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Estrogen receptors in gastric cancer:Advances and perspectives

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World Journal of Gastroenterology 2016年第8期22卷 2475-2482页

作者： Muhammad Saif ur Rahman Jiang Cao Clinical Research Center The Second Affiliated Hospital Zhejiang University School of Medicine

Worldwide, gastric cancer is one of the most common malignancies with high mortality. Various aspects of thedevelopment and progression of gastric cancer continue to be extensively investigated in order to further our understanding and provide more effective means for the prevention, diagnosis, and treatment of the disease. Estrogen receptors(ERs) are steroid hormone receptors that regulate cellular activities in many physiological and pathological processes in different tissues. There are two distinct forms of ERs, namely ERα and ERβ, with several alternative-splicing isoforms for each. They show distinct tissue distribution patterns and exert different biological functions. Dysregulation of ERs has been found to be associated closely with many diseases, including cancer. A number of studies have been conducted to investigate the role of ERs in gastric cancer, the possible mechanisms underlying these roles, and the clinical relevance of deregulated ERs in gastric cancer patients. To date, inconsistent associations of different ERs with gastric cancer have been reported. These inconsistencies may be caused by variations in in vitro cell models and clinical samples, including assay conditions and protocols with regard to different forms of ERs. Given the potential of the deregulated ERs as diagnostic/prognostic markers or therapeutic targets for gastric cancer, it will be important to identify/confirm the association of each ER isoform with gastric cancer, to determine the specific roles and interactions that these individual ER isoforms play under specific conditions in the development and/or progression of gastric cancer, and to elucidate precisely these mechanisms. In this review, we summarize the achievements from early ER studies in gastric cancer to the most up-to-date discoveries, with an effort to provide a comprehensive understanding of the role of ERs roles in gastric cancer and its possible mechanisms. Furthermore, we propose directions for future investig

关键词： Gastric cancer Estrogen receptor Isoform Carcinogenesis Mechanism Genomic pathway Nongenomic pathway

Antimicrobial resistance and underlying mechanisms in Staphylococcus aureus isolates

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1059-1064页

作者： Ebru Sebnem yilmaz Ozkan Aslantas Department of Biology Faculty of Art and Sciences Mustafa Kemal University Department of Microbiology Faculty of Veterinary Medicine Mustafa Kemal University

Objective: To investigate the antimicrobial susceptibility of 97 clinical Staphylococcus aureus(S. aureus) strains against 14 antimicrobials and corresponding resistance ***: The antimicrobial susceptibility of the isolates was determined using a disk diffusion method and antimicrobial resistance genes were screened by polymerase chain reaction. Mutations responsible for ciprofloxacin and rifampicin resistance were investigated by polymerase chain reaction and DNA ***: All isolates were found to be susceptible to vancomycin. Various rates of resistance to penicillin(83.5%), ampicillin(77.3%), erythromycin(63.9%), tetracycline(16.5%), amoxicillin/clavulanic acid(16.5%), ciprofloxacin(15.5%), trimethoprim/sulfamethoxazole(15.5%), oxacillin(13.4%), fusidic acid(12.4%), rifampin(6.2%), clindamycin(6.2%), gentamicin(6.2%) and mupirocin(5.2%) were determined. In addition,different combinations of resistance genes were identified among resistant *** resistant isolates had mutations in codon 84(Ser84 Leu) and 106(Gly106 Asp) in the gyr A gene. Mutations in grl A were mostly related to Ser80 Phe substitution. Leu466 Ser mutation in the rpo B gene was detected in all rifampin resistant isolates. All methicillin resistant S. aureus isolates were SCCmec type ***: In conclusion, it was determined that the isolates were resistant to different classes of antimicrobials at varying rates and resistance was mediated by different genetic mechanisms. Therefore, continuous monitoring of resistance in S. aureus strains is necessary to control their resistance for clinically important antimicrobials.

