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Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer

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Oncology Research 2024年第1期32卷 227-239页

作者： WEI HU THOMAS WARTMANN MARCO STRECKER ARISTOTELIS PERRAKIS ROLANd CRONER ARPAd SZALLASI WENJIE SHI ulf d.kahlert The Fourth Clinical Medical College of Yangzhou University Nantong Rich HospitalNantongChina Molecular and Experimental Surgery Clinic for General-Visceral-Vascular and Transplant SurgeryFaculty of Medicine and University Hospital MagdeburgOtto-von-Guericke UniversityMagdeburgGermany department of Pathology and Experimental Cancer Research Semmelweis UniversityBudapestHungary

Transient receptor potential(TRP)channels are strongly associated with colon cancer development and *** study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient ***-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,***,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional *** support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy *** findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAd).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAd *** of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk ***-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased Cd86 and Pd-1 expression ***,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAd patients,highlighting its role as a hub gene of ***,this signature emerged as an independent prognosis factor for COAd patients(p=6.48e-06)and expression of model gene are validated by public data a

关键词： Colon cancer Transient receptor potential channels Prognostic signature Chemotherapy efficiency TRPM5

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质子磁荷半径:新疑难?

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Science Bulletin 2024年第4期69卷 419-421页

作者：林勇辉 Hans-Werner Hammer ulf-G.Meiûner Helmholtz Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnBonn D-53115Germany Technische Universität darmstadt Department of PhysicsInstitut für KernphysikDarmstadt 64289Germany ExtreMe Matter Institute EMMI and Helmholtz Forschungsakademie Hessen für FAIR GSI Helmholtzzentrum für Schwerionenforschung GmbHDarmstadt 64291Germany Institute for Advanced Simulation and Institut für Kernphysik Forschungszentrum JülichJülich D-52425Germany Tbilisi State University Tbilisi 0186Georgia

The electric radius,rE,and the magnetic radius,rM,of the proton are fundamental quantities of low-energy QCd,as they are a measure of the probe-dependent size of the proton.

关键词： radius quantities fundamental

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Triviality of Quantum Electrodynamics Revisited

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Communications in Theoretical Physics 2018年第3期69卷 263-265页

作者： d.djukanovic J.Gegelia ulf-G.Meiβner Helmholtz Institute Mainz University of MainzD-55099 MainzGermany Institute for Advanced Simulation Institut flit Kernphysik and Julich Center for Hadron PhysicsForschungszentrum JulichD-52425 JfilichGermany Tbilisi State University 0186 TbilisiGeorgia Helmholtz Institut fiir Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany

Quantum electrodynamics is often considered to be a trivial *** is based on a number of evidences,both numerical and *** of the strong indications for triviality of QEd is the existence of the Landau pole for the running *** show that by treating QEd as the leading order approximation of an effective field theory and including the next-to-leading order corrections,the Landau pole is *** also analyze the cutoff dependence of the bare coupling at two-loop order and conclude that the conjecture,that for reasons of self-consistency,QEd needs to be trivial is a mere artefact of the leading order approximation to the corresponding effective field theory.

关键词： theory of quantized fields renormalization photons

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How machine learning conquers the unitary limit

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Communications in Theoretical Physics 2021年第3期73卷 64-72页

作者： Bastian Kaspschak ulf-G MeiBner Helmholtz-Institut fiir Strahlen-und Kemphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Advanced Simulation Institut fiir Kemphysikand Jiilich Center for Hadron PhysicsForschungszentrum JiilichD-52425 JiilichGermany Tbilisi State University 0186 TbilisiGeorgia

Machine learning has become a premier tool in physics and other fields of *** has been shown that the quantum mechanical scattering problem cannot only be solved with such techniques,but it was argued that the underlying neural network develops the Bom series for shallow ***,classical machine learning algorithms fail in the unitary limit of an infinite scattering *** unitary limit plays an important role in our understanding of bound strongly interacting fermionic systems and can be realized in cold atom ***,we develop a formalism that explains the unitary limit in terms of what we define as unitary limit *** not only allows to investigate the unitary limit geometrically in potential space,but also provides a numerically simple approach towards unnaturally large scattering lengths with standard multilayer *** scope is therefore not limited to applications in nuclear and atomic physics,but includes all systems that exhibit an unnaturally large scale.

