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Asian Journal of Andrology 2015年第1期17卷 163-164页

作者： Salih Budak Orcun Celik Hakan Turk Tufan Suelozgen Yusuf ozlem Ilbey Department of Urology Tepecik Educational and Research Hospital Izmir 35170Turkey.

Dear Editor, Burned-out tumors of the testis are extremely rare form oftesticular malignancies, and they could disappear or regress spontaneously and completely. These tumors could be presented by metastatic form in retroperitoneum, lungs, retroperitoneal lymph nodes, and liver. In recent studies, differential diagnosis, clinic features, treatment modalities and follow-up outcome of burned-out tumor from primary retroperitoneal germ cell tumor are discussed. If patient with retroperitoneal lymph node involvement and histology of ＂testicular tumor＂ burned-out tumor of the testis was suspected.

关键词： Extragonadal tumor with the burned-out

A hepatocellular carcinoma–bone metastasis-on-a-chip model for studying thymoquinone-loaded anticancer nanoparticles

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Bio-Design and Manufacturing 2020年第3期3卷 189-202页

作者： Fatemeh Sharifi ozlem Yesil-Celiktas Aslihan Kazan Sushila Maharjan Saghi Saghazadeh Keikhosrow Firoozbakhsh Bahar Firoozabadi Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMAUSA School of Mechanical Engineering Sharif University of TechnologyTehranIran Department of Bioengineering Faculty of EngineeringEge UniversityBernovaIzmirTurkey

We report the development of a metastasis-on-a-chip platform to model and track hepatocellular carcinoma(HCC)-bone metastasis and to analyze the inhibitory effect of an herb-based compound,thymoquinone(TQ),in hindering the migration of liver cancer cells into the bone *** bioreactor consisted of two chambers,one accommodating encapsulated HepG2 cells and one bone-mimetic niche containing hydroxyapatite(HAp).Above these chambers,amicroporous membrane was placed to resemble the vascular barrier,where medium was circulated over the *** was observed that the liver cancer cells proliferated inside the tumor microtissue and disseminated from the HCC chamber to the circulatory flow and eventually entered the bone *** number of metastatic HepG2 cells to the bone compartment was remarkably higher in the presence of HAp in the *** was then used as ametastasis-controlling agent in both free form and encapsulated nanoparticles,to analyze its suppressing effect on HCC *** indicated that the nanoparticle-encapsulated TQ provided a longer period of inhibitory *** summary,HCC-bone metastasis-on-a-chip platform was demonstrated to model certain key aspects of the cancer metastasis process,hence corroborating the potential of enabling investigations on metastasis-associated biology as well as improved anti-metastatic drug screening.

关键词： Tumor-on-a-chip Organ-on-a-chip Hydroxyapatite Hepatocellular carcinoma Thymoquinone

Sertraline-induced reproductive toxicity in male rats： evaluation of possible underlying mechanisms

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Asian Journal of Andrology 2017年第6期19卷 672-679页

作者： ozlem Atli Merve Baysal Gozde Aydogan-Kilic Volkan Kilic Seyda Ucarcan Burak Karaduman Sinem Ilgin Department of Pharmaceutical Toxicology Faculty of Pharmacy Anadolu University Eskisehir 26470 Turkey Department of Biology Faculty of Science Anadolu University Eskisehir 26470 Turkey

This study was conducted to clarify the toxic effects of sertraline （SRT） on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg kg-1 for 28 consecutive days. At the end of the treatment period, sperm concentration, sperm motility, and sperm morphology were investigated by computer-assisted sperm analysis system whereas sperm DNA damage was detected by comet assay. The oxidative status of the testes was investigated, and a histopathological examination was conducted. Serum testosterone, follicle-stimulating hormone （FSH）, and luteinizing hormone （LH） levels were measured to determine the effects of SRT on the spermatogenesis process. One-way ANOVA, post-hoc Dunnett＇s T3 test for the sperm comet assay, and post-hoc Tukey＇s test for the others were performed for statistical analysis. The results showed that SRT caused an increase in sperm DNA damage and induced histopathological lesions in all groups treated with SRT. There was abnormal sperm morphology and increased malondialdehyde （MDA） in the 10 mg kg-1 treatment group. More dramatic changes were observed in the 20 mg kg-1 treatment group. Decreased sperm count was accompanied by a significant increase in abnormal sperm morphology, DNA damage, and degeneration in cellular-tubular structures. Serum LH and testosterone levels were elevated in the 20 mg kg-~ treatment group. Decreased glutathione （GSH） and increased MDA were signs of enhanced oxidative stress （OS）. In conclusion, SRT induced testicular toxicity in a dose-dependent manner and OS is suggested as a crucial mechanism.

