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Probing anomalous top-Higgs couplings at the HL-LHC via H→WW~* decay channels

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Chinese Physics C 2019年第1期43卷 9-15页

作者： Yao-Bei Liu Stefano moretti Henan Institute of Science and Technology School of Physics & Astronomy University of Southampton

We study the prospects of probing the anomalous tHq(q=u,c)couplings via SS2L or 3L signatures at the High Luminosity(HL-LHC)run of the 14 Te V CERN *** focus on signals of the tH associated production followed by the decay modes t→b?^+ν_?and H→W W~*,and ■ production followed by the decay modes t→b?^+ν_?and■where?=e,μ.Based on two types of H→W W~*decay topologies,one assuming the semileptonic decay mode H→W W~*→?^+νjj and the other the fully leptonic decay mode■,we perform a full simulation for signals and *** is shown that,at the future HL-LHC,the branching ratio Br(t→uh)(Br(t→ch))can be probed to 1.17(1.56)×10^(-3)for the same-sign di-lepton channel,and to7.1×10^(-4)(1.39×10^(-3))for the 3L channel at 3σsensitivity.

关键词： anomalous top-higgs couplings flavor changing neutral currents LHC

Working toward an integrated plasticity/network framework for repetitive transcranial magnetic stimulation to inform tailored treatments

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Neural Regeneration Research 2024年第7期19卷 1423-1424页

作者： Jessica moretti Jennifer Rodger Experimental and Regenerative Neurosciences School of Biological SciencesUniversity of Western AustraliaCrawleyWAAustralia Brain Plasticity Lab Perron Institute for Neurological and Translational ScienceNedlandsWAAustralia

Non-invasive brain stimulation techniques(NIBS),including repetitive transcranial magnetic stimulation(rTMS) and transcranial electric stim ulation(tES),are increasingly being adopted clinically for treatment of neuropsychiatric and neurological disorders,albeit with varying *** rationale behind the use of NIBS has historically been that stim ulation techniques modulate neuronal activity in the targeted region and consequently induce plasticity which can lead to therapeutic outcomes.

关键词： stimulation transcranial treatment

Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity

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Neural Regeneration Research 2022年第2期17卷 292-299页

作者： Federica Ferrari Antonio moretti Roberto Federico Villa Department of Biology and Biotechnology Laboratory of Pharmacology and Molecular Medicine of Central Nervous SystemUniversity of PaviaVia FerrataPaviaItaly

Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic stroke and lead to worsened clinical outcome and increased mortality. However, post-stroke hyperglycemia is also present in a number of non-diabetic patients after acute ischemic stroke, presumably as a stress response. The aim of this review is to summarize the main effects of hyperglycemia when associated to ischemic injury in acute stroke patients, highlighting the clinical and neurological outcomes in these conditions and after the administration of the currently approved pharmacological treatment, i.e. insulin. The disappointing results of the clinical trials on insulin(including the hypoglycemic events) demand a change of strategy based on more focused therapies. Starting from the comprehensive evaluation of the physiopathological alterations occurring in the ischemic brain during hyperglycemic conditions, the effects of various classes of glucose-lowering drugs are reviewed, such as glucose-like peptide-1 receptor agonists, DPP-4 inhibitors and sodium glucose cotransporter 2 inhibitors, in the perspective of overcoming the up-to-date limitations and of evaluating the effectiveness of new potential therapeutic strategies.

