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中国黄金珠宝 2009年第1期 98-99页

作者： u&me u&me

2008中国的浪漫、唯美不只是北京奥运会的开、闭幕式。没有哪个元素比“中国”在今年更获得世界的热捧，在世界这个最长的“T台”上，难道不是中国最精彩？

关键词：中国式北京奥运会闭幕式世界

unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny me Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan u.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red meDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Cenozoic ultrahigh-temperature metamorphism in pelitic granulites from the Mogok metamorphic belt, Myanmar

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Science China Earth Sciences 2021年第11期64卷 1873-1892页

作者： Si CHEN Yi CHEN Yibing LI Bin Su Qinghua ZHANG me me AuNG Kyaing SEIN State Key Laboratory of Lithospheric Evolution and Institutions of Earth ScienceInstitute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China university of Chinese Academy of Sciences Beijing 100049China Geology Department Myitkyina UniversityKachin StateMyitkyina 01012Myanmar Myanmar Geosciences Society Hlaing University CampusYangon 11062Myanmar

ultrahigh-temperature(uHT)metamorphism is critical for understanding the most extreme thermal evolution of continental ***,uHT metamorphism predominantly occurred in the Precambrian and is rarely observed in the modern ***,we report the discovery of~25 Ma uHT granulites from the Mogok metamorphic belt(MMB)in Myanmar via a combined study of petrology and *** studied pelitic granulites well preserve a peak mineral assemblage of garnet+sillimanite+plagioclase(antiperthite)+K-feldspar+quartz+Ti-rich biotite+rutile+***(P)-temperature(T)pseudosections and conventional geothermobarometry data only constrain the P-T conditions of the peak stage toutile(3005–4308 ppm)and high Ti contents(up to 9.2 wt% TiO_(2))in the biotite demonstrate that the Mogok granulites may have experienced uHT *** Zr-in-rutile thermometer and X_(Grs) isopleth in the pseudosections yield peak P-T conditions of~12 kbar and>900°*** situ SIMS and LAICP-MS u-Pb dating and trace element analyses show that both metamorphic zircon cores and rims have flat heavy rare earth element(HREE)patterns with negative Eu *** metamorphic zircon rims show the lowest HREE contents and yield ^(206)Pb/^(238)u ages of 24.9±0.5 and 25.4±0.6 Ma,respectively,representing the timing of uHT *** results indicate that the central MMB underwent~25 Ma uHT metamorphism,which is possibly induced by continental rifting along the thinned orogenic *** data,as well as reported Cenozoic uHT events,further suggest that uHT metamorphism can be produced in the modern plate tectonic regime by lithospheric extension.

关键词： Mogok metamorphic belt ultrahigh-temperature metamorphism Pelitic granulites Zr-in-rutile thermometry Zircon chronology

Magnetoresistivity studies for BiPb-2223 phase added by BaSnO3 nanoparticles

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Journal of Advanced Ceramics 2017年第2期6卷 100-109页

作者： Mai me.BARAKAT Khulud HABANJAR Department of Physics Faculty of Science Alexandria University Alexandria Egypt Department of Physics Faculty of Science Beirut Arab University Beirut Lebanon

Co-precipitation method and conventional solid-state reaction technique were used to synthesize BaSnO3 nanoparticles and (BaSnO3)x/Bi1.6Pb0.4Sr2Ca2Cu3O10+δ (0≤x≤ 1.50w t％) samples,respectively.X-ray powder diffraction (XRD),scanning electron microscopy (SEM),and electrical resistivity data were used to characterize BiPb-2223 phase added by BaSnO3 *** relative volume fraction and superconducting transition temperature Tc of BiPb-2223 phase were enhanced by increasing BaSnO3 addition up to 0.50 wt％.These parameters were decreased with further increase of *** resistive transition broadening under different applied DC magnetic fields (0.29-4.40kG) was analyzed through thermally activated flux creep (TAFC) model and Ambegaokar-Halperin (AH) *** of the derived flux pinning energy u,critical current density Jc (0) estimated from AH parameter C(B),and upper critical magnetic field Bc2 (0),were recorded by adding BaSnO3 nanoparticles up to 0.50 wt％,beyond which these parameters were *** magnetic field dependence of the flux pinning energy and critical current density decreased as a power-law relation,which indicated the single junction sensitivity between the superconducting grains to the applied magnetic ***,the increase in the applied magnetic field did not affect the electronic thermal conductivity Ke above the superconducting transition temperature and suppressed it below Tc.

