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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： r.A.JAFArI-TALOOKOLAeI H.GHANDVAr e.JuMAeV S.KHATIr T.CuONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University university of Business and Science Center for engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Coarse to Fine: The role of Severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive review

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Journal of Wuhan university of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana r Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITe-Nordic eMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Security Strategy of Digital Medical Contents Based on Blockchain in Generative AI Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Marek r.Ogiela Division of Computer Science and engineering Sunmoon UniversityAsan31460Republic of Korea AGH university of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Ion-acoustic waves at the night side of Titan's ionosphere:higher-order approximation

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Communications in Theoretical Physics 2020年第5期72卷 70-77页

作者： S M Ahmed e r Hassib u M Abdelsalam r e Tolba W M Moslem Department of Mathematics Faculty of ScienceSuez UniversitySuezEgypt Department of Mathematics Faculty of ScienceFayoum UniversityFayoumEgypt Department of Mathematics Rustaq College of EducationOman Centre for Theoretical Physics The British University in Egypt(BUE)El-Shorouk CityCairoEgypt Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt

Nonlinear solitary waves are investigated for a plasma system at the night side of Titan's *** plasma model consists of three positive ions,namely C2H5^+,HCNH^+,and C3H5^+,as well as Maxwellian *** basic set of fluid equations is reduced to a Korteweg de-Vries(KdV)equation and linear inhomogeneous higher order KdV(LIHO-KdV)*** solitary wave solutions of both equations are obtained using a renormalization *** solitary waves'existence region and the wave profile are investigated,and their dependences on the plasma parameters at the night side of Titan's ionosphere are *** solitary waves'phase velocities are subsonic or supersonic,and the propagating pulses are usually *** effect of higher-order corrections on the perturbation theory is *** is found that the higher-order contribution makes the amplitude slightly taller,which is suitable for describing the solitary waves when the amplitude augments.

关键词： plasmas ion-acoustic waves planets and satellites:atmospheres

Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZu—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Challenges and prospects of plastic waste management in Nigeria

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Waste Disposal and Sustainable energy 2019年第2期1卷 117-126页

作者： r.u.Duru e.e.Ikpeama J.A.Ibekwe Department of Pure and Industrial Chemistry University of Port HarcourtPort HarcourtNigeria 15791 Pebblebrook Drive BellevilleMI 48111USA Department of Oil and Gas Chemistry University of AberdeenAberdeenScotlandUK

The combined properties of low cost,lightweight,and resistance to chemicals and corrosion has increased the use of plastic materials for packaging and storage purposes in preference to other ***,there is a continued increase in their proportion in domestic solid wastes worldwide as well as the concern of their impacts on the *** developed and developing countries have put in place and continue to improve their plastic waste disposal,collection,and recycling methods to reduce these *** Nigeria with a population of about 186 million,there are little or no available data on the use of plastic materials in relation to city populations,their disposal,collection,and recycling *** are a few numbers of plastic waste recycling companies in a fewer number of cities and disposal practices for the greater percentage of the plastic wastes that are not captured for recycling possess immediate and future danger for the *** work reviews the consumption of plastics,its waste generation,collection,and treatment in Nigeria and a few selected *** problems associated with inadequate management of the wastes were emphasized and recommendations were proffered to not only highlight research and investment opportunities that are inherent in plastic waste management in Nigeria,but also provide a background for the formulation of sustainable regulatory policies by the government to address the problems.

关键词： Plastic waste Disposal recycling environment Investment Waste management

Hsa-mir-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanhong Peng Meng Chen Lin Zhong Luji Huang F u Cheng Xindan Sheng Xin Yang Manzhao Ouyang George A Calin Zhiwei He China-America Cancer research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene expression Omnibus (GeO) databases. MicrorNAs were selected using the TarBase, mirTarBase, and mirBase databases. The regulatory role of the microrNA hsa-mir-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-mir-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCr (qPCr). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-mir-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-mir-214-3p on B7H3 was examined. enzyme-linked immunosorbent assays (eLISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-mir-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-mir-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-mir-214-3p on the 3' uTr of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-mir-214-3p Immunotherapy