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Numerical Analysis and Design of an EMF Birdcage Wearable Device for the Treatment of Alzheimer’s Disease: A Feasibility Study

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Journal of Biomedical Science and Engineering 2022年第8期15卷 219-227页

作者： Felipe P. Perez David Michael Arvidson tyler phoenix taylor Maryam Rahmani Maher Rizkalla Department of Medicine Division of General Internal Medicine and Geriatrics Indiana University School of Medicine Indianapolis USA Department of Electrical and Computer Engineering Indiana University-Purdue University Indianapolis USA

In this study, we performed a numerical analysis of a novel EMF Birdcage wearable device for the treatment of Alzheimer’s disease (AD). We designed the new device to generate and radiate a frequency of 64 MHz and a specific absorption rate (SAR) of 0.6 W/kg to a simulated human brain tissue. We determined these parameters from our experimental studies on primary human brain cultures at the Indiana University School of Medicine (IUSM). We found that this frequency and SAR decreased the toxic Aβ levels in the cell cultures. The frequency of 64 MHZ has good skin depth penetration, which will easily pass through the various head layers, including hair, skin, fat, dura, the cerebrospinal (CSF), and grey matter, and reach deeply into the brain tissues. The SAR of 0.6 W/kg was achieved with lower power input and energy, decreasing the probability of thermal injury. Therefore, these parameters enhance the safety of these potential treatments. This Birdcage device emulates a small-scale MRI machine, producing the same 64 MHz frequency at much lower operating input power. In this work, we utilized a high-frequency simulation system (HFSS/EMPro) software to produce the birdcage structure for the required EMF parameters. The 64 MHz radiating frequency produced the scattering S11 parameter of −15 dbs. We obtained a SAR of 0.6 W/kg when an input power of 100 W was applied. The coil dimensions were found to be near 15 cm in height and 22 cm in diameter, which fits in wearable systems. We found that the distribution of the electric field and SAR radiate homogeneously over the simulated human head with good penetration into the brain, which proves to be an appropriate potential therapeutic strategy for Alzheimer’s disease.

关键词： Alzheimer Disease Birdcage Treatment HFSS EMF Temperature

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Differences in incidence,staging,and survival of urologic cancers in patients under 65 living in the US-Mexico border region

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当代泌尿学（英文） 2023年第2期17卷 118-124页

作者： Zachariah D.taylor Lauren Chew tyler Tumey Charlotte C.Gard Michael E.Woods Department of Urology Main Line HealthBryn MawrPAUSA Department of Osteopathic Medicine Philadelphia College of Osteopathic MedicinePhiladelphiaPAUSA Department of Osteopathic Medicine Burrell College of Osteopathic MedicineLas CrucesNMUSA Department of Economics Applied Statistics and International BusinessNew Mexico State UniversityLas CrucesNMUSA Department of Osteopathic Medicine Burrell College of Osteopathic MedicineLas CrucesNMUSA Department of Physiologyand Pathology Burrell College of Osteopathic MedicineLas CrucesNMUSA

Objectives:To describe and compare the incidence,stage at diagnosis,and survival for genitourinary cancers in the border regions and in Hispanic-Americans.Materials and methods:A population-based search was performed using the Surveillance,Epidemiology,and End Results Program 18 database and the Texas Cancer Registry from 2000 to *** regression models were performed with adjusted for age,gender,race,cancer type,cancer stage,insurance status,and cause of death were used to compare cancer-specific survival.Results:A total of 63,236 kidney and renal pelvis,38,398 bladder,1 70,640 prostate,24,313 testicular cancer cases were ***-specific survivalwas found to beimproved in Hispanic-Americans in kidney and renal pelvis(hazard ratio[HR],0.903,95％con-fidence interval[CI],0.856-0.952,p=0.0001),and bladder cancers(HR,0.81 7,95％CI,0.743-0.898,p＜0.001),despite a more ad-vanced stage at diagnosis in Hispanics with bladder cancer(p＜0.0074).Testicular cancer has a survival disadvantage for individuals living in the border region(HR,1.31 5,95％CI,1.124-1.539,p=0.0006).Conclusions:Disparities exist between Hispanic-Americans and Non-Hispanic White and also between individuals living in the border counties when compared to other *** is most significant in individuals with testicular cancer residing in the border region who demonstrate worse overall survival.