关键词： BiPb-2223 BaSnO3 nanoparticles flux pinning energy critical current density

Ranking parameters in urban energy models for various building forms and climates using sensitivity analysis

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建筑模拟(英文) 2023年第9期16卷 1587-1600页

作者： Aysegul Demir Dilsiz Kaitlynn Ng Jérôme Kämpf Zoltan Nagy Department of Civil and Architectural Engineering and Construction Management University of WyomingLaramie WYUSA Intelligent Environments Lab Department of CivilArchitectural and Environmental EngineeringThe University of Texas at AustinAustin TXUSA Energy Informatics Group Idiap Research Institute1920 MartignySwitzerland

urban Building Energy Modelling(uBEM)allows us to simulate buildings’energy performances at a larger ***,creating a reliable urban-scale energy model of new or existing urban areas can be difficult since the model requires overly detailed input data,which is not necessarily publicly *** calibration is a necessary step to reduce the uncertainties and simulation results in order to develop a reliable and accurate *** to the concerns over computational resources and the time needed for calibration,a sensitivity analysis is often required to identify the key parameters with the most substantial impact before the calibration is deployed in ***,we study the sensitivity of uncertain input parameters that affect the annual heating and cooling energy demand by employing an urban-scale energy model,*** goal is to determine the relative influence of each set of input parameters and their interactions on heating and cooling loads for various building forms under different ***,we conduct a global sensitivity analysis for annual cooling and heating consumption under different climate *** upon this,we investigate the changes in input sensitivity to different building forms,focusing on the indices with the largest Total-order ***,we determine First-order indices and Total-order effects of each input parameter included in the urban building energy *** also provide tables,showing the important parameters on the annual cooling and heating demand for each climate and each building *** find that if the desired calibration process require to decrease the number of the inputs to save the computational time and cost,calibrating 5 parameters;temperature set-point,infiltration rate,floor u-value,*** u-value and roof u-value would impact the results over 55%for any climate and any building form.

关键词： global sensitivity analysis Sobol’method urban energy modeling building stocks energy modelling parameter screening Sobol’indices sustainable urban planning

Substorm onset of near-earth magnetotail origin observed by coordinated satellites and ground-based observations

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Substorm onset of near-earth magnetotail origin observed by ...

Trends in incidence and management of cancer of the ampulla of Vater

第十二届全国日地空间物理学术讨论会

作者： H．Rème Y．Lucek H．u．Frey CESR/CNRS ToulouseFrance Space and Atmospheric Physics Imperial CollegeSW7 2BZLondonUK Space Sciences Laboratory University of CaliforniaBerkeleyUSA

＜正＞With a favorable constellation of spacecrafts and ground-based magnetometer network,a study has been made on a substorm event on 3 August 2004,focused on where and how the onset is initiated in the *** substorm expansion （EP） onset was identified by both ground magnetometers and auroral *** of Pi2 pulsations showed a pseudo-breakup about 16 min before the EP ***

关键词：

来源： cnki会议评论

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cnki会议

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World Journal of Gastroenterology 2014年第29期20卷 10144-10150页

作者： Florian Rostain Samia Hamza Antoine Drouillard Jean Faivre Anne-Marie Bouvier C?me Lepage Registre Bourguignon des Cancers Digestifs INSERM U866CHU de DijonFaculté de Médecine21079 Dijon CedexFrance

AIM: To provide trends in incidence, management and survival of cancer of the ampulla of Vater in a well-defined French population.

关键词： Cancer of the ampulla of Vater Incidence Survival Treatment Epidemiology

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缅甸抹谷变质带新生代超高温变质作用

中国科学：地球科学 2021年第11期51卷 1872-1893页

作者：陈思陈意李仪兵苏斌张庆华 me me AuNG Kyaing SEIN 中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029 中国科学院青藏高原地球科学卓越创新中心北京100101 中国科学院大学北京100049 Geology Department Myitkyina UniversityKachin StateMyitkyina 01012Myanmar Myanmar Geosciences Society Hlaing University CampusYangon 11062Myanmar

超高温变质作用是探知大陆地壳极端热演化的重要窗口,广泛分布于前寒武纪,在新生代极少出现.文章通过详细的岩石学和年代学研究,在缅甸抹谷变质带中发现了~25Ma的超高温泥质麻粒岩,峰期矿物组合为石榴子石+夕线石+斜长石(反条纹长石)+... 详细信息

