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Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3836-3846页

作者： Melissa M.Clemens Stefanie Kennon-McGill Joel H.Vazquez Owen W.Stephens Erich A.Peterson Donald J.Johann Felicia D.Allard Eric u.Yee Sandra SMcCullough Laura P.James Brian N.Finck Mitchell R.McGill Department of Pharmacology and Toxicology College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Interdisciplinary Graduate Program in Biomedical Sciences Graduate SchoolUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Environmental and Occupational Health Fay W.Boozman College of Public HealthUniversity of Arkansas for Medical SciencesLittle RockAR 72205USA Winthrop P.Rockefeller Cancer Institute University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Pediatrics College of MedicineUniversity of Arkansas for Medical SciencesLittle RockAR2205USA Division of Geriatrics and Nutritional Sciences Department of Internal MedicineWashington University School of MedicineSt.LouisMO 63110USA Center for Dietary Supplement Research University of Arkansas for Medical SciencesLittle RockAR 72205USA

We previously demonstrated that endogenous phosphatidic acid(PA)promotes liver regeneration after acetaminophen(APAP)***,we hypothesized that exogenous PA is also *** test that,we treated mice with a toxic APAP dose at 0 h,followed by PA or vehicle(Veh)*** then collected blood and liver at 6,24,and 52 ***-treatment with PA 2 h after APAP protected against liver injury at 6 h,and the combination of PA and N-acetyl-L-cysteine(NAC)reduced injury more than NAC ***,PA did not affect canonical mechanisms of APAP ***,transcriptomics revealed that PA activated interleukin-6(IL-6)signaling in the *** with that,serum IL-6 and hepatic signal transducer and activator of transcription 3(Stat3)phosphorylation increased in PA-treated ***,PA failed to protect against APAP in IL-6-deficient ***,IL-6 expression increased 18-fold in adipose tissue after PA,indicating that adipose is a source of PA-induced circulating ***,however,exogenous PA did not alter regeneration,despite the importance of endogenous PA in liver repair,possibly due to its short *** data demonstrate that exogenous PA is also beneficial in APAP toxicity and reinforce the protective effects of IL-6 in this model.

关键词： Acute liver injury Acute liver failure Adipokine Cytokine Dietary supplement Drug-induced liver injury Hepatotoxicity Lipid

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二位置陀螺寻北仪静态误差分析

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压电与声光 2000年第5期22卷 309-312页

作者：卜继军魏贵玲吕志清四川压电与声光技术研究所重庆400060

对二位置寻北仪的静态误差源进行了详细的讨论 ,给出了一种寻北仪静态误差分析方法 ,并得出在各误差源作用下的误差模型。分析表明 ,由于几种典型的误差源产生的寻北误差与方位角的三角函数成正比或为常值 ,有较强的规律性。

关键词：寻北仪静态误差误差源陀螺

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Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-α-induced inflammatory activation of synovial fibroblasts

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Cellular & Molecular Immunology 2022年第10期19卷 1185-1195页

作者： Ruby J.Siegel Anil K.Singh Paul M.Panipinto Farheen S.Shaikh Judy Vinh Sang u.Han H.Mark Kenney Edward M.Schwarz Cynthia S.Crowson Sadik A.Khuder Basil S.Khuder David A.Fox Salahuddin Ahmed Department of Pharmaceutical Sciences Washington State University College of Pharmacy and Pharmaceutical SciencesSpokaneWAUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Department of Quantitative Health Sciences and Division of Rheumatology Mayo ClinicRochesterMNUSA Department of Medicine and Public Health University of ToledoToledoOHUSA Department of Pathology and Laboratory Medicine Phoenix Children’s HospitalPhoenixAZUSA Department of Medicine Division of Rheumatology and Clinical Autoimmunity Center of ExcellenceUniversity of Michigan Medical SystemAnn ArborMIUSA Division of Rheumatology University of Washington School of MedicineSeattleWAUSA

Extracellular sulfatase-2(Sulf-2)influences receptor-ligand binding and subsequent signaling by chemokines and growth factors,yet Sulf-2 remains unexplored in inflammatory cytokine signaling in the context of rheumatoid arthritis(RA).In the present study,we characterized Sulf-2 expression in RA and investigated its potential role in TNF-α-induced synovial inflammation using primary human RA synovial fibroblasts(RASFs).Sulf-2 expression was significantly higher in serum and synovial tissues from patients with RA and in synovium and serum from hTNFtg *** sequencing analysis of TNF-α-stimulated RASFs showed that Sulf-2 siRNA modulated~2500 genes compared to scrambled *** Pathway Analysis of RNA sequencing data identified Sulf-2 as a primary target in fibroblasts and macrophages in *** blot,ELISA,and qRT‒PCR analyses confirmed that Sulf-2 knockdown reduced the TNF-α-induced expression of ICAM1,VCAM1,CAD11,PDPN,CCL5,CX3CL1,CXCL10,and *** studies identified the protein kinase C-delta(PKCδ)and c-Jun N-terminal kinase(JNK)pathways as key in the TNF-α-mediated induction of proteins related to cellular adhesion and *** of Sulf-2 abrogated TNF-α-induced RASF ***-2 knockdown with siRNA and inhibition by OKN-007 suppressed the TNF-α-induced phosphorylation of PKCδand JNK,thereby suppressing the nuclear translocation and DNA binding activity of the transcription factors AP-1 and NF-κBp65 in human ***,Sulf-2 expression positively correlated with the expression of TNF receptor 1,and coimmunoprecipitation assays demonstrated the binding of these two proteins,suggesting they exhibit crosstalk in TNF-α*** study identified a novel role of Sulf-2 in TNF-αsignaling and the activation of RA synoviocytes,providing the rationale for evaluating the therapeutic targeting of Sulf-2 in preclinical models of RA.

