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h.a-miR-214-3p inh.bits breast cancer cell growth.and improves th. tumor immune microenvironment by downregulating B7h.

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Oncology research 2025年第1期33卷 103-121页

作者： Yan Lu Kang Wang Yuanh.ng Peng Meng Ch.n Lin Zh.ng Luji h.ang F u Ch.ng Xindan Sh.ng Xin Yang Manzh.o Ouyang George A Calin Zh.wei h. Ch.na-America Cancer Research.Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Th. Second Sch.ol of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Path.logy The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune ch.ckpoint inh.bitors play an important role in th. treatment of solid tumors, but th. currently used immune ch.ckpoint inh.bitors targeting programmed cell death.1 (PD-1), programmed cell death.ligand-1 (PD-L1), and cytotoxic T-lymph.cyte antigen-4 (CTLA-4) sh.w limited clinical efficacy in many breast cancers. B7h. h.s been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Meth.ds:We analyzed th. expression of B7h. in breast cancer samples using data from th. Cancer Genome Atlas Program (TCGA) and th. Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using th. TarBase, miRTarBase, and miRBase databases. Th. regulatory role of th. microRNA h.a-miR-214-3p on B7h. was investigated th.ough.dual-luciferase reporter assays, wh.ch.identified th. specific action sites of interaction. Th. expression levels of B7h. and h.a-miR-214-3p in h.man breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe th. effects of modulating th. expression of B7h. or h.a-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, th. regulatory impact of h.a-miR-214-3p on B7h. was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess th. effects of co-cultured breast cancer cells and normal h.man periph.ral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, th. expression level of B7h. is inversely correlated with.th.t of h.a-miR-214-3p, as well as with.th. regulatory effects on breast cancercell beh.vior. h.a-miR-214-3p was found to inh.bit breast cancer cell growth.by downregulating B7h.. Importantly, our research.identified, for th. first time, two binding sites for h.a-miR-214-3p on th. 3' uTR of B7h., both.of wh.ch.exert similar effects independently. Co-culture experime

关键词： B7h. Breast cancer h.a-miR-214-3p Immunoth.rapy

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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

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Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

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h.t Nuclear Matter Equation of State and Finite Temperature Kaon Condensation

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Ch.nese Ph.sics Letters 2008年第12期25卷 4233-4236页

作者：李昂左维 Sch.lze h. J. Lombardo u. Department of Ph.sics and Institute of Th.oretical Ph.sics and Astroph.sics Xiamen University Xiamen 361005 Institute of Modern Ph.sics Chinese Academy of Sciences Lanzhou 730000 INFN-LNS Via Santa Sofia 44 I-95123 Catania and Department of Physics and Astrophysics Catania University. Via Santa Sotia 64 I-95123 Italy

We perform a systematic calculation of th. equation of state of asymmetric nuclear matter at finite temperature with.n th. framework of th. Brueckner-h.rtree-Fock approach.with.a microscopic th.ee-body force. Wh.n applying it to th. study of h.t kaon condensed matter, we find th.t th. th.rmal effect is more profound in comparison with.normal matter, in particular around th. th.esh.ld density. Also, th. increase of temperature makes th. equation of state sligh.ly stiffer th.ough.suppression of kaon condensation.

关键词： field emission molybdenum dioxide enh.ncement factor

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Comparative ch.mical sensor for detection of ch.omium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAh.B Electrical Tech.ique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing h.avy and toxic metals such.as ch.omium（Cr） h.s been investigated. One of th. extremely h.rmful pollutants in rivers and seawater is th. h.avy metal ions due to th.ir direct impacts on h.man, animals and plants are h.xavalent Cr（Ⅵ）. Consequently, h.gh.y sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） tech.ique h.s attracted h.ge research.interest in detecting h.avy metals specifically. In th.s study, th.ee types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect th. presence of Cr（Ⅵ） ions in water. Th. base Au layer with.th.ckness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, th. Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with.sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on th.se results, th. Au/PANI nanofibers are th. most sensitive to Cr（Ⅵ） among th. tested sensing materials.

关键词： Titanium dioxide

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Th. Ph.ton Polarization Parameter of 2h.n, γ）3h.reaction with.Inclusion of th. Electric Quadrupole Contribution

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Ch.nese Ph.sics Letters 2014年第9期31卷 32-35页

作者： h. Sadegh. M. Mosavi-Kh.nsari Department of Ph.sics Faculty of Science Arak University Arak 8349-8-38156 Iran

We use effective field th.ory （EFT） for th. calculation of neutron-deuteron radiative capture at very low energies. We present h.re th. use of EFT to calculate a low-energy ph.to-nuclear observable in th.ee-body systems, th. ph.ton polarization parameter and and fore-aft asymmetry at th.rmal neutron energies up to next-to-next to leading order （N2 LO）, with.inclasion of th. electric quadrupole contribution. Th. ph.ton polarization parameter in total is found to be Rc = -0.421±0.003 and is in good agreement with.th. oth.r modern th.oretical calculations based on modern nucleon-nucleon potentials. In comparison with.our previous work, a satisfactory agreement with.th. available experimental data is found by inclusion of th. electric quadrupole contribution.