超高温变质作用是探知大陆地壳极端热演化的重要窗口,广泛分布于前寒武纪,在新生代极少出现.文章通过详细的岩石学和年代学研究,在缅甸抹谷变质带中发现了~25Ma的超高温泥质麻粒岩,峰期矿物组合为石榴子石+夕线石+斜长石(反条纹长石)+钾长石+石英+富Ti黑云母+金红石+钛铁矿.尽管传统矿物温压计和压力(P)-温度(T)视剖面图限定其峰期变质压力900°C和~12kbar.锆石SIMS和LA-ICP-MS u-Pb定年及微量元素分析显示,变质锆石都具有重稀土(HREE)平坦的配分模式和Eu的负异常特征.两个麻粒岩样品中HREE含量最低的变质锆石分别给出了(24.9±0.5)和(25.4±0.6)Ma的206Pb/238u年龄,代表了超高温变质时代.研究结果表明,抹谷地区在~25Ma经历了超高温变质作用,这可能是板块汇聚边缘的大陆张裂引发岩石圈伸展导致的,进一步论证了在现代板块构造体制下岩石圈伸展是诱发超高温变质作用的关键机制.

关键词：抹谷变质带超高温变质作用泥质麻粒岩金红石Zr温度计锆石年代学

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断陷盆地构造枢纽部位油气富集规律

中国石油大学学报（自然科学版） 2011年第2期35卷 39-44,56页

作者：喻顺吕修祥柳广弟徐宏节解启来刘小平中国石油大学地球科学学院北京102249 中国石油大学油气资源与探测国家重点实验室北京102249 中国石化东北石油局吉林长春130056 华南农业大学资源环境学院广东广州510642

以十屋断陷为例,根据其构造演化、主要断层特征及油气成藏条件分析,揭示多旋回断陷盆地构造枢纽带与油气富集关系。结果表明:十屋断陷枢纽部位经历了断陷期、断拗过渡期、拗陷期、萎缩隆升期等复杂的构造演化,多期差异构造变形及断裂活... 详细信息

以十屋断陷为例,根据其构造演化、主要断层特征及油气成藏条件分析,揭示多旋回断陷盆地构造枢纽带与油气富集关系。结果表明:十屋断陷枢纽部位经历了断陷期、断拗过渡期、拗陷期、萎缩隆升期等复杂的构造演化,多期差异构造变形及断裂活动导致了小宽枢纽带南段和北段具有相似性及差异性,后期构造反转发育部位多为早期断层发育部位,且主要集中在主干断层上,构造运动产生位移被断裂和褶皱吸收;不同阶段的隆起部位相叠加,使枢纽部位与构造高点相对位置发生变化,枢纽部位相对位置由原来的古隆起演变为斜坡部位;枢纽部位早期为油气的有利指向区,晚期具有良好的保存条件,同时发育多类型圈闭、有利沉积相组合及生储盖组合,围绕枢纽带可形成复式油气聚集带。

关键词：十屋断陷枢纽部位古隆起断陷盆地油气富集

urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study

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World Journal of Gastroenterology 2016年第16期22卷 4191-4200页

作者： I Jane Cox Abil E Aliev Mary me Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson Institute of Hepatology London Foundation for Liver Research Department of Chemistry University College London Division of Digestive Diseases Department of Surgery and Cancer Imperial College London Department of Hepatology Bangabandhu Sheikh Mujib Medical University Department of medical Sciences Toshiba General Hospital

AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma (HCC) patients compared to cirrhosis patients and ***: urine samples from 42 Bangladeshi patients with HCC (39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance (NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis (PCA) and orthogonal partial least squared discriminant analysis (OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLS-DA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance (ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the Mann-Whitney u test was used to compare metabolite levels depending on hepatitis B e-antigen (HBeAg) status and treatment with anti-viral therapy. A Benjamini-Hochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P ur clinical subgroups. Serum alanine aminotransferase (ALT) was significantly higher in the HCC group compared to controls (P um α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group (P = 0.004). A three-factor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. metabolites that contributed to the discrimination between the subgr

关键词： urinary metabolic profiling Hepatocellular carcinoma Nuclear magnetic resonance spectroscopy Hepatitis B Bangladesh