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Naturally acidic and metalliferous waters at unmined volcanogenic massive sulfide deposits in the Bonnifield mining district, Alaska Range, east-central Alaska

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Chinese Journal Of Geochemistry 2006年第B08期25卷 232-232页

作者： Robert G. Eppinger Paul H. Briggs Cynthia Dusel-Bacon stuart A. Giles Larry P. Gough Jane m.Hammarstrom Bernard E. Hubbard u.s. Geological survey Central Mineral Resources Team Denver Colorado USA u.s. Geological survey Western Mineral Resources Team Menlo Park California USA u.s. Geological survey Eastern Mineral Resources Team Reston Virginia USA

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乳腺癌真空辅助旋切术后保乳手术的可行性

中国临床医学 2016年第6期23卷 710-714页

作者：陈宏亮王懋莉张征丁昂复旦大学附属妇产科医院乳腺外科上海200011

目的:探讨超声引导下真空辅助活检(vacuum-assisted biopsy,VAB)切除乳腺癌肿块后保乳手术的可行性与安全性。方法:选择2008年1月至2014年12月VAB肿块切除术后行保乳手术治疗的45例浸润性导管癌(invasive ductal carcinoma,IDC)患者(VAB... 详细信息

目的:探讨超声引导下真空辅助活检(vacuum-assisted biopsy,VAB)切除乳腺癌肿块后保乳手术的可行性与安全性。方法:选择2008年1月至2014年12月VAB肿块切除术后行保乳手术治疗的45例浸润性导管癌(invasive ductal carcinoma,IDC)患者(VAB组)。选取同一时期单发、直径小于2cm、肿块切除活检后行保乳手术的147例IDC患者为对照组。分析并比较两组患者的临床病理特征与预后。结果:VAB组肿块均单发、直径m且不可触及,影像学检查误诊为良性。所有VAB手术只行1次穿刺,穿刺点距离肿块的平均距离为(2.52±0.89)cm。中位切割8次,影像学检查示完全切除,平均手术时间(25.4±7.6)min,术中未发生活动性出血。保乳手术距VAB术平均(4.50±0.92)d;局部扩大切除病灶的各个切缘均阴性;无患者发生肿瘤细胞针道或皮肤穿刺点种植;3例残腔残留少量导管原位癌病灶,但无浸润性癌灶。VAB组与对照组平均年龄、年龄构成、肿块直径、肿瘤组织学分级、脉管侵犯、淋巴结分期、前哨淋巴结阳性率、肿瘤分子分型及辅助治疗、腋窝手术差异均无统计学意义。两组间5年无病生存期(disease-free survival,DFs)和5年总生存期(overall survival,Os)差异均无统计学意义。结论:VAB切除不可触及的较小乳腺癌肿块后续行保乳手术安全可行,值得进一步大样本研究。

关键词：真空辅助活检乳腺癌保乳手术超声引导

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早产儿重度甲状腺功能减退负荷过大1例

世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 44-44页

作者： Khashu m. Chessex P. Chanoine J.-P. 宁亮 Div.of Endocrinol.and Diabet.unit Department of Pediatrics Brit.Columbia Children's Hosp.U. Vancouver BC V6H 3V4 Canada

use of iodinated skin disinfectants in the perinatal period can result in significant iodine overload of the neonate and transient *** authors report a case of unusually severe hypothyroidism requiring l-thyroxine (L-T4) replacement therapy in a premature neonate after prolonged use of iodinated skin disinfectants for a complex skin *** iodine overload should be minimized, and in cases with significant iodine exposure, thyroid-stimulating hormone should be monitored, especially in preterm neonates who are exquisitely sensitive to the antithyroid effects of iodine excess.

关键词：甲状腺功能减退早产新生儿左旋甲状腺素暴露史皮肤消毒高度敏感性围生期促甲状腺激素

协同刺激分子CD80、CD86以及IFNγ在溃疡性结肠炎发病机制中的意义

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 10-10页

作者： scarpa m. Behboo R. Angriman I. 王志宇 Azienda Ospedaliera di Padova Università di Padova Sez. Clinica Chirurgica I Via Giustiniani 2 35128 Padova Italy Dr

several studies showed that costimulatory signals on antigen presenting cells are up- regulated in inflammatory bowel disease. We quantified the expression of CD80, CD86, and IFNγ in colonie mucosa of patients affected by ulcerative c olitis and correlated it with clinical and biochemical parameters to identify th e context of this up regulation. We enrolled 21 patients affected by ulcerative colitis and 6 healthy subjects. We evaluated for each patient gender, age, durat ion of disease, clinical, endoscopic and histologic disease activity index, medi cal therapy, EsR, serum CRP, WBC, and serum α 1- acid glycoprotein. CD80, CD86 , and IFNγ expression in the colonie mucosa was quantified using reverse trans cription polymerase chain reaction. statistical analysiswas performed using mann - Whitney u test and spearman’ s rank correlation test. significance was set a t Ps detectable in seven patients, while CD86 and IFNγ expressio n was evident in all uC patients. CD80 and CD86 were not detectable in control s pecimens. Colonie CD80 expression was correlated to the age of the patients. CD8 6 expression showed an inverse correlation with duration of disease and a direct correlation with serum CRP levels and histologic grade of disease activity. IFN γ was not correlated with any of the examined parameter. Our study confirms a major role in ulcerative colitis pathogenesis for CD86 which correlates with his tologic grade of disease and with serum CRP levels, and its up- regulation seem s to be higher at the beginning of the disease. In “ in vivo" conditions IFNγ may not be the only factor responsible for CD86 up- regulation in the ulcerati ve colitis colonic mucosa.

