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Peroxisome proliferator-activated receptors for hypertension

World Journal of Cardiology 2014年第8期6卷 744-754页

作者： Daisuke usuda Tsugiyasu Kanda Department of Community Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan

Peroxisome proliferator-activated receptors(PPARs) are ligand-activated transcription factors belonging to the nuclear receptor superfamily, which is composed of four members encoded by distinct genes(α, β, γ, and δ). The genes undergo transactivation or transrepression under specific mechanisms that lead to the induction or repression of target gene expression. As is the case with other nuclear receptors, all four PPAR isoforms contain five or six structural regions in four functional domains; namely, A/B, C, D, and E/F. PPARs have many functions, particularly functions involving control of vascular tone, inflammation, and energy homeostasis, and are, therefore, important targets for hypertension, obesity, obesity-induced inflammation, and metabolic syndrome in general. Hence, PPARs also represent drug targets, and PPARα and PPARγ agonists are used clinically in the treatment of dyslipidemia and type 2 diabetes mellitus, respectively. Because of their pleiotropic effects, they have been identified as active in a number of diseases and are targets for the development of a broad range of therapies for a variety of diseases. It is likely that the range of PPARγ agonist therapeutic actions will result in novel approaches to lifestyle and other diseases. The combination of PPARs with reagents or with other cardiovascular drugs, such as diuretics and angiotensin Ⅱ receptor blockers, should be *** article provides a review of PPAR isoform characteristics, a discussion of progress in our understanding of the biological actions of PPARs, and a summary of PPAR agonist development for patient management. We also include a summary of the experimental and clinical evidence obtained from animal studies and clinical trials conducted to evaluate the usefulness and effectiveness of PPAR agonists in the treatment of lifestyle-related diseases.

关键词： Peroxisome proliferator-activated receptors Nuclear receptor Isoform mRNA Blood pressure Hypertension Obesity Angiotensin Ⅱ receptor blocker Diabetes mellitus

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软件工程中的问题及前景

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计算机工程与应用 1986年第1期 13-28页

作者： C.V.Ramamoorthy,Atul Prakash,Wei-Tek Tsai,Yutaka usuda,刘景 Trans.on software Engineering Trans.on software Engineering Trans.on software Engineering Trans.on software Engineering 主编 UC教授博士 IEEE 主编 UC教授博士 IEEE 主编 UC教授博士 IEEE 主编 UC教授博士 IEEE

随着软件应用问题越来越复杂,软件工程必将获得发展。规范语言(Specificationlanguages)、快速放样(rapid prototyping),复杂性度量(complexity metrics)和维护技术(maintenance techniques)将是其最重要的成果。

关键词：软件设计规范软件工程代价估计可靠性增长模型可执行规范程序员维护代价软件生存期

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Hepatocellular carcinoma, with portal thrombus after viral eradication, disappeared by 5-fluorouracil and interferon

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World Journal of Hepatology 2010年第11期2卷 416-418页

作者： Tomofumi Miura Nobuaki Suzuki Junichiro Nakamura Satoshi Yamada Tsutomu Miura Masahiko Yanagi Hiroyuki usuda Iwao Emura Toru Takahashi Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital Division of Medical Technology Nagaoka Red Cross Hospital Division of Pathology Nagaoka Red Cross Hospital

Hepatocarcinogenesis after a sustained virological response (SVR) in type C chronic hepatitis and cirrhosis is an important issue in endemic areas; hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) therapy is especially very hard. We herein report a first case in which combination therapy with interferon-α and continuous intra-arterial infusion of 5-fluorouracil (designated as FAIT) provided a complete response in HCC with PVTT after SVR. Therefore, we think that FAIT is a good option to treat HCC with or without PVTT, even after SVR.

关键词： Hepatocellular carcinoma Portal vein tumor thrombus Sustained virological response 5-Fluorouracil intra-arterial infusion

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汉语音韵研究在日本(2011-2012年)

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语言历史论丛 2015年第1期 68-81页

作者：臼田真佐子日本爱知大学文学部

日本中国学会报》是由日本中国学会主办的学术刊物,除了会员的论文之外,还登载学界动态《学界展望》。国内的大学教师轮着担任撰写《学界展望》(中国哲学、中国文学和中国语言学),《学界展望·语言学》2011-2012年(载《日本中国学会报》... 详细信息