关键词： Bladder cancer Border region Kidney cancer Prostate cancer Testicular cancer

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Significant Lifetime Enhancement in QLEDs by Reducing Interfacial Charge Accumulation via Fluorine Incorporation in the ZnO Electron Transport Layer

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Nano-Micro Letters 2022年第12期14卷 432-446页

作者： Dong Seob Chung tyler Davidson-Hall Giovanni Cotella Quan Lyu Peter Chun Hany Aziz Department of Electrical and Computer Engineering Waterloo Institute for NanotechnologyUniversity of Waterloo200 University Avenue WestWaterlooON N2L 3G1Canada Ipswich Research Centre Huawei Technologies Research&Development(UK)Ltd.Phoenix House(B55)Adastral ParkIpswich IP53REUK Ottawa IC Laboratory Huawei Canada19 Allstate ParkwayMarkhamON L3R 5B4Canada

ZnO nanoparticles are widely used for the electron transport layers(ETLs)of quantum dots light emitting devices(QLEDs).In this work we show that incorporating fluorine(F)into the ZnO ETL results in significant enhancement in device electroluminescence stability,leading to LT50 at 100 cd m^(−2) of 2,370,000 h in red QLED,47X longer than the control devices.X-ray photo-electron spectroscopy,time-of-flight secondary ion mass spectroscopy,photoluminescence and electrical measurements show that the F passivates oxygen vacancies and reduces electron traps in *** photoluminescence versus bias measurements and capacitance-voltage-luminance measurements reveal that the CF4 plasma-treated ETLs lead to increased electron concentration in the QD and the QD/hole transport layer interface,subsequently decreasing hole accumulation,and hence the higher *** findings provide new insights into the critical roles that optimizing charge distribution across the layers play in influencing stability and present a novel and simple approach for extending QLED lifetimes.

关键词： Colloidal quantum dots Quantum dots light emitting device Device stability Zinc oxide nanoparticles Fluorine

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A systematic review of the management of acute superior mesenteric vein thrombosis in adults

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Journal of Pancreatology 2020年第3期3卷 111-120页

作者： Eimear phoenix Jonathan Beck Timothy J.Patterson Robert A.J.Spence Mark A.taylor Gary M.Spence Department of General Surgery Ulster Hospital DundonaldDundonaldUK Hepatobiliary Surgical Unit Mater Infirmorum HospitalBelfastUK

Background:Acute thrombosis of the superior mesenteric vein(SMV)is a rare but potentially catastrophic *** separate from portal venous thrombosis due to a higher proportion of associated thrombophilic disorders and intestinal infarction,SMV thrombosis warrants a distinct approach to *** aim of this review is to report the evidence for current ***:A systematic review was carried out in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** clinical trials databases and 4 trial registries were *** search was not limited by language or study type,but was limited to an adult population(18 years and above).The search period was between January 1,2000 and February 28,*** review was registered in the PROSPERO database:*** was assessed using the ROBINS-I ***:A total of 7989 studies were identified,resulting in 19 observational studies being *** studies reported on anti-coagulation,1 reported on anti-coagulation plus endovascular thrombectomy,9 reported on thrombolysis,and 10 reported on the role of *** assessment showed that confounding was a significant area of potential *** review has reported that the management of SMV thrombosis is centered around a patients’perceived hemodynamic *** there is evidence of perforation or peritonism then surgical intervention is ***,anti-coagulation or thrombolysis is ***:The data reported were compared with,and added to,that presented by the European Society for Vascular Surgery 2017 *** the source data were heterogenous,with multiple sources of bias and statistical comparison was not achievable.