关键词： unitary limit machine learning quantum physics

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Anthropic considerations in nuclear physics

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Science Bulletin 2015年第1期60卷 43-54页

作者： ulf-G.Meiner Helmholtz-Institut fü r Strahlen- und Kernphysik (Theorie) and Bethe Center for Theoretical Physics Universitt BonnD-53155 Bonn Germany Institute for Advanced Simulation (IAS-4) Institut fu¨ rKernphysik (IKP-3) J lich Center for Hadron PhysicsJARA HPC and JARA FAME Forschungszentrum Ju¨ lichD-52425 Ju¨ lich Germany Kavli Institute for Theoretical Physics China Chinese Academy of Sciences

In this short review, I discuss the sensitivity of the generation of the light and the life-relevant elements such as carbon and oxygen under changes of the parame- ters of the Standard Model pertinent to nuclear physics. Chiral effective field theory allows for a systematic and precise description of the forces between two, three and four nucleons. In this framework, variations under the light quark masses and the electromagnetic fine-structure constant can also be consistently calculated. Combining chiral nuclear effective field theory with Monte Carlo simulations allows to further calculate the properties of nuclei, in particular of the Hoyle state in carbon, that plays a crucial role in the gener- ation of the life-relevant elements in hot, old stars. The dependence of the triple-alpha process on the fundamental constants of nature is calculated, and some implications for our anthropic view of the Universe are discussed.

关键词： Anthropic principle Nuclear physics Effective field theory

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The Roper resonance in a finite volume

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Communications in Theoretical Physics 2020年第7期72卷 49-59页

作者： daniel Severt ulf-G Meiβner Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Advanced Simulation Institut für Kernphysik and Jülich Center for Hadron PhysicsForschungszentrum JülichD-52425 JiilichGermany Tbilisi State University 0186 TbilisiGeorgia

We calculate the energy levels corresponding to the Roper resonance based on a two-flavor chiral effective Lagrangian for pions,nucleons,deltas,and the Roper resonance at the leading one-loop *** show that the Roper m... 详细信息

关键词： Lattice QCd Roper resonance finite volume methods

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diffusion-controlled Adsorption Kinetics at Air/Solution Surface Studied by Maximum Bubble Pressure Method

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Chinese Journal of Chemical Engineering 2004年第4期12卷 577-581页

作者：刘俊吉王创业 MESSOW ulf School of Science Tianjin University Tianjin 300072 China solution at temperature 25℃were measuredby means of Wilhelmy plate method and maximal bubble pressure method respectively. As t→0 the theoreticalanalysis is in good agreement with experimental results and the dependence of γ(t) on is linear.

In studying the diffusion-controlled adsorption kinetics of aqueous surfactant solutions at the air/solution surface by means of the maximal bubble pressure method, Fick's diffusion equation for a sphere should be used. In this paper the equation was solved by means of Laplace transformation under different initial and boundary conditions. The dynamic surface adsorption F(t) for a surfactant solution, which was used to describe the diffusion-controlled adsorption kinetics at the solution surface, was derived. different from the planar surface adsorption, the dynamic surface adsorption F(t) for the short time consists of two terms: one is the same as Ward-Tordai equation and the other reflects the geometric effect caused by the spherical bubble surface. This effect should not be neglected for the very small radius of the capillary. The equilibrium surface tension γeq and the dynamic surface tension γ(t) of aqueous C10E6 [CH3(CH2)9(OCH2CH2)6OH] solution at temperature 25℃ were measuredby means of Wilhelmy plate method and maximal bubble pressure method respectively. As t→ 0, the theoreticalanalysis is in good agreement with experimental results and the dependence of γ(t) on is linear.