日本中国学会报》是由日本中国学会主办的学术刊物,除了会员的论文之外,还登载学界动态《学界展望》。国内的大学教师轮着担任撰写《学界展望》(中国哲学、中国文学和中国语言学),《学界展望·语言学》2011-2012年(载《日本中国学会报》64-65,2012-2013年)由我校的教师和毕业生等执笔(1)。日本学者把中国学者所说的中国语言学叫做“中国语学”,“中国语学”包括语法、音韵、文字、方言和汉语教学等。本人写了2011-2012年音韵、文字和训诂方面的学界动态。本文内容以音韵为主,把本人写的日文翻译成中文(1)。另外,写《学界展望》的时候,发现了几个问题,其中一个是近代音的分期划分。关于这些问题,在日本中国语学会关西地区例会(2013年12月8日)已经讨论了(2)。

关键词：音韵学界动态 2011-2012年

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Impact of lipoprotein lipase gene polymorphisms on ulcerative colitis

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World Journal of Gastroenterology 2006年第39期12卷 6325-6330页

作者： Toshihito Kosaka Junji Yoshino Kazuo Inui Takao Wakabayashi Kazumu Okushima Takashi Kobayashi Hironao Miyoshi Yuta Nakamura shigekazu Hayashi Taizou Shiraishi Masatoshi Watanabe Takayuki Yamamoto Ai Nakahara Takahiko Katoh Department of Internal Medicine Second Teaching Hospital Fujita Health University School of Medicine 3-6-10 Otobashi Nakagawaku Nagoya 454-8509 Japan Department of Gastroenterology Nagoya Ekisaikai Hospital 4-66 Shounencho Nakagawaku Nagoya 454-8502 Japan Department of Pathologic Oncology Mie University Graduate School of Medicine 2-174 Edobashi Tsu Mie 514-8507 Japan School of Engineering Yokohama National University 79-5 Tokiwadai Hodogaya-ku Yokohama 240-8501 Japan Inflammatory bowel disease centre and department of surgery Yokkaichi Social Insulance Hospital 10-8 Hazuyamacho Yokkaichi Mie Japan Department of Public Health Miyazaki Medical College University of Miyazaki 5200 Kihara Miyazaki 889-1692 Japan

AIM: To examine the influence of lipoprotein lipase (LPL) gene polymorphism in ulcerative colitis (UC) patients. METHODS: Peripheral blood was obtained from 131 pa- tients with UC and 106 healthy controls for DNA extrac- tion. We determined LPL gene polymorphisms affecting the enzyme at Ser447stop, as well as HindⅢ and Pvu Ⅱ polymorphisms using PCR techniques. PCR products were characterized by PCR-RFLP and direct sequencing. Polymorphisms were examined for association with clini- cal features in UC patients. Genotype frequencies for LPL polymorphisms were also compared between UC patients and controls. RESULTS: In patients with onset at age 20 years or younger, C/G and G/G genotypes for Ser447stop poly- morphism were more prevalent than C/C genotype (OR = 3.13, 95% CI = 0.95-10.33). Patients with H+/- or H-/-genotype for HindⅢ polymorphism also were more nu- merous than those with H+/+ genotype (OR = 2.51, 95% CI = 0.85-7.45). In the group with H+/+ genotype for HindⅢ polymorphism, more patients had serum triglyc- eride concentrations over 150 mg/dL than patients with H+/- or H-/- genotype (P < 0.01, OR = 6.46, 95% CI = 1.39-30.12). Hypertriglycemia was also more prevalent in patients with P+/+ genotypes for PvuⅡ polymorphism (P < 0.05, OR = 3.0, 95% CI = 1.06-8.50). Genotype fre- quency for LPL polymorphism did not differ significantly between UC patients and controls. CONCLUSION: Ser447stop and HindⅢ LPL polymor- phisms may influence age of onset of UC, while HindⅢ and PvuⅡ polymorphisms influence serum triglyceride in UC patients.

关键词：脂蛋白肠溃疡基因多态性病理

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Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs

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World Journal of Gastroenterology 2005年第44期11卷 6954-6959页

作者： Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura Satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi Division of Advanced Surgical Science and Technology Department of Surgery

AIM: To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in ***: The right lateral lobe of pigs, i.e. the 25%of the liver, was transplanted orthotopically. The pigs were divided into two groups: graft without portocaval shunt (n = 11) and graft with portocaval shunt (n=11).Survival rate, portal flow, hepatic arterial flow, and histological findings were ***: In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h after transplantation. In the group with portocaval shunt,eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 mL/min/100 g liver tissue,respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 mL/min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively (P＜0.01). As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed after reperfusion, but these findings were not recognized in the group with portocaval ***: These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury.