关键词： Acute mesenteric ischemia Mesenteric vein Thrombus

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The barren stalk2 Gene Is Required for Axillary Meristem Development in Maize

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Molecular Plant 2019年第3期12卷 374-389页

作者： Hong Yao Andrea Skirpan Brian Wardell Michaela S.Matthes Norman B.Best tyler McCubbin Amanda Durbak taylor Smith Simon Malcomber Paula McSteen Division of Biological Sciences Interdisciplinary Plant GroupBond Life Sciences CenterUniversity of MissouriColumbiaMO65211USA Department of Biology Penn State UniversityUniversity ParkPA16802USA Department of Biological Sciences California State UniversityLongBeachCA90840USA Division of Biological Sciences Interdisciplinary Plant GroupColumbiaMO65211USA Present address:National Science Foundation 2415 Eisenhower AvenueAlexandriaVA22314USA

The diversity of plant architecture is determined by axillary meristems (AMs). AMs are produced from small groups of stem cells in the axils of leaf primordia and generate vegetative branches and reproductive inflorescences . Previous studies identified genes critical for AM development that function in auxin biosynthesis, transport, and signaling. barren stalkl (ba1), a basic helix-loop-helix transcription factor, acts downstream of auxin to control AM formation. Here, we report the cloning and characterization of barren stalk2 (ba2), a mutant that fails to produce ears and has fewer branches and spikelets in the tassel, indicating that ba2 functions in reproductive AM development. Furthermore, the ba2 mutation suppresses tiller growth in the teosinte branchedl mutant, indicating that ba2 also plays an essential role in vegetative AM development. The ba2 gene encodes a protein that co-localizes and heterodimerizes with BA1 in the nucleus . Characterization of the genetic interaction between ba2 and ba1 demonstrates that ba1 shows a gene dosage effect in ba2 mutants, providing further evidence that BA1 and BA2 act together in the same pathway. Characterization of the molecular and genetic interaction between ba2 and additional genes required for the regulation of ba1 further supports this finding. The ba1 and ba2 genes are orthologs of rice genes, LAX PANICLE1 (LAX1) and LAX2, respectively, hence providing insights into pathways controlling AMs development in grasses.

关键词： maize axillary meristem inflorescenee auxin

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学会融入世界:适应未来生存的教育

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陕西师范大学学报（哲学社会科学版） 2021年第5期50卷 137-149页

作者： [澳]阿弗里卡·泰勒 [加]维罗妮卡·帕西尼—凯奇巴 [澳]明迪·布莱瑟 [美]伊维塔·西洛瓦冯用军(译) 何芳(译) 刘凤(译) 堪培拉大学创意与文化研究中心澳大利亚堪培拉2601 韦仕敦大学教育学院加拿大安大略N6A 3k7 埃迪斯科文大学教育学院澳大利亚珀斯6027 亚利桑那州立大学全球教育高级研究中心美国菲尼克斯85212 陕西师范大学教育学部北京联合大学公共外语教学部

面对人类造成的多重生存威胁,我们呼吁教育要围绕地球未来生存进行重新构想和调整。为此目的,我们提出从现在到2050年以后7项富有远见的教育宣言。提出这些宣言基于3个前提:第一,人类和地球的可持续性是一体的;第二,任何为了实现可持续... 详细信息

面对人类造成的多重生存威胁,我们呼吁教育要围绕地球未来生存进行重新构想和调整。为此目的,我们提出从现在到2050年以后7项富有远见的教育宣言。提出这些宣言基于3个前提:第一,人类和地球的可持续性是一体的;第二,任何为了实现可持续发展的未来而继续将人类与世界其他部分分离的企图都是妄想和徒劳的;第三,若要从根本上重新构想我们在这个相互依存的世界中的地位和作用,就需要发挥教育的关键作用。为此要彻底转变教育模式:从了解世界后再采取行动到学会融入并成为我们所在世界的组成部分。我们实现这种转变的能力决定了我们未来的生存。

关键词：学会融入世界未来生存生存教育教育宣言可持续发展

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