关键词： Sulfatase-2 TNF-α Rheumatoid arthritis Synovial fibroblasts Signal transduction

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Cassava Yield, Garrification Traits and Economic Returns as Influenced by Different Genotypes in an ultisol

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American Journal of Plant Sciences 2022年第6期13卷 744-755页

作者： Nyaudoh Ndaeyo Justina u. Okon Chiedozie N. Egesi Okechukwu N. Eke-Okoro Francis O. Ogbe Department of Crop Science University of Uyo Uyo Nigeria National Root Crops Research Institute Umudike Nigeria

Field trials were conducted at the university of uyo Teaching and Research Farm in 2009/2010 and 2010/2011 to evaluate cassava yield, garrification traits, and economic returns as influenced by genotypes grown in an ultisol. uyo is located between latitudes 4°30' and 5°27'N and longitudes 7°50'E and 80°20'E. The area, which lies within the humid tropical rainforest zone of southeastern Nigeria, has an annual mean rainfall of 2500 mm with a bimodal rainfall pattern, monthly sunshine of 3.14 hours, and a mean annual temperature of 28°C. The experimental site was previously put into cultivation of some arable crops such as fluted pumpkin, okra, and waterleaf before it was fallowed for two years. A randomized complete block design, replicated three times was used. Treatments were 16 cassava genotypes (ar1-82, NR02/0028, NR03/0174, CR12-45, NR03/0211, TMS98/2132, TMS01/1206, TMS01/1368, TMS01/1371, CR36-5, NR02/0007, NR03/0155, ar37-108, TMS01/1412, TMS30572 and local best variety “Obubit okpo”). Results obtained via combined (pooled) analysis of the two seasons indicated that cassava yield differed significantly among the genotypes. NR02/0018 (42.50 t/ha) out-yielded others by 17% - 52% followed by NR 02/0007 (35.42 t/ha), and NR 03/0155 (32.08 t/ha). TMS 98/2132 had the most preferred garrification attributes followed by NR 02/0018, NR 02/0007, and NR03/01155. NR 02/0018 genotype gave the highest economic returns followed by NR 02/0007 and NR03/0155. NR02/0018 superseded others in yield, garrification traits, and economic returns, which is therefore recommended.

关键词： Cassava Genotypes Yield Garrification Traits Economic Returns

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水下高压空气环境下GMAW电弧特性试验

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焊接学报 2010年第12期31卷 17-20页

作者：黄继强薛龙吕涛蒋力培北京石油化工学院光机电装备技术北京市重点实验室北京102617

采用高压试验舱模拟水下高压干式焊接环境,以压缩空气为气源进行加压,通过防燃爆试验验证在0.1~0.7 MPa范围内,在CO2和混合气（80%ar＋20%CO2）作为保护气源的情况下,可以进行正常的GMAW焊接过程.在此基础上,通过试验研究了高压空气环境... 详细信息

采用高压试验舱模拟水下高压干式焊接环境,以压缩空气为气源进行加压,通过防燃爆试验验证在0.1~0.7 MPa范围内,在CO2和混合气（80%ar＋20%CO2）作为保护气源的情况下,可以进行正常的GMAW焊接过程.在此基础上,通过试验研究了高压空气环境下GMAW电弧特性,分别考察了环境压力、焊接电流、焊丝伸出长度和保护气种类及流量对焊接电弧特性的影响规律,并给出试验结果.借助最小二乘法对试验数据进行拟合,得出了高压空气环境下GMAW电弧电压的数学模型.

关键词：水下焊接熔化极气体保护焊电弧高压焊接

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常温直流对靶溅射制备高TCR氧化钒薄膜

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天津大学学报 2006年第7期39卷 806-809页

作者：吴淼胡明吕宇强刘志刚天津大学电子信息工程学院天津300072

常温下用直流对靶磁控溅射的方法在玻璃基片上制备出了高电阻温度系数(TCR)氧化钒薄膜.通过设计正交试验,系统分析了ar和O_2的标准体积比、溅射功率、工作压强和热处理时间对氧化钒薄膜TCR的影响.对最佳工艺条件下制得的薄膜进行电阻温... 详细信息

常温下用直流对靶磁控溅射的方法在玻璃基片上制备出了高电阻温度系数(TCR)氧化钒薄膜.通过设计正交试验,系统分析了ar和O_2的标准体积比、溅射功率、工作压强和热处理时间对氧化钒薄膜TCR的影响.对最佳工艺条件下制得的薄膜进行电阻温度特性测试,TCR达到-3.3%/K,室温方块电阻为28.5kΩ,个别样品的TCR达到-4%/K以上.扫描电子显微镜(SEM)和原子力显微镜(AFM)的形貌分析显示,这种制备方法结合适当的退火可以制备出氧化钒多晶薄膜,晶粒尺寸在纳米数量级.X射线光电子能谱(XPS)分析发现,高TCR薄膜样品中钒的总体价态接近+4价.所有结果表明,制得的氧化钒薄膜电性能满足红外探测器的要求,且该工艺能与CMOS工艺兼容.

