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Interview of robert ***

Science Ch.na Ch.mistry 2011年第12期54卷 2018-2020页

作者： Xue, Ziling Grubbs, robert h. Univ Tennessee Knoxville TN 37996 USA CALTECh Pasadena CA 91125 USA Stanford Univ Stanford CA 94305 USA

robert h. Grubbs is a Nobel Laureate and th. Victor and Eliza-beth.Atkins Professor of Ch.mistry at th. California Institute of Tech.ology, USA. h. grew up in th. State of Kentucky,

关键词：诺贝尔奖获得者采访加州理工学院肯塔基州

Multi-Scale Dilated Convolution Network for SPECT-MPI Cardiovascular Disease Classification with.Adaptive Denoising and Attenuation Correction

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 299-327页

作者： A.robert Singh.Suganya Ath.sayamani Gyanendra Prasad Josh. Bh.nu Sh.esth. Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia Sch.ol of Computing Sastra Deemed to be UniversityThanjavur613401Tamil NaduIndia Department of Artificial Intelligence&Software Kangwon National UniversitySamcheok25913Republic of Korea Department of Information Convergence System Graduate School of Smart ConvergenceKwangwoon UniversitySeoul01897Republic of Korea

Myocardial perfusion imaging(MPI),wh.ch.uses single-ph.ton emission computed tomograph.(SPECT),is a well-known estimating tool for medical diagnosis,employing th. classification of images to sh.w situations in coronary artery disease(CAD).Th. automatic classification of SPECT images for different tech.iques h.s ach.eved near-optimal accuracy wh.n using convolutional neural networks(CNNs).Th.s paper uses a SPECT classification framework with.th.ee steps:1)Image denoising,2)Attenuation correction,and 3)Image *** denoising is done by a U-Net arch.tecture th.t ensures effective image *** correction is implemented by a convolution neural network model th.t can remove th. attenuation th.t affects th. feature extraction process of ***,a novel multi-scale diluted convolution(MSDC)network is *** merges th. features extracted in different scales and makes th. model learn th. features more *** scales of filters with.size 3×3 are used to extract *** th.ee steps are compared with.state-of-th.-art *** proposed denoising arch.tecture ensures a h.gh.quality image with.th. h.gh.st peak signal-to-noise ratio(PSNR)value of *** proposed classification meth.d is compared with.th. five different CNN models,and th. proposed meth.d ensures better classification with.an accuracy of 96%,precision of 87%,sensitivity of 87%,specificity of 89%,and F1-score of 87%.To demonstrate th. importance of preprocessing,th. classification model was analyzed with.ut denoising and attenuation correction.

关键词： SPECT-MPI CAD MSDC denoising attenuation correction classification

Th.ee-Stage Transfer Learning with.AlexNet50 for MRI Image Multi-Class Classification with.Optimal Learning Rate

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 155-183页

作者： Suganya Ath.sayamani A.robert Singh.Gyanendra Prasad Josh. Woong Ch. Sch.ol of Computing Sastra Deemed to be UniversityThanjavur613401India Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Department of AI and Software Engineering Kangwon National UniversitySamcheok25913Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool th.t provides detailed images of a patient’s anatomical and ph.siological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret th.se images,wh.ch.can be labor-intensive and time-consuming due to th. vast amount of *** address th.s ch.llenge,mach.ne learning,and deep learning approach.s can be utilized to improve th. accuracy and efficiency of anomaly detection in MRI *** manuscript presents th. use of th. Deep AlexNet50 model for MRI classification with.discriminative learning *** are th.ee stages for learning;in th. first stage,th. wh.le dataset is used to learn th. *** th. second stage,some layers of AlexNet50 are frozen with.an augmented dataset,and in th. th.rd stage,AlexNet50 with.an augmented dataset with.th. augmented *** meth.d used th.ee publicly available MRI classification datasets:h.rvard wh.le brain atlas(h.BA-dataset),th. Sch.ol of Biomedical Engineering of South.rn Medical University(SMU-dataset),and Th. National Institute of Neuroscience and h.spitals brain MRI dataset(NINS-dataset)for *** h.perparameter optimizers like Adam,stoch.stic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW h.ve been used to compare th. performance of th. learning ***-dataset registers maximum classification *** evaluated th. performance of th. proposed classification model using several quantitative metrics,ach.eving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning h.perparameter tuning optimizer

h.man endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruch.t Laura Reich. Andrew Ch.n robert h.epner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to h.man endogenous retrovirus type-W(h.RV-W): Genomic inh.ritance from th. past includes retroviral sequences th.t h.ve been stably incorporated into our genomes and account for up to 8% of h.man DNA.

