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Matrin-3 dysfunction in myopathy and motor neuron degeneration

Neural Regeneration Research 2022年第3期17卷 575-576页

作者： Caroline Ward udai bhan pandey Department of Pediatrics Division of Child NeurologyChildren’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA Department of Human Genetics School of Public HealthSchool of Public HealthUniversity of Pittsburgh Center for Neuroscience Institute Children’s Hospital of PittsburghUniversity of Pittsburgh Medical CenterPittsburghPAUSA

The MATR3 protein was first identified comprising the nuclear matrix,an essential part of preserving the skeletal framework of the nucleus,amongst other nuclear *** mainly of intrinsically disordered regions,the prote... 详细信息

关键词： domains. preserving disordered

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Atypical Olfactory Neuroblastoma Presenting as Sinonasal Polyposis with Nasopharyngeal Extension: A Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第5期4卷 394-400页

作者： Jagdish Prasad Purohit Chandra bhan Bhoopendra Singh Ajay Pratap Singh Siva Selvaraj Manish pandey Vijay Krishna Sharma Department of ENT Head and Neck Surgery MLB Medical College Jhansi India

Background: Olfactory neuroblastoma also known as Esthesioneuroblastoma (ENB) is a tumor arising from the basal layer of olfactory epithelium in the superior recess of the nasal cavity in the region of cribriform plate. Incidence peaks once in 11 - 20 years of age and again in 50 - 60 years of age. It is equally found in men and women. Aim: The main aim of this case report is to characterize the clinical features of ENB showing nasopharyngeal involvement and its importance in the differential diagnosis of sinonasal neuroendocrine malignancies. Case presentation: Two cases are reported. The first case was a 21-year-old male with symptoms of nasal obstruction, recurrent epistaxis, nasal discharge, headache and paresthesia over the face with an evolution of 1 year with no previous history of trauma. Diagnostic nasal endoscopy revealed reddish gray mass filling bilateral nasal cavities. Posterior rhinoscopy revealed mass coming through choanae and filling the nasopharynx. Endoscopic resection of tumor was done and postoperatively all the symptoms of the patient resolved. The second case was a 62-year-old male with complaints of nasal obstruction, nasal discharge, recurrent epistaxis, anosmia and difficulty in swallowing. On computed tomography, anteriorly, the mass was extending up to external nares and posteriorly up to the nasopharynx, superiorly up to nasal roof and inferiorly up to hard palate. No obvious erosion of floor of anterior cranial fossa was seen. No intracranial extension was seen. Surgery was advised but patient refused to undergo any treatment. Conclusion: This study highlights the characteristics and clinical features of ENB showing nasopharyngeal involvement and their importance in the differential diagnosis of sinonasal neuroendocrine malignancies.

关键词： Esthesioneuroblastoma Cribriform Plate Neuroectodermal

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Tumour Associated Tissue Eosinophilia as a Prognostic Indicator in Squamous Cell Carcinoma of Upper Aerodigestive Tract

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International Journal of Otolaryngology and Head & Neck Surgery 2016年第2期5卷 54-58页

作者： Chandra bhan Kartikeya Purohit Jagdish Prasad Purohit Ajay Pratap Singh Bhoopendra Singh Siva Selvaraj Manish pandey Vineet Kumar Vineet Kumar Department of ENT Head and Neck Surgery MLB Medical College Jhansi India

Immune response is known to develop against malignant tumours. Malignant tumours express newer antigen on their cell surface membrane which elicit immunological reaction in and around tumoural tissue. In early part of immune reaction neutrophil, eosinophil migrates followed by monocyte-macrophage cell. Tumor associated tissue eosinophilia (TATE) is believed to play a significant role in the biological behavior of the carcinoma. Eosinophil infiltrate in association with the head and neck squamous cell carcinoma (SCC) have been reviewed from time-to-time. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of this study was to investigate and evaluate the possible role of the tumour associated tissue eosinophilia (TATE) as a predictive indicator for the grading and establishing prognosis of the upper aerodigestive tract squamous cell carcinoma (SCC).

关键词： Tumour Associated Tissue Eosinophilia (TATE) Squamous Cell Carcinoma (SCC)

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