关键词： acute ischemic stroke diabetes mellitus DPP-4 inhibitor glucose-like peptide-1 receptor agonist hyperglycemia hypoglycemia insulin physiopathology sodium glucose cotransporter 2 inhibitor

Topology optimization of piezoelectric bi-material actuators with velocity feedback control

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Frontiers of Mechanical Engineering 2019年第2期14卷 190-200页

作者： Mariana moretti Emilio C.N.SILVA School of Engineering University of Sao PauloSao PauloSP 05508-030Brazil

In recent years,the new technologies and discoveries on manufacturing materials have encouraged researchers to investigate the appearance of material properties that are not naturally *** featuring a specific stiffness,or structures that combine non-structural and stmctural functions are applied in the aerospace,electronics and medical industry ***,structures designed for dynamic actuation with reduced vibration response are the focus of this *** bi-material and multifunctional concepts are considered for the design of a controlled piezoelectric actuator with vibration suppression by means of the topology optimization method(TOM).The bi-material piezoelectric actuator(BPEA)has its metallic host layer designed by the TOM,which defines the structural function,and the electric function is given by two piezo-ceramic layers that act as a sensor and an actuator coupled with a constant gain active velocity feedback control(AVFC).The AVFC,provided by the piezoelectric layers,affects the structural damping of the system through the velocity state variables readings in time *** dynamic equation analyzed throughout the optimization procedure is fully elaborated and *** dynamic response for the rectangular fbur-noded finite element analysis is obtained by the Newmark's time-integration method,which is applied to the physical and the adjoint systems,given that the adjoint formulation is needed for the sensitivity analysis.A gradient-based optimization method is applied to minimize the displacement energy output measured at a predefined degree-of-freedom of the BPEA when a transient mechanical load is *** are obtained for different control gain values to evaluate their influence on the final topology.

关键词： topology optimization method bi-material piezoactuator active velocity feedback control timedomain transient analysis host structure design vibration suppression

Goncrete block pavements in urban and local roads:Analysis of stress-strain condition and proposal for a catalogue

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 557-566页

作者： Paola Di Mascio Laura moretti Americo Capannolo Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00184Italy

Although the construction of block pavements has grown fast in the last decades,there is still a need for simple tools that could be applied to design *** paper analyzed and verified concrete block pavements for urban and local roads composed of rectangular concrete pavers with plane side surfaces(no interlocking effect).The examined blocks were laid on a bedding sand layer,a cement treated base layer and a granular unbound foundation *** commercial finite element(FE)software ANSYS?was used to calculate the response of the pavement when subjected to different loading,construction *** wheel positions,five blocks patterns,three bedding sand thicknesses and joints gaps have been considered to evaluate stress-strain condition on pavement *** and rutting verification was performed respectively for bound and unbound pavement materials using analytical curves available in the *** the end of this study,a proposal for a catalogue is *** has nine pavement sets,because it takes into account three values of subgrade capacity(30,90,and 150 MPa of resilient modulus)and three levels of traffic(400,000,1,500,000,and 4,000,000 passages of commercial vehicles during the service life).The obtained results provide an inexpensive procedure for the preliminary design of concrete block pavements.

关键词： Block pavement Finite element model Concrete pavers Local roads Urban roads

Broadband beam steering for misaligned multi-mode OAM communication systems

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Journal of Systems Engineering and Electronics 2021年第4期32卷 779-788页

作者： TIAN Zhengjuan CHEN Rui LONG Wenxuan ZHOU Hong moretti Marco School of Communication Engineering Xidian UniversityXi’an 710071China Department of Information Engineering University of PisaPisa 56126Italy

Orbital angular momentum(OAM)at radio frequency(RF)has attracted more and more attention as a novel approach of multiplexing a set of orthogonal OAM modes on the same frequency channel to achieve high spectral efficiency(SE).However,the precondition for maintaining the orthogonality among different OAM modes is perfect alignment of the transmit and receive uniform circular arrays(UCAs),which is difficult to be satisfied in practical wireless communication ***,to achieve available multi-mode OAM broadband wireless communication,we first investigate the effect of oblique angles on the transmission performance of the multi-mode OAM broadband system in the non-parallel misalignment ***,we compare the UCA-based RF analog and baseband digital transceiver structures and corresponding beam steering *** analysis and numerical simulations validate that the SE of the misaligned multi-mode OAM broadband system is quite low,while analog and digital beam steering(DBS)both can significantly improve the SE of the ***,DBS can obtain higher SE than analog beam steering especially when the bandwidth and the number of array elements are large,which validates that the baseband digital transceiver with DBS is more suitable for multi-mode OAM broadband wireless communication systems in practice.