关键词： Staphylococcus aureus Antimicrobial resistance Resistance mechanisms Point mutation

Decoding 17-Beta-hydroxysteroid Dehydrogenase 13:A Multifaceted Perspective on Its Role in Hepatic Steatosis and Associated Disorders

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Journal of Clinical and Translational Hepatology 2024年第10期12卷 857-864页

作者： Coskun Ozer Demirtas Yusuf yilmaz Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkiye Institute of Gastroenterol-ogy Marmara UniversityistanbulTurkiye Department of Gastroenterology School of MedicineRecep Tayyip Erdogan UniversityRizeTurkiye The Global NASH Council WashingtonDCUSA

Chronic liver disease(CLD)represents a significant global health burden,with hepatic steatosis-associated disorders—such as metabolic dysfunction-associated steatohepatitis(MASH),alcoholic liver disease,and hepatitis C virus infection—being major *** genome-wide association studies have identified the rs72613567:TA variant in the 17-beta-hydroxysteroid dehydrogenase 13(HSD17B13)gene as a protective factor against the development and progression of these *** this review,we summarized the current evidence surrounding the HSD17B13 rs72613567 variant,aiming to elucidate its impact on CLD risk and outcomes,and to explore the potential mechanisms behind its hepatoprotective *** rs72613567:TA variant induces a splice donor site mutation,resulting in a truncated,nonfunctional HSD17B13 *** studies have demonstrated that this loss-of-function mutation confers protection against the development of cirrhosis and hepatocellular carcinoma(HCC)in patients with MASH,alcoholic liver disease,and hepatitis C virus ***,the rs72613567:TA variant has been associated with reduced liver enzyme levels and improved survival in HCC *** this variant into genetic risk scores has shown promise in predicting the progression of fatty liver disease to cirrhosis and ***,inhibiting HSD17B13 expression through RNA interference and small molecule inhibitors has emerged as a potential therapeutic strategy for ***,the precise molecular mechanisms underlying the hepatoprotective effects of the HSD17B13 rs72613567 variant remain to be fully *** research should focus on clarifying the structure-function relationship of HSD17B13 and its role in liver pathophysiology to facilitate the development of targeted therapies for CLD associated with hepatic steatosis.

关键词： 17-Beta-hydroxysteroid dehydrogenase 13 Chronic liver disease Polymorphism Genetics Risk factor Hepatocellular carcinoma Metabolic dysfunction-associated steatohepatitis

Non Planar Electrostatic Solitary Wave Structures in Negative Ion Degenerate Plasma

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Chinese Physics Letters 2011年第4期28卷 148-151页

作者： S.Hussain N.Akhtar Saeed-ur-Rehman Theoretical Plasma Physics Division PINSTECHNiloreIslamabad Department of Physics and Applied Mathematics PIEAS NiloreIslamabad

Theoretical and numerical studies are performed for quantum ion acoustic solitons in planar and non-planar geometries in an unmagnetized homogenous plasma consisting of warm positive and negative ions with nonthermal electrons.A deformed Korteweg de Vries(DKdV)equation is derived by using the reductive perturbation *** numerical solution to the DKdV equation indicates that the quantum parameter,temperatures of positive ions,temperture of negative ions and electron density blatantly influence the propagation speed and the structure of quantum ion acoustic *** geometrical effects on the structure of quantum ion acoustic wave are *** is shown that the amplitude and propagation speed in spherical geometry is larger as compared to cylinderical and planar geometries for different values of the above-mentioned parameters.

关键词： method quantum planar

unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis

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World Journal of Gastroenterology 2013年第25期19卷 4015-4022页

作者： Mehmet yilmaz Sami Akbulut Koray Kutluturk Nurhan Sahin Ebru Arabaci Cengiz Ara Sezai yilmaz Department of Surgery Liver Transplant Institute Inonu University Faculty of Medicine Department of Pathology Inonu University Faculty of Medicine