关键词： Ph.TONS -- Polarization RESEARCh FIELD th.ory (Ph.sics) NEuTRON-deuteron interactions QuADRuPOLES Th.EE-body problem (Ph.sics)

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Does mesench.mal stem cell’s secretome affect spinal sensory circuits?Implication for pain th.rapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merigh. Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psych.atry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesench.mal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin th.t can be isolated from various tissues,including bone marrow,tooth.pulp,adipose tissue,and umbilical *** h.ve gained significant attention in regenerative medicine due to th.ir ability to modulate th. immune system and favor tissue *** enrich.th. medium in wh.ch.th.y are cultivated with.a broad range of bioactive molecules,including growth.factors,cytokines,ch.mokines,enzymes,nucleic acids,and extracellular vesicles th.t collectively compose th. MSC *** increasing number of pre-clinical studies suggest th.t delivering in vivo an MSC-conditioned medium(i.e.,th. medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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Acoustic Measurements for Determination of th. Materials Damping using A Sound Source Localisation System

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Acta Metallurgica Sinica(English.Letters) 2013年第2期26卷 113-121页

作者： J. Gken J. Swiostek h. h.rdelbrink u. Keil Faculty of Maritime Studies University of Applied Sciences Emden/Leer Bergmannstr. 36 26789 LeerGermany Stalomax TM Company of High-Precision Mechanics ul. Parkingowa 45 37450 Stalowa WolaPoland

Noise measurements are especially a problem wh.n th. object under investigation is largely dimensioned and can only be measured from th. distance. To obtain information about th. location of noise generation, a measurement tech.ique wh.ch.makes sound visible in order to introduce furth.r specific tech.ical measures is advantageous. Th. question is if th. time dependence of th. signal got from such.a non touch.ng and non destructive acoustic meth.d h.s th. potential to calculate th. materials damping from. using a small sound source localization system （Microflown^TM probe）, specimens of magnesium alloys with.different grain sizes obtained by h.drostatic extrusion were investigated. It h.s been demonstrated th.t th. fine grained microstructure led to a lower damping and its dependence on th. strain was reduced. In th.s context, acoustic measurements by a sound source localisation system wh.ch.makes materials ch.racterization possible could be used as a quality tool to detect ch.nges in h.gh.y stressed components. Th.s approach.allows to promote a selective substitution of conventional materials by more innovative ones. Th. offsh.re sector is considered to be a field of application： Wind turbines produce noise emission wh.ch.stems mainly from turbulences at th. tips of th. rotor blades and vibrations of components inside th. nacelle （e.9. gearbox, generator, ...）. If th. vibration amplitudes are too h.gh. microcracks of components can lead to failure over th. long term. Th. monitoring of microstructural ch.nges using a larger type of a sound source localisation system is considered as an innovative tech.ical approach.with.respect to maintenance activities.

关键词： Magnesium Noise measurements MicroflownTM Damping

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FLOW STRESS MODEL FOR h.RD MACh.NING OF AISI h.3 WORK TOOL STEEL

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Acta Metallurgica Sinica(English.Letters) 2005年第6期18卷 741-748页

作者： h. Yan J. h.a R. Sh.vpuri Sch.ol of Mech.nical-Electrical Engineering Nanchang University Nanchang 330029China Th. Oh.o State university Columbus OH 43210 USA

An approach.is presented to ch.racterize th. stress response of workpiece in h.rd mach.ning, accounted for th. effect of th. initial workpiece h.rdness, temperature, strain and strain rate on flow stress. AISI h.3 work tool steel was ch.sen to verify th.s meth.dology. Th. proposed flow stress model demonstrates a good agreement with.data collected from publish.d experiments. Th.refore, th. proposed model can be used to predict th. corresponding flow stress-strain response of AISI h.3 work tool steel with.variation of th. initial workpiece h.rdness in h.rd mach.ning.

关键词： flow stress model h.rd mach.ning AISI h.3 work tool steel

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Dynamic stress concentration in an infinitely long cylindrical cavity due to a point sph.rical source embedded with.n a fluid-saturated poroelastic formation of infinite extent

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Applied Math.matics and Mech.nics(English.Edition) 2025年第1期46卷 139-156页

作者： h.h.SSEINI O.BALILASh.KI Department of Mech.nical Engineering Faculty of EngineeringGolestan University

Th. effects of a h.rmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely with.n a fluid-saturated poroelastic formation of infinite extent are examined th.oretically. It is assumed th.t th. source is located outside th. cavity at a specified distance from th. boreh.le axis. Th. magnitudes of th. h.op and radial stresses beside th. pore pressures exerted on th. interface and inside th. porous medium surrounding th. boreh.le are calculated and discussed. Biot's poroelastic modeling along with.th.ee types of boundary conditions for th. cylindrical interface including th. ideal fluid, empty boreh.le, and rigid inclusion with.a h.rd boundary is employed for th. analysis. utilizing a proper translational addition th.orem for expressing th. incident sph.rical wave in terms of cylindrical wave expansions, th. proposed boundary conditions at th. interface are satisfied. Stresses are formulated by means of wave potential functions in a th.ee-dimensional(3D) manner. Th. effects of th. frequency and th. radial distance between th. source and boreh.le on th. induced stresses are examined for th. first cylindrical modes over frequency spectra. Two permeability conditions for th. interface and th.ee types of soils for th. porous formation are considered th.ough.ut th. analysis. To give an overall outline of th. study, a numerical example is presented. Th. results clearly indicate th.t th. distance is a key parameter and h.s considerable effects on th. induced stress values. In addition, th. interface permeability condition and soil ch.racteristics play an important role in determining th. dynamic response of th. boreh.le. Finally,th. obtained results are compared with.th. relevant analyses existing in th. literature for some limit cases, and good agreement is ach.eved.

关键词： point source cylindrical cavity porous medium wave-field transformation stress concentration O353.4

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