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Molecular Assessment of Non-Muscle Invasive and Muscle Invasive Bladder Tumors: Mapping of Putative Urothelial Stem Cells and Toll-Like Receptors (TLR) Signaling

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Journal of Cancer Therapy 2015年第2期6卷 129-140页

作者： Rafael Mamprin Stopiglia Wagner Eduardo Matheus Patrick Vianna Garcia Athanase Billis Mariana Anteghini Castilho Vitor Hugo Figueiredo de Jesus ubirajara ferreira Wagner José Fávaro Department of Urology School of Medicine University of Campinas-UNICAMP Sao Paulo Brazil Laboratory of Urogenital Carcinogenesis and Immunotherapy Institute of Biology University of Campinas-UNICAMP Sao Paulo Brazil Department of Pathology School of Medicine University of Campinas-UNICAMP Sao Paulo Brazil Botucatu School of Medicine Universidade Estadual Paulista-UNESP Botucatu Brazil

Purpose: The main objectives of this study were to characterize and compare the urothelial stem cells (healthy and cancer cells) and TLRs features in the urinary bladder of men without lesionsand with non-muscle-invasive and muscle invasive urothelial tumors. Materials and Methods: Thirty samples of the urinary bladder of 50 to 80-year-old men, with and without diagnosis of malignant urothelial lesions were used. The 30 samples were divided into 3 groups (n = 10 per group): Normal Group;Non-Muscle Invasive Bladder Cancer Group;Muscle Invasive Bladder Cancer Group. The samples were histopathologically and immunohistochemically analyzed. The study was conducted at teaching Hospital of the University of Campinas (UNICAMP). Results: The CD44 and CD133 immunoreactivities were significantly intense in the muscle-invasive cancer group when compared to the other groups. The ABCG2 biomarker demonstrated intense immunoreactivities in both non-muscle and muscle invasive groups, and absent immunoreactivity in the normal group. All groups showed weak CD117 immunoreactivity. Putative Healthy Stem Cells (CD44/CD133/ CD117+) occurred in all groups. Putative Cancer Stem Cells (CD44/CD133/ABCG2+) only occurred in the non-muscle and muscle invasive cancer groups. TLR2 immunoreactivity was significantly lower in the non-muscle invasive cancer group and absent in the muscle invasive cancer group. TLR4 immunoreactivity was significantly lower in both cancer groups. Conclusions: This study leads us to the conclusion that putative cancer stem cell occurrence was sensitive to the decreased in TLR2 and TLR4 immunoreactivities. Also, TLR2 and TLR4 demonstrated their involvement in the regulation of the different biomarkers for putative healthy and cancer urothelial stem cells, probably acting as negative regulators of urothelial carcinogenesis. Taken together data obtained suggest that use of TLRs agonists could be a promising alternative for the treatment of non-muscle and muscle invasive bl

关键词： Non-Muscle Invasive Bladder Cancer Muscle Invasive Bladder Cancer Toll-Like Receptors Cancer Stem Cell Stem Cells Biomarkers

Organic Vegetables Quality Arising from the Brazilian Family-Run Farm

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Food and Nutrition Sciences 2014年第15期5卷 1538-1544页

作者： Thadia Turon Costa da Silva Verona Borges ferreira Silvia Magalhaes Couto Armando ubirajara Oliveira Sabaa Srur Department of Food Technology Federal Rural University of Rio de JaneiroRio de JaneiroBrazil Nutrition Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Research Group in Fruits and Vegetables Processing CNPqUFRJRio de JaneiroBrazil

The present study has its aim to evaluate the different dimensions of organic vegetables quality from the Brazilian family-run farm, especially the evaluation of composition, antioxidant activity, microbiological characteristics and pesticide residues. There were evaluated carrot, broccoli, kale and white cabbage grown by organic farmers in the highlander region of Rio de Janeiro state. There were determined humidity, lipids grade, total protein content, mineral residues (ashes), soluble and insoluble fibers, soluble solids, total acidity, pH, and pesticide residues. The antioxidant activity was determined using DPPH (2, 2-diphenyl-1-picrylhydrazyl) free radical removal. Among the analyzed vegetables, the effectiveness of the antioxidant capacity was obtained, in decreasing order, by broccoli, kale, white cabbage and carrot. According to the microbiological parameter, evaluated vegetables have shown satisfactory sanitary quality. Pesticide residues were not found above the detection limit for both authorized and unauthorized analyzed crops.