AIM: To investigate the prevalence and implications of unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis. METHODS: The demographic and histopathological data of 1621 patients (≥ 16 years-old) who underwent appendectomy to treat an initial diagnosis of acute appendicitis between January 1999 and November 2011 were retrospectively assessed. Microscopic findings were used to classify the patients under six categories: appendix vermiformis, phlegmonous appendicitis, gan- grenous appendicitis, perforated appendicitis, supurative appendicitis, and unusual histopathologic findings. The demographic and clinicopathologic characteristics of patients with unusual histopathologic findings were evaluated in detail, and re-analysis of archived resected appendix specimens was carried out. RESuLTS: A total of 912 males and 709 females, from16 to 94 years old, were included in the study and comprised 789 cases of suppurative appendicitis, 370 cases of appendix vermiformis, 243 cases of perforated gangrenous appendicitis, 53 cases of flegmaneous appendicitis, 32 cases of gangrenous appendicitis, and 134 (8.3%) cases of unusual histopathological findings. The unusual histopathological findings included fibrous obliteration (n = 62), enterobius vermicularis (n = 31), eosinophilic infiltration (n = 10), mucinous cystadenoma (n = 8), carcinoid tumor (n = 6), granulomatous inflammation (n = 5), adenocarcinoma (n = 4; one of them mucinous), and mucocele (n = 3), adenomatous polyp (n = 1), taenia sup (n = 1), ascaris lumbricoides (n = 1), appendiceal diverticula (n = 1), and B cell non-hodgkin lymphoma (n = 1). None of the 11 patients with subsequent diagnosis of tumor were suspected of cancer prior to the appendectomy. CONCLuSION: Even when the macroscopic appearance of appendectomy specimens is normal, histopathological assessment will allow early diagnosis of many unusual diseases.

关键词： Appendicitis Appendectomy specimens Histopathology unusual findings Appendiceal malignancy

Authentication of Vehicles and Road Side units in Intelligent Transportation System

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Computers, Materials & Continua 2020年第7期64卷 359-371页

作者： Muhammad Waqas Shanshan Tu Sadaqat ur Rehman Zahid Halim Sajid Anwar Ghulam Abbas Ziaul Haq Abbas Obaid ur Rehman Beijing Key Laboratory of Trusted Computing Faculty of Information TechnologyBeijing University of TechnologyBeijing100124China Faculty of Computer Science&Engineering Ghulam Ishaq Khan Institute of Engineering Sciences&TechnologyTopi23460Pakistan Beijing Electro-Meahnical Engineering Institute Beijing100074China Faculty of Electrical Engineering Ghulam Ishaq Khan Institute of Engineering Sciences&TechnologyTopi23460Pakistan Department of Electrical Engineering Sarhad University of Science and Information TechnologyPeshawar25000Pakistan

Security threats to smart and autonomous vehicles cause potential consequences such as traffic accidents,economically damaging traffic jams,hijacking,motivating to wrong routes,and financial losses for businesses and *** and autonomous vehicles are connected wirelessly,which are more attracted for attackers due to the open nature of wireless *** of the problems is the rogue attack,in which the attacker pretends to be a legitimate user or access point by utilizing fake *** figure out the problem of a rogue attack,we propose a reinforcement learning algorithm to identify rogue nodes by exploiting the channel state information of the communication *** consider the communication link between vehicle-to-vehicle,and *** evaluate the performance of our proposed technique by measuring the rogue attack probability,false alarm rate(FAR),mis-detection rate(MDR),and utility function of a receiver based on the test threshold values of reinforcement learning *** results show that the FAR and MDR are decreased significantly by selecting an appropriate threshold value in order to improve the receiver’s utility.

关键词： Intelligent transportation system authentication rogue attack

Vegetation-environment relationship in Pinus wallichiana forests of the Swat Hindukush range of Pakistan

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Journal of Forestry Research 2020年第1期31卷 185-195页

作者： Inayat ur Rahman Nasrullah Khan Kishwar Ali Siraj Ahmad Laboratory of Plant Ecology and Dendrochronology Department of BotanyUniversity of Malakand

understanding the influence of environmental variables on the spatial distribution of ecological communities is essential to predict the response of vegetation to various environmental *** theory suggests that multiple environmental factors shape local species assemblages and should influence the various components of community structure and composition in different *** study aimed to classify Pinus wallichiana dominated forests in the Swat Hindukush range mountains to understand the relative influence of multiple environmental filters on its composition and *** forests represent the most typical of the species distribution in northern Pakistan and were not subjected to any phytosociological *** this purpose,thirty forest stands,spanning a wide range of physical habitats were sampled using 10 x 10 m plots and the importance value index was *** floristic and environmental data were subjected to Ward’s agglomerative cluster analysis for objective classification and ordinated with NMS ordination for pattern description and testing the vegetation-environmental *** floristically and ecologically distinct communities were recognized along the topographic gradient(elevation,r=0.377;slope,r=0.5548) coupled with soil physical(clay,r=0.2782;silt,r=0.3225) and chemical properties(pH,r=0.4975;lime,r=3982).An elevation gradient of 100 m separated the low(Pinus wallichiana-Quercus dilatata community)and middle elevations forest stands(*** pure population) from the highland population type(Pinus wallichiana-Cedrus deodara community).The floristics and structure of these forest types respond directly or indirectly to topographic and soil variables which were evidenced from the floristic composition,species richness,and community *** characteristics of the communities changed from heterogenous,dense stands to sparsely dispersed conifers,broadleaved-evergreen,and deciduous vegetation types along