关键词： DNA damage oxidative stress reproductive toxicity sertraline

Implications of a new, biostratigraphically well-controlled, radio-isotopic age for the lower Telychian Stage of the Llandovery Series （Lower Silurian, Sweden）

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Episodes 2008年第3期31卷 309-314页

作者： Stig M. Bergstrom Funda ozlem Toprak Warren D. Huff Roland Mundil School of Earth Sciences Division of Geological Sciences The Ohio State University 155 S. Oval Mall Columbus Ohio 43210 USA. Department of Geoiogy University of Cincinnati Cincinnati Ohio 45221 USA Berkeley Geochronology Center 2455 Ridge Road Berkeley California 94709 USA.

Radio-isotopic analysis of single zircons from two early Telychian K-bentonites, one of which is among the most widespread Lower Paleozoic volcanic ash falls in northern Europe, yields overlapping weighted mean 206Pb/238U ages of 438.7 ± 1.0 Ma and 437.8 ± 0.5 Ma, respectively. The former age is from zircons of the Osmundsberg K-bentonite from the type locality at Osmundsberget in the Siljan area of central Sweden where it occurs in the lower part of the Spirograptus turriculatus Graptolite Zone and in the lower part of the Angochitina longicollis Chitinozoan Zone. Zircons giving the latter age are from a bed previously identified as the Osmundsberg K-bentonite at the Kallholn Quarry in the same area. Based on new biostratigraphic data, the latter bed is now considered to be slightly younger than the Osmundsberg K-bentonite. The dated stratigraphic level of the ash layers is slightly younger than the base of the Telychian Stage and thus represents a minimum age for the Aeronian/Telychian Stage boundary. A U-Pb age of > 438 Ma for the base of this stage, however, is older and in conflict with estimates in the most recent compilation of the Silurian time scale. In view of the fact that only three radio-isotopic dates from the entire Llandovery have been previously accepted, this new and biostratigraphically exceptionally well-controlled radio-isotopic date fills an important gap in the Lower Silurian geochronology.

关键词：无线电同位素蓝达夫里阶志留纪

Fintech investments in European banks:a hybrid IT2 fuzzy multidimensional decision‑making approach

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Financial Innovation 2021年第1期7卷 826-853页

作者： Gang Kou ozlem Olgu Akdeniz Hasan Dincer Serhat Yuksel School of Business Administration Southwestern University of Finance and EconomicsChengdu 611130China College of Administrative Sciences and Economics Koc UniversityRumeli Feneri YoluSarıyerIstanbul 34450Turkey School of Business Istanbul Medipol UniversityKavacık CampusBeykozIstanbul 34810Turkey

Financial technology(Fintech)makes a significant contribution to the financial system by reducing costs,providing higher quality services and increasing customer ***,new studies play an essential role to improve Fintech *** study evaluates Fintech-based investments of European banking services with an application of an original methodology that considers interval type-2(IT2)fuzzy decision-making trial and evaluation laboratory and IT2 fuzzy TOPSIS *** findings are controlled for consistency by applying the VIKOR ***,we conduct a sensitivity analysis by considering six distinct *** study contributes to the existing literature by identifying the most important Fintech-based investment alternatives to improve the financial performance of European *** empirical findings illustrate that results are coherent,reliable,and identify“competitive advantage”as the most important factor among Fintech-based ***,“payment and money transferring systems”are the most important Fintech-based investment *** is recommended that,among Fintech-based investments,European banks should mainly focus on payment and money transferring alternatives to attract the attention of customers and satisfy their *** is also believed to have a positive impact on the ease of bank’receivable *** important point is that Fintech-based investments in money transferring systems could help to decrease costs.