关键词：白内障肝移植猪动物实验

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通过测量接触网振动探测滑板沟槽型磨耗的方法

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国外铁道车辆 2014年第2期51卷 19-24页

作者： Takayuki usuda 孙利苹杨君张娟歌陈秀芳徐世木

某些因素如接触线和受电弓滑板之间的打火会导致滑板产生磨耗。一旦产生局部磨耗,则很可能形成沟槽型磨耗。为防止此类事故的发生,介绍了新开发的一种通过测量接触线的振动探测滑板沟槽型磨耗的方法,并给出了相应的试验结果。

关键词：受电弓滑板磨耗日本

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SGF29 and Sry pathway in hepatocarcinogenesis

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World Journal of Biological Chemistry 2015年第3期6卷 139-147页

作者： Nobuya Kurabe shigekazu Murakami Fumio Tashiro Department of Tumor Pathology Hamamatsu University School of Medicine Department of Biological Science and Technology Faculty of Industrial Science and Technology Tokyo University of Science

Deregulated c-Myc expression is a hallmark of many human cancers. We have recently identified a role of mammalian homolog of yeast SPT-ADA-GCN5-acetyltransferas(SAGA) complex component, SAGAassociated factor 29(SGF29), in regulating the c-Myc overexpression. Here, we discuss the molecular nature of SFG29 in SPT3-TAF9-GCN5-acetyltransferase complex, a counterpart of yeast SAGA complex, and the mechanism through which the elevated SGF29 expression contribute to oncogenic potential of c-Myc in hepatocellularcarcinoma(HCC). We propose that the upstream regulation of SGF29 elicited by sexdetermining region Y(Sry) is also augmented in HCC. We hypothesize that c-Myc elevation driven by the deregulated Sry and SGF29 pathway is implicated in the male specific acquisition of human HCCs.

关键词： c-Myc SPT3-TAF9-GCN5-acetyltransferase complex SGF29 Sry Hepatocarcinogenesis

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食用香甜味沙拉酱对β胡萝卜素吸收的影响

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食品科学 2015年第3期36卷 188-192页

作者：李超超增田泰伸木村守臼田美香王唯徐文斌奚印慈上海海洋大学食品学院上海201306 日本丘比株式会社东京1820002

目的:通过动物实验、体外实验确认食用香甜味沙拉酱对β-胡萝卜素吸收的影响效果。方法:采用高效液相色谱(high performance liquid chromatography,HPLC)技术进行β-胡萝卜素定量分析;参考93号饲料(AIN-93)配方,分组连续喂养大鼠12 d,... 详细信息

目的:通过动物实验、体外实验确认食用香甜味沙拉酱对β-胡萝卜素吸收的影响效果。方法:采用高效液相色谱(high performance liquid chromatography,HPLC)技术进行β-胡萝卜素定量分析;参考93号饲料(AIN-93)配方,分组连续喂养大鼠12 d,测定不同组别大鼠肝脏中β-胡萝卜素的含量;配制人工胃液,分别将磨碎的芒果与香甜味沙拉酱和大豆油混合,模拟胃液蠕动搅拌不同时间,并测定油相中β-胡萝卜素含量;分别给大鼠灌胃等量的β-胡萝卜素以及油量相等的香甜味沙拉酱与大豆油,比较香甜味沙拉酱与大豆油在大鼠胃中停留的时间并测定油相中β-胡萝卜素含量。结果:大鼠肝脏中β-胡萝卜素含量为香甜味沙拉酱组>大豆油组(P大豆油组,搅拌60 min组>搅拌30 min组(P大豆油组(P<0.05),且香甜味沙拉酱在胃中停留的时间更长。结论:食用香甜味沙拉酱比单纯食用大豆油更能够促进β-胡萝卜素的吸收转化;香甜味沙拉酱更能促进富含β-胡萝卜素水果中的β-胡萝卜素的吸收。

关键词：香甜味沙拉酱 β胡萝卜素大豆油高效液相色谱肝脏胃液

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Near-infrared polarimetry of the GG Tauri A binary system

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Research in Astronomy and Astrophysics 2014年第11期14卷 1438-1446页

作者： Yoichi Itoh Yumiko Oasa Tomoyuki Kudo Nobuhiko Kusakabe Jun Hashimoto Lyu Abe Wolfgang Brandner Timothy D.Brandt Joseph C.Carson Sebastian Egner Markus Feldt Carol A.Grady Olivier Guyon Yutaka Hayano Masahiko Hayashi Saeko S.Hayashi Thomas Henning Klaus W.Hodapp Miki Ishii Masanori Iye Markus Janson Ryo Kandori Gillian R.Knapp Masayuki Kuzuhara Jungmi Kwon Taro Matsuo Michael W.McElwain Shoken Miyama Jun-Ichi Morino Amaya Moro-Martin Tetsuo Nishimura Tae-Soo Pyo Eugene Serabyn Takuya Suenaga Hiroshi Suto Ryuji Suzuki Yasuhiro H.Takahashi Naruhisa Takato Hiroshi Terada Christian Thalmann Daigo Tomono Edwin L.Turner Makoto Watanabe John Wisniewski Toru Yamada Satoshi Mayama Thayne Currie Hideki Takami Tomonori usuda Motohide Tamura Nishi-Harima Astronomical Observatory Center for AstronomyUniversity of Hyogo407-2NishigaichiSayoHyogo 679-5313Japan Faculty of Education Saitama University255 Shimo-OkuboSakuraSaitamaSaitama338-8570Japan Subaru Telescope National Astronomical Observatory of Japan650 North Ahoku PlaceHiloHI 96720USA National Astronomical Observatory of Japan 2-21-1OsawaMitakaTokyo181-8588Japan H.L.Dodge Department of Physics & Astronomy University of Oklahoma440 W Brooks St.NormanOK 73019USA Laboratoire Lagrange (UMR 7293) Universit de Nice-Sophia AntipolisCNRSObservatoire de la Cote d’Azur28 avenue Valrose06108 Nice Cedex 2France Max Planck Institute for Astronomy Knigstuhl 1769117 HeidelbergGermany Department of Astrophysical Science Princeton UniversityPeyton HallIvy LanePrincetonNJ 08544USA Department of Physics and Astronomy College of Charleston58 Coming St.CharlestonSC29424USA Subaru Telescope National Astronomical Observatory of Japan650 North A’ohoku PlaceHiloHI 96720USA Exoplanets and Stellar Astrophysics Laboratory Code 667Goddard Space Flight CenterGreenbeltMD 20771USA Eureka Scientific 2452 DelmerSuite 100Oakland CA 96002USA Goddard Center for Astrobiology GreenbeltMD 20771USA Institute for Astronomy University of Hawaii640 N.Aohoku PlaceHiloHI 96720USA Department of Earth and Planetary Sciences Tokyo Institute of TechnologyOokayamaMeguro-kuTokyo 152-8551Japan Department of Astronomy Kyoto UniversityKitashirakawa-Oiwake-choSakyo-kuKyotoKyoto 606-8502Japan Hiroshima University 1-3-2KagamiyamaHigashihiroshimaHiroshima 739-8511Japan Department of Astrophysics CAB-CSIC/INTA28850 Torrejón de ArdozMadridSpain Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA91109USA Department of Astronomical Science The Graduate University for Advanced Studies2-21-1OsawaMitakaTokyo181-8588Japan Department of Astronomy The University of Tokyo7-3-1HongoBunkyo-kuTokyo113-0033Japan Astronomical Institute "Anton Pannekoek" University

A high angular resolution near-infrared image that shows the intensity of polarization for the GG Tau A binary system was obtained with the Subaru Telescope. The image shows a circumbinary disk scattering the light from the central binary. The azimuthal profile of the intensity of polarization for the circumbinary disk is roughly reproduced by a simple disk model with the Henyey-Greenstein phase function and the Rayleigh function, indicating there are small dust grains at the surface of the disk. Combined with a previous observation of the circumbinary disk, our image indicates that the gap structure in the circumbinary disk orbits counterclockwise, but material in the disk orbits clockwise. We propose that there is a shadow caused by material located between the central binary and the circumbinary disk. The separations and position angles of the stellar components of the binary in the past 20 yr are consistent with the binary orbit with a = 33.4 AU and e = 0.34.

关键词： stars individual (GG Tauri) -- stars pre-maln sequence - techniques high angular resolution

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