJ-100的BIIR/NBR并用胶相比,添加改性沥青CJ-100的BIIR/NBR并用胶的相容性较好,加工性能改善,气密性、耐屈挠和耐臭氧性能提高;添加5份改性沥青CJ-100的BIIR/NBR(并用比为80/20)并用胶物理性能、气密性、耐屈挠和耐臭氧性能较好,气密性接近全BIIR胶料,有望用于全钢载重子午线轮胎气密层。

关键词：溴化丁基橡胶丁腈橡胶并用胶微观结构改性沥青相容剂气密性

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Existence and uniqueness of Global Solution for Certain Degenerate Reaction-Diffusion Systems

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福建师大福清分校学报 1993年第1期11卷 113-128,112页

作者： Lu Guo-fu(Math. Dept. , Fu Qing Branch of F’u Jian Normal univ. ) Math.Dept. FuQingBranchofFuJianNormalUniv.

In this paper we discuss the following nonlinear degenerate parabolic systems u_i=△a_i(u_i)+b_i(x,t,u_i)Du_i+f_i(x,t,u)for i = 1,2, …, m and u = (u_1,…, u_m) is a vector function, with Dirichlet boundary condition. under some structure conditions on a_i,b_i and f_i and initial data u_i^o∈Li(Ω) for some pi>p_i^o = 1,2,…,m, the result on existence and uniquence of global solution is established.

关键词：退化反应扩散方程组解唯一性存在性

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Do Quantity and Quality of Irradiance Influence Migration Behavior Motile Cells of the Green Alga, <i>ulva fasciata</i>?

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Open Journal of Marine Science 2014年第4期4卷 316-325页

作者： Hyun-Woung Shin Han Seong Lee Sang Mok Jung Min Kyu choo Ji Young cho Kwang Soo Lee Celia M. Smith Department of Life Science and Biotechnology Soonchunhyang University Asan City South Korea Department of Sport Science Soonchunhyang University Asan City South Korea Department of Botany University of Hawaii Honolulu USA

Motile cells of the green alga, ulva fasciata respond to the quantity and quality of irradiance simultaneously. The specific responses of motile cell types (gametes and spores) by irradiance influence migration behavior in coastal water environment. Gametes maximally aggregated at the highest white light intensity (250 μmol·m-2·s-1), while spores maximally aggregated in the dark (0 μmol m-2·s-1) of this study. Gametes maximally aggregated in green irradiance over blue, red and dark while spore maximally aggregated in the dark. The results of quantity are spectral responses are likely to be underline the ecological success and physiological strategies in varied irradiance environments includes: 1) gametes respond to specific quantities and spectral irradiance;2) spores respond negatively to quantity and quality of irradiance to enhance the probability of finding substratum;and 3) populations of adults that come from these motile cells behaviors. The specific quantities and spectral qualities of irradiance responses show specific ecological migration that can be attributed to photosynthesis under limiting irradiance in coastal waters for the motile cells of u. fasciata.

关键词： Irradiance Migration Behavior ulva fasciata Gamete Spore

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