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Neural Regeneration Research 2015年第2期10卷 213-218页

作者： Ilaria Dal Prà Anna Chiarini ubaldo armato Histology & Embryology Section Department of Life & Reproduction Sciences University of Verona Medical School

Astrocytes＇ roles in late-onset Alzheimer＇s disease （LOAD） promotion are important, since they survive soluble or fibrillar amyloid-β peptides （Aβs） neurotoxic effects, undergo alterations of intracellular and intercellular Ca2＋ signaling and gliotransmitters release via the Aβ/a7-nAChR （αT-nicotinic acetylcholine receptor） signaling, and overproduce/oversecrete newly synthesized Aβ42 oligomers, NO, and VEGF-A via the Aβ/CaSR （calcium-sensing receptor） signaling. Recently, it was suggested that the NMDAR （N-methyl-D-aspartate receptor） inhibitor nitromemantine would block the synapse-destroying effects of Aβ/α7-nAChR signaling. Yet, this and the progressive extracellular accrual and spreading of Aβ42 oligomers would be stopped well upstream by NPS 2143, an allosteric CaSR antagonist （calcilytic）.

关键词： Alzheimer's disease amyloid-β astrocytes Ca2+ calcilytic calcium-sensing receptor nitromemantine NPS 2143 aT-nicotinic acetylcholine receptor

Exosomes of adult human fibroblasts cultured on 3D silk fibroin nonwovens intensely stimulate neoangiogenesis

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Burns & Trauma 2021年第1期9卷 488-506页

作者： Peng Hu Anna Chiarini Jun Wu Giuliano Freddi Kaiyu Nie ubaldo armato Ilaria Dal Prà Human Histology&Embryology Section Department of SurgeryDentistryPaediatrics&GynaecologyUniversity of Verona Medical SchoolStrada Le Grazie 8I-37134VeronaVenetiaItaly Department of Burns&Plastic Surgery The Affiliated Hospital of ZunYi Medical University149 Dalian RoadZunYi City563003 Guizhou ProvinceChina Department of Burns and Plastic Surgery Second People’s HospitalUniversity of Shenzhen3002 Sungang West RoadFutian DistrictShenzhen518000Guangdong ProvinceChina Silk Biomaterials S.r.l. Via Cavour 2I-22074LomazzoLombardyItaly

Background:Bombyx mori silk fibroin is a biomacromolecule that allows the assembly of scaffolds for tissue engineering and regeneration purposes due to its cellular adhesiveness,high biocompatibility and low *** work showed that two types of 3D silk fibroin nonwovens(3D-SFnws)implanted into mouse subcutaneous tissue were promptly vascularized via undefined molecular *** present study used nontumorigenic adult human dermal fibroblasts(HDFs)adhering to a third type of 3D-SFnws to assess whether HDFs release exosomes whose contents promote ***:Electron microscopy imaging and physical tests defined the features of the novel carded/hydroentangled *** were cultured on 3D-SFnws and polystyrene plates in an exosome-depleted *** amounts and D-glucose consumption revealed the growth and metabolic activities of HDFs on ***9-expressing total exosome fractions were from conditioned media of 3D-SFnws and 2D polystyrene plates HDF *** growth factors(AGFs)in equal amounts of the two groups of exosomal proteins were analysed via doubleantibody arrays.A tube formation assay using human dermal microvascular endothelial cells(HDMVECs)was used to evaluate the exosomes’angiogenic ***:The novel features of the 3D-SFnws met the biomechanical requirements typical of human soft *** experimental day 15,3D-SFnws-adhering HDFs had increased 4.5-fold in numbers and metabolized 5.4-fold more D-glucose than at day 3 in *** to polystyrene-stuck HDFs,exosomes from 3D-SFnws-adhering HDFs carried significantly higher amounts of AGFs,such as interleukin(IL)-1α,IL-4 and IL-8;angiopoietin-1 and angiopoietin-2;angiopoietin-1 receptor(or Tie-2);growth-regulated oncogene(GRO)-α,GRO-βand GRO-γ;matrix metalloproteinase-1;tissue inhibitor metalloproteinase-1;and urokinase-type plasminogen activator surface receptor,but lesser amounts of anti-angiogenic tissue inhibitor metalloproteinase-2 and

关键词： Silk fibroin Nonwovens Dermis Fibroblast Human endothelial cell Exosome Cytokine Chemokine Angiogenesis Regeneration Tissue engineering

Mesenchymal stromal cells-exosomes:a promising cell-free therapeutic tool for wound healing and cutaneous regeneration

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Burns & Trauma 2019年第1期7卷 346-355页

作者： Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang ubaldo armato Ilaria Dal Prà Anna Chiarini Department of Burns&Plastic Surgery The Affiliated Hospital of ZunYi Medical UniversityDalian Road 149ZunYi City 563000Gui Zhou ProvinceChina Human Histology and Embryology Unit University of Verona Medical SchoolStrada Le Grazie 837134 VeronaItaly

Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types,growth factors,extracellular matrix(ECM),nerves,and blood *** stromal cells(MSCs)take part in all the skin wound healing stages playing active and beneficial roles in animal models and ***,which are among the key products MSCs release,mimic the effects of parental *** can shuttle various effector proteins,messenger RNA(mRNA)and microRNAs(miRNAs)to modulate the activity of recipient cells,playing important roles in wound ***,using exosomes avoids many risks associated with cell ***,as a novel type of cell-free therapy,MSC-exosome-mediated administration may be safer and more efficient than whole *** this review,we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous *** addition,we address the hypothesis of MSCs microenvironment extracellular vesicles(MSCs-MEVs)or MSCs microenvironment exosomes(MSCs-MExos)that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic *** review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration.