关键词： Organic Food Vegetables Pesticide Antioxidant Capacity Food Composition

Total Phenolic Compounds and Antioxidant Activity of Organic Vegetables Consumed in Brazil

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Food and Nutrition Sciences 2015年第9期6卷 798-804页

作者： Verona Borges ferreira Thadia Turon Costa da Silva Silvia Regina Magalhaes Couto Armando ubirajara Oliveira Sabaa Srur Centro de Ciencias da Saude Instituto de Nutricao Josue de CastroUniversidade Federal do Rio de JaneiroRio de JaneiroBrasil

Organic olericulture differs from conventional agriculture due to the absence of pesticide, synthetic fertilizers, genetically modified organisms, some food additives and ionizing radiation, producing vegetables with a different chemical composition and with different amounts of bioactive compounds. The objective of this study was to quantify, in organic vegetables consumed in Brazil, the amount of total phenolic compounds using Folin-Ciocalteu reagent and the antioxidant activity through DPPH method. Among the analyzed vegetables, the effectiveness in the antioxidant capacity was obtained in decreasing order, by the broccoli (69.35), kale (63.20), cabbage (35.72) and carrot (20.39), expressed in % of DPPH consumption after 30 minutes of reaction. The amount of total phenolic compounds (mg GAE/ml of fluid extract-FE) present in the kale (0.606), broccoli (0.511), cabbage (0.214) and carrots (0.124) demonstrates a positive correlation between phenolic amounts and the antioxidant activity of the vegetables analyzed.

关键词： Organic Food Bioactive Compounds Vegetables Antioxidant DPPH

ENERGY ESTIMATES FOR DELAY DIFFUSION-REACTION EQUATIONS

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Journal of Computational Mathematics 2008年第4期26卷 536-553页

作者： J.A.ferreira P.M.daSilva CMUC-Departamento Departamento

In this paper we consider nonlinear delay diffusion-reaction equations with initial and Dirichlet boundary conditions. The behaviour and the stability of the solution of such initial boundary value problems （IBVPs） are studied using the energy method. Simple numerical methods are considered for the computation of numerical approximations to the solution of the nonlinear IBVPs. Using the discrete energy method we study the stability and convergence of the numerical approximations. Numerical experiments are carried out to illustrate our theoretical results.

关键词： Delay diffusion reaction equation Energy method Stability Convergence.

A Rapid Parameter of Enzyme-Treated Cellulosic Material Revealed by Reducing Sugar Release

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Journal of Renewable Materials 2024年第3期12卷 539-551页

作者： Verônica Távilla ferreira Silva Adriane Maria ferreira Milagres Departamento de Biotecnologia Escola de Engenharia de LorenaUniversidade de São PauloLorenaSP12602-810Brazil

This study was conducted to evaluate the effectiveness of enzymes in purifying and reducing the degree of polymerization of cellulose for the production of dissolving *** goal was to determine the contributions of xylanase(X)and endoglucanase(EG)in the treatment of pulp,specifically by quantifying the formation of soluble and insoluble reducing sugars using the dinitrosalycilic acid(DNS)***,the release of soluble reducing sugars(RSSol)was enhanced after xylanase treatment,while endoglucanase(EG)treatment led to changes in insoluble reducing sugars(RSIns).The maximum synergism was observed for RSIns when a high ratio of endoglucanase to xylanase(320EG:5X/g pulp)was *** relative contribution of endoglucanase to RSins was determined to be 15.6%of the total reducing *** viscosity of pulps treated with xylanase decreased only by 7%,whereas endoglucanase treatment significantly reduced viscosity by 45%.Modifications in the particle size were observed after pulp treatment with the combination of endoglucanase and *** summary,the DNS test is a rapid and effective method for evaluating the efficiency of enzyme treatments on *** measurement of RSIns correlates with changes in pulp viscosity to different extents,providing valuable insights into the effectiveness of enzyme treatments.

关键词： Endoglucanase xylanase cellulose fiber pulp synergism

Analysis of the impact of large scale seismic retrofitting strategies through the application of a vulnerability-based approach on traditional masonry buildings

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Earthquake Engineering and Engineering Vibration 2017年第2期16卷 329-348页

作者： Tiago Miguel ferreira Rui Maio Romeu Vicente ISISE Department of Civil EngineeringUniversity of MinhoCampus de Azurém RISCO Department of Civil EngineeringUniversity of AveiroCampus Universitário de Santiago

The buildings＇ capacity to maintain minimum structural safety levels during natural disasters, such as earthquakes, is recognisably one of the aspects that most influence urban resilience. Moreover, the public investment in risk mitigation strategies is fimdamental, not only to promote social and urban and resilience, but also to limit consequent material, human and environmental losses. Despite the growing awareness of this issue, there is still a vast number of traditional masonry buildings spread throughout many European old city centres that lacks of adequate seismic resistance, requiring therefore urgent retrofitting interventions in order to both reduce their seismic vulnerability and to cope with the increased seismic requirements of recent code standards. Thus, this paper aims at contributing to mitigate the social and economic impacts of earthquake damage scenarios through the development of vulnerability-based comparative analysis of some of the most popularretrofitting techniques applied after the 1998 Azores earthquake. The influence of each technique individually and globally studied resorting to a seismic vulnerability index methodology integrated into a GIS tool and damage and loss scenarios are constructed and critically discussed. Finally, the economic balance resulting from the implementation of that techniques are also examined.