关键词： Financial technology European banking industry Interval type-2 fuzzy TOPSIS DEMATEL

Late clinical characteristics of infants with retinopathy of prematurity and treated with cryotherapy

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 567-571页

作者： Eren Cerman Deniz Ozarslan Ozcan Hande Celiker Muhsin Eraslan ozlem Sahin Haluk Kazokoglu Department of Ophthalmology Marmara University School of Medicine Department of Ophthalmology Akcakale State Hospital

AIM： To describe the clinical characteristics and late results of patients with retinopathy of prematurity（ROP）treated with ＂6h cryotherapy＂.·METHODS： Out of 1252 infants screened for ROP, 52 patients were treated with temporal 6h cryotherapy from1997 to 2005 were recalled to our clinic. Among these 23 patients were available and 46 eyes of 23 infants were included to evaluate for visual acuity, refractive error,ocular alignment, nystagmus, retinal examination（abnormal branching of retinal vessels, retinal thinning,latis degenerations, tortuosity of vessels, straightening of temporal vessels, narrowing of the angle of vessel in the juxtapapillary entrance, pigment changes, macular heterotopia）, optic atrophy and optic disc cupping, axial length at birth and axial length at 1y.·RESULTS： The median age at examination was 7（5-18）*** 32.6% of patients, the visual acuity was ≤20/200 and the mean best corrected visual acuity was 20/35 as measured with a Snellen chart. Mean spherical refractive error was-1.76±2.69 D. The degree of myopia at the last examination was found to be correlated with the elongation of the eye in the first year of life. Exotropia was present in 17.4%（n =8） of infants and esotropia in13%（n =6）. The most common retinal abnormality was abnormal branching of retinal vessels（82.6%） followed by retinal thinning（52.2%）.·CONCLUSION： The late clinical outcomes of infants with ROP treated in our clinic with cryotherapy seems to comparable with results of laser treatment.

关键词： retinopathy of prematurity cryotherapy late outcomes

Cytomegalovirus gastritis after rituximab treatment in a nonHodgkln's lymphoma patient

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World Journal of Gastroenterology 2006年第12期12卷 1978-1979页

作者： ugur Unluturk Sercan Aksoy ozlem Yonem Yusuf Bayraktar Gulten Tekuzman Hacettepe University Faculty of Medicine Department of Internal Medicine Ankara Turkey Hacettepe University Institute of Ontology Ankara Turkey Hacettepe University Faculty of Medicine Department of Internal Medicine Unit of Gastroenterology Ankara Turkey

TO THE EDITORRituximab is a chimeric monoclonal antibody againstCD20 antigen expressed on most B cells and is used forthe treatment of malignant lymphomas expressing theCD20 *** temporarily eliminates normal B-lym-phocytes without a substantial decrease in serum immuno-globulin ***,several serious viral infectionshave been reported in association with rituximab ***-tomegalovirus(CMV)is one of the agents that may be acause of morbidity and mortality in *** the face of exogenous or endogenouscauses of immunosuppression,cytomegalovirus can

关键词：巨细胞病毒胃炎非霍奇金淋巴瘤病理机制临床表现

Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 938-944页

作者： ozlem Yalcin Tok Levent Tok Inci Meltem Atay Tugba Cakmak Argun Nazire Demirci Alime Gunes Department of Ophthalmology Süleyman Demirel University Research and Education Hospital Department of Psychiatry Süleyman Demirel University Research and Education Hospital