关键词： diffusion-controlled adsorption kinetics dynamic surface tension maximum bubble pressure method

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Analysis of Bingham fluid radial flow in smooth fractures

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第5期12卷 1112-1118页

作者： Liangchao Zou ulf Håkansson Vladimir Cvetkovic division of Resources Energy and InfrastructureDepartment of Sustainable DevelopmentEnvironmental Science and EngineeringRoyal Institute of TechnologyStockholm10044Sweden division of Soil and Rock Mechanics Department of Civil and Architectural EngineeringRoyal Institute of TechnologyStockholm10044Sweden Skanska Sweden AB Stockholm11274Sweden

Solutions for radial flow of a Bingham fluid are analyzed in this *** aims to eliminate confusions in the literature concerning the plug flow region in different solutions for analysis and design of grouting in rock *** analyses based on the force balance equation reveal that the plug flow region in Bingham radial flow is independent of the fracture radius,and is not a growth function adapted from the solution of one-dimensional(1d)slit flow according to‘similarity’.Based on the shear stress distribution,we analytically proposed that a non-uniform plug flow region cannot *** Bingham fluid(grout)penetration and flowrate evolution as functions of grouting time are given using the correct expression for the plug flow *** radius-independent plug flow region and the presented flowrate evolution equation are also verified *** radial flow,the relative penetration length is equal to the relative width of plug flow region,which is the same as that for 1d channel *** in analytical solutions for grout penetration and flowrate evolution were also *** clarification of the plug flow region and evaluation of discrepancies in analytical solutions presented in this work could simplify modeling and design of grouting in rock engineering applications.

关键词： Rock grouting Radial flow of Bingham fluids Plug flow region Force balance Energy dissipation Analytical solution

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The proton radius:from a puzzle to precision

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Science Bulletin 2020年第4期65卷 257-258页

作者： Hans-Werner Hammer ulf-GMeiBner Institut für Kernphysik Technische Universitat Darmstadt64289 DarmstadtGermany ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH64291 DarmstadtGermany Helmholtz Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Institute for Advanced Simulation and Institut für Kernphysik Forschungszentrum JülichD-52425 JülichGermany Tbilisi State University 0186 TbilisiGeorgia

The proton charge radius rP is a fundamental quantity in particle physics,as it challenges our understanding of the so successful Standard Model in the non-perturbative regime of the strong *** is defined by the slope of the proton charge form factor GE p etT at zero momentum transfer,with t the invariant four-momentum transfer *** proton charge radius was first indirectly measured in the Nobel prize winning electron scattering experiments by Hofstadter et al.[1,2],who fitted the form factor data with a dipole form and extracted the radius from the slope of the dipole.

关键词： dISPERSION-THEORETICAL ANALYSIS FORM-FACTORS NUCLEON SCATTERING HYdROGEN SIZE

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On the constituent counting rule for hard exclusive processes involving multi-quark states

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Chinese Physics C 2017年第5期41卷 91-96页

作者：郭奉坤 ulf-G.Mei?ner 王伟 State Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of Sciences Helmholtz-Institut fr Strahlen- und Kernphysik and Bethe Center for Theoretical Physics Universitt Bonn Institute for Advanced Simulation Institut fr Kernphysik and Jlich Center for Hadron PhysicsForschungszentrum Jlich INPAC Shanghai Key Laboratory for Particle Physics and CosmologyDepartment of Physics and AstronomyShanghai Jiao-Tong University

At high energy,the cross section at finite scattering angle of a hard exclusive process falls off as a power of the Manderstam variable *** all involved quark-gluon compositions undergo hard momentum transfers,the fall-off scaling is determined by the underlying valence structures of the initial and final hadrons,known as the constituent counting *** spite of the complication due to helicity conservation,it has been argued that when applied to exclusive process with exotic multiquark states,the counting rule is a powerful way to determine the valence degrees of freedom inside hadron *** this work,we demonstrate that for hadrons with hidden flavors,the naive application of the constituent counting rule is problematic,since it is not mandatory for all components to participate in hard scattering at the scale s1/*** illustrate the problems in the viewpoint based on effective field *** clarify the misleading results that may be obtained from the constituent counting rule in exclusive processes with exotic candidates such as Z_c~±（cd/cu）,Z_b~±（bd/bdu）,X（3872）,etc.

关键词： quark exclusive constituent hadron meson exotic problematic clarify momentum valence

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