关键词： Blue pine forests Classification-ordination Ecological gradient Hindukush range mountains Species composition

Dynamics and Small Signal Stability Analysis of PMSG-based Wind Farm with an MMC-HVDC System

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CSEE Journal of Power and Energy Systems 2020年第1期6卷 226-235页

作者： Yifan Wang Chengyong Zhao Chunyi Guo Atiq ur Rehman The State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

The permanent magnet synchronous generator (PMSG)-based wind farm with a modular multilevel converter (MMC) based HVDC system exhibits various oscillations and can experience dynamic instability due to the interactions between different controllers of the wind farm and MMC stations, which have not been properly examined in the existing literatures. This paper presents a dynamic modeling approach for small signal stability analysis of PMSG-based wind farms with a MMC- HVDC system. The small signal model of the study system is validated by the comprehensive electromagnetic transient (EMT) simulations in PSCAD/EMTDC. Then the eigenvalue approach and participation factors analysis are utilized to comprehensively evaluate the impact of different controllers, system’s parameters and the circulating current suppressing controller (CCSC) on the small signal stability of the entire system. From eigenvalue analysis, it is revealed that as the output active power of the wind farm increases within the rated range, the overall system will exhibit a sub-synchronous oscillation (SSO) instability mode, an extremely weak damping mode, and a low frequency oscillation instability mode. From participation factors analysis, it is observed that the SSO mode and weak damping mode are primarily related to the internal dynamics of the MMC, which can be suppressed or improved by CCSC. It is determined that the low frequency oscillation mode is primarily caused by the interactions between the phase locked loop (PLL) control of the wind farm and the voltage and frequency (V-F) control of the MMC station. The analysis also depicts that the larger proportional gain value of the V-F control of the MMC station and smaller PLL bandwidth of the wind farm can enhance the small signal stability of the entire system.

关键词： HVDC modular multilevel converter(MMC) permanent magnet synchronous generator(PMSG) small signal stability sub-synchronous oscillation(SSO) wind farm

Nanocarbon-based electrode materials applied for supercapacitors

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Rare Metals 2022年第12期41卷 3957-3975页

作者： Yu-Xiang Yang Kang-Kang Ge Sajid ur Rehman Hong Bi School of Chemistry and Chemical Engineering School of Materials Science and EngineeringAnhui UniversityHefei 230601China CIRIMAT UMR CNRS 5085UniversitéPaul Sabatier ToulouseⅢToulouse 31062France CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China

As one of the promising energy storage and conversion systems,supercapacitors(SCs)are highly favored owing to their high power density and good service *** all the key components of supercapacitor devices,the design and investigation of electrode materials play an essential role in determining the whole electrochemical charge storage ***,nanocarbon-based materials(e.g.,graphene,carbon dots,graphene quantum dots,etc.)have been widely used as SC electrode materials because of their good physical structure and chemical properties,providing a new route to further improve the energy density and life span of ***,we review the latest progress of nanocarbon-based materials(including nanocarbon and nanocarbon-based composite materials)as electrode materials in SCs *** recent progress of carbon dots,graphene,carbon nanotubes,and other nanocarbon materials electrodes is summarized,while the capacitance and energy density of the above nanocarbon electrodes still need to be ***,the preparation and performance of nanocarbonbased composite electrodes comprising transition metal oxides,conductive polymer,and metal-organic framework derived porous carbon are ***,we outline major challenges and propose some ideas on building better nanocarbon-based SC electrodes.

关键词： Supercapacitor(SC) Nanocarbon Electrode materials Carbon dots Nanocarbon-based composite