关键词： Cutaneous regeneration Mesenchymal stromal cell Exosomes Wound healing Microenvironment

A novel method for objectively, rapidly and accurately evaluating burn depth via near infrared spectroscopy

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Burns & Trauma 2021年第1期9卷 393-400页

作者： Meifang Yin Yongming Li Yongquan Luo Mingzhou Yuan ubaldo armato Ilaria Dal Prà Lijun Zhang Dayong Zhang Yating Wei Guang Yang Lixian Huang Pin Wang Jun Wu Department of Burn and Plastic Surgery Institute Translational MedicineThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen 518035China School of Microelectronics and Communication Engineering Chongqing UniversityChongqing 400044China Institute of Fluid Physics China Academy of Engineering PhysicsMianyangSichuan 621900China Department of Burn Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Human Histology&Embryology Section Department of SurgeryDentistryPediatrics&GynecologyUniversity of Verona Medical SchoolStrada Le Grazie 8Verona 37134Italy

The accurate and objective evaluation of burn depth is a significant challenge in burn wound ***,we used near infrared spectroscopy(NIRS)technology to measure the different depth of thermal burns in ex vivo porcine *** on the intensity of the spectral signals and the diffuse reflection theory,we extracted the optical parameters involved in functional(total hemoglobin andwater content)and structural(tissue scattered size and scattered particles)features that reflect the changes in burn ***,we applied support vector regression to construct a model including the optical property parameters and the burn ***,we histologically verified the burn depth data collected via *** results showed that our inversion model could achieve an average relative error of about 7.63%,while the NIRS technology diagnostic accuracy was in the range of 50μ*** the first time,this novel technique provides physicians with real-time burn depth information objectively and accurately.

关键词： Burn depth Near infrared spectroscopy Support vector regression

Social Balances in the Design Space

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Journal of Civil Engineering and Architecture 2021年第3期15卷 167-173页

作者： Francesco armato Stefano Follesa Universitàdegli Studi di Firenze Firenze FI 50121Italy

A socio-territorial balance settles and develops through the diversity of ingredients that participate in new forms of sociality:new ways of living and expressing everyday life:new technologies conceived with alternative mobilities,new systems of aggregation and shared participations,just to make some examples:car-sharing,co-working,social-spaces,...,places of sharing,physical or virtual,social media online,or other places where people meet to satisfy their needs and *** project must have a complete vision,in order to clarify the various scenarios that arise from time to time,continuous interaction between things,people,and space,in order to address and solve problems,such as health,education,poverty,and climate *** local daily principle of sustainability and self-sustainability,each territory must find its identity dimension in its own historical and cultural stratification,a dimension which for Alberto Magnaghi is based on indissociable fundamental principles:cultural,social,economic,geographical and *** new solutions must be less impactful and with greater attention to the social reality:localized,intercultural,flexible,innovative and participatory,only this way it is possible to obtain a strategic design that focuses on an integrated whole:products,services and communication.

关键词： Smart urban design sharing interaction contamination urban regeneration

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城市福利:城市家具对于城市振兴的重要性

装饰 2019年第7期 17-19页

作者： (意)弗朗西斯科·艾尔玛多 (意)露切塔·佩特莉妮方蓉(译) 楼毅俊(译) 佛罗伦萨大学建筑学院佛罗伦萨艺术设计研究院

城市是一个能源、创造力、创新力综合体现的容器。在这样的一个大环境下,设计是一个从多元角度对近代城市进行描绘和理解的学科,并为城市公共空间项目做出了重大的贡献。人行道和街道之间的夹缝空间可以成为安装定制工业设计产品的场所... 详细信息

城市是一个能源、创造力、创新力综合体现的容器。在这样的一个大环境下,设计是一个从多元角度对近代城市进行描绘和理解的学科,并为城市公共空间项目做出了重大的贡献。人行道和街道之间的夹缝空间可以成为安装定制工业设计产品的场所,这是一项对于改善人类生活方式的良好实践:打造一个随处可以相遇并分享的空间。

关键词：城市规划户外设计城市家具分享聚合认同性

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骨抑制像胸片提高局灶性肺炎的检出率

国际医学放射学杂志 2013年第1期 97-98页

作者： F.LiH.MacMahon R.EngelmannH.MacMahon L.PesceH.MacMahon S.G.armato IIIH.MacMahon H.MacMahon 程悦 Department of Radiology MC-2026The University of Chicago5841 S.Maryland AvenueChicagoIL 60637USA

目的评价放射医师仅用常规胸片与联合使用常规胸片和骨抑制像胸片对于检出局灶性肺炎的能力。方法本观察研究包括36例病人的常规胸片,共有肺炎所致的46个局灶性斑片影(10例为双侧斑片),还有20张没有局灶性斑片的胸片。采用骨抑制图像处... 详细信息

目的评价放射医师仅用常规胸片与联合使用常规胸片和骨抑制像胸片对于检出局灶性肺炎的能力。方法本观察研究包括36例病人的常规胸片,共有肺炎所致的46个局灶性斑片影(10例为双侧斑片),还有20张没有局灶性斑片的胸片。采用骨抑制图像处理系统对56张胸片进行后处理,生成骨抑制影像。共有8位放射医师,6位主治医师,2位住院医师,先对常规胸片阅片,然后再增加骨抑制像,分别对每侧肺内是否存在肺炎所致的局灶性斑片进行评价。采用ROC曲线分析评价各观察者的诊断。结果对于这46侧阳性肺和66侧阴性肺,8位医师的ROC曲线下面积的平均值从仅用常规胸片的0.844提高到常规胸片联合骨抑制像的0.880(P<0.001)。结论使用骨抑制像可以提高放射医师在胸片中检出局灶性肺炎的能力。

关键词：局灶性肺炎检出胸片放射医师