AIMTo evaluate the clinical findings of toxic keratopathy associated with abuse of topical anesthetics and the treatment efficacy of amniotic membrane transplantation (AMT).METHODSFifteen eyes of 10 patients with abuse of topical anesthetics were included in this study. The data collected included patients' demographic information, initial best corrected visual acuity (BCVA), clinical findings, time to AMT, duration of epithelization, additional treatments, posttreatment BCVA, and the results of psychiatric *** patients were male, with the mean age of 37.9±5.4y. The patients had received 0.5% proparacaine hydrochloride due to pain resulting from foreign bodies, such as welding flash burns and car battery explosions, for a mean of 18.2±12.4d. The mean initial BCVA of the patients was 0.069±0.100. All patients had persistent epithelial defects, stromal infiltration, ring ulcer, and corneal edema. Initially, medical treatment was attempted in all cases. Because of severe pain, persistent epithelial defects and progressing stromal thinning did not improve with medical treatment, thus, the patients underwent AMT. The mean posttreatment BCVA of the patients was 0.33±0.27. All of them, except for two patients, showed improved visual acuity. One patient underwent evisceration for corneal melting and endophthalmitis in another center, and one patient underwent evisceration for severe pain of unknown origin. All 5 patients who consented to a psychiatric examination had depression, had personality disorder, and used *** appears to be an effective method for pain relief, rapid epithelial and stromal healing; however, visual prognosis is still poor despite medical and surgical interventions.

关键词： amniotic membrane transplantation ring stromal infiltration topical anesthetic abuse toxic keratopathy

Clinical characteristics of Caroli’s disease

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World Journal of Gastroenterology 2007年第13期13卷 1930-1933页

作者： ozlem Yonem Yusuf Bayraktar Hacettepe University Faculty of Medicine Department of Gastroenterology Sihhiye 06100 Ankara Turkey Hacettepe University Faculty of Medicine Department of Gastroenterology Sihhiye 06100 Ankara Turkeyr MD Series Editor

Caroli's disease is a rare congenital condition chara- cterized by non-obstructive saccular or fusiform dilatation of larger intrahepatic bile ducts. Cholangitis, liver cirrhosis, and cholangiocarcinoma are its potential complications. The diagnosis of Caroli's disease depends on demonstrating that the cystic lesions are in continuity with the biliary tree which can be showed by ultrasonography, computerized tomography, endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography or magnetic resonance cholangiopancreatography. Treatment of Caroli's disease relies on the location of the biliary abnormalities. While localized forms confined to one lobe can be treated with surgery, liver transplantation is the only effective modality for diffuse forms. Although a rare disorder; Caroli's disease should always be considered in the differential diagnosis of chronic cholestasis of unknown cause.

关键词：先天性肝内胆管扩张临床特征肝移植内镜逆行胆管胰腺造影

Effects of astaxanthin on antioxidant parameters in ARPE-19 cells on oxidative stress model

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 930-935页

作者： Yigit Musa Günes Alime Uguz Cihangir Yalcin Tok ozlem Tok Levent Oz Ahmi Naziroglu Mustafa Department of Ophthalmology Süleyman Demirel University Research and Education HospitalCünür-Isparta 32200Turkey Department of Biophysics Faculty of MedicineSüleyman Demirel University Research and Education HospitalCünür-Isparta 32200Turkey

AIM: To observe the protective effect of astaxanthin(AST) against hydroquinone(HQ) mediated cell death in the apoptotic cascade and evaluate intracellular Ca2+ release, caspase-3, and-9 activation, reactive oxygen species(ROS) production in ARPE-19 ***: We cultured ARPE-19 cells in special mediums and performed MTT tests to determine protective effect of AST, before exposing the cells to HQ in an incubator. We analyzed intracellular Ca2+ release experiments, mitochondrial membrane depolarization, glutathione(GSH), glutathione peroxidase(GSH-Px) and ROS experiments, and apoptosis ***: ROS production ranges depend on the amount of cell death. We computed the correlation between ROS ranges and cell death by 20,70-dichlorofluorescein fluorescence, and Ca2+ levels by Fura-2-AM. HQ-induced cell death found out to rise ranges of caspase-3 and-9, and mitochondrial depolarization. These three steps were delayed by AST ***: ARPE-19 cells are avoided from HQinduced ROS production and caspase-3 and-9 activation by AST. AST may limit the range of caspase synthesis, Ca2+ release and excess production of ROS with antiapoptotic effect. This study proposes a new therapeutic approach for the treatment of age-related macular degeneration.

关键词： apoptosis ARPE-19 cell astaxanthin oxidative stress