关键词： CD80 CD86 IFNγ 协同刺激分子溃疡性结肠炎疾病活动度炎症性肠病肠黏膜酸性糖蛋白疾病活动指数

尿脂联素水平是1型糖尿病肾病进展为终末期肾病的独立预测因子

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糖尿病天地(临床) 2015年第9期9卷 446-446页

作者：吴佩文杨立勇 Panduru Nm saraheimo m Forsblom C 福建医科大学附属第一医院内分泌科

Diabetes Care杂志发表一篇论著,提出尿脂联素(u ADP)可作为1型糖尿病肾病(diabetic nephropathy,DN)进展的可靠预测因子。这项前瞻性随访研究的参与者来自F i n n i s h Diabetic Nephropathy study(Finn Diane)研究,自1998年1月至2002年12月,包括2090名1型糖尿病患者,对照组为111名无糖尿病者,中位随访期5.8(4.4～6.9)年。研究中测定受试者u ADP水平。肾功能分

关键词：型糖尿病 ADP AER 大量白蛋白尿尿脂联素终末期肾病预测因子预测要因

Barrett食管的冷冻消融术:一项先导性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 26-26页

作者： Johnston m.H Eastone J.A Horwhat J.D. 尹勇 Gastroenterology GIClinicNationl Naval Medical Center 8901 Wisconsin Ave Bethesda MD 20889 United StatesDr.

Background: Numerous ablative modalities have demonstrated varying degrees of efficacy in the eradication of Barrett‘s esophagus (BE). However, they are associated with either high cost, patient discomfort, complications, tedious applica tion, residual underlying BE, or some combination of the above. The aim of this study was to evaluate the safety and the efficacy of a new cryogenic device by u sing liquid nitrogen sprayed through an open tipped cryogenic catheter placed th rough the accessory channel of an upper endoscope. methods: A prospective, singl e center studywas performed on patients with a long-standing history of BE foll owed in a Barrett‘s registry. Patients with degrees of dysplasia ranging from n one to multifocal high-grade dysplasia were treated. All patients were treated with 40 mg rabeprazole 3 times per day during the treatment period. Elimination of acid reflux was confirmed via 24-hour esophageal pH studies. Cryoablation wa s applied hemicircumferentially to 4-cm-long segments at monthly intervals, un til the entire segment of BE was eliminated. Results: Eleven patients were treat ed. There was reversal of BE in all patients. In 9 of 11 (78%) patients who com pleted the protocol, there was complete endoscopic and histologic reversal of BE . There was no subsquamous specialized intestinal metaplasia at the 6-month fol low-up. No complications occurred. Conclusions: Based on preliminary results, l ow-pressure spray cryoablation of BE under direct endoscopic visualization is s afe and easy to perform. Its relative lack of patient discomfort and its simplic ity and demonstrated efficacy make it a modality that should be further explored in the ablation of GI mucosal lesions such as BE and perhaps early esophageal c ancer.

关键词： Barrett 冷冻消融术酸反流早期食管癌雷贝拉唑不典型增生喷洒液操作时间低温射频胃

1例日本白点状视网膜炎患者的RLBP1基因新突变

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 23-23页

作者： Nakamura m. Ito Y. miyake Y. 杨秀梅 Department of Ophthalmol ogy Nagoya University Graduate School of Medicine 65 Tsuruma-cho Showa-ku Nagoya 466-8550 Japan Dr.

PuRPOsE: To report a novel mutation in the RLBP1 gene and optical coherence to mographic findings in a Japanese patient with retinitis punctata albescens. DEsI GN: Observational case report. mETHODs: The RLBP1 gene was analyzed by direct ge nomic sequencing. A complete ophthalmologic examination was performed. REsuLTs: Compound heterozygous mutations in the RLBP1 gene were identified in the patient . The mutations were a novel missense Arg103Trp mutation and a missense Arg234Tr p mutation, the causative mutation of Bothnia dystrophy. The patient’s fundi sh owed numerouswhite dots with diffuse retinalmottling and bilateralmacular degene ration. Her visual function deteriorated progressively during 12-year follow-u p. Optical coherence tomography demonstrated decreased retinal thickness, especi ally the photoreceptor layer. CONCLusION: A novel mutation in RLBP1 gene was fou nd in a Japanese patient with retinitis punctata albescens. Degenerative changes of the outer retina were detected by optical coherence tomography.