关键词： orbital angular momentum(OAM) uniform circular array(UCA) broadband wireless communication misalignment beam steering

Long term immunological perturbations post DAA therapy in chronic HCV/HIV co-infected patients

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BIOCELL 2022年第12期46卷 2695-2699页

作者： SONIA moretti FLAVIA MANCINI ALESSANDRA BORSETTI National HIV/AIDS Research Center Istituto Superiore di SanitàRome00161Italy

Direct-acting antiviral(DAA)therapies are efficacious for the achievement of sustained virologic response(SVR)in almost all treated hepatitis C virus(HCV)-infected ***,the impacts of HCV eradication on immune function and chronic immune activation in the long-term remain controversial and limited,especially in patients co-infected with human immunodeficiency virus(HIV).Indeed,although restoration of many immune responses clearly can be observed,several features of immune perturbations persist over time after HCV *** the degree and reasons of the partial recovery of the immune system in chronic HCV/HIV coinfection after HCV elimination is pivotal to avoid disease progression and possible long-term clinical outcomes in cured patients,as well as contributing to the development of immunotherapy drug design.

关键词： HCV infection HCV/HIV co-infection DAA therapy Immune activation Inflammation Immune system

Spectral and Energy Efficiency of Line-of-Sight OAM-MIMO Communication Systems

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China Communications 2020年第9期17卷 119-127页

作者： Rui Chen Hong Zhou Wen-Xuan Long Marco moretti State Key Laboratory of ISN Xidian UniversityXi'an 710071China University of Pisa Dipartimento di Ingegneria dell’InformazioneItaly

Not only high spectral efficiency(SE)but also high energy efficiency(EE)are required for future wireless communication *** orbital angular momentum(OAM)provides a new perspective of mode multiplexing to improve ***,there are few studies on the EE performance of OAM mode *** this paper,we investigate the SE and EE of a misaligned uniform concentric circle array(UCCA)-based multi-carrier multimode OAM and multiple-input multiple-output(MCMM-OAM-MIMO)system in the line-ofsight(LoS)channel,in which two transceiver architectures implemented by radio frequency(RF)analog synthesis and baseband digital synthesis are *** distance and angle of arrival(AoA)estimation are utilized for channel estimation and signal detection,whose training overhead is much less than that of traditional MIMO *** results validate that the UCCA-based MCMM-OAM-MIMO system is superior to conventional MIMOOFDM system in the EE and SE performances.

关键词： orbital angular momentum(OAM) uniform concentric circle array(UCCA) spectral efficiency(SE) energy efficiency(EE)

Study of cytoskeleton from microscopic point of view:Our experience

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BIOCELL 2022年第4期46卷 881-884页

作者： CINZIA SIGNORINI GIULIA COLLODEL ELENA moretti Department of Molecular and Developmental Medicine of University of Siena SienaI-53100Italy

The manuscript deals with our studies and experiences in the assessment of cytoskeleton in different cellular models and *** immunofluorescent study of several cytoskeletal proteins was relevant in the evaluation of a therapy for osteoarthritis,in case of alkaptonuria and in testing the efficacy of docetaxel in neuroblastoma cancer cells leading to apoptosis.A relevant part of our experience focus on the study of cytoskeleton in seminiferous epithelium and spermatozoa,identifying alterations affecting blood-testis barrier after a silver nanoparticle treatment,chromosomal segregation in case of varicocele,sperm motility and diagnosing systematic sperm defects as“Primary ciliary dyskinesia”and“Dysplasia of the fibrous sheath”.The evaluation of cytoskeleton represents a specific and sensitive analysis in establishing the health status of different cells.

关键词： cytoskeleton Environment Immunocytochemistry Pathological condition