关键词：直流对靶磁控溅射氧化钒薄膜电阻温度系数正交试验

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Retraction Note: A note on the unsteady flow of a fractional Maxwell fluid through a circular cylinder

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Acta Mechanica Sinica 2012年第5期28卷 1510-1510页

作者： M. Athar A. u. Awan Corina Fetecau Abdus Salam School of Mathematical Sciences GC University Lahore

Retraction to: Acta Mechanica Sinica (2012) 28(2): 308-314 DOI 10.1007/S10409-012-0004-Z This article is retracted at the request of the Editor-in-Chief because of similarity to previously published material, specific... 详细信息

关键词： Maxwell Retraction Note A note on the unsteady flow of a fractional Maxwell fluid through a circular cylinder flow

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Journal of the American Heart Association|肝硬化退伍军人心肺血流动力学与病死率的关系:一项回顾性队列研究

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临床肝胆病杂志 2024年第6期40卷 1254-1254页

作者：杜佳霖温晓玉吉林大学第一医院肝胆胰内科

门脉性肺动脉高压(PoPH)与患者病死率增加相关,可能会限制肝脏疾病的治疗选择。目前缺乏与PoPH心肺血流动力学相关的临床风险连续性的数据。2024年4月,美国辛辛那提大学医学系Jose等探讨了肝硬化退伍军人心肺血流动力学与死亡率的关系。

关键词：肺血流动力学回顾性队列研究医学系门脉性肺动脉高压临床风险辛辛那提大学肝硬化病死率

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^(40)ar—^(39)ar法国际标准样BSP—1角闪石的测定

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质谱学报 1993年第3期14卷 5-19页

作者：桑海清王松山胡世玲裘冀 u.G.Cordani K.Kawashita 中国科学院地质研究所北京100029 巴西圣保罗大学地球科学院

利用RGA—10质谱计和析氢仪联合装置对BSP—1角闪石进行了K—ar及^(40)ar—^(39)ar年龄测定,坪年龄为2054±2Ma;谱线平坦,^(40)ar^(?)保存性很好,K/Ca和CI/K比值稳定;^(40)ar—^(39)ar等时年龄为2053Ma,^(40)ar/^(36)ar初始值为294.2,与大气ar丰度一致。国内外13个实验室参加了该角闪石K和^(40)ar^(?),的定值分析,其结果为:K=0.725±0.003(%),^(40)ar^(?)=109.06±0.26(10^(-6)cc-STP/g),由此求出的K—ar年龄为2060±8Ma,与坪年龄、等时年龄吻合。这些结果表明,BSP—1角闪石结晶时未捕获大气ar,结晶以来未受过热扰动,保持着良好的^(40)K、^(40)ar^(?)封闭体系,是很理想的^(40)ar—^(39)ar法的国际标准样。

关键词： BSP-1角闪石氩40-氩39 年龄

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人工触发闪电通道的导电特性

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光谱学与光谱分析 2007年第10期27卷 1929-1932页

作者：张华明袁萍苏茂根吕世华西北师范大学物理与电子工程学院中国科学院寒区旱区环境与工程研究所甘肃兰州730000

用光学多道分析仪(OMA)获得了山东地区人工触发闪电回击过程的发射光谱。与以往的自然闪电光谱相比,除了氮、氧的中性原子及一次电离的离子谱和Hα谱线外,这次人工触发闪电的光谱还记录到了微量元素arⅠ602.5nm及arⅡ666.5nm的谱线。在... 详细信息

用光学多道分析仪(OMA)获得了山东地区人工触发闪电回击过程的发射光谱。与以往的自然闪电光谱相比,除了氮、氧的中性原子及一次电离的离子谱和Hα谱线外,这次人工触发闪电的光谱还记录到了微量元素arⅠ602.5nm及arⅡ666.5nm的谱线。在局部热力学平衡近似下,根据光谱线的相对强度等参量,计算了闪电通道等离子体的温度;利用Hα线的Stark加宽、通过半经验方法获得了闪电通道的电子密度;首次结合等离子体理论得到了闪电通道的电导率,并由此讨论了通道的导电特性,分析了通道电导率与回击电流之间的相关性,为进一步计算回击电流提供了参考数据。结果分析得出:闪电通道是良导体,电子是通道电流的主要载体;一般情况下,人工触发闪电的通道亮度比自然闪电通道大,而通道回击电流小于自然闪电。

关键词：电导率电子温度电子密度

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