关键词： urban resilience masonry buildings retrofitting strategies vulnerability-based approach loss estimation

The role of culture for coastal disaster risk reduction measures:Empirical evidence from northern and southern Europe

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Advances in Climate Change Research 2020年第4期11卷 297-309页

作者： Grit MARTINEZ Susana COSTAS Oscar ferreira Ecologic Institute Berlin10717Germany Centro de Investigacao Marinha e Ambiental(CIMA) Universidade do AlgarveFaro8005-139Portugal Centro de Investigacao Marinha e Ambiental(CIMA) Faculty of Sciences and TechnologyUniversidade do AlgarveFaro8005-139Portugal

Recent and historic high-impact events have demonstrated significant flood risks to many coastal areas in Europe and across the *** the behavior of humans in relation to risk management poses grand challenges for both natural and social sciences and *** study analyzes the cultural aspects of coastal risk management and illustrates path-dependencies of concrete disaster risk reduction measures in relation to local contexts in European coastal regions in Northern and South Western *** adopts a comparative approach by targeting risk perception and risk management related to coastal floods and erosion,induced by storms and sea level rise,in two contrasting coastal areas:German coastal state SchleswigeHolstein at the Baltic Sea(especially the communities Eckernf€orde and Timmendorfer Strand)and the Portuguese barrier island system of Ria Formosa(especially the community of Faro Beach).Both regions are very low lying with only a few meters above sea level and exposed to similar hazards such as erosion and floods induced by coastal storms,and while they are both attractive touristic destinations,they are culturally,socio-economically and politically very *** geographical and the socio-cultural contexts of the case study regions are assessed first using an explorative approach,followed by an analysis of the relevance of cultural aspects for the implementation of disaster risk reduction *** study addresses both first responders(city authorities,citizens)and *** is found that the choice of risk reduction measures hinges on the values underlying people's perspectives about the desired outcomes of specific measures and that the role of identity and meaning making are still undervalued in decision making *** concludes that subjective capacities formed by cultural identities,knowledge,trust coupled with a variety of factors of socio-economic and political texture are important to understand local decision making

关键词： Culture Values Knowledge Risk perception Disaster risk reduction measures Coastal zones Baltic Sea Atlantic

Communicating with the non-dominant hemisphere:Implications for neurological rehabilitation

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Neural Regeneration Research 2013年第13期8卷 1236-1246页

作者： Fabricio ferreira de Oliveira Sheilla de Medeiros Correia Marin Paulo Henrique ferreira Bertolucci Department of Neurology and Neurosurgery Escola Paulista de Medicina Federal University of So Paulo (UNIFESP) So Paulo SP

Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. Despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language tasks are undertaken. Mechanisms of language recovery after brain injury to the dominant hemisphere seem to be relatively stereotyped, including activations of perilesional areas in the acute phase and of homologues of language areas in the non-dominant hemisphere in the subacute phase, later returning to dominant hemisphere activation in the chronic phase. Plasticity mechanisms reopen the critical period of language development, more specifically in what leads to disinhibition of the non-dominant hemisphere when brain lesions affect the dominant hemisphere. The non-dominant hemisphere plays an important role during recovery from aphasia, but currently available rehabilitation therapies have shown limited results for efficient language improvement. Large-scale randomized controlled trials that evaluate well-defined interventions in patients with aphasia are needed for stimulation of neuroplasticity mechanisms that enhance the role of the non-dominant hemisphere for language recovery. Ineffective treatment approaches should be replaced by more promising ones and the latter should be evaluated for proper application. The data generated by such studies could substantiate evidence-based rehabilitation strategies for patients with aphasia.

关键词： neural regeneration reviews linguistics aphasia language speech non-dominant hemisphere disability evaluation prognosis cerebrum function grants-supported paper neuroregeneration

Evidence-based Practice of Chinese Medicine in Physical Rehabilitation Science

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Chinese Journal of Integrative Medicine 2013年第10期19卷 723-729页

作者： Arthur de Sá ferreira Laboratory of Computational Simulation and Modeling in Rehabilitation Program of Rehabilitation ScienceCentro Universitario Augusto MottaRio de JaneiroRJBrazil(21041-021) Department of Physical Therapy UniversidadeSalgado de OliveiraNiteróiRJBrazil(21041-021)

Chinese medicine is among other traditional medical systems practiced either as a coadjutant intervention to Greek medicine or as the unique therapeutic intervention for illness prevention, treatment or rehabilitation. The complete spectrum from that traditional system includes acupuncture and moxibustion, herbal and food therapy, massage therapy （tuina）, physical exercises （taijiquan）, and breathing exercises （qigong）. In this article, it is presented several randomized controlled trials and systematic reviews on the application of all therapeutic modalities from Chinese medicine in the physical rehabilitation scenario. The discussed studies encompasses both ＂positive＂ and ＂negative＂ results of Chinese medicine intervention for disabilities due to illnesses of the nervous, musculoskeletal or cardiovascular systems. Additionally, the importance of the personalized approach for Chinese medicineand rehabilitation is emphasized together with the need for reproducible methods for pattern differentiation and intervention selection. Chinese medicine resources are recognized as promising methods for therapeutic rehabilitation and can be incorporated into the rehabilitation science. The wide variety of therapeutic resources explains why Chinese medicine is currently a multidisciplinary practice for health protection and promotion, early diagnosis and treatment as well as rehabilitation with roles in the public health care system.

关键词： rehabilitation physical therapy Chinese medicine