关键词：视网膜炎 RLBP1 光感受器视网膜外层眼部检查黄斑变性视功能杂合突变精氨酸观察性

拟行冠状动脉搭桥术的非sT段抬高型急性冠状动脉综合征患者中急性使用氯吡格雷与预后的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 50-页

作者： mehta R.H. Roe m.T. mulgund J. 黄浙勇 Division of Cardiology the Duke Clinical Research Institute Durham NC United States Dr.

Objectives: We sought to characterize patterns of clopidogrel use before coronary artery bypass grafting(CABG) and examine the drug’s impact on risks for postoperative transfusions among patients with non-sT-segment elevation acute coronary syndromes(NsTE ACs). Background: Adherence in community practice to American College of Cardiology/American Heart Association guidelines for clopidogrel use among NsTE ACs patients has not been previously characterized. methods: We evaluated 2,858 NsTE ACs patients undergoing CABG at 264 hospitals participating in the CRusADE(Can Rapid Risk stratification of unstable Angina Patients suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines) Initiative. We examined the patterns of acute clopidogrel therapy and its association with bleeding risks among those having “early”CABG ≤5 days and again among those having “late”surgery >5 days after catheterization. Results: Within 24 h of admission, 852 patients(30%) received clopidogrel. In contrast to national guidelines, 87%of clopidogrel-treated patients underwent CABG ≤5 days after treatment. Among those receiving CABG within ≤5 days of last treatment, the use of clopidogrel was associated with a significant increase in blood transfusions(65.0%vs. 56.9%, adjusted odds ratio[OR] 1.36, 95%confidence interval[CI] 1.10 to 1.68) as well as the need for transfusion of ≥4 u of blood(27.7%vs. 18.4%, OR 1.70, 95%CI 1.32 to 2.19). In contrast, acute clopidogrel therapy was not associated with higher bleeding risks if CABG was delayed >5 days(adjusted OR 1.18, 95%CI 0.54 to 2.58). Conclusions: Despite guideline recommendations, the overwhelming majority of NsTE ACs patients treated with acute clopidogrel needing CABG have their surgery within ≤5 days of treatment. A failure to delay surgery is associated with increased blood transfusion requirements that must be weighed against the potential clinical and economic impacts of such delays.

关键词：氯吡格雷急性冠状动脉综合征冠状动脉搭桥术患者 sT

First radiative shock experiments on the sG-II laser

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High Power Laser science and Engineering 2021年第2期9卷 193-200页

作者： Francisco suzuki-Vidal Thomas Clayson Chantal stehlé uddhab Chaulagain Jack W.D.Halliday mingying sun Lei Ren Ning Kang Huiya Liu Baoqiang Zhu Jianqiang Zhu Carolina De Almeida Rossi Teodora mihailescu Pedro Velarde manuel Cotelo John m.Foster Colin N.Danson Christopher spindloe Jeremy P.Chittenden Carolyn Kuranz Blackett Laboratory Imperial College LondonLondonUK First Light Fusion Ltd YarntonUK LERmA Sorbonne-UniversitéObservatoire de ParisCNRSFrance ELI Beamlines Center Institute of PhysicsCzech Academy of SciencesDolni BrezanyCzech Republic shanghai Institute of Optics and Fine mechanics Chinese Academy of SciencesShanghaiChina Instituto de Fusión Nuclear Guillermo Velarde Universidad Politécnica de MadridMadridSpain AWE plc. AldermastonReadingUK science and Technology Facilities Council Rutherford Appleton LaboratoryHarwell CampusChiltonDidcotUK university of michigan Ann ArborMIUSA Current affiliation:magdrive Ltd HarwellUK

We report on the design and first results from experiments looking at the formation of radiative shocks on the shenguangII(sG-II)laser at the shanghai Institute of Optics and Fine mechanics in ***-heating of a two-layer CH/CH–Br foil drives a∼40 km/s shock inside a gas cell filled with argon at an initial pressure of 1 *** use of gas-cell targets with large(several millimetres)lateral and axial extent allows the shock to propagate freely without any wall interactions,and permits a large field of view to image single and colliding counter-propagating shocks with time-resolved,pointprojection X-ray backlighting(∼20µm source size,4.3 keV photon energy).single shocks were imaged up to 100 ns after the onset of the laser drive,allowing to probe the growth of spatial nonuniformities in the shock *** results are compared with experiments looking at counter-propagating shocks,showing a symmetric drive that leads to a collision and stagnation from∼40 ns *** present a preliminary comparison with numerical simulations with the radiation hydrodynamics code ARWEN,which provides expected plasma parameters for the design of future experiments in this facility.

关键词： high energy density physics laboratory astrophysics plasma physics high-power laser laser-driven shocks experiments X-ray backlighting X-ray radiography