关键词： endogenous inflammation h.man

Lipid droplets in th. nervous system:involvement in cell metabolic h.meostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuch.n Zh.ng Yiqing Ch.n Ch.ng Zh.ang Jingxuan Qi robert Ch.nh.a Zh.o Jiao Wang Sch.ol of Life Sciences Shanghai UniversityShanghaiChina Sch.ol of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Ch.nese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Th.rapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and oth.r cells in th. nervous *** droplet formation begins with.th. synth.sis of neutral lipids in th. endoplasmic ***,lipid droplets were recognized for th.ir role in maintaining lipid metabolism and energy h.meostasis;h.wever,recent research.h.s sh.wn th.t lipid droplets are h.gh.y adaptive organelles with.diverse functions in th. nervous *** addition to th.ir role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exh.bit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of th. role of lipid droplets in th. nervous system,covering topics such.as biogenesis,cellular specificity,and ***,it will explore th. association between lipid droplets and neurodegenerative *** th. involvement of lipid droplets in cell metabolic h.meostasis related to th. nervous system is crucial to determine th. underlying causes and in exploring potential th.rapeutic approach.s for th.se diseases.

关键词： Alzh.imer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

Sleep as a window to understand and regulate Alzh.imer's disease:emerging roles of th.lamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： h.oqi Sun Sh.qian Sh.n robert J.Th.mas M.Brandon Westover Can Zh.ng Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research.Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzh.imer 's disease(AD) is a common neurodegenerative disorder and th. primary cause of dementia. Considerable evidence supports th. “amyloid h.poth.sis,” stating th.t th. path.genesis of AD is primarily caused by th. deposition of amyloid-β(Aβ), wh.ch.drives tau ph.sph.rylation, neuroinflammation, and neurodegeneration in th. brain. Th. amyloid h.poth.sis is strength.ned by th. significant and moderate benefit of lecanemab, a h.manized antibody th.ough.an anti-amyloid mech.nism,sh.wing slowed clinical decline(van Dyck et al.,2023). Th. recent positive results of anti-amyloid trials h.ve brough. back focus on th. amyloid h.poth.sis th.ough.bioch.mical, genetic, and ph.rmacological approach.s(Zh.ng, 2023).

关键词： Alzh.imer inflammation h.poth.sis

Climate Ch.nge:No Going Back

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Ch.na Today 2025年第1期74卷 42-44页

作者： robert WALKER Beijing Normal University Royal Society of Arts Academy of Social Sciences in th. U.K

With.a commitment to reduce emissions,and its investment in green tech.ology bringing down global costs,Ch.na is emerging as th. leader in figh.ing climate *** knows th.t our world is getting *** also know *** out po... 详细信息

关键词： investment bringing figh.ing

Novel approach.s for th. molecular classification of prostate cancer

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Asian Journal of Andrology 2010年第5期12卷 620-622页

作者： robert h. Getzenberg Department of Urology James Buchanan Brady Urological Institute The Johns Hopkins University School of MedicineBaltimore 21287 MD USA

Among th. urologic cancers, prostate cancer is by far th. most common, and it appears to h.ve th. potential to affect almost all men th.ough.ut th. world as th.y age. A number of studies h.ve sh.wn th.t many men with.prostate cancer will not die from th.ir disease, but rath.r with.th. disease but from oth.r causes. Th.se men h.ve a form of prostate cancer th.t is described as ＂very low risk＂ and h.s often been called indolent.

关键词： Prostate Cancer (genus) Neoplasms Men Beers Aluminium Classification

h.perexcitable neurons and altered non-neuronal cells in th. compressed spinal ganglion

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生理学报 2008年第5期60卷 597-602页

作者： robert h. LaMotte Ch.o MA Department of Anesth.siology Yale University School of Medicine 333 Cedar Street New Haven CT 06510 USA

Th. cell body or soma in th. dosal root ganglion(DRG) is normally excitable and th.s excitability can increase and persist after an injury of periph.ral sensory *** a rat model of radicular pain,an intraforaminal implantation of a rod th.t ch.onically compressed th. lumbar DRG("CCD" model) resulted in neuronal somal h.perexcitability and spontaneous activity th.t was accompanied by h.peralgesia in th. ipsilateral h.nd *** th. 5th.day after onset of CCD,th.re was a novel upregulation in neuronal expression of th. ch.mokine,monocyte ch.moattractant protein-1(MCP-1 or CCL2) and also its receptor,*** neurons developed,in response to topically applied MCP-1,an excitatory response th.t th.y normally do not *** also activated non-neuronal cells including,for example,th. endoth.lial cells as evidenced by angiogenesis in th. form of an increased number of capillaries in th. DRG after 7 days.A working h.poth.sis is th.t th. CCD induced ch.nges in neurons and non-neuronal cells th.t may act togeth.r to promote th. survival of th. injured *** release of ligands such.as CCL2,in addition to possibly activating nociceptive neurons(maintaining th. pain),may also act to preserve injured cells in th. face of isch.mia and h.poxia,for example,by promoting ***,somal h.perexcitability,as often said of inflammation,may represent a double edged sword.

关键词：神经元非神经细胞脊神经节临床分析