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Recent advances in treatment of follicular lymphoma: efficacy of PI3Kα/δ inhibitor (TQ-B3525)

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2341-2343页

作者： takuya Watanabe Department of Internal Medicine and Gastroenterology Watanabe Internal Medicine Aoyama ClinicNiigata-city 9502002Japan

The commented study reports the results of monotherapy using TQ-B3525,a novel phosphatidylinositol-3 kinase(PI3K)inhibitor developed in China,in patients with refractory/relapsed follicular lymphoma(r/r FL).

关键词： PI3K lymphoma treatment

Gene targeted and immune therapies for nodal and gastrointestinal follicular lymphomas

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World Journal of Gastroenterology 2023年第48期29卷 6179-6197页

作者： takuya Watanabe Department of Internal Medicine and Gastroenterology Watanabe Internal Medicine Aoyama ClinicNiigata 9502002Japan

Follicular lymphoma(FL)is the most common indolent B-cell lymphoma(BCL)***,its incidence has increased in Europe,the United States,and Asia,with the number of gastrointestinal FL cases expected to *** abnormalities related to t(14;18)translocation,BCL2 overexpression,NF-κB pathway-related factors,histone acetylases,and histone methyltransferases cause FL and enhance its ***,microRNAs are commonly used in diagnosing FL and predicting patient *** clinical trials on novel therapeutics targeting these genetic abnormalities and immunomodulatory mechanisms have been conducted,resulting in a marked improvement in therapeutic outcomes for *** developing these innovative therapeutic agents targeting specific genetic mutations and immune pathways has provided hope for curative options,FL treatment has become more complex,requiring combinatorial therapeutic ***,optimal treatment combinations have not yet been achieved,highlighting the importance of a complete understanding regarding the pathogenesis of gastrointestinal ***,this article reviews key research on the molecular pathogenesis of nodal FL and novel therapies targeting the causative genetic ***,the results of clinical trials are summarized,with a particular focus on treating nodal and gastrointestinal FLs.

关键词： Gastrointestinal follicular lymphoma Genetic mutation analysis using nextgeneration sequencing MicroRNA Gene targeted therapy Immune therapy

Treatment strategies for nodal and gastrointestinal follicular lymphoma:Current status and future development

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World Journal of Gastroenterology 2010年第44期16卷 5543-5554页

作者： takuya Watanabe Department of Internal Medicine and Gastroenterology Medical HospitalThe Nippon Dental University School of Life Dentistry at Niigata

In recent years,therapies for follicular lymphoma (FL) have steadily improved.A series of phase Ⅲ trials comparing the effect of rituximab with chemotherapy vs chemotherapy alone in treating FL have indicated significant improvements in progression-free survival (PFS) and overall *** studies have found that prolonged response durations and PFS were obtained with maintenance therapy using rituximab or interferon after completion of first line *** patients with relapsed or refractory FL,phase Ⅱ studies have assessed the effectiveness of combination therapies using a Toll-like receptor-9 agonist (1018ISS),oblimersen sodium (a Bcl-2 antisense oligonucleotide),bendamustine,and rituximab,as well as veltuzumab,a new humanized anti-CD20 antibody,and *** addition,the effectiveness of yttrium-90 ibritumomab tiuxetan and iodine-131 tositumomab as radioimmunotherapies has been ***,three phase Ⅲ studies on an idiotype vaccine are near ***,these vaccines,which appeared highly effective in phase Ⅰ and Ⅱ trials,do not appear to result in prolonged *** report will summarize the current knowledge on therapies for treatment of FL,and will conclude with a brief discussion of feasiblefuture options for effective ***,we added descriptions of the management of gastrointestinal FL,which is considered to be controversial because it is rare.

关键词： Anti-CD20 monoclonal antibody (rituximab) Follicular lymphoma Idiotype vaccines Immunoradiotherapy Treatment strategies

Recent advances in treatment of nodal and gastrointestinal follicular lymphoma

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World Journal of Gastroenterology 2023年第23期29卷 3574-3594页

作者： takuya Watanabe Department of Internal Medicine and Gastroenterology Watanabe Internal Medicine Aoyama ClinicNiigata-city 9502002Japan

Follicular lymphoma(FL)is the most common low-grade lymphoma,and although nodal FL is highly responsive to treatment,the majority of patients relapse repeatedly,and the disease has been incurable with a poor ***,primary FL of the gastrointestinal tract has been increasingly detected in Japan,especially due to recent advances in small bowel endoscopy and increased opportunities for endoscopic examinations and endoscopic ***,many cases are detected at an early stage,and the prognosis is good in many *** contrast,in Europe and the United States,gastrointestinal FL has long been considered to be present in 12%-24%of Stage-IV patients,and the number of advanced gastrointestinal cases is expected to *** editorial provides an overview of the recent therapeutic advances in nodal FL,including antibody-targeted therapy,bispecific antibody therapy,epigenetic modulation,and chimeric antigen receptor T-cell therapy,and reviews the latest therapeutic manuscripts published in the past *** on an understanding of the therapeutic advances in nodal FL,we also discuss future possibilities for gastroenterologists to treat gastrointestinal FL,especially in advanced cases.

关键词： Nodal and gastrointestinal follicular lymphoma Antibody-based therapy Bispecific antibody therapy Phosphatidylinositol-3 kinase inhibitor Epigenetic modulator Chimeric antigen receptor-T cell therapy

Docking and Molecular Dynamics Study of the Carbohydrate Binding Module from Trichoderma reesei Cel7A on the Surfaces of the Cellulose Ⅲ_(1) Crystal

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Journal of Renewable Materials 2020年第8期8卷 863-878页

作者： Toshifumi Yui takuya Uto Faculty of Engineering University of MiyazakiMiyazaki889-2192Japan Organization for Promotion of Tenure Track University of MiyazakiMiyazaki889-2192Japan

We report the systematic survey of the binding free energies at the interface between a carbohydrate binding module(CBM)of Cel7A and the celluloseⅢ_(1)crystal model using grid docking searches and molecular dynamics *** two hydrophobic crystal surfaces were involved in the distinct energy minima of the binding free *** complex models,each with the CBM at the minimum energy position,stably formed in the solution *** binding free energies of the celluloseⅢ_(1)complex models,based on both static and dynamics states,were comparable to those of the native cellulose complex ***,the celluloseⅢ_(1)crystal had a larger binding surface,which is compatible with the observed high enzymatic activity of Cel7A for the celluloseⅢ_(1)substrate.

关键词： Carbohydrate binding module Cel7A celluloseⅢ_(1) docking analysis

Coexisting Phenomena of Surge and Rotating Stall in an Axial Flow Compressor

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Journal of Thermal Science 2013年第6期22卷 547-554页

作者： takuya ABE Hiroaki MITSUI Yutaka OHTA Graduate Student Graduate School of Science and EngineeringWaseda University Department of Applied Mechanics and Aerospace Engineering Waseda University

The unsteady inner flow structure of a single-stage axial flow compressor under the coexisting conditions of surge and rotating stall was experimentally investigated via detailed measurements of the unsteady characteristics and the internal flow velocity fluctuations. The main relevant feature of the tested compressor is a shock tube with a capacity tank connected in series to the compressor outlet through slits and a concentric duplex pipe: surge and rotating stall can both be generated by connecting the shock tube. Research attention is focused on the unsteady behavior of a rotating stall during the surge cycle. The size of the rotating stall cell during the recovery process of an irregular surge cycle was experimentally determined by the circumferential flow velocity fluctuations ahead of the rotor blade. The results suggested that the size of the rotating stall cell at the switching point of the performance curve between large and small cycles is considered to be the key parameter in determining the following surge cycle. In addition, the surge cycle is largely influenced by the unsteady behavior of the rotating stall cell.

关键词： Axial flow compressor Surge Rotating stall Coexisting state of surge and rotating stall

A sulfur–microporous carbon composite positive electrode for lithium/sulfur and silicon/sulfur rechargeble batteries

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Progress in Natural Science:Materials International 2015年第6期25卷 612-621页

作者： takuya Takahashi Masaki Yamagata Masashi Ishikawa Department of Chemistry and Materials Engineering Faculty of ChemistryMaterials and BioengineeringKansai University

Sulfur is an advantageous material as a promising next-generation positive electrode material for high-energy lithium batteries due to a high theoretical capacity of 1672 m A h g 1although its discharge potential is somewhat modest:ca.2 V vs Li/***,a sulfur positive electrode has some crucial problems for practical use,which are mainly attributed to the dissolution of its intermediate products in charge–discharge *** order to resolve the dissolution problem of lithium polysulfide,we attempted to synthesize a sulfur–microporous activated carbon(AC) composite positive ***,we have systematically researched the battery performance of sulfur–microporous AC positive electrode with variations of electrolytes as well as negative electrodes,and found its promising positive electrode performance for a nextgeneration rechargeable battery.

关键词： Sulfur Micropore Ionic liquid Silicon Lithium-ion battery

Plasma depletions lasting into daytime during the recovery phase of a geomagnetic storm in May 2017:Analysis and simulation of GPS total electron content observations

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Earth and Planetary Physics 2021年第5期5卷 427-434页

作者： Yuichi Otsuka Atsuki Shinbori takuya Sori takuya Tsugawa Michi Nishioka Joseph D.Huba Institute for Space-Earth Environmental Research Nagoya UniversityNagoyaJapan National Institute of Information and Communications Technology TokyoJapan Syntek Technologies FairfaxVAUSA

This paper reports that plasma density depletions appearing at middle latitudes near sunrise survived until afternoon on 29 May 2017 during the recovery phase of a geomagnetic *** analyzing GPS data collected in Japan,we investigate temporal variations in the horizontal two-dimensional distribution of total electron content(TEC)during the geomagnetic *** SYM-H index reached-142 n T around 08 UT on 28 May *** depletions extending up to approximately 38°N along the meridional direction appeared over Japan around 05 LT(LT=UT+9 hours)on 29 May 2017,when TEC rapidly increased at sunrise due to the solar extreme ultraviolet(EUV)*** TEC depletions appeared sequentially over Japan for approximately 8 hours in sunlit *** 06 LT on 29 May,when the plasma depletions first appeared over Japan,the background TEC was enhanced to approximately 17 TECU,and then decreased to approximately 80%of the TEC typical of magnetically quiet *** conclude that this temporal variation of background plasma density in the ionosphere was responsible for the persistence of these plasma depletions for so long in *** using the Naval Research Laboratory:Sami2 is Another Model of the Ionosphere(SAMI2),we have evaluated how plasma production and ambipolar diffusion along the magnetic field may affect the rate of plasma depletion *** shows that the plasma density increases at the time of plasma depletion appearance;subsequent decreases in the plasma density appear to be responsible for the long-lasting persistence of plasma depletions during *** plasma density depletion in the top side ionosphere is not filled by the plasma generated by the solar EUV productions because plasma production occurs mainly at the bottom side of the ionosphere.

关键词： plasma bubble GPS ionosphere ionospheric irregularity SAMI2

Unexpected/contrary behavior of aerosol mass concentration in response to the individual components'concentration reduction in Kitakyushu,Japan

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Journal of Environmental Sciences 2024年第1期135卷 630-639页

作者： Xi Zhang takuya Murakami Jinhe Wang Masahide Aikawa Faculty of Environmental Engineering The University of Kitakyushu1-1HibikinoWakamatsuKitakyushuFukuoka 808-0135Japan Resources and Environment Innovation Research Institute School of Municipal and Environmental EngineeringShandong Jianzhu UniversityJinan 250101China

In the suburbs of Kitakyushu,Japan,the inorganic aerosol mass concentration(IAM)was about 32.7μg/m^(3),with the aerosol pH of *** study the thermodynamics of aerosol when its individual components'concentration is reduced,sensitive tests were performed using the ISORROPIAⅡmodel,in which the seven control species—TNaCl,TNH_(4)^(+),TSO_(4)^(2-),TNO_(3)^(-),TMg^(2+),TK^(+),and TCa^(2+)—were taken into *** and inorganic aerosol pH after reducing TNaCl,TNO_(3)^(-),TMg^(2+),TK^(+),and TCa^(2+)responded linearly(0%≤concentration reduction ratio(CRR)≤100%,with the exception of 100%in TNaCl);the nonlinear variations of these two parameters could be observed by controlling TNH_(4)^(+)and TSO_(4)^(2-).Unexpected aerosol behavior occurred at 100%reduction of TNaCl,which was caused by the sudden increase of NO_(3)^(-),NH_(4)^(+),and aerosol liquid water content(ALWC);the increase of IAM was also observed after controlling TSO_(4)^(2-)(60%≤CRR≤100%)and TCa^(2+)(0%≤CRR≤100%),which was mainly related to the variation of ALWC driven by the response of CaSO_(4).Multiple regression analysis showed that ALWC was statistically and strongly related to the variations of NO_(3)^(-),Cl-,SO_(4)^(2-),HSO_(4)^(-),HNO_(3),and NH_(3)(P<0.05),with regression coefficients of 1.68,5.23,1.83,2.81,0.34,and 0.57,*** highest coefficient(5.23)was found for Cl^(-),revealing that sea salts significantly influenced particle ***,this study comprehensively investigated aerosol characteristics and inner responses for the reduction of components,which is of great significance for a better understanding of atmospheric chemistry in Kitakyushu,Japan.

关键词： Sensitive tests Reduction Gas-particle conversion process Aerosol